Isothiazoline derivatives as insecticidal compounds

ABSTRACT

The present invention provides compounds of formula (I) wherein P is P0, heterocyclyl or heterocyclyl substituted by one to five Z formula (II); Y 1 , Y 2 , Y 3  and Y 4  are independently of each other C—H, C—R 5 , or nitrogen; G1 is oxygen or sulfur; X 4  is C 1 -C 8  haloalkyl; R 4  is aryl or aryl substituted by one to five R 9 , or heteroaryl or heteroaryl substituted by one to five R 9 ; and R 1 , R 2 , R 4 , R 5 , R 9  and Z are as defined in the claims. The invention also provides compositions comprising the compounds of formula (I), intermediates useful in the preparation of compounds of formula (I) and methods of using the compounds of formula (I) to control insects, acarines, nematodes or molluscs.

RELATED APPLICATION INFORMATION

This application is a 371 of International Application No. PCT/EP2012/066579, filed 27 Aug. 2012, which claims priority to EP Patent Application No. 12175166.3, filed 05 Jul. 2012, and EP Patent Application No. 11181057.8 filed 13 Sep. 2011.

The present invention relates to certain isothiazoline derivatives, to processes and intermediates for preparing these derivatives, to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising these derivatives and to methods of using these derivatives to control insect, acarine, nematode and mollusc pests.

Certain isoxazoline derivatives with insecticidal properties are disclosed, for example, in EP 1,731,512. However there is a continuing need to find new biologically active compounds as well as new biologically active compounds displaying superior properties for use as agrochemical active ingredients, for example greater biological activity, different spectrum of activity, increased safety profile, or increased biodegradability.

It has now surprisingly been found that certain isothiazoline derivatives have highly potent insecticidal properties and show significantly improved bio-degradability compared to the corresponding isoxazoline analogues.

The present invention provides compounds of formula (I)

wherein

-   P is P0, heterocyclyl or heterocyclyl substituted by one to five Z;

-   Y¹, Y², Y³ and Y⁴ are independently of each other C—H, C—R⁵, or     nitrogen; -   G¹ is oxygen or sulfur; -   R¹ is hydrogen, C₁-C₈alkyl, C₁-C₈alkoxy-, C₁-C₈alkylcarbonyl-, or     C₁-C₈alkoxycarbonyl-; -   R² is C₁-C₈alkyl or C₁-C₈alkyl substituted by one to five R⁶,     C₃-C₁₀cycloalkyl or C₃-C₁₀cycloalkyl substituted by one to five R⁷,     aryl-C₁-C₄alkylene- or aryl-C₁-C₄alkylene- wherein the aryl moiety     is substituted by one to five R⁸, heterocyclyl-C₁-C₄alkylene- or     heterocyclyl-C₁-C₄alkylene- wherein the heterocyclyl moiety is     substituted by one to five R⁸, aryl-N(R²⁰)— or aryl-N(R²⁰)— wherein     the aryl moiety is substituted by one to five R⁸,     heterocyclyl-N(R²⁰)— or heterocyclyl-N(R²⁰)— wherein the     heterocyclyl moiety is substituted by one to five R⁸, aryl or aryl     substituted by one to five R⁸, heterocyclyl or heterocyclyl     substituted by one to five R⁸, C₁-C₈alkylaminocarbonyl-C₁-C₄     alkylene, C₁-C₈haloalkylaminocarbonyl-C₁-C₄ alkylene,     C₃-C₈cycloalkyl-aminocarbonyl-C₁-C₄ alkylene,     C₁-C₈alkylaminocarbonyl-, C₁-C₈haloalkylaminocarbonyl,     C₃-C₈cycloalkyl-aminocarbonyl, C₁-C₆alkyl-O—N═CH—,     C₁-C₆haloalkyl-O—N═CH—; -   or R¹ and R² together represent group A

-   G² is O(R¹³), N(R¹⁴)(R¹⁵) or S(R¹⁶); -   G³ is N(R¹⁷)(R¹⁸) or S(R¹⁹); -   X⁴ is C₁-C₈haloalkyl; -   R⁴ is aryl or aryl substituted by one to five R⁹, or heteroaryl or     heteroaryl substituted by one to five R⁹; -   each R⁵ is independently halogen, cyano, nitro, C₁-C₈alkyl,     C₁-C₈haloalkyl, C₁-C₈alkenyl, C₁-C₈haloalkenyl, C₁-C₈alkynyl,     C₁-C₈haloalkynyl, C₃-C₁₀cycloalkyl, C₁-C₈alkoxy-, C₁-C₈haloalkoxy-,     C₁-C₈alkylthio-, C₁-C₈haloalkylthio-, C₁-C₈alkylsulfinyl-,     C₁-C₈haloalkylsulfinyl-, C₁-C₈alkylsulfonyl-, or     C₁-C₈haloalkylsulfonyl-; or two R⁵ on adjacent carbon atoms together     form a —CH═CH—CH═CH— bridge; -   each R⁶ is independently halogen, cyano, nitro, hydroxy, amino,     C₁-C₈alkylamino, (C₁-C₈alkyl)₂amino, C₁-C₈alkylcarbonylamino,     C₁-C₈haloalkylcarbonylamino, C₁-C₈alkoxy-, C₁-C₈haloalkoxy-, aryloxy     or aryloxy substituted by one to five R¹⁰, aryloxy-C₁-C₄alkylene or     aryloxy-C₁-C₄alkylene wherein the aryl moiety is substituted by one     to five R¹⁰, C₁-C₈alkylcarbonyl-, C₁-C₈alkoxycarbonyl-, mercapto,     C₁-C₈alkylthio-, C₁-C₈haloalkylthio-, C₁-C₈alkylsulfinyl-,     C₁-C₈haloalkylsulfinyl-, C₁-C₈alkylsulfonyl-,     C₁-C₈haloalkylsulfonyl-, aryl-C₁-C₄alkylthio or aryl-C₁-C₄alkylthio     wherein the aryl moiety is substituted by one to five R¹⁰; -   each R⁷ is independently halogen, C₁-C₈alkyl, C₁-C₈alkenyl,     C₁-C₈alkynyl, C₁-C₈alkyl-O—N═, C₁-C₈haloalkyl-O—N═; C₁-C₈alkoxy,     C₁-C₈akoxycarbonyl; -   each R⁸ is independently halogen, cyano, nitro, oxo, C₁-C₈alkyl,     C₁-C₈haloalkyl, C₁-C₈cyanoalkyl, C₂-C₈alkenyl, C₂-C₈haloalkenyl,     C₂-C₈alkynyl, C₂-C₈haloalkynyl, C₃-C₁₀cycloalkyl,     C₃-C₁₀cycloalkyl-C₁-C₄alkylene, hydroxy, C₁-C₈alkoxy-,     C₁-C₈haloalkoxy-, mercapto, C₁-C₈alkylthio-, C₁-C₈haloalkylthio-,     C₁-C₈alkylsulfinyl-, C₁-C₈haloalkylsulfinyl-, C₁-C₈alkylsulfonyl-,     C₁-C₈haloalkylsulfonyl-, C₁-C₈alkylaminosulfonyl,     (C₁-C₈alkyl)₂aminosulfonyl-, C₁-C₈alkylcarbonyl-,     C₁-C₈alkoxycarbonyl-, aryl or aryl substituted by one to five R¹⁰,     heterocyclyl or heterocyclyl substituted by one to five R¹⁰,     aryl-C₁-C₄alkylene or aryl-C₁-C₄alkylene wherein the aryl moiety is     substituted by one to five R¹⁰, heterocyclyl-C₁-C₄alkylene or     heterocyclyl-C₁-C₄alkylene wherein the heterocyclyl moiety is     substituted by one to five R¹⁰, aryloxy or aryloxy substituted by     one to five R¹⁰, aryloxy-C₁-C₄alkylene or aryloxy-C₁-C₄alkylene     wherein the aryl moiety is substituted by one to five R¹⁰; -   each R⁹ is independently halogen, cyano, nitro, C₁-C₈alkyl,     C₁-C₈haloalkyl, C₂-C₈alkenyl, C₂-C₈haloalkenyl, C₂-C₈alkynyl,     C₂-C₈haloalkynyl, hydroxy, C₁-C₈alkoxy-, C₁-C₈haloalkoxy-, mercapto,     C₁-C₈alkylthio-, C₁-C₈haloalkylthio-, C₁-C₈alkylsulfinyl-,     C₁-C₈haloalkylsulfinyl-, C₁-C₈alkylsulfonyl-,     C₁-C₈haloalkylsulfonyl-, C₁-C₈alkylcarbonyl-, C₁-C₈alkoxycarbonyl-,     aryl or aryl substituted by one to five R¹⁰, or heterocyclyl or     heterocyclyl substituted by one to five R¹⁰; -   each R¹⁰ is independently halogen, cyano, nitro, C₁-C₄alkyl,     C₁-C₄haloalkyl, C₁-C₄alkoxy-, or C₁-C₄haloalkoxy-; -   each Z is independently halogen, C₁-C₁₂alkyl or C₁-C₁₂alkyl     substituted by one to five R⁶, nitro, C₁-C₁₂alkoxy or C₁-C₁₂alkoxy     substituted by one to five R⁶, cyano, C₁-C₁₂alkylsulfinyl,     C₁-C₁₂alkylsulfonyl, C₁-C₁₂haloalkylsulfinyl,     C₁-C₁₂haloalkylsulfonyl, hydroxyl or thiol; -   R¹³, R¹⁶ and R¹⁹ are independently C₁-C₄ alkyl; -   R¹⁴, R¹⁵, R¹⁷, and R¹⁸ are independently hydrogen or C₁-C₄ alkyl; -   R²⁰ is hydrogen or C₁-C₄ alkyl; -   or a salt or N-oxide thereof.

The compounds of formula (I) may exist in different geometric or optical isomers or tautomeric forms. This invention covers all such isomers and tautomers and mixtures thereof in all proportions as well as isotopic forms such as deuterated compounds. The invention also covers N-oxides and salts. The compounds of the invention may contain one or more additional asymmetric carbon atoms and may exist as enantiomers (or as pairs of diastereoisomers) or as mixtures of such.

Alkyl groups (either alone or as part of a larger group, such as alkoxy-, alkylthio-, alkylsulfinyl-, alkylsulfonyl-, alkylcarbonyl- or alkoxycarbonyl-) can be in the form of a straight or branched chain and are, for example, methyl, ethyl, propyl, prop-2-yl, butyl, but-2-yl, 2-methyl-prop-1-yl or 2-methyl-prop-2-yl. The alkyl groups are preferably C₁-C₆, more preferably C₁-C₄, most preferably C₁-C₃ alkyl groups. Where an alkyl moiety is said to be substituted, the alkyl moiety is preferably substituted by one to four substituents, most preferably by one to three substituents.

Alkylene groups can be in the form of a straight or branched chain and are, for example, —CH₂—, —CH₂—CH₂—, —CH(CH₃)—, —CH₂—CH₂—CH₂—, —CH(CH₃)—CH₂—, or —CH(CH₂CH₃)—. The alkylene groups are preferably C₁-C₃, more preferably C₁-C₂, most preferably C₁ alkylene groups.

Alkenyl groups can be in the form of straight or branched chains, and can be, where appropriate, of either the (E)- or (Z)-configuration. Examples are vinyl and allyl. The alkenyl groups are preferably C₂-C₆, more preferably C₂-C₄, most preferably C₂-C₃ alkenyl groups.

Alkynyl groups can be in the form of straight or branched chains. Examples are ethynyl and propargyl. The alkynyl groups are preferably C₂-C₆, more preferably C₂-C₄, most preferably C₂-C₃ alkynyl groups.

Halogen is fluorine, chlorine, bromine or iodine.

Haloalkyl groups (either alone or as part of a larger group, such as haloalkoxy-, haloalkylthio-, haloalkylsulfinyl- or haloalkylsulfonyl-) are alkyl groups which are substituted by one or more of the same or different halogen atoms and are, for example, difluoromethyl, trifluoromethyl, chlorodifluoromethyl or 2,2,2-trifluoro-ethyl.

Haloalkenyl groups are alkenyl groups which are substituted by one or more of the same or different halogen atoms and are, for example, 2,2-difluoro-vinyl or 1,2-dichloro-2-fluoro-vinyl.

Haloalkynyl groups are alkynyl groups which are substituted by one or more of the same or different halogen atoms and are, for example, 1-chloro-prop-2-ynyl.

Cycloalkyl groups or carbocyclic rings can be in mono- or bi-cyclic form and are, for example, cyclopropyl, cyclobutyl, cyclohexyl and bicyclo[2.2.1]heptan-2-yl. The cycloalkyl groups are preferably C₃-C₈, more preferably C₃-C₆ cycloalkyl groups. Where a cycloalkyl moiety is said to be substituted, the cycloalkyl moiety is preferably substituted by one to four substituents, most preferably by one to three substituents.

Aryl groups (either alone or as part of a larger group, such as aryl-alkylene-) are aromatic ring systems which can be in mono-, bi- or tricyclic form. Examples of such rings include phenyl, naphthyl, anthracenyl, indenyl or phenanthrenyl. Preferred aryl groups are phenyl and naphthyl, phenyl being most preferred. Where an aryl moiety is said to be substituted, the aryl moiety is preferably substituted by one to four substituents, most preferably by one to three substituents.

Heteroaryl groups (either alone or as part of a larger group, such as heteroaryl-alkylene-) are aromatic ring systems containing at least one heteroatom and consisting either of a single ring or of two or more fused rings. Preferably, single rings will contain up to three heteroatoms and bicyclic systems up to four heteroatoms which will preferably be chosen from nitrogen, oxygen and sulfur. Examples of monocyclic groups include pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl (e.g. 1.2.4 triazoyl), furanyl, thiophenyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl and thiadiazolyl. Examples of bicyclic groups include purinyl, quinolinyl, cinnolinyl, quinoxalinyl, indolyl, indazolyl, benzimidazolyl, benzothiophenyl and benzothiazolyl. Monocyclic heteroaryl groups are preferred, pyridyl being most preferred. Where a heteroaryl moiety is said to be substituted, the heteroaryl moiety is preferably substituted by one to four substituents, most preferably by one to three substituents.

Heterocyclyl groups or heterocyclic rings (either alone or as part of a larger group, such as heterocyclyl-alkylene-) are defined to include heteroaryl groups and in addition their unsaturated or partially unsaturated analogues. Examples of monocyclic groups include isoxazolyl, thietanyl, pyrrolidinyl, tetrahydrofuranyl, [1,3]dioxolanyl, piperidinyl, piperazinyl, [1,4]dioxanyl, and morpholinyl or their oxidised versions such as 1-oxo-thietanyl and 1,1-dioxo-thietanyl. Examples of bicyclic groups include 2,3-dihydro-benzofuranyl, benzo[1,4]dioxolanyl, benzo[1,3]dioxolanyl, chromenyl, and 2,3-dihydro-benzo[1,4]dioxinyl. Where a heterocyclyl moiety is said to be substituted, the heterocyclyl moiety is preferably substituted by one to four substituents, most preferably by one to three substituents.

Preferred values of P, Y¹, Y², Y³, Y⁴, G¹, Z, R¹, R², X⁴, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹ and R¹⁰ are, in any combination, as set out below.

Preferably, P is P0, or a heterocycle selected from H1 to H9.

k is 0, 1 or 2.

When P is a heterocycle, P is preferably H2 or H6.

More preferably P is P0.

In one group of compounds P is P0. In another group of compounds P is a heterocycle, preferably selected form H1 to H9, more preferably H2 or H6.

Preferably no more than two of Y¹, Y², Y³ and Y⁴ are nitrogen, more preferably no more than one of Y¹, Y², Y³ and Y⁴ is nitrogen.

Preferably Y¹ is C—H or C—R⁵, most preferably Y¹ is C—H.

Preferably Y² is C—H or C—R⁵, most preferably Y² is C—H.

Preferably Y³ is C—H or C—R⁵, most preferably Y³ is C—H.

Preferably Y⁴ is C—H or C—R⁵, most preferably Y⁴ is C—R⁵.

In one preferred group of compounds Y¹ is C—R^(5b), C—H or nitrogen, Y² and Y³ are independently C—H or nitrogen and Y⁴ is C—R⁵; wherein no more than two of Y¹, Y² and Y³ are nitrogen and wherein Y² and Y³ are not both nitrogen, and wherein R^(5b) when present forms a —CH═CH—CH═CH— bridge with R⁵.

In another preferred group of compounds Y¹ is C—H, Y² is C—H or nitrogen, Y³ is C—H or nitrogen and Y⁴ is C—R⁵, wherein Y² and Y³ are not both nitrogen.

In another preferred group of compounds Y¹ is C—H, Y² is C—H, Y³ is C—H and Y⁴ is C—R⁵.

Preferably G¹ is oxygen.

Preferably R¹ is hydrogen, methyl, ethyl, methylcarbonyl-, or methoxycarbonyl-, more preferably hydrogen, methyl or ethyl, most preferably hydrogen.

Preferably, R² is C₁-C₈alkyl or C₁-C₈alkyl substituted by one to five R⁶, C₃-C₁₀cycloalkyl or C₃-C₁₀cycloalkyl substituted by one to five R⁷, aryl-C₁-C₄alkylene- or aryl-C₁-C₄alkylene- wherein the aryl moiety is substituted by one to five R⁸, heterocyclyl-C₁-C₄alkylene- or heterocyclyl-C₁-C₄alkylene- wherein the heterocyclyl moiety is substituted by one to five R⁸, aryl or aryl substituted by one to five R⁸, heterocyclyl or heterocyclyl substituted by one to five R⁸, C₁-C₈alkylaminocarbonyl-C₁-C₄ alkylene, C₁-C₈haloalkylaminocarbonyl-C₁-C₄ alkylene, C₃-C₈cycloalkyl-aminocarbonyl-C₁-C₄ alkylene, or group C1

wherein R¹¹ is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, cyclopropyl, cyclopropyl-methyl, cyclobutyl, cyclobutyl-methyl, oxetanyl, thietanyl, trifluoroethyl, difluoroethyl, allyl, propargyl, cyanomethyl, benzyl, benzyl substituted by one to three R¹², or R¹¹ is pyridyl-methyl- or pyridyl-methyl-substituted by one to three R¹²; and each R¹² is independently fluoro, chloro, bromo, trifluoromethyl, trifluoromethoxy, cyano or methoxy.

More preferably R² is C₁-C₈alkyl or C₁-C₈alkyl substituted by one to five R⁶, C₃-C₁₀cycloalkyl or C₃-C₁₀cycloalkyl substituted by one to five R⁷, aryl-C₁-C₄alkylene- or aryl-C₁-C₄alkylene- wherein the aryl moiety is substituted by one to five R⁸, heterocyclyl-C₁-C₄alkylene- or heterocyclyl-C₁-C₄alkylene- wherein the heterocyclyl moiety is substituted by one to five R⁸, aryl or aryl substituted by one to five R⁸, heterocyclyl or heterocyclyl substituted by one to five R⁸, C₁-C₈alkylaminocarbonyl-C₁-C₄ alkylene, C₁C₈haloalkylaminocarbonyl-C₁-C₄ alkylene, C₃-C₈cycloalkyl-aminocarbonyl-C₁-C₄ alkylene, or group C1 wherein each aryl group is a phenyl group and each heterocyclyl group is independently selected from pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, tetrahydrothiophenyl, tetrazolyl, furanyl, thiophenyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, quinolinyl, cinnolinyl, quinoxalinyl, indolyl, indazolyl, benzimidazolyl, benzothiophenyl, benzothiazolyl, oxetanyl, thietanyl, oxo-thietanyl, dioxo-thietanyl, pyrrolidinyl, tetrahydrofuranyl, [1,3]dioxolanyl, piperidinyl, piperazinyl, [1,4]dioxanyl, and morpholinyl, 2,3-dihydro-benzofuranyl, benzo[1,3]dioxolanyl, and 2,3-dihydro-benzo[1,4]dioxinyl.

More preferably R² is C₁-C₈alkyl or C₁-C₈alkyl substituted by one to five R⁶, C₃-C₁₀cycloalkyl or C₃-C₁₀cycloalkyl substituted by one to five R⁷, aryl-C₁-C₄alkylene- or aryl-C₁-C₄alkylene- wherein the aryl moiety is substituted by one to five R⁸, heterocyclyl-C₁-C₄alkylene- or heterocyclyl-C₁-C₄alkylene- wherein the heterocyclyl moiety is substituted by one to five R⁸, aryl or aryl substituted by one to five R⁸, heterocyclyl or heterocyclyl substituted by one to five R⁸, C₁-C₈alkylaminocarbonyl-C₁-C₄ alkylene, C₁-C₈haloalkylaminocarbonyl-C₁-C₄ alkylene, C₃-C₈cycloalkyl-aminocarbonyl-C₁-C₄ alkylene, or group C1, wherein each aryl group is a phenyl group and each heterocyclyl group is selected from 1,2,3 triazolyl, 1,2,4 triazolyl, tetrazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, tetrahydrothiophenyl, isoxazolinyl, pyridyl, tetrahydrofuranyl, imidazolyl, pyrazolyl, pyrrolyl, thiazolyl, oxetanyl, thietanyl, oxo-thietanyl and dioxo-thietanyl.

More preferably still R² is C₁-C₈alkyl or C₁-C₈alkyl substituted by one to five R⁶, C₃-C₁₀cycloalkyl or C₃-C₁₀cycloalkyl substituted by one to five R⁷, aryl-C₁-C₄alkylene- or aryl-C₁-C₄alkylene- wherein the aryl moiety is substituted by one to five R⁸, heterocyclyl-C₁-C₄alkylene- or heterocyclyl-C₁-C₄alkylene- wherein the heterocyclyl moiety is substituted by one to five R⁸, aryl or aryl substituted by one to five R⁸, heterocyclyl or heterocyclyl substituted by one to five R⁸, C₁-C₈alkylaminocarbonyl-C₁-C₄ alkylene, C₁-C₈haloalkylaminocarbonyl-C₁-C₄ alkylene, C₃-C₈cycloalkyl-aminocarbonyl-C₁-C₄ alkylene, or group C1, wherein each aryl group is a phenyl group and each heterocyclyl group is selected from pyridyl, tetrahydrofuranyl, imidazolyl, pyrazolyl, pyrrolyl, thiazolyl, oxetanyl, thietanyl, oxo-thietanyl and dioxo-thietanyl.

More preferably still R² is C₁-C₈alkyl or C₁-C₈alkyl substituted by one to five R⁶, C₃-C₁₀cycloalkyl or C₃-C₁₀cycloalkyl substituted by one to five R⁷, phenyl-C₁-C₄alkylene- or phenyl-C₁-C₄alkylene- wherein the phenyl moiety is substituted by one to five R⁸, pyridyl-C₁-C₄alkylene- or pyridyl-C₁-C₄alkylene- wherein the pyridyl moiety is substituted by one to four R⁸, tetrahydrofuranyl-C₁-C₄alkylene- or tetrahydrofuranyl-C₁-C₄alkylene- wherein the tetrahydrofuranyl moiety is substituted by one to five R⁸, imidazolyl-C₁-C₄alkylene- or imidazolyl-C₁-C₄alkylene- wherein the imidazolyl moiety is substituted by one to three R⁸, pyrazolyl-C₁-C₄alkylene- or pyryazolyl-C₁-C₄alkylene- wherein the pyrazolyl moiety is substituted by one to three R⁸, pyrrolyl-C₁-C₄alkylene- or pyrrolyl-C₁-C₄alkylene- wherein the pyrrolyl moiety is substituted by one to four R⁸, thiazolyl-C₁-C₄alkylene- or thiazolyl-C₁-C₄alkylene- wherein the thiazolyl moiety is substituted by one to four R⁸, oxetanyl-C₁-C₄ alkylene or oxetanyl-C₁-C₄ alkylene wherein the oxetanyl moiety is substituted by one to five R⁸, thietanyl-C₁-C₄ alkylene or thietanyl-C₁-C₄ alkylene wherein the thietanyl moiety is substituted by one to five R⁸, oxo-thietanyl-C₁-C₄ alkylene or oxo-thietanyl-C₁-C₄ alkylene wherein the oxo-thietanyl moiety is substituted by one to five R⁸, dioxo-thietanyl-C₁-C₄ alkylene or dioxo-thietanyl-C₁-C₄ alkylene wherein the dioxo-thietanyl moiety is substituted by one to five R⁸, oxetanyl or oxetanyl substituted by one to five R⁸, thietanyl or thietanyl substituted by one to five R⁸, oxo-thietanyl or oxo-thietanyl substituted by one to five R⁸, dioxo-thietanyl or dioxo-thietanyl substituted by one to five R⁸, C₁-C₈alkylaminocarbonyl-C₁-C₄ alkylene, C₁-C₈haloalkylaminocarbonyl-C₁-C₄ alkylene, C₃-C₈cycloalkyl-aminocarbonyl-C₁-C₄ alkylene, or group C1.

Even more preferably R² is C₁-C₈alkyl or C₁-C₈alkyl substituted by one to five R⁶, C₃-C₁₀cycloalkyl or C₃-C₁₀cycloalkyl substituted by one to five R⁷, phenyl-C₁-C₄alkylene- or phenyl-C₁-C₄alkylene- wherein the phenyl moiety is substituted by one to five R⁸, pyridyl-C₁-C₄alkylene- or pyridyl-C₁-C₄alkylene- wherein the pyridyl moiety is substituted by one to four R⁸, oxetanyl or oxetanyl substituted by one to five R⁸, thietanyl-C₁-C₄ alkylene or thietanyl-C₁-C₄ alkylene wherein the thietanyl moiety is substituted by one to five R⁸, oxo-thietanyl-C₁-C₄ alkylene or oxo-thietanyl-C₁-C₄ alkylene wherein the oxo-thietanyl moiety is substituted by one to five R⁸, dioxo-thietanyl-C₁-C₄ alkylene or dioxo-thietanyl-C₁-C₄ alkylene wherein the dioxo-thietanyl moiety is substituted by one to five R⁸, thietanyl or thietanyl substituted by one to five R⁸, oxo-thietanyl or oxo-thietanyl substituted by one to five R⁸, dioxo-thietanyl or dioxo-thietanyl substituted by one to five R⁸, C₁-C₈alkylaminocarbonyl-C₁-C₄ alkylene, C₁-C₈haloalkylaminocarbonyl-C₁-C₄ alkylene, or C₃-C₈cycloalkyl-aminocarbonyl-C₁-C₄ alkylene, or group C1.

Yet even more preferably R² is C₁-C₈alkyl or C₁-C₈alkyl substituted by one to three halogen atoms, C₃-C₁₀cycloalkyl or C₃-C₁₀cycloalkyl substituted by one or two groups independently selected from fluoro and methyl, phenyl-C₁-C₄alkylene- or phenyl-C₁-C₄alkylene- wherein the phenyl moiety is substituted by one to five R⁸, pyridyl-C₁-C₄alkylene- or pyridyl-C₁-C₄alkylene- wherein the pyridyl moiety is substituted by one to four R⁸, thietanyl, oxo-thietanyl, dioxo-thietanyl, C₁-C₈alkylaminocarbonyl-methylene, C₁-C₈haloalkylaminocarbonyl-methylene, C₃-C₈cycloalkyl-aminocarbonyl-methylene, or group C1.

A group of preferred compounds are those wherein R² is C₁-C₆alkyl or C₁-C₆alkyl substituted by one to five R⁶, for example ethyl-, butyl-, but-2-yl-, 3-bromo-propyl-, 2,2,2-trifluoro-ethyl-, 3,3,3-trifluoro-propyl-, 2-methoxy-ethyl-, and 1-methoxy-prop-2-yl-.

A group of preferred compounds are those wherein R² is C₃-C₈cycloalkyl or C₃-C₈cycloalkyl substituted by one to five R⁷, for example cyclobutyl-, 2-fluoro-cyclopropyl and 2-methyl-cyclohex-1-yl-.

A group of preferred compounds are those wherein R² is aryl-C₁-C₂alkylene- or aryl-C₁-C₂alkylene- wherein the aryl moiety is substituted by one to five R⁸, for example phenyl-methyl-, 1-phenyl-eth-1-yl-, 2-phenyl-eth-1-yl-, (3-chloro-phenyl)-methyl-, (2-fluoro-phenyl)-methyl-, (4-methoxy-phenyl)-methyl-, (2-trifluoromethyl-phenyl)-methyl-, and (2-trifluoromethoxy-phenyl)-methyl-.

A group of preferred compounds are those wherein R² is heterocyclyl-C₁-C₂alkylene- or heterocyclyl-C₁-C₂alkylene- wherein the heterocyclyl moiety is substituted by one to five R⁸, for example (pyrid-2-yl)-methyl-, (pyrid-3-yl)-methyl-, (2-chloro-pyrid-5-yl)-methyl-, (1-methyl-1H-imidazol-4-yl)-methyl-, (furan-2-yl)-methyl-, 2-(thiophen-2′-yl)-eth-1-yl-, 2-(indol-3′-yl)-eth-1-yl-, (1H-benzimidazol-2-yl)-methyl-, (oxetan-2-yl)-methyl-, (tetrahydrofuran-2-yl)-methyl-, 2-([1′,3′]dioxolan-2′-yl)-eth-1-yl-, 2-(morpholin-4′-yl)-eth-1-yl-, 2-(benzo[1′,3′]dioxol-5′-yl)-eth-1-yl-, (2,3-dihydro-benzo[1,4]dioxin-6-yl)-methyl-, thietan-2-yl-methyl-, 1-oxo-thietan-2-yl-methyl-, 1,1-dioxo-thietan-2-yl-methyl-, thietan-3-yl-methyl-, 1-oxo-thietan-3-yl-methyl-, 1,1-dioxo-thietan-3-yl-methyl-, thietan-3-yl-ethyl-, 1-oxo-thietan-3-yl-ethyl-, and 1,1-dioxo-thietan-3-yl-ethyl-, preferably thietan-2-yl-methyl-, 1-oxo-thietan-2-yl-methyl-, 1,1-dioxo-thietan-2-yl-methyl-, thietane-3-yl-methyl-, 1-oxo-thietan-3-yl-methyl-, 1,1-dioxo-thietan-3-yl-methyl-, thietan-3-yl-ethyl-, 1-oxo-thietan-3-yl-ethyl-, and 1,1-dioxo-thietan-3-yl-ethyl-.

A group of preferred compounds are those wherein R² is heterocyclyl-C₁-C₂alkylene- or heterocyclyl-C₁-C₂alkylene- wherein the heterocyclyl moiety is substituted by one to five R⁸ in which the heterocyclyl group is selected from 1,2,3 triazolyl, 1,2,4 triazolyl, tetrazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, tetrahydrothiophenyl, isoxazolinyl, pyridyl, tetrahydrofuranyl, imidazolyl, pyrazolyl, pyrrolyl, thiazolyl, oxetanyl, thietanyl, oxo-thietanyl and dioxo-thietanyl, preferably the heterocyclyl group is selected from thietanyl, oxo-thietanyl and dioxo-thietanyl.

A group of preferred compounds are those wherein R² is heteroaryl-C₁-C₂alkylene- or heteroaryl-C₁-C₂alkylene- wherein the heteroaryl moiety is substituted by one to five R⁸.

A group of preferred compounds are those wherein R² is aryl or aryl substituted by one to five R⁸, for example 2-chloro-phenyl-, 3-fluoro-phenyl-, 2-methyl-phenyl-, 2-chloro-6-methyl-phenyl-, 2-trifluoromethyl-phenyl-, and 2,4-dimethoxy-phenyl-.

A group of preferred compounds are those wherein R² is heterocyclyl or heterocyclyl substituted by one to five R⁸, for example 3-methyl-pyrid-2-yl-, 1,3-dimethyl-1H-pyrazol-5-yl-, 4-methyl-thiazol-2-yl-, 5-methyl-thiadiazol-2-yl-, quinolin-2-yl-, quinolin-5-yl-, benzothiazol-6-yl-, 4-methyl-benzothiazol-2-yl-, thietan-3-yl-, 1-oxo-thietan-3-yl-, 1,1-dioxo-thietan-3-yl-, and 3-methyl-thietan-3-yl-, more preferably R² is oxetanyl, thietanyl, oxo-thietanyl or dioxo-thietanyl each optionally substituted by one to five R⁸, most preferably R² is thietanyl, oxo-thietanyl or dioxo-thietanyl each optionally substituted by one to five R⁸. It is particularly preferred that the oxetanyl, thietanyl, oxo-thietanyl or dioxo-thietanyl ring is linked via the 3-position.

A group of preferred compounds are those wherein R² is heterocyclyl- or heterocyclyl substituted by one to five R⁸ in which the heterocyclyl group is selected from 1,2,3 triazolyl, 1,2,4 triazolyl, tetrazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, tetrahydrothiophenyl, isoxazolinyl, pyridyl, tetrahydrofuranyl, imidazolyl, pyrazolyl, pyrrolyl, thiazolyl, oxetanyl, thietanyl, oxo-thietanyl and dioxo-thietanyl, preferably the heterocyclyl group is selected from thietanyl, oxo-thietanyl and dioxo-thietanyl.

A group of preferred compounds are those wherein R² is C₁-C₈alkylaminocarbonyl-C₁-C₄ alkylene, C₁-C₈haloalkylaminocarbonyl-C₁-C₄ alkylene, or C₃-C₈cycloalkyl-aminocarbonyl-C₁-C₄ alkylene, more preferably C₁-C₄alkylaminocarbonyl-C₁-C₄ alkylene, C₁-C₄haloalkylaminocarbonyl-C₁-C₄ alkylene, or C₃-C₆cycloalkyl-aminocarbonyl-C₁-C₄ alkylene, most preferably C₁-C₄alkylaminocarbonyl-C₁-C₂ alkylene or C₁-C₄haloalkylaminocarbonyl-C₁-C₂ alkylene.

A group of preferred compounds are those wherein R¹ and R² together represent group A

wherein G² and G³ are as defined above, for example group A1, A2, A3 or A4

wherein R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, R¹⁸ and R¹⁹ are as defined above. R¹³, R¹⁷, R¹⁸ and R¹⁹ are preferably C₁-C₄alkyl, more preferably methyl or ethyl/R¹⁴ and R¹⁵ are preferably hydrogen.

A group of preferred compounds are those wherein R² is group C1.

A group of preferred compounds are those wherein R² is group C2.

wherein L is a bond, methylene or ethylene; one of A¹ and A² is S, SO or SO₂ and the other is —C(R^(3a))R^(3a)—; R³ is hydrogen or methyl; each R^(3a) is independently hydrogen or methyl; and preferably L is a bond, preferably R³ and each R^(3a) is hydrogen; preferably A¹ is —C(R⁴)R⁴—, more preferably —CH₂—; preferably A² is S, SO or SO₂.

In one group of compounds P is selected from P0 and P1 to P44 and R² is group C1 or C2

Preferably X⁴ is chlorodifluoromethyl or trifluoromethyl, most preferably trifluoromethyl.

Preferably R⁴ is aryl or aryl substituted by one to five R⁹, more preferably aryl substituted by one to three R⁹, more preferably phenyl substituted by one to three R⁹. In one group of compounds R is group (B)

wherein X² is C—X⁶ or nitrogen (preferably C—X⁶); X¹, X³ and X⁶ are independently hydrogen, halogen or trihalomethyl, e.g. wherein at least two of X¹, X³ and X⁶ are not hydrogen; even more preferably R⁴ is 3,5-dichlorophenyl-, 3-chloro-4-fluorophenyl-, 3-fluoro-4-chlorophenyl-, 3,4-dichlorophenyl-, 3-chloro-4-bromophenyl-, 3,5-dichloro-4-fluorophenyl-, 3,4,5-trichlorophenyl-, 3,5-dichloro-4-iodophenyl-, 3,4,5-trifluorophenyl-, 3-chloro-5-bromophenyl-, 3-chloro-5-fluorophenyl-, 3-chloro-5-(trifluoromethyl)phenyl-, 3,4-dichloro-5-(trifluoromethyl)phenyl-, 3,5-bis(trifluoromethyl)phenyl-, 4-chloro-3,5-bis(trifluoromethyl)phenyl-, 3-(trifluoromethyl)phenyl-, 2,6-dichloro-4-pyridyl-, 2,6-bis(trifluoromethyl)-4-pyridyl-, more preferably 3-chloro-5-bromophenyl-, 3-chloro-5-(trifluoromethyl)phenyl-, 3,5-dichloro-4-fluorophenyl-, 3,4,5-trichlorophenyl-, 3,5-bis(trifluoromethyl)phenyl-, 3-(trifluoromethyl)phenyl-, 2,6-dichloro-4-pyridyl-, 2,6-bis(trifluoromethyl)-4-pyridyl-, 3,5-dichloro-4-bromophenyl-, 3-bromo-5-(trifluoromethyl)phenyl-, 3,5-dibromophenyl-, or 3,4-dichlorophenyl-, even more preferably 3,5-dichloro-phenyl, 3,5-dichloro-4-fluorophenyl-, 3,4,5-trichlorophenyl-, 3,5-bis(trifluoromethyl)phenyl-, most preferably R⁴ is 3,5-dichloro-phenyl.

In one group of compounds R⁴ is 3,5-dichloro-phenyl. In one group of compounds R⁴ is 3,5-dichloro-4-fluorophenyl-. In one group of compounds R⁴ is 3,4,5-trichlorophenyl-. In one group of compounds R⁴ is 3,5-bis(trifluoromethyl)phenyl.

Preferably each R⁵ is independently halogen, cyano, nitro, NH₂, C₁-C₈alkyl, C₁-C₈haloalkyl, C₃-C₅cycloalkyl, C₃-C₅halocycloalkyl, C₁-C₈alkenyl, C₁-C₈haloalkenyl, C₁-C₈alkoxy-, or C₁-C₈haloalkoxy-, preferably halogen, cyano, nitro, NH₂, C₁-C₂alkyl, C₁-C₂haloalkyl, C₃-C₅cycloalkyl, C₃-C₅halocycloalkyl, C₁-C₂alkoxy, C₁-C₂haloalkoxy; more preferably chloro, bromo, fluoro, trifluoromethyl, methyl, ethyl, methoxy, nitro, trifluoromethoxy, cyano, cyclopropyl, even more preferably R⁵ is chloro, bromo, fluoro, methyl or trifluoromethyl, most preferably methyl.

In one group of compounds R⁵ is chloro. In one group of compounds R⁵ is bromo. In one group of compounds R⁵ is methyl. In one group of compounds R⁵ is halogen.

Preferably each R⁶ is independently halogen, cyano, nitro, hydroxy, C₁-C₈alkoxy-, C₁-C₈haloalkoxy-, C₁-C₈alkylcarbonyl-, C₁-C₈alkoxycarbonyl-, mercapto, C₁-C₈alkylthio-, C₁-C₈haloalkylthio-, C₁-C₈alkylsulfinyl-, C₁-C₈haloalkylsulfinyl-, C₁-C₈alkylsulfonyl-, or C₁-C₈haloalkylsulfonyl-, more preferably each R⁶ is independently halogen, cyano, nitro, hydroxy, C₁-C₈alkoxy-, C₁-C₈haloalkoxy-, mercapto, C₁-C₈alkylthio-, C₁-C₈haloalkylthio-, more preferably bromo, chloro, fluoro, methoxy, or methylthio, most preferably chloro, fluoro, or methoxy.

Preferably each R⁷ is independently halogen or C₁-C₈alkyl, more preferably each R⁷ is independently chloro, fluoro or methyl, most preferably fluoro or methyl.

Preferably each R⁸ is independently halogen, cyano, nitro, C₁-C₈alkyl, C₁-C₈haloalkyl, C₂-C₈alkenyl, C₂-C₈haloalkenyl, C₂-C₈alkynyl, C₂-C₈haloalkynyl, hydroxy, C₁-C₈alkoxy-, C₁-C₈haloalkoxy-, mercapto, C₁-C₈alkylthio-, C₁-C₈haloalkylthio-, C₁-C₈alkylsulfinyl-, C₁-C₈haloalkylsulfinyl-, C₁-C₈alkylsulfonyl-, C₁-C₈haloalkylsulfonyl-, C₁-C₈alkylcarbonyl-, C₁-C₈alkoxycarbonyl-, aryl or aryl substituted by one to five R¹⁰, or heterocyclyl or heterocyclyl substituted by one to five R¹⁰, more preferably each R⁸ is independently halogen, cyano, nitro, C₁-C₈alkyl, C₁-C₈haloalkyl, C₁-C₈alkoxy-, C₁-C₈haloalkoxy-, more preferably bromo, chloro, fluoro, cyano, nitro, methyl, ethyl, trifluoromethyl, methoxy, difluoromethoxy, or trifluoromethoxy, most preferably bromo, chloro, fluoro, cyano or methyl.

Preferably each R⁹ is independently halogen, C₁-C₈alkyl, C₁-C₈haloalkyl, C₁-C₈alkoxy-, C₁-C₈haloalkoxy-, C₁-C₈alkylthio-, or C₁-C₈haloalkylthio-, more preferably bromo, chloro, fluoro, trifluoromethyl, methoxy, or methylthio, most preferably bromo or chloro.

Preferably each R¹⁰ is independently bromo, chloro, fluoro, cyano, nitro, methyl, ethyl, trifluoromethyl, methoxy, difluoromethoxy, or trifluoromethoxy, more preferably bromo, chloro, fluoro, nitro, or methyl, most preferably chloro, fluoro, or methyl.

Preferably R¹¹ is methyl, ethyl or trifluoroethyl.

Preferably each Z is independently halogen, cyano, C₁-C₄alkyl, C₁-C₄haloalkyl, C₁-C₄alkoxy, or C₁-C₄haloalkoxy, more preferably each Z is independently hydrogen, halogen, methyl, halomethyl, methoxy or halomethoxy.

In one embodiment E1 the present invention provides compounds of formula (Ia-1)

wherein G¹, R¹, R², X⁴, R⁴ and R⁵ are as defined for compounds of formula (I); or a salt or N-oxide thereof. The preferences for G¹, R¹, R², X⁴, R⁴ and R⁵ are the same as the preferences set out for the corresponding substituents of compounds of the formula (I).

In one embodiment E2 the present invention provides compounds of formula (Ia-2)

wherein G¹, R¹, R², X⁴, and R⁴ are as defined for compounds of formula (I); or a salt or N-oxide thereof. The preferences for G¹, R¹, R², X⁴ and R⁴ are the same as the preferences set out for the corresponding substituents of compounds of the formula (I).

In a further embodiment E3 the present invention provides compounds of formula (Ia-3)

wherein G¹, R¹, R², X⁴, and R⁴ are as defined for compounds of formula (I); or a salt or N-oxide thereof. The preferences for G¹, R¹, R², X⁴ and R⁴ are the same as the preferences set out for the corresponding substituents of compounds of the formula (I).

In a further embodiment E4 the present invention provides compounds of formula (Ib-1)

wherein X⁴, R⁴ and R⁵ are as defined for compounds of formula (I) and Het is selected from H1 to H9 as defined for compounds of formula (I); or a salt or N-oxide thereof. The preferences for X⁴, R⁴, R⁵, and Het are the same as the preferences set out for the corresponding substituents of compounds of the formula (I).

In a further embodiment E5 the present invention provides compounds of formula (Ib-2)

wherein X⁴ and R⁴ are as defined for compounds of formula (I) and Het is selected from H1 to H9 as defined for compounds of formula (I); or a salt or N-oxide thereof. The preferences for X⁴, R⁴ and Het are the same as the preferences set out for the corresponding substituents of compounds of the formula (I).

In a further embodiment E6 the present invention provides compounds of formula (Ib-3)

wherein X⁴ and R⁴ are as defined for compounds of formula (I) and Het is selected from H1 to H9 as defined for compounds of formula (I); or a salt or N-oxide thereof. The preferences for X⁴, R⁴ and Het are the same as the preferences set out for the corresponding substituents of compounds of the formula (I).

In a further embodiment E7 the present invention provides compounds of formula (Ic)

wherein

-   P is as defined for compounds of formula I including preferred     definitions thereof; -   Y¹ is C—R^(5b), CH or nitrogen; -   Y² and Y³ are independently CH or nitrogen; -   wherein no more than two of Y¹, Y² and Y³ are nitrogen and wherein     Y² and Y³ are not both nitrogen; -   R⁵ is hydrogen, halogen, cyano, nitro, NH₂, C₁-C₂alkyl,     C₁-C₂haloalkyl, C₃-C₅cycloalkyl, C₃-C₅halocycloalkyl, C₁-C₂alkoxy,     C₁-C₂haloalkoxy; -   R^(5b) when present together with R⁵ forms a —CH═CH—CH═CH— bridge; -   X² is C—X⁶ or nitrogen; -   X¹, X³ and X⁶ are independently hydrogen, halogen or trihalomethyl,     wherein at least two of X¹, X³ and X⁶ are not hydrogen; -   X⁴ is trifluoromethyl, difluoromethyl or chlorodifluoromethyl.

In a further embodiment E8 the present invention provides compounds of formula (Ic) wherein R⁴, X¹, X², X³, X⁴ and X⁶ are as defined for the compounds of formula Ic and P is selected from P0 and P1 to P44; G¹ is oxygen; R¹ is hydrogen; R² is A1 or A2; L is a bond, methylene or ethylene; one of A¹ and A² is S, SO or SO₂ and the other is —C(R^(3a))R^(3a)—; R³ is hydrogen or methyl; each R^(3a) is independently hydrogen or methyl; R¹¹ is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, cyclopropyl, cyclopropyl-methyl, cyclobutyl, cyclobutyl-methyl, oxetanyl, thietanyl, trifluoroethyl, difluoroethyl, allyl, propargyl, cyanomethyl, benzyl, benzyl substituted by one to three R¹², or R¹¹ is pyridyl-methyl- or pyridyl-methyl-substituted by one to three R¹²; each R¹² is independently fluoro, chloro, bromo, trifluoromethyl, trifluoromethoxy, cyano or methoxy.

In a further embodiment E9 the present invention provides compounds of formula (Ic) wherein P is selected from P0 and P1 to P44; G¹ is oxygen; R¹ is hydrogen; R² is A1 or A2; R³ and R^(3a) are hydrogen; R⁵ is chloro, bromo, fluoro, methyl, trifluoromethyl; R¹¹ is methyl, ethyl or trifluoroethyl; L is a bond; A¹ is —CH₂—; A² is S, SO or SO₂; Y¹ is CH, Y² is CH, and Y³ is CH; X¹, X³ and X⁶ are independently hydrogen, halogen or trifluoromethyl, wherein at least two of X¹, X³ and X⁶ are not hydrogen; X² is C—X⁶; X⁴ is trifluoromethyl, or chlorodifluoromethyl.

Certain intermediates are novel and as such form further aspects of the invention.

One group of novel intermediates are compounds of formula (Int-I)

wherein X⁴, R⁴, Y¹, Y², Y³ and Y⁴ are as defined for a compound of formula (I), G¹ is oxygen, and R is hydroxy, C₁-C₁₅alkoxy or halogen, such as bromo, chloro or fluoro; or a salt or N-oxide thereof. The preferences for X⁴, R⁴, Y¹, Y², Y³ and Y⁴ are the same as the preferences set out for the corresponding substituents of a compound of formula (I). Preferably R is hydroxy, C₁-C₆alkoxy or chloro.

A further group of novel intermediates are compounds of formula (Int-II)

wherein X⁴, R⁴, Y¹, Y², Y³ and Y⁴ are as defined for a compound of formula (I), and X^(B) is a leaving group such as halogen, C₁-C₈alkoxy, C₁-C₈alkylsulfonyloxy, C₁-C₈haloalkylsulfonyloxy, C₁-C₈arylsulfonyloxy, optionally substituted C₁-C₈arylsulfonyloxy (aryl is preferably phenyl), diazonium salts (e.g. X^(B) is —N₂ ⁺ Cl⁻, —N₂ ⁺ BF₄ ⁻, —N₂ ⁺ Br⁻, —N₂ ⁺ PF₆ ⁻), phosphonate esters (e.g. —OP(O)(OR)₂, wherein R is methyl or ethyl), preferably bromo, iodo, chloro, trifluoromethylsulfoxy, p-toluenesulfoxy, diazonium chloride; or a salt or N-oxide thereof. The preferences for X⁴, R⁴, Y¹, Y², Y³ and Y⁴ are the same as the preferences set out for the corresponding substituents of a compound of formula (I).

A further group of novel intermediates are compounds of formula (Int-III)

wherein Y¹, Y², Y³ and Y⁴ are as defined for compounds of formula (I), Px is P as defined above, a leaving group, such as halogen, C₁-C₈alkoxy, C₁-C₈alkylsulfonyloxy, C₁-C₈haloalkylsulfonyloxy, C₁-C₈arylsulfonyloxy, optionally substituted C₁-C₈arylsulfonyloxy (aryl is preferably phenyl), diazonium salts (e.g. X^(B) is —N₂ ⁺ Cl⁻, —N₂ ⁺ BF₄ ⁻, —N₂ ⁺ Br⁻, —N₂ ⁺ PF₆ ⁻), phosphonate esters (e.g. —OP(O)(OR)₂, wherein R is methyl or ethyl), preferably bromo, iodo, chloro, trifluoromethylsulfoxy, p-toluenesulfoxy, diazonium chloride, or C(O)R wherein R is halogen, OH or C₁-C₁₅alkoxy, or a salt or N-oxide thereof. The preferences for Y¹, Y², Y³ and Y⁴ and the preferences at position Px when Px is P or heterocycle are the same as the preferences set out for the corresponding substituents of a compound of formula (I).

A group of compounds of formula (Int-III) are compounds of formula (Int-IV)

wherein Y¹, Y², Y³, Y⁴, R¹ and R² are as defined for compounds of formula (I). The preferences for Y¹, Y², Y³, Y⁴, R¹ and R² are the same as the preferences set out for the corresponding substituents of a compound of formula (I).

Another group of compounds of formula (Int-III) are compounds of formula (Int-V)

wherein Y¹, Y², Y³ and Y⁴ are as defined for the compounds of formula (I), and Pn is a heterocyclyl or heteocyclyl substituted by one to five Z, as defined for substituent P of compounds of formula I. The preferences for Y¹, Y², Y³ and Y⁴ and Pn are the same as the preferences set out for the corresponding substituents of a compound of formula (I).

A further group of novel intermediates are compounds of formula (Int-VI)

wherein X⁴, R⁴, Y¹, Y², Y³ and Y⁴ are as defined for the compounds of formula (I), and Px is as defined for the compound of formula (Int-III), Z¹ is hydrogen, halogen, cyano, C₁-C₈alkyl, optionally substituted aryl-C₁-C₄alkylene-, C₁-C₈alkylcarbonyl-, optionally substituted arylsulfonyl- or optionally substituted arylthio-, or a salt or N-oxide thereof. The preferences for X⁴, R⁴, Y¹, Y², Y³ and Y⁴ are the same as the preferences set out for the corresponding substituents of a compound of formula (I). Z¹ is preferably hydrogen, benzyl, halogen (preferably chloro) or cyano. Aryl is preferably phenyl and is preferably optionally substituted by one or more groups selected from halogen, cyano, C₁-C₄alkyl, C₁-C₄ haloalkyl, C₁-C₄alkoxy or C₁-C₄haloalkoxy.

A further group of novel intermediates are compounds of formula (Int-VII)

wherein X⁴, R⁴, Y¹, Y², Y³ and Y⁴ are as defined for the compounds of formula (I), and Px is as defined for the compound of formula (Int-III), Z¹ is hydrogen, halogen, cyano, C₁-C₈alkyl, optionally substituted aryl-C₁-C₄alkylene-, C₁-C₈alkylcarbonyl-, optionally substituted arylsulfonyl- or optionally substituted arylthio- and Z² is hydrogen or hydroxyl or C₁-C₈alkoxy- or C₁-C₈alkylsulfonyloxy- or arylsulfonyloxy- or aryl-C₁-C₄alkylene- or aryl. The preferences for X⁴, R⁴, Y¹, Y², Y³ and Y⁴ are the same as the preferences set out for the corresponding substituents of a compound of formula (I). Z¹ is preferably hydrogen, benzyl, halogen (preferably chloro) or cyano. Aryl is preferably phenyl and is preferably optionally substituted by one or more groups selected from halogen, cyano, C₁-C₄alkyl, C₁-C₄ haloalkyl, C₁-C₄alkoxy or C₁-C₄haloalkoxy.

A further group of novel intermediates are compounds of formula (Int-VIII)

wherein X⁴, R⁴, Y¹, Y², Y³ and Y⁴ are as defined for the compounds of formula (I), and Px is as defined for the compound of formula (Int-III), and Z³ is thiol or optionally substituted aryl-C₁-C₈alkylsulfinyl-. The preferences for X⁴, R⁴, Y¹, Y², Y³ and Y⁴ are the same as the preferences set out for the corresponding substituents of a compound of formula (I). Aryl is preferably phenyl and is preferably optionally substituted by one or more groups selected from halogen, cyano, C₁-C₄alkyl, C₁-C₄ haloalkyl, C₁-C₄alkoxy or C₁-C₄haloalkoxy.

Compounds of formula I include at least one chiral centre and may exist as compounds of formula I* or compounds of formula I**.

Generally compounds of formula I** are more biologically active than compounds of formula I*. The invention includes mixtures of compounds I* and I** in any ratio e.g. in a molar ratio of 1:99 to 99:1, e.g. 10:1 to 1:10, e.g. a substantially 50:50 molar ratio. In an enantiomerically (or epimerically) enriched mixture of formula I**, the molar proportion of compound I** compared to the total amount of both enantiomers (or epimers) is for example greater than 50%, e.g. at least 55, 60, 65, 70, 75, 80, 85, 90, 95, 96, 97, 98, or at least 99%. Likewise, in enantiomerically (or epimerically) enriched mixture of formula I*, the molar proportion of the compound of formula I* compared to the total amount of both enantiomers (or epimers) is for example greater than 50%, e.g. at least 55, 60, 65, 70, 75, 80, 85, 90, 95, 96, 97, 98, or at least 99%. Enantiomerically (or epimerically) enriched mixtures of formula I** are preferred. Each compound disclosed in Tables 1P-120P and Tables 1Q to 240Q represents a disclosure of a compound according to the compound of formula I*, and a disclosure according to the compound of formula I**.

TABLE G Group number R² G.001 ethyl- G.002 butyl- G.003 but-2-yl- G.004 3-bromo-propyl- G.005 2,2,2-trifluoro-ethyl- G.006 3,3,3-trifluoro-propyl- G.007 2-methoxy-ethyl- G.008 1-methoxy-prop-2-yl- G.009 cyclobutyl- G.010 2-methyl-cyclohex-1-yl- G.011 phenyl-methyl- G.012 1-phenyl-eth-1-yl- G.013 2-phenyl-eth-1-yl- G.014 (3-chloro-phenyl)-methyl- G.015 (2-fluoro-phenyl)-methyl- G.016 (4-methoxy-phenyl)-methyl- G.017 (2-trifluoromethyl-phenyl)-methyl- G.018 (2-trifluoromethoxy-phenyl)-methyl- G.019 (pyrid-2-yl)-methyl- G.020 (pyrid-3-yl)-methyl- G.021 (2-chloro-pyrid-5-yl)-methyl- G.022 (1-methyl-1H-imidazol-4-yl)-methyl- G.023 (furan-2-yl)-methyl- G.024 2-(thiophen-2′-yl)-eth-1-yl- G.025 2-(indol-3′-yl)-eth-1-yl- G.026 (1H-benzimidazol-2-yl)-methyl- G.027 (oxetan-2-yl)-methyl- G.028 (tetrahydrofuran-2-yl)-methyl- G.029 2-([1′,3′]dioxolan-2′-yl)-eth-1-yl- G.030 2-(morpholin-4′-yl)-eth-1-yl- G.031 2-(benzo[1′,3′]dioxol-5′-yl)-eth-1-yl- G.032 (2,3-dihydro-benzo[1,4]dioxin-6-yl)-methyl- G.033 2-chloro-phenyl- G.034 3-fluoro-phenyl- G.035 2-methyl-phenyl- G.036 2-chloro-6-methyl-phenyl- G.037 2-trifluoromethyl-phenyl- G.038 2,4-dimethoxy-phenyl- G.039 3-methyl-pyrid-2-yl- G.040 1,3-dimethyl-1H-pyrazol-5-yl- G.041 4-methyl-thiazol-2-yl- G.042 5-methyl-thiadiazol-2-yl- G.043 quinolin-2-yl- G.044 quinolin-5-yl- G.045 benzothiazol-6-yl- G.046 4-methyl-benzothiazol-2-yl- G.047 thietan-3-yl- G.048 1-oxo-thietan-3-yl- G.049 1,1-dioxo-thietan-3-yl- G.050 3-methyl-thietan-3-yl- G.051 N-(2,2,2-Trifluoro-ethyl)-acetamide-2-yl G.052 thietan-2-yl-methyl- G.053 1-oxo-thietan-2-yl-methyl- G.054 1,1-dioxo-thietan-2-yl-methyl- G.055 thietan-3-yl-methyl- G.056 1-oxo-thietan-3-yl-methyl- G.057 1,1-dioxo-thietan-3-yl-methyl- G.058 thietan-3-yl-ethyl- G.059 1-oxo-thietan-3-yl-ethyl- G.060 1,1-dioxo-thietan-3-yl-ethyl- G.061 2-fluoro-cyclopropyl G.062 n-Butyl G.063 2-Methoxy-1-methyl-ethyl G.064 1-Oxo-thietan-3-yl G.065 2-ethyl-isoxazolidin-3-one-4-yl G.066 Dihydro-thiophen-2-one-3-yl G.067 6-Ethoxycarbonyl-cyclohex-3-enyl G.068 2-Benzylsulfanyl-ethyl G.069 4-Methanesulfonyl-benzyl G.070 N′,N′-Dimethylamino-ethyl G.071 sec-Butyl G.072 Butan-1-ol-2-yl G.073 2,2-Difluoro-ethyl G.074 Ethynyl-cyclohexyl G.075 2-Morpholin-4-yl-ethyl G.076 3-Pyrrolidin-1-yl-propyl G.077 3-Piperidin-1-yl-propyl G.078 [3-(4-Chloro-phenyl)-isoxazol-5-yl]-methyl G.079 Phenethyl G.080 1,2,2,6,6-Pentamethyl-piperidin-4-yl G.081 2-Phenoxy-ethyl G.082 3-Chloro-benzyl G.083 2-Acetylamino-ethyl G.084 4-Pyrazol-1-yl-benzyl G.085 2-Methylsulfanyl-ethyl G.086 2-Piperidin-1-yl-benzyl G.087 4-Phenoxy-benzyl G.088 (6-Chloro-pyridin-3-yl)-methyl G.089 1-Benzyl-pyrrolidin-3-yl G.090 2-(4-Benzyl-piperazin-1-yl)-ethyl G.091 Furan-2-yl-methyl G.092 1H-Indazol-5-yl G.093 4-Pyrrol-1-yl-phenyl G.094 4-Piperidin-1-yl-phenyl G.095 2-Methylsulfanyl-phenyl G.096 4-Methyl-2-oxo-2H-chromen-7-yl G.097 4-Dimethylsulfamoyl-phenyl G.098 2,5-Dimethyl-2H-pyrazol-3-yl G.099 5-Methylsulfanyl-1H-[1,2,4]triazol-3-yl G.100 4-Hydroxy-6-methyl-pyrimidin-2-yl G.101 Quinolin-2-yl G.102 5-Methyl-3-phenyl-isoxazol-4-yl G.103 9H-Purin-6-yl G.104 5-Acetyl-4-methyl-thiazol-2-yl G.105 4-Methyl-benzothiazol-2-yl G.106 5-Methyl-[1,3,4]thiadiazol-2-yl G.107 4,6-Dimethyl-2H-pyrazolo[3,4-b]pyridin-3-yl G.108 3-(2,2,2-Trifluoro-ethoxyimino)-cyclobutyl G.109 2-Thietan-3-yl-ethyl G.110 2-(1,1-Dioxo-thietan-3-yl)-ethyl G.111 3-Oxo-2-(2,2,2-trifluoro-ethyl)-isoxazolidin-4-yl G.112

G.113

G.114 2-(2,2,2-trifluoro-ethyl)-isoxazolidin-3-one-4-yl G.115 2-(2,2-Difluoro-ethyl)-isoxazolidin-3-one-4-yl G.116 2-(2-Fluoro-ethyl)-isoxazolidin-3-one-4-yl

TABLE P X1, X2, X3 X4 R5 Y1, Y2, Y3 P.0001 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0002 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0003 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0004 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0005 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0006 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0007 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0008 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0009 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0010 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0011 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0012 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0013 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0014 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0015 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0016 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0017 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0018 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0019 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0020 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0021 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0022 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0023 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0024 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0025 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0026 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0027 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0028 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0029 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0030 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0031 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0032 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0033 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0034 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0035 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0036 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0037 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0038 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0039 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0040 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0041 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0042 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0043 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0044 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0045 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0046 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0047 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0048 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0049 X¹ is chloro, X² is C—F, X³ is difluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0050 X¹ is chloro, X² is C—F, X³ is difluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0051 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0052 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0053 X¹ is chloro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0054 X¹ is chloro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0055 X¹ is chloro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0056 X¹ is chloro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0057 X¹ is chloro, X² is C—F, X³ is difluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0058 X¹ is chloro, X² is C—F, X³ is difluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0059 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0060 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0061 X¹ is chloro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0062 X¹ is chloro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0063 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0064 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0065 X¹ is chloro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0066 X¹ is chloro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0067 X¹ is chloro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0068 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0069 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0070 X¹ is chloro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0071 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0072 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0073 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0074 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0075 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0076 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0077 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0078 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0079 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0080 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0081 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0082 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0083 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0084 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0085 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0086 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0087 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0088 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0089 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0090 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0091 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0092 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0093 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0094 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0095 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0096 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0097 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0098 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0099 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0100 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0101 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0102 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0103 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0104 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0105 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0106 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0107 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0108 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0109 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0110 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0111 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0112 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0113 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0114 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0115 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0116 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0117 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0118 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0119 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0120 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0121 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0122 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0123 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0124 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0125 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0126 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0127 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0128 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0129 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0130 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0131 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0132 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0133 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0134 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0135 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0136 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0137 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0138 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0139 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0140 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0141 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0142 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0143 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0144 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is CH P.0145 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0146 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0147 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0148 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0149 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0150 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0151 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0152 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0153 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0154 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0155 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0156 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0157 X¹ is chloro, X² is C—Br, X³ is difluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0158 X¹ is chloro, X² is C—Br, X³ is difluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0159 X¹ is chloro, X² is C—Br, X³ is difluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0160 X¹ is chloro, X² is C—Br, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0161 X¹ is chloro, X² is C—Br, X³ is difluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0162 X¹ is chloro, X² is C—Br, X³ is difluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0163 X¹ is chloro, X² is C—Br, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0164 X¹ is chloro, X² is C—Br, X³ is difluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0165 X¹ is chloro, X² is C—Br, X³ is difluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0166 X¹ is chloro, X² is C—Br, X³ is difluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0167 X¹ is chloro, X² is C—Br, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0168 X¹ is chloro, X² is C—Br, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0169 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0170 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0171 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0172 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0173 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0174 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0175 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0176 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0177 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0178 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0179 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0180 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0181 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0182 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0183 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0184 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0185 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0186 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0187 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0188 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0189 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0190 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0191 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0192 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0193 X¹ is chloro, X² is C—F, X³ is difluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0194 X¹ is chloro, X² is C—F, X³ is difluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0195 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0196 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0197 X¹ is chloro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0198 X¹ is chloro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0199 X¹ is chloro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0200 X¹ is chloro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0201 X¹ is chloro, X² is C—F, X³ is difluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0202 X¹ is chloro, X² is C—F, X³ is difluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0203 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0204 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0205 X¹ is chloro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0206 X¹ is chloro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0207 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0208 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0209 X¹ is chloro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0210 X¹ is chloro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0211 X¹ is chloro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0212 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0213 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0214 X¹ is chloro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0215 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0216 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0217 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0218 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0219 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0220 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0221 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0222 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0223 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0224 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0225 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0226 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0227 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0228 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0229 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0230 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0231 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0232 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0233 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0234 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0235 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0236 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0237 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0238 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0239 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0240 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0241 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0242 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0243 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0244 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0245 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0246 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0247 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0248 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0249 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0250 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0251 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0252 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0253 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0254 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0255 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0256 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0257 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0258 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0259 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0260 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0261 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0262 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0263 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0264 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0265 X¹ is chloro, X² is C—I, X³ is difluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0266 X¹ is chloro, X² is C—I, X³ is difluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0267 X¹ is chloro, X² is C—I, X³ is difluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0268 X¹ is chloro, X² is C—I, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0269 X¹ is chloro, X² is C—I, X³ is difluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0270 X¹ is chloro, X² is C—I, X³ is difluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0271 X¹ is chloro, X² is C—I, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0272 X¹ is chloro, X² is C—I, X³ is difluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0273 X¹ is chloro, X² is C—I, X³ is difluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0274 X¹ is chloro, X² is C—I, X³ is difluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0275 X¹ is chloro, X² is C—I, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0276 X¹ is chloro, X² is C—I, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0277 X¹ is chloro, X² is C—I, X³ is trifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0278 X¹ is chloro, X² is C—I, X³ is trifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0279 X¹ is chloro, X² is C—I, X³ is trifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0280 X¹ is chloro, X² is C—I, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0281 X¹ is chloro, X² is C—I, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0282 X¹ is chloro, X² is C—I, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0283 X¹ is chloro, X² is C—I, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0284 X¹ is chloro, X² is C—I, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0285 X¹ is chloro, X² is C—I, X³ is trifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0286 X¹ is chloro, X² is C—I, X³ is trifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0287 X¹ is chloro, X² is C—I, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0288 X¹ is chloro, X² is C—I, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0289 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0290 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0291 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0292 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0293 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0294 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0295 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0296 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0297 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0298 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0299 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0300 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0301 X¹ is fluoro, X² is C—F, X³ is difluoromethyl bromo Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0302 X¹ is fluoro, X² is C—F, X³ is difluoromethyl chloro Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0303 X¹ is fluoro, X² is C—F, X³ is difluoromethyl cyano Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0304 X¹ is fluoro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0305 X¹ is fluoro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0306 X¹ is fluoro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0307 X¹ is fluoro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0308 X¹ is fluoro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0309 X¹ is fluoro, X² is C—F, X³ is difluoromethyl methyl Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0310 X¹ is fluoro, X² is C—F, X³ is difluoromethyl nitro Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0311 X¹ is fluoro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0312 X¹ is fluoro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0313 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0314 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0315 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0316 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0317 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0318 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0319 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0320 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0321 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0322 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0323 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0324 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is fluoro CH, Y³ is CH P.0325 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is CH P.0326 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0327 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is CH P.0328 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0329 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0330 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0331 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is CH P.0332 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0333 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0334 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0335 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0336 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0337 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is CH P.0338 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0339 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is CH P.0340 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0341 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0342 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0343 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is CH P.0344 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0345 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0346 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0347 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0348 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0349 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is CH P.0350 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0351 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is CH P.0352 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0353 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0354 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0355 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is CH P.0356 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0357 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0358 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0359 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0360 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0361 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is CH P.0362 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0363 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is CH P.0364 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0365 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0366 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0367 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is CH P.0368 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0369 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0370 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0371 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0372 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0373 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is CH P.0374 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0375 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is CH P.0376 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0377 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0378 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0379 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is CH P.0380 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0381 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0382 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0383 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0384 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0385 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is CH P.0386 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0387 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is CH P.0388 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0389 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0390 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0391 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is CH P.0392 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0393 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0394 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0395 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0396 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0397 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is CH P.0398 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0399 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is CH P.0400 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0401 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0402 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0403 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is CH P.0404 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0405 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0406 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0407 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0408 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0409 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is CH P.0410 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0411 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is CH P.0412 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0413 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0414 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0415 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is CH P.0416 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0417 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0418 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0419 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0420 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0421 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is CH P.0422 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0423 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is CH P.0424 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0425 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0426 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0427 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is CH P.0428 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0429 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0430 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is CH P.0431 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is CH P.0432 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is CH P.0433 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0434 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0435 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0436 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0437 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0438 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0439 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0440 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0441 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0442 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0443 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0444 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0445 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0446 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0447 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0448 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0449 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0450 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0451 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0452 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0453 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0454 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0455 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0456 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0457 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0458 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0459 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0460 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0461 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0462 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0463 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0464 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0465 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0466 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0467 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0468 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is CH P.0469 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0470 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0471 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0472 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0473 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0474 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0475 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0476 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0477 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0478 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0479 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0480 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0481 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0482 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0483 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0484 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0485 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0486 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0487 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0488 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0489 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0490 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0491 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0492 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0493 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0494 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0495 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0496 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0497 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0498 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0499 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0500 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0501 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0502 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0503 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0504 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0505 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0506 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0507 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0508 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0509 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0510 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0511 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0512 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0513 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0514 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0515 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0516 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0517 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0518 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0519 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0520 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0521 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0522 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0523 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0524 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0525 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0526 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0527 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0528 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0529 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0530 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0531 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0532 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0533 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0534 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0535 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0536 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0537 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0538 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0539 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0540 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0541 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0542 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0543 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0544 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0545 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0546 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0547 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0548 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0549 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0550 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0551 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0552 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0553 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0554 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0555 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0556 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0557 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0558 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0559 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0560 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0561 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0562 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0563 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0564 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0565 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0566 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0567 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0568 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0569 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0570 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0571 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0572 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0573 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0574 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0575 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0576 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is CH P.0577 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0578 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0579 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0580 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0581 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0582 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0583 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0584 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0585 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0586 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0587 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0588 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0589 X¹ is chloro, X² is N, X³ is difluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0590 X¹ is chloro, X² is N, X³ is difluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0591 X¹ is chloro, X² is N, X³ is difluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0592 X¹ is chloro, X² is N, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0593 X¹ is chloro, X² is N, X³ is difluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0594 X¹ is chloro, X² is N, X³ is difluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0595 X¹ is chloro, X² is N, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0596 X¹ is chloro, X² is N, X³ is difluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0597 X¹ is chloro, X² is N, X³ is difluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0598 X¹ is chloro, X² is N, X³ is difluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0599 X¹ is chloro, X² is N, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0600 X¹ is chloro, X² is N, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0601 X¹ is chloro, X² is N, X³ is trifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is CH P.0602 X¹ is chloro, X² is N, X³ is trifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0603 X¹ is chloro, X² is N, X³ is trifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is CH P.0604 X¹ is chloro, X² is N, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0605 X¹ is chloro, X² is N, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0606 X¹ is chloro, X² is N, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0607 X¹ is chloro, X² is N, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is CH P.0608 X¹ is chloro, X² is N, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0609 X¹ is chloro, X² is N, X³ is trifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0610 X¹ is chloro, X² is N, X³ is trifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is CH P.0611 X¹ is chloro, X² is N, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is CH P.0612 X¹ is chloro, X² is N, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is CH P.0613 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0614 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0615 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0616 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0617 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0618 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0619 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0620 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0621 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0622 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0623 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0624 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0625 X¹ is trifluoromethyl, X² is N, difluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0626 X¹ is trifluoromethyl, X² is N, difluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0627 X¹ is trifluoromethyl, X² is N, difluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0628 X¹ is trifluoromethyl, X² is N, difluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0629 X¹ is trifluoromethyl, X² is N, difluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0630 X¹ is trifluoromethyl, X² is N, difluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0631 X¹ is trifluoromethyl, X² is N, difluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0632 X¹ is trifluoromethyl, X² is N, difluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0633 X¹ is trifluoromethyl, X² is N, difluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0634 X¹ is trifluoromethyl, X² is N, difluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0635 X¹ is trifluoromethyl, X² is N, difluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0636 X¹ is trifluoromethyl, X² is N, difluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0637 X¹ is trifluoromethyl, X² is N, trifluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0638 X¹ is trifluoromethyl, X² is N, trifluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0639 X¹ is trifluoromethyl, X² is N, trifluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0640 X¹ is trifluoromethyl, X² is N, trifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0641 X¹ is trifluoromethyl, X² is N, trifluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0642 X¹ is trifluoromethyl, X² is N, trifluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0643 X¹ is trifluoromethyl, X² is N, trifluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0644 X¹ is trifluoromethyl, X² is N, trifluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0645 X¹ is trifluoromethyl, X² is N, trifluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0646 X¹ is trifluoromethyl, X² is N, trifluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0647 X¹ is trifluoromethyl, X² is N, trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0648 X¹ is trifluoromethyl, X² is N, trifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is CH P.0649 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0650 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0651 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0652 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0653 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0654 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0655 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0656 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0657 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0658 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0659 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0660 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0661 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0662 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0663 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0664 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0665 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0666 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0667 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0668 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0669 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0670 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0671 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0672 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0673 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0674 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0675 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0676 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0677 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0678 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0679 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0680 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0681 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0682 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0683 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0684 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0685 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0686 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0687 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0688 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0689 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0690 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0691 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0692 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0693 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0694 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0695 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0696 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0697 X¹ is chloro, X² is C—F, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0698 X¹ is chloro, X² is C—F, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0699 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0700 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0701 X¹ is chloro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0702 X¹ is chloro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0703 X¹ is chloro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0704 X¹ is chloro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0705 X¹ is chloro, X² is C—F, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0706 X¹ is chloro, X² is C—F, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0707 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0708 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0709 X¹ is chloro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0710 X¹ is chloro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0711 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0712 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0713 X¹ is chloro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0714 X¹ is chloro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0715 X¹ is chloro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0716 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0717 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0718 X¹ is chloro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0719 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0720 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0721 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0722 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0723 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0724 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0725 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0726 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0727 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0728 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0729 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0730 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0731 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0732 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0733 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0734 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0735 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0736 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0737 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0738 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0739 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0740 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0741 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0742 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0743 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0744 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0745 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0746 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0747 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0748 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0749 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0750 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0751 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0752 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0753 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0754 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0755 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0756 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0757 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0758 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0759 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0760 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0761 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0762 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0763 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0764 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0765 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0766 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0767 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0768 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0769 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0770 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0771 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0772 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0773 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0774 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0775 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0776 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0777 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0778 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0779 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0780 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0781 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0782 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0783 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0784 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0785 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0786 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0787 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0788 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0789 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0790 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0791 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0792 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, hydrogen Y³ is CH P.0793 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0794 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0795 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0796 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0797 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0798 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0799 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0800 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0801 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0802 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0803 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0804 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0805 X¹ is chloro, X² is C—Br, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0806 X¹ is chloro, X² is C—Br, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0807 X¹ is chloro, X² is C—Br, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0808 X¹ is chloro, X² is C—Br, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0809 X¹ is chloro, X² is C—Br, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0810 X¹ is chloro, X² is C—Br, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0811 X¹ is chloro, X² is C—Br, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0812 X¹ is chloro, X² is C—Br, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0813 X¹ is chloro, X² is C—Br, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0814 X¹ is chloro, X² is C—Br, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0815 X¹ is chloro, X² is C—Br, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0816 X¹ is chloro, X² is C—Br, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0817 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0818 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0819 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0820 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0821 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0822 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0823 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0824 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0825 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0826 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0827 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0828 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0829 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0830 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0831 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0832 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0833 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0834 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0835 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0836 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0837 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0838 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0839 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0840 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0841 X¹ is chloro, X² is C—F, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0842 X¹ is chloro, X² is C—F, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0843 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0844 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0845 X¹ is chloro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0846 X¹ is chloro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0847 X¹ is chloro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0848 X¹ is chloro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0849 X¹ is chloro, X² is C—F, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0850 X¹ is chloro, X² is C—F, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0851 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0852 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0853 X¹ is chloro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0854 X¹ is chloro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0855 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0856 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0857 X¹ is chloro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0858 X¹ is chloro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0859 X¹ is chloro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0860 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0861 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0862 X¹ is chloro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0863 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0864 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0865 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0866 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0867 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0868 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0869 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0870 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0871 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0872 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0873 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0874 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0875 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0876 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0877 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0878 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0879 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0880 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0881 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0882 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0883 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0884 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0885 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0886 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0887 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0888 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0889 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0890 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0891 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0892 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0893 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0894 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0895 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0896 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0897 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0898 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0899 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0900 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0901 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0902 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0903 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0904 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0905 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0906 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0907 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0908 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0909 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0910 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0911 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0912 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0913 X¹ is chloro, X² is C—I, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0914 X¹ is chloro, X² is C—I, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0915 X¹ is chloro, X² is C—I, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0916 X¹ is chloro, X² is C—I, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0917 X¹ is chloro, X² is C—I, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0918 X¹ is chloro, X² is C—I, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0919 X¹ is chloro, X² is C—I, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0920 X¹ is chloro, X² is C—I, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0921 X¹ is chloro, X² is C—I, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0922 X¹ is chloro, X² is C—I, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0923 X¹ is chloro, X² is C—I, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0924 X¹ is chloro, X² is C—I, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0925 X¹ is chloro, X² is C—I, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.0926 X¹ is chloro, X² is C—I, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.0927 X¹ is chloro, X² is C—I, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.0928 X¹ is chloro, X² is C—I, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0929 X¹ is chloro, X² is C—I, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0930 X¹ is chloro, X² is C—I, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.0931 X¹ is chloro, X² is C—I, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.0932 X¹ is chloro, X² is C—I, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0933 X¹ is chloro, X² is C—I, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0934 X¹ is chloro, X² is C—I, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.0935 X¹ is chloro, X² is C—I, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.0936 X¹ is chloro, X² is C—I, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.0937 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, fluoro Y³ is CH P.0938 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, fluoro Y³ is CH P.0939 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, fluoro Y³ is CH P.0940 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, fluoro Y³ is CH P.0941 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, fluoro Y³ is CH P.0942 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, fluoro Y³ is CH P.0943 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, fluoro Y³ is CH P.0944 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, fluoro Y³ is CH P.0945 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, fluoro Y³ is CH P.0946 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, fluoro Y³ is CH P.0947 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, fluoro Y³ is CH P.0948 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, fluoro Y³ is CH P.0949 X¹ is fluoro, X² is C—F, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, fluoro Y³ is CH P.0950 X¹ is fluoro, X² is C—F, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, fluoro Y³ is CH P.0951 X¹ is fluoro, X² is C—F, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, fluoro Y³ is CH P.0952 X¹ is fluoro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, fluoro Y³ is CH P.0953 X¹ is fluoro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, fluoro Y³ is CH P.0954 X¹ is fluoro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, fluoro Y³ is CH P.0955 X¹ is fluoro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, fluoro Y³ is CH P.0956 X¹ is fluoro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, fluoro Y³ is CH P.0957 X¹ is fluoro, X² is C—F, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, fluoro Y³ is CH P.0958 X¹ is fluoro, X² is C—F, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, fluoro Y³ is CH P.0959 X¹ is fluoro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, fluoro Y³ is CH P.0960 X¹ is fluoro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, fluoro Y³ is CH P.0961 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, fluoro Y³ is CH P.0962 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, fluoro Y³ is CH P.0963 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, fluoro Y³ is CH P.0964 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, fluoro Y³ is CH P.0965 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, fluoro Y³ is CH P.0966 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, fluoro Y³ is CH P.0967 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, fluoro Y³ is CH P.0968 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, fluoro Y³ is CH P.0969 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, fluoro Y³ is CH P.0970 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, fluoro Y³ is CH P.0971 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, fluoro Y³ is CH P.0972 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, fluoro Y³ is CH P.0973 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, bromo Y³ is CH P.0974 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, bromo Y³ is CH P.0975 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, bromo Y³ is CH P.0976 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, bromo Y³ is CH P.0977 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.0978 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, bromo Y³ is CH P.0979 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, bromo Y³ is CH P.0980 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.0981 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, bromo Y³ is CH P.0982 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, bromo Y³ is CH P.0983 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.0984 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.0985 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, bromo Y³ is CH P.0986 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, bromo Y³ is CH P.0987 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, bromo Y³ is CH P.0988 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, bromo Y³ is CH P.0989 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.0990 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, bromo Y³ is CH P.0991 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, bromo Y³ is CH P.0992 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.0993 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, bromo Y³ is CH P.0994 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, bromo Y³ is CH P.0995 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.0996 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.0997 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, bromo Y³ is CH P.0998 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, bromo Y³ is CH P.0999 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, bromo Y³ is CH P.1000 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1001 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1002 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, bromo Y³ is CH P.1003 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, bromo Y³ is CH P.1004 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1005 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1006 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, bromo Y³ is CH P.1007 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1008 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1009 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, bromo Y³ is CH P.1010 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, bromo Y³ is CH P.1011 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, bromo Y³ is CH P.1012 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1013 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1014 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, bromo Y³ is CH P.1015 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, bromo Y³ is CH P.1016 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1017 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1018 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, bromo Y³ is CH P.1019 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1020 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1021 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, bromo Y³ is CH P.1022 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, bromo Y³ is CH P.1023 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, bromo Y³ is CH P.1024 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1025 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1026 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, bromo Y³ is CH P.1027 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, bromo Y³ is CH P.1028 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1029 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1030 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, bromo Y³ is CH P.1031 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1032 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1033 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, bromo Y³ is CH P.1034 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, bromo Y³ is CH P.1035 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, bromo Y³ is CH P.1036 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1037 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1038 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, bromo Y³ is CH P.1039 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, bromo Y³ is CH P.1040 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1041 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1042 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, bromo Y³ is CH P.1043 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1044 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1045 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, bromo Y³ is CH P.1046 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, bromo Y³ is CH P.1047 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, bromo Y³ is CH P.1048 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1049 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1050 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, bromo Y³ is CH P.1051 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, bromo Y³ is CH P.1052 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1053 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1054 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, bromo Y³ is CH P.1055 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1056 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1057 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, bromo Y³ is CH P.1058 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, bromo Y³ is CH P.1059 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, bromo Y³ is CH P.1060 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1061 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1062 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, bromo Y³ is CH P.1063 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, bromo Y³ is CH P.1064 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1065 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1066 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, bromo Y³ is CH P.1067 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1068 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1069 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, bromo Y³ is CH P.1070 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, bromo Y³ is CH P.1071 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, bromo Y³ is CH P.1072 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1073 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1074 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, bromo Y³ is CH P.1075 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, bromo Y³ is CH P.1076 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1077 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1078 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, bromo Y³ is CH P.1079 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, bromo Y³ is CH P.1080 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, bromo Y³ is CH P.1081 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1082 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1083 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1084 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1085 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1086 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1087 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1088 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1089 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1090 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1091 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1092 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1093 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1094 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1095 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1096 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1097 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1098 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1099 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1100 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1101 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1102 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1103 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1104 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1105 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1106 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1107 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1108 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1109 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1110 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1111 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1112 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1113 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1114 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1115 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1116 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, trifluoromethyl Y³ is CH P.1117 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1118 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1119 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1120 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1121 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1122 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1123 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1124 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1125 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1126 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1127 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1128 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1129 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1130 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1131 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1132 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1133 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1134 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1135 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1136 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1137 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1138 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1139 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1140 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1141 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1142 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1143 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1144 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1145 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1146 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1147 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1148 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1149 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1150 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1151 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1152 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1153 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1154 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1155 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1156 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1157 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1158 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1159 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1160 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1161 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1162 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1163 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1164 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1165 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1166 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1167 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1168 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1169 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1170 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1171 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1172 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1173 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1174 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1175 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1176 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1177 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1178 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1179 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1180 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1181 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1182 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1183 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1184 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1185 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1186 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1187 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1188 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1189 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1190 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1191 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1192 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1193 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1194 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1195 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1196 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1197 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1198 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1199 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1200 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1201 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1202 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1203 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1204 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1205 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1206 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1207 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1208 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1209 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1210 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1211 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1212 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1213 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1214 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1215 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1216 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1217 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1218 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1219 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1220 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1221 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1222 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1223 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1224 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, X³ is hydrogen Y³ is CH P.1225 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.1226 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.1227 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.1228 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.1229 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.1230 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.1231 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.1232 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.1233 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.1234 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.1235 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.1236 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.1237 X¹ is chloro, X² is N, X³ is difluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.1238 X¹ is chloro, X² is N, X³ is difluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.1239 X¹ is chloro, X² is N, X³ is difluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.1240 X¹ is chloro, X² is N, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.1241 X¹ is chloro, X² is N, X³ is difluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.1242 X¹ is chloro, X² is N, X³ is difluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.1243 X¹ is chloro, X² is N, X³ is difluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.1244 X¹ is chloro, X² is N, X³ is difluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.1245 X¹ is chloro, X² is N, X³ is difluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.1246 X¹ is chloro, X² is N, X³ is difluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.1247 X¹ is chloro, X² is N, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.1248 X¹ is chloro, X² is N, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.1249 X¹ is chloro, X² is N, X³ is trifluoromethyl bromo Y¹ is N, Y² is CH, chloro Y³ is CH P.1250 X¹ is chloro, X² is N, X³ is trifluoromethyl chloro Y¹ is N, Y² is CH, chloro Y³ is CH P.1251 X¹ is chloro, X² is N, X³ is trifluoromethyl cyano Y¹ is N, Y² is CH, chloro Y³ is CH P.1252 X¹ is chloro, X² is N, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, chloro Y³ is CH P.1253 X¹ is chloro, X² is N, X³ is trifluoromethyl ethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.1254 X¹ is chloro, X² is N, X³ is trifluoromethyl fluoro Y¹ is N, Y² is CH, chloro Y³ is CH P.1255 X¹ is chloro, X² is N, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is CH, chloro Y³ is CH P.1256 X¹ is chloro, X² is N, X³ is trifluoromethyl methoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.1257 X¹ is chloro, X² is N, X³ is trifluoromethyl methyl Y¹ is N, Y² is CH, chloro Y³ is CH P.1258 X¹ is chloro, X² is N, X³ is trifluoromethyl nitro Y¹ is N, Y² is CH, chloro Y³ is CH P.1259 X¹ is chloro, X² is N, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, chloro Y³ is CH P.1260 X¹ is chloro, X² is N, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, chloro Y³ is CH P.1261 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl bromo Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1262 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl chloro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1263 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl cyano Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1264 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1265 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl ethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1266 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl fluoro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1267 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl hydrogen Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1268 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl methoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1269 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl methyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1270 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl nitro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1271 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1272 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1273 X¹ is trifluoromethyl, X² is N, difluoromethyl bromo Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1274 X¹ is trifluoromethyl, X² is N, difluoromethyl chloro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1275 X¹ is trifluoromethyl, X² is N, difluoromethyl cyano Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1276 X¹ is trifluoromethyl, X² is N, difluoromethyl cyclopropyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1277 X¹ is trifluoromethyl, X² is N, difluoromethyl ethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1278 X¹ is trifluoromethyl, X² is N, difluoromethyl fluoro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1279 X¹ is trifluoromethyl, X² is N, difluoromethyl hydrogen Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1280 X¹ is trifluoromethyl, X² is N, difluoromethyl methoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1281 X¹ is trifluoromethyl, X² is N, difluoromethyl methyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1282 X¹ is trifluoromethyl, X² is N, difluoromethyl nitro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1283 X¹ is trifluoromethyl, X² is N, difluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1284 X¹ is trifluoromethyl, X² is N, difluoromethyl trifluoromethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1285 X¹ is trifluoromethyl, X² is N, trifluoromethyl bromo Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1286 X¹ is trifluoromethyl, X² is N, trifluoromethyl chloro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1287 X¹ is trifluoromethyl, X² is N, trifluoromethyl cyano Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1288 X¹ is trifluoromethyl, X² is N, trifluoromethyl cyclopropyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1289 X¹ is trifluoromethyl, X² is N, trifluoromethyl ethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1290 X¹ is trifluoromethyl, X² is N, trifluoromethyl fluoro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1291 X¹ is trifluoromethyl, X² is N, trifluoromethyl hydrogen Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1292 X¹ is trifluoromethyl, X² is N, trifluoromethyl methoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1293 X¹ is trifluoromethyl, X² is N, trifluoromethyl methyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1294 X¹ is trifluoromethyl, X² is N, trifluoromethyl nitro Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1295 X¹ is trifluoromethyl, X² is N, trifluoromethyl trifluoromethoxy Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1296 X¹ is trifluoromethyl, X² is N, trifluoromethyl trifluoromethyl Y¹ is N, Y² is CH, X³ is trifluoromethyl Y³ is CH P.1297 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1298 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1299 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1300 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1301 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1302 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1303 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1304 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1305 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1306 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1307 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1308 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1309 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1310 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1311 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1312 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1313 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1314 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1315 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1316 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1317 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1318 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1319 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1320 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1321 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1322 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1323 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1324 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1325 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1326 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1327 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1328 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1329 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1330 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1331 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1332 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1333 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is N, hydrogen Y³ is CH P.1334 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1335 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is N, hydrogen Y³ is CH P.1336 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1337 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1338 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1339 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, hydrogen Y³ is CH P.1340 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1341 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1342 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1343 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1344 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1345 X¹ is chloro, X² is C—F, X³ is difluoromethyl bromo Y¹ is N, Y² is N, hydrogen Y³ is CH P.1346 X¹ is chloro, X² is C—F, X³ is difluoromethyl chloro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1347 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyano Y¹ is N, Y² is N, hydrogen Y³ is CH P.1348 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1349 X¹ is chloro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1350 X¹ is chloro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1351 X¹ is chloro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, hydrogen Y³ is CH P.1352 X¹ is chloro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1353 X¹ is chloro, X² is C—F, X³ is difluoromethyl methyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1354 X¹ is chloro, X² is C—F, X³ is difluoromethyl nitro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1355 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1356 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1357 X¹ is chloro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is N, Y² is N, hydrogen Y³ is CH P.1358 X¹ is chloro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1359 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is N, Y² is N, hydrogen Y³ is CH P.1360 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1361 X¹ is chloro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1362 X¹ is chloro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1363 X¹ is chloro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is N, hydrogen Y³ is CH P.1364 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1365 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1366 X¹ is chloro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1367 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1368 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1369 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is N, hydrogen Y³ is CH P.1370 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1371 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is N, hydrogen Y³ is CH P.1372 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1373 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1374 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1375 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, hydrogen Y³ is CH P.1376 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1377 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1378 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1379 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1380 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1381 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is N, Y² is N, hydrogen Y³ is CH P.1382 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1383 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is N, Y² is N, hydrogen Y³ is CH P.1384 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1385 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1386 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1387 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, hydrogen Y³ is CH P.1388 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1389 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1390 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1391 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1392 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1393 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is N, Y² is N, hydrogen Y³ is CH P.1394 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1395 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is N, Y² is N, hydrogen Y³ is CH P.1396 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1397 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1398 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1399 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is N, hydrogen Y³ is CH P.1400 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1401 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1402 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1403 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1404 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1405 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is N, hydrogen Y³ is CH P.1406 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1407 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is N, hydrogen Y³ is CH P.1408 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1409 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1410 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1411 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, hydrogen Y³ is CH P.1412 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1413 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1414 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1415 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1416 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1417 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is N, Y² is N, hydrogen Y³ is CH P.1418 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1419 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is N, Y² is N, hydrogen Y³ is CH P.1420 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1421 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1422 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1423 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, hydrogen Y³ is CH P.1424 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1425 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1426 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1427 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1428 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1429 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is N, Y² is N, hydrogen Y³ is CH P.1430 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1431 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is N, Y² is N, hydrogen Y³ is CH P.1432 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1433 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1434 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1435 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is N, hydrogen Y³ is CH P.1436 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1437 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1438 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is N, Y² is N, hydrogen Y³ is CH P.1439 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, hydrogen Y³ is CH P.1440 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, hydrogen Y³ is CH P.1441 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1442 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1443 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1444 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1445 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1446 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1447 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1448 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1449 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1450 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1451 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1452 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1453 X¹ is chloro, X² is C—Br, X³ is difluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1454 X¹ is chloro, X² is C—Br, X³ is difluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1455 X¹ is chloro, X² is C—Br, X³ is difluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1456 X¹ is chloro, X² is C—Br, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1457 X¹ is chloro, X² is C—Br, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1458 X¹ is chloro, X² is C—Br, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1459 X¹ is chloro, X² is C—Br, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1460 X¹ is chloro, X² is C—Br, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1461 X¹ is chloro, X² is C—Br, X³ is difluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1462 X¹ is chloro, X² is C—Br, X³ is difluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1463 X¹ is chloro, X² is C—Br, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1464 X¹ is chloro, X² is C—Br, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1465 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1466 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1467 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1468 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1469 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1470 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1471 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1472 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1473 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1474 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1475 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1476 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1477 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1478 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1479 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1480 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1481 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1482 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1483 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1484 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1485 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1486 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1487 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1488 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1489 X¹ is chloro, X² is C—F, X³ is difluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1490 X¹ is chloro, X² is C—F, X³ is difluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1491 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1492 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1493 X¹ is chloro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1494 X¹ is chloro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1495 X¹ is chloro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1496 X¹ is chloro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1497 X¹ is chloro, X² is C—F, X³ is difluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1498 X¹ is chloro, X² is C—F, X³ is difluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1499 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1500 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1501 X¹ is chloro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1502 X¹ is chloro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1503 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1504 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1505 X¹ is chloro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1506 X¹ is chloro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1507 X¹ is chloro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1508 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1509 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1510 X¹ is chloro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1511 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1512 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1513 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1514 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1515 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1516 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1517 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1518 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1519 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1520 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1521 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1522 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1523 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1524 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1525 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1526 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1527 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1528 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1529 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1530 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1531 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1532 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1533 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1534 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is N, Y² is N, P.1562 X¹ is chloro, X² is C—I, X³ is difluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1563 X¹ is chloro, X² is C—I, X³ is difluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1564 X¹ is chloro, X² is C—I, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1565 X¹ is chloro, X² is C—I, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1566 X¹ is chloro, X² is C—I, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1567 X¹ is chloro, X² is C—I, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1568 X¹ is chloro, X² is C—I, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1569 X¹ is chloro, X² is C—I, X³ is difluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1570 X¹ is chloro, X² is C—I, X³ is difluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1571 X¹ is chloro, X² is C—I, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1572 X¹ is chloro, X² is C—I, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1573 X¹ is chloro, X² is C—I, X³ is trifluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1574 X¹ is chloro, X² is C—I, X³ is trifluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1575 X¹ is chloro, X² is C—I, X³ is trifluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1576 X¹ is chloro, X² is C—I, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1577 X¹ is chloro, X² is C—I, X³ is trifluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1578 X¹ is chloro, X² is C—I, X³ is trifluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1579 X¹ is chloro, X² is C—I, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1580 X¹ is chloro, X² is C—I, X³ is trifluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1581 X¹ is chloro, X² is C—I, X³ is trifluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1582 X¹ is chloro, X² is C—I, X³ is trifluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1583 X¹ is chloro, X² is C—I, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1584 X¹ is chloro, X² is C—I, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1585 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is N, fluoro Y³ is CH P.1586 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is N, fluoro Y³ is CH P.1587 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is N, fluoro Y³ is CH P.1588 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, fluoro Y³ is CH P.1589 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is N, fluoro Y³ is CH P.1590 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is N, fluoro Y³ is CH P.1591 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, fluoro Y³ is CH P.1592 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is N, fluoro Y³ is CH P.1593 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is N, fluoro Y³ is CH P.1594 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is N, fluoro Y³ is CH P.1595 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, fluoro Y³ is CH P.1596 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, fluoro Y³ is CH P.1597 X¹ is fluoro, X² is C—F, X³ is difluoromethyl bromo Y¹ is N, Y² is N, fluoro Y³ is CH P.1598 X¹ is fluoro, X² is C—F, X³ is difluoromethyl chloro Y¹ is N, Y² is N, fluoro Y³ is CH P.1599 X¹ is fluoro, X² is C—F, X³ is difluoromethyl cyano Y¹ is N, Y² is N, fluoro Y³ is CH P.1600 X¹ is fluoro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, fluoro Y³ is CH P.1601 X¹ is fluoro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, fluoro Y³ is CH P.1602 X¹ is fluoro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, fluoro Y³ is CH P.1603 X¹ is fluoro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, fluoro Y³ is CH P.1604 X¹ is fluoro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, fluoro Y³ is CH P.1605 X¹ is fluoro, X² is C—F, X³ is difluoromethyl methyl Y¹ is N, Y² is N, fluoro Y³ is CH P.1606 X¹ is fluoro, X² is C—F, X³ is difluoromethyl nitro Y¹ is N, Y² is N, fluoro Y³ is CH P.1607 X¹ is fluoro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, fluoro Y³ is CH P.1608 X¹ is fluoro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is N, fluoro Y³ is CH P.1609 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is N, Y² is N, fluoro Y³ is CH P.1610 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is N, Y² is N, fluoro Y³ is CH P.1611 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is N, Y² is N, fluoro Y³ is CH P.1612 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is N, fluoro Y³ is CH P.1613 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is N, Y² is N, fluoro Y³ is CH P.1614 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is N, Y² is N, fluoro Y³ is CH P.1615 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is N, fluoro Y³ is CH P.1616 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is N, Y² is N, fluoro Y³ is CH P.1617 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is N, Y² is N, fluoro Y³ is CH P.1618 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is N, Y² is N, fluoro Y³ is CH P.1619 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, fluoro Y³ is CH P.1620 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, fluoro Y³ is CH P.1621 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is N, bromo Y³ is CH P.1622 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is N, bromo Y³ is CH P.1623 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is N, bromo Y³ is CH P.1624 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, bromo Y³ is CH P.1625 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1626 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is N, bromo Y³ is CH P.1627 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, bromo Y³ is CH P.1628 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1629 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is N, bromo Y³ is CH P.1630 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is N, bromo Y³ is CH P.1631 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1632 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1633 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is N, Y² is N, bromo Y³ is CH P.1634 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is N, Y² is N, bromo Y³ is CH P.1635 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is N, Y² is N, bromo Y³ is CH P.1636 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, bromo Y³ is CH P.1637 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1638 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, bromo Y³ is CH P.1639 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, bromo Y³ is CH P.1640 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1641 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is N, Y² is N, bromo Y³ is CH P.1642 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is N, Y² is N, bromo Y³ is CH P.1643 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1644 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1645 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is N, Y² is N, bromo Y³ is CH P.1646 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is N, Y² is N, bromo Y³ is CH P.1647 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is N, Y² is N, bromo Y³ is CH P.1648 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is N, bromo Y³ is CH P.1649 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1650 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is N, Y² is N, bromo Y³ is CH P.1651 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is N, bromo Y³ is CH P.1652 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1653 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is N, Y² is N, bromo Y³ is CH P.1654 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is N, Y² is N, bromo Y³ is CH P.1655 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1656 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1657 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is N, bromo Y³ is CH P.1658 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is N, bromo Y³ is CH P.1659 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is N, bromo Y³ is CH P.1660 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, bromo Y³ is CH P.1661 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1662 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is N, bromo Y³ is CH P.1663 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, bromo Y³ is CH P.1664 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1665 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is N, bromo Y³ is CH P.1666 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is N, bromo Y³ is CH P.1667 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1668 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1669 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is N, Y² is N, bromo Y³ is CH P.1670 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is N, Y² is N, bromo Y³ is CH P.1671 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is N, Y² is N, bromo Y³ is CH P.1672 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, bromo Y³ is CH P.1673 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1674 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, bromo Y³ is CH P.1675 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, bromo Y³ is CH P.1676 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1677 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is N, Y² is N, bromo Y³ is CH P.1678 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is N, Y² is N, bromo Y³ is CH P.1679 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1680 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1681 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is N, Y² is N, bromo Y³ is CH P.1682 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is N, Y² is N, bromo Y³ is CH P.1683 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is N, Y² is N, bromo Y³ is CH P.1684 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is N, bromo Y³ is CH P.1685 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1686 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is N, Y² is N, bromo Y³ is CH P.1687 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is N, bromo Y³ is CH P.1688 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1689 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is N, Y² is N, bromo Y³ is CH P.1690 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is N, Y² is N, bromo Y³ is CH P.1691 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1692 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1693 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is N, bromo Y³ is CH P.1694 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is N, bromo Y³ is CH P.1695 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is N, bromo Y³ is CH P.1696 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, bromo Y³ is CH P.1697 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1698 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is N, bromo Y³ is CH P.1699 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, bromo Y³ is CH P.1700 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1701 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is N, bromo Y³ is CH P.1702 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is N, bromo Y³ is CH P.1703 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1704 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1705 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is N, Y² is N, bromo Y³ is CH P.1706 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is N, Y² is N, bromo Y³ is CH P.1707 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is N, Y² is N, bromo Y³ is CH P.1708 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, bromo Y³ is CH P.1709 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1710 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, bromo Y³ is CH P.1711 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, bromo Y³ is CH P.1712 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1713 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is N, Y² is N, bromo Y³ is CH P.1714 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is N, Y² is N, bromo Y³ is CH P.1715 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1716 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1717 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is N, Y² is N, bromo Y³ is CH P.1718 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is N, Y² is N, bromo Y³ is CH P.1719 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is N, Y² is N, bromo Y³ is CH P.1720 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is N, bromo Y³ is CH P.1721 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1722 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is N, Y² is N, bromo Y³ is CH P.1723 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is N, bromo Y³ is CH P.1724 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1725 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is N, Y² is N, bromo Y³ is CH P.1726 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is N, Y² is N, bromo Y³ is CH P.1727 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, bromo Y³ is CH P.1728 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, bromo Y³ is CH P.1729 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1730 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1731 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1732 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1733 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1734 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1735 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1736 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1737 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1738 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1739 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1740 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1741 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1742 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1743 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1744 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1745 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1746 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1747 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1748 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1749 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1750 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1751 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1752 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1753 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1754 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1755 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1756 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1757 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1758 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1759 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1760 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1761 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1762 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1763 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1764 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, trifluoromethyl Y³ is CH P.1765 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1766 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1767 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1768 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1769 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1770 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1771 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1772 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1773 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1774 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1775 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1776 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1777 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1778 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1779 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1780 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1781 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1782 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1783 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1784 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1785 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1786 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1787 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1788 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1789 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1790 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1791 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1792 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1793 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1794 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1795 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1796 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1797 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1798 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1799 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1800 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1801 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1802 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1803 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1804 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1805 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1806 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1807 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1808 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1809 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1810 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1811 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1812 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1813 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1814 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1815 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1816 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1817 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1818 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1819 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1820 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1821 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1822 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1823 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1824 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1825 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1826 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1827 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1828 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1829 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1830 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1831 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1832 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1833 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1834 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1835 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1836 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1837 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1838 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1839 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1840 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1841 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1842 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1843 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1844 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1845 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1846 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1847 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1848 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1849 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1850 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1851 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1852 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1853 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1854 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1855 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1856 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1857 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1858 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1859 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1860 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1861 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1862 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1863 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1864 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1865 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1866 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1867 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1868 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1869 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1870 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1871 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1872 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, X³ is hydrogen Y³ is CH P.1873 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1874 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1875 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1876 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1877 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1878 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1879 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1880 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1881 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1882 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1883 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1884 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1885 X¹ is chloro, X² is N, X³ is difluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1886 X¹ is chloro, X² is N, X³ is difluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1887 X¹ is chloro, X² is N, X³ is difluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1888 X¹ is chloro, X² is N, X³ is difluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1889 X¹ is chloro, X² is N, X³ is difluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1890 X¹ is chloro, X² is N, X³ is difluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1891 X¹ is chloro, X² is N, X³ is difluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1892 X¹ is chloro, X² is N, X³ is difluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1893 X¹ is chloro, X² is N, X³ is difluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1894 X¹ is chloro, X² is N, X³ is difluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1895 X¹ is chloro, X² is N, X³ is difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1896 X¹ is chloro, X² is N, X³ is difluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1897 X¹ is chloro, X² is N, X³ is trifluoromethyl bromo Y¹ is N, Y² is N, chloro Y³ is CH P.1898 X¹ is chloro, X² is N, X³ is trifluoromethyl chloro Y¹ is N, Y² is N, chloro Y³ is CH P.1899 X¹ is chloro, X² is N, X³ is trifluoromethyl cyano Y¹ is N, Y² is N, chloro Y³ is CH P.1900 X¹ is chloro, X² is N, X³ is trifluoromethyl cyclopropyl Y¹ is N, Y² is N, chloro Y³ is CH P.1901 X¹ is chloro, X² is N, X³ is trifluoromethyl ethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1902 X¹ is chloro, X² is N, X³ is trifluoromethyl fluoro Y¹ is N, Y² is N, chloro Y³ is CH P.1903 X¹ is chloro, X² is N, X³ is trifluoromethyl hydrogen Y¹ is N, Y² is N, chloro Y³ is CH P.1904 X¹ is chloro, X² is N, X³ is trifluoromethyl methoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1905 X¹ is chloro, X² is N, X³ is trifluoromethyl methyl Y¹ is N, Y² is N, chloro Y³ is CH P.1906 X¹ is chloro, X² is N, X³ is trifluoromethyl nitro Y¹ is N, Y² is N, chloro Y³ is CH P.1907 X¹ is chloro, X² is N, X³ is trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, chloro Y³ is CH P.1908 X¹ is chloro, X² is N, X³ is trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, chloro Y³ is CH P.1909 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl bromo Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1910 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl chloro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1911 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl cyano Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1912 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl cyclopropyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1913 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl ethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1914 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl fluoro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1915 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl hydrogen Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1916 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl methoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1917 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl methyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1918 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl nitro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1919 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1920 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl trifluoromethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1921 X¹ is trifluoromethyl, X² is N, difluoromethyl bromo Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1922 X¹ is trifluoromethyl, X² is N, difluoromethyl chloro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1923 X¹ is trifluoromethyl, X² is N, difluoromethyl cyano Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1924 X¹ is trifluoromethyl, X² is N, difluoromethyl cyclopropyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1925 X¹ is trifluoromethyl, X² is N, difluoromethyl ethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1926 X¹ is trifluoromethyl, X² is N, difluoromethyl fluoro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1927 X¹ is trifluoromethyl, X² is N, difluoromethyl hydrogen Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1928 X¹ is trifluoromethyl, X² is N, difluoromethyl methoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1929 X¹ is trifluoromethyl, X² is N, difluoromethyl methyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1930 X¹ is trifluoromethyl, X² is N, difluoromethyl nitro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1931 X¹ is trifluoromethyl, X² is N, difluoromethyl trifluoromethoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1932 X¹ is trifluoromethyl, X² is N, difluoromethyl trifluoromethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1933 X¹ is trifluoromethyl, X² is N, trifluoromethyl bromo Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1934 X¹ is trifluoromethyl, X² is N, trifluoromethyl chloro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1935 X¹ is trifluoromethyl, X² is N, trifluoromethyl cyano Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1936 X¹ is trifluoromethyl, X² is N, trifluoromethyl cyclopropyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1937 X¹ is trifluoromethyl, X² is N, trifluoromethyl ethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1938 X¹ is trifluoromethyl, X² is N, trifluoromethyl fluoro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1939 X¹ is trifluoromethyl, X² is N, trifluoromethyl hydrogen Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1940 X¹ is trifluoromethyl, X² is N, trifluoromethyl methoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1941 X¹ is trifluoromethyl, X² is N, trifluoromethyl methyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1942 X¹ is trifluoromethyl, X² is N, trifluoromethyl nitro Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1943 X¹ is trifluoromethyl, X² is N, trifluoromethyl trifluoromethoxy Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1944 X¹ is trifluoromethyl, X² is N, trifluoromethyl trifluoromethyl Y¹ is N, Y² is N, X³ is trifluoromethyl Y³ is CH P.1945 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.1946 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.1947 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.1948 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.1949 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.1950 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.1951 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.1952 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.1953 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.1954 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.1955 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.1956 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.1957 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.1958 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.1959 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.1960 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.1961 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.1962 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.1963 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.1964 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.1965 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.1966 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.1967 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.1968 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.1969 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.1970 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.1971 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.1972 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.1973 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.1974 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.1975 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.1976 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.1977 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.1978 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.1979 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.1980 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.1981 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1982 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1983 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1984 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1985 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1986 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1987 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1988 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1989 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1990 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1991 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1992 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1993 X¹ is chloro, X² is C—F, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1994 X¹ is chloro, X² is C—F, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1995 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1996 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1997 X¹ is chloro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1998 X¹ is chloro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.1999 X¹ is chloro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2000 X¹ is chloro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2001 X¹ is chloro, X² is C—F, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2002 X¹ is chloro, X² is C—F, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2003 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2004 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2005 X¹ is chloro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2006 X¹ is chloro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2007 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2008 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2009 X¹ is chloro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2010 X¹ is chloro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2011 X¹ is chloro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2012 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2013 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2014 X¹ is chloro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2015 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2016 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2017 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2018 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2019 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2020 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2021 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2022 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2023 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2024 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2025 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2026 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2027 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2028 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2029 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2030 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2031 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2032 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2033 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2034 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2035 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2036 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2037 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2038 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2039 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2040 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2041 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2042 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2043 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2044 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2045 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2046 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2047 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2048 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2049 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2050 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2051 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2052 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2053 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2054 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2055 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2056 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2057 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2058 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2059 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2060 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2061 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2062 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2063 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2064 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2065 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2066 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2067 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2068 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2069 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2070 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2071 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2072 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2073 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2074 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2075 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2076 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2077 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2078 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2079 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2080 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2081 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2082 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2083 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2084 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2085 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2086 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2087 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2088 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, hydrogen Y³ is CH P.2089 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2090 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2091 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2092 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2093 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2094 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2095 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2096 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2097 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2098 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2099 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2100 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2101 X¹ is chloro, X² is C—Br, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2102 X¹ is chloro, X² is C—Br, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2103 X¹ is chloro, X² is C—Br, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2104 X¹ is chloro, X² is C—Br, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2105 X¹ is chloro, X² is C—Br, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2106 X¹ is chloro, X² is C—Br, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2107 X¹ is chloro, X² is C—Br, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2108 X¹ is chloro, X² is C—Br, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2109 X¹ is chloro, X² is C—Br, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2110 X¹ is chloro, X² is C—Br, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2111 X¹ is chloro, X² is C—Br, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2112 X¹ is chloro, X² is C—Br, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2113 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2114 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2115 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2116 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2117 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2118 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2119 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2120 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2121 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2122 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2123 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2124 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2125 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2126 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2127 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2128 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2129 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2130 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2131 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2132 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2133 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2134 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2135 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2136 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2137 X¹ is chloro, X² is C—F, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2138 X¹ is chloro, X² is C—F, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2139 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2140 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2141 X¹ is chloro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2142 X¹ is chloro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2143 X¹ is chloro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2144 X¹ is chloro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2145 X¹ is chloro, X² is C—F, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2146 X¹ is chloro, X² is C—F, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2147 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2148 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2149 X¹ is chloro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2150 X¹ is chloro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2151 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2152 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2153 X¹ is chloro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2154 X¹ is chloro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2155 X¹ is chloro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2156 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2157 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2158 X¹ is chloro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2159 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2160 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2161 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2162 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2163 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2164 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2165 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2166 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2167 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2168 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2169 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2170 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2171 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2172 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2173 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2174 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2175 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2176 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2177 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2178 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2179 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2180 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2181 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2182 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2183 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2184 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2185 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2186 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2187 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2188 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2189 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2190 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2191 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2192 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2193 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2194 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2195 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2196 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2197 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2198 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2199 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2200 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2201 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2202 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2203 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2204 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2205 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2206 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2207 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2208 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2209 X¹ is chloro, X² is C—I, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2210 X¹ is chloro, X² is C—I, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2211 X¹ is chloro, X² is C—I, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2212 X¹ is chloro, X² is C—I, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2213 X¹ is chloro, X² is C—I, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2214 X¹ is chloro, X² is C—I, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2215 X¹ is chloro, X² is C—I, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2216 X¹ is chloro, X² is C—I, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2217 X¹ is chloro, X² is C—I, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2218 X¹ is chloro, X² is C—I, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2219 X¹ is chloro, X² is C—I, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2220 X¹ is chloro, X² is C—I, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2221 X¹ is chloro, X² is C—I, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2222 X¹ is chloro, X² is C—I, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2223 X¹ is chloro, X² is C—I, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2224 X¹ is chloro, X² is C—I, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2225 X¹ is chloro, X² is C—I, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2226 X¹ is chloro, X² is C—I, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2227 X¹ is chloro, X² is C—I, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2228 X¹ is chloro, X² is C—I, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2229 X¹ is chloro, X² is C—I, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2230 X¹ is chloro, X² is C—I, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2231 X¹ is chloro, X² is C—I, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2232 X¹ is chloro, X² is C—I, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2233 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, fluoro Y³ is CH P.2234 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, fluoro Y³ is CH P.2235 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, fluoro Y³ is CH P.2236 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, fluoro Y³ is CH P.2237 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, fluoro Y³ is CH P.2238 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, fluoro Y³ is CH P.2239 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, fluoro Y³ is CH P.2240 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, fluoro Y³ is CH P.2241 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, fluoro Y³ is CH P.2242 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, fluoro Y³ is CH P.2243 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, fluoro Y³ is CH P.2244 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, fluoro Y³ is CH P.2245 X¹ is fluoro, X² is C—F, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, fluoro Y³ is CH P.2246 X¹ is fluoro, X² is C—F, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, fluoro Y³ is CH P.2247 X¹ is fluoro, X² is C—F, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, fluoro Y³ is CH P.2248 X¹ is fluoro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, fluoro Y³ is CH P.2249 X¹ is fluoro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, fluoro Y³ is CH P.2250 X¹ is fluoro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, fluoro Y³ is CH P.2251 X¹ is fluoro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is N, fluoro Y³ is CH P.2252 X¹ is fluoro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, fluoro Y³ is CH P.2253 X¹ is fluoro, X² is C—F, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, fluoro Y³ is CH P.2254 X¹ is fluoro, X² is C—F, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, fluoro Y³ is CH P.2255 X¹ is fluoro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, fluoro Y³ is CH P.2256 X¹ is fluoro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, fluoro Y³ is CH P.2257 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, fluoro Y³ is CH P.2258 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, fluoro Y³ is CH P.2259 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, fluoro Y³ is CH P.2260 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, fluoro Y³ is CH P.2261 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, fluoro Y³ is CH P.2262 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, fluoro Y³ is CH P.2263 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, fluoro Y³ is CH P.2264 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, fluoro Y³ is CH P.2265 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, fluoro Y³ is CH P.2266 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, fluoro Y³ is CH P.2267 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, fluoro Y³ is CH P.2268 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, fluoro Y³ is CH P.2269 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, bromo Y³ is CH P.2270 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, bromo Y³ is CH P.2271 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, bromo Y³ is CH P.2272 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2273 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2274 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, bromo Y³ is CH P.2275 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, bromo Y³ is CH P.2276 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2277 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2278 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, bromo Y³ is CH P.2279 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2280 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2281 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, bromo Y³ is CH P.2282 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, bromo Y³ is CH P.2283 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, bromo Y³ is CH P.2284 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2285 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2286 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, bromo Y³ is CH P.2287 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is N, bromo Y³ is CH P.2288 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2289 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2290 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, bromo Y³ is CH P.2291 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2292 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2293 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, bromo Y³ is CH P.2294 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, bromo Y³ is CH P.2295 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, bromo Y³ is CH P.2296 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2297 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2298 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, bromo Y³ is CH P.2299 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, bromo Y³ is CH P.2300 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2301 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2302 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, bromo Y³ is CH P.2303 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2304 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2305 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, bromo Y³ is CH P.2306 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, bromo Y³ is CH P.2307 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, bromo Y³ is CH P.2308 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2309 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2310 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, bromo Y³ is CH P.2311 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, bromo Y³ is CH P.2312 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2313 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2314 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, bromo Y³ is CH P.2315 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2316 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2317 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, bromo Y³ is CH P.2318 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, bromo Y³ is CH P.2319 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, bromo Y³ is CH P.2320 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2321 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2322 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, bromo Y³ is CH P.2323 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is N, bromo Y³ is CH P.2324 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2325 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2326 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, bromo Y³ is CH P.2327 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2328 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2329 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, bromo Y³ is CH P.2330 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, bromo Y³ is CH P.2331 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, bromo Y³ is CH P.2332 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2333 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2334 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, bromo Y³ is CH P.2335 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, bromo Y³ is CH P.2336 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2337 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2338 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, bromo Y³ is CH P.2339 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2340 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2341 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, bromo Y³ is CH P.2342 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, bromo Y³ is CH P.2343 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, bromo Y³ is CH P.2344 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2345 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2346 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, bromo Y³ is CH P.2347 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, bromo Y³ is CH P.2348 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2349 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2350 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, bromo Y³ is CH P.2351 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2352 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2353 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, bromo Y³ is CH P.2354 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, bromo Y³ is CH P.2355 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, bromo Y³ is CH P.2356 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2357 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2358 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, bromo Y³ is CH P.2359 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y₁ is CH, Y² is N, bromo Y³ is CH P.2360 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2361 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2362 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, bromo Y³ is CH P.2363 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2364 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2365 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, bromo Y³ is CH P.2366 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, bromo Y³ is CH P.2367 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, bromo Y³ is CH P.2368 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2369 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2370 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, bromo Y³ is CH P.2371 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, bromo Y³ is CH P.2372 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2373 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2374 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, bromo Y³ is CH P.2375 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, bromo Y³ is CH P.2376 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, bromo Y³ is CH P.2377 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2378 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2379 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2380 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2381 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2382 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2383 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2384 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2385 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2386 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2387 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2388 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2389 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2390 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2391 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2392 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2393 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2394 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2395 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2396 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2397 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2398 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2399 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2400 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2401 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2402 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2403 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2404 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2405 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2406 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2407 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2408 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2409 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2410 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2411 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2412 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, trifluoromethyl Y³ is CH P.2413 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2414 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2415 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2416 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2417 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2418 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2419 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2420 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2421 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2422 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2423 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2424 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2425 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2426 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2427 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2428 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2429 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2430 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2431 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2432 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2433 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2434 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2435 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2436 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2437 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2438 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2439 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2440 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2441 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2442 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2443 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2444 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2445 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2446 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2447 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2448 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2449 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2450 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2451 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2452 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2453 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2454 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2455 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2456 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2457 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2458 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2459 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2460 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2461 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2462 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2463 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2464 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2465 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2466 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2467 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2468 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2469 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2470 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2471 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2472 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2473 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2474 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2475 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2476 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2477 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2478 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2479 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2480 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2481 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2482 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2483 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2484 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2485 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2486 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2487 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2488 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2489 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2490 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2491 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2492 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2493 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2494 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2495 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2496 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2497 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2498 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2499 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2500 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2501 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2502 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2503 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2504 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2505 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2506 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2507 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2508 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2509 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2510 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2511 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2512 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2513 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2514 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2515 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2516 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2517 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2518 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2519 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2520 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, X³ is hydrogen Y³ is CH P.2521 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2522 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2523 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2524 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2525 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2526 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2527 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2528 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2529 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2530 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2531 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2532 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2533 X¹ is chloro, X² is N, X³ is difluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2534 X¹ is chloro, X² is N, X³ is difluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2535 X¹ is chloro, X² is N, X³ is difluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2536 X¹ is chloro, X² is N, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2537 X¹ is chloro, X² is N, X³ is difluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2538 X¹ is chloro, X² is N, X³ is difluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2539 X¹ is chloro, X² is N, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2540 X¹ is chloro, X² is N, X³ is difluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2541 X¹ is chloro, X² is N, X³ is difluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2542 X¹ is chloro, X² is N, X³ is difluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2543 X¹ is chloro, X² is N, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2544 X¹ is chloro, X² is N, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2545 X¹ is chloro, X² is N, X³ is trifluoromethyl bromo Y¹ is CH, Y² is N, chloro Y³ is CH P.2546 X¹ is chloro, X² is N, X³ is trifluoromethyl chloro Y¹ is CH, Y² is N, chloro Y³ is CH P.2547 X¹ is chloro, X² is N, X³ is trifluoromethyl cyano Y¹ is CH, Y² is N, chloro Y³ is CH P.2548 X¹ is chloro, X² is N, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2549 X¹ is chloro, X² is N, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2550 X¹ is chloro, X² is N, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is N, chloro Y³ is CH P.2551 X¹ is chloro, X² is N, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is N, chloro Y³ is CH P.2552 X¹ is chloro, X² is N, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2553 X¹ is chloro, X² is N, X³ is trifluoromethyl methyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2554 X¹ is chloro, X² is N, X³ is trifluoromethyl nitro Y¹ is CH, Y² is N, chloro Y³ is CH P.2555 X¹ is chloro, X² is N, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, chloro Y³ is CH P.2556 X¹ is chloro, X² is N, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, chloro Y³ is CH P.2557 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl bromo Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2558 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl chloro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2559 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl cyano Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2560 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2561 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl ethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2562 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl fluoro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2563 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl hydrogen Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2564 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl methoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2565 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl methyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2566 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl nitro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2567 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2568 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2569 X¹ is trifluoromethyl, X² is N, difluoromethyl bromo Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2570 X¹ is trifluoromethyl, X² is N, difluoromethyl chloro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2571 X¹ is trifluoromethyl, X² is N, difluoromethyl cyano Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2572 X¹ is trifluoromethyl, X² is N, difluoromethyl cyclopropyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2573 X¹ is trifluoromethyl, X² is N, difluoromethyl ethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2574 X¹ is trifluoromethyl, X² is N, difluoromethyl fluoro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2575 X¹ is trifluoromethyl, X² is N, difluoromethyl hydrogen Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2576 X¹ is trifluoromethyl, X² is N, difluoromethyl methoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2577 X¹ is trifluoromethyl, X² is N, difluoromethyl methyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2578 X¹ is trifluoromethyl, X² is N, difluoromethyl nitro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2579 X¹ is trifluoromethyl, X² is N, difluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2580 X¹ is trifluoromethyl, X² is N, difluoromethyl trifluoromethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2581 X¹ is trifluoromethyl, X² is N, trifluoromethyl bromo Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2582 X¹ is trifluoromethyl, X² is N, trifluoromethyl chloro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2583 X¹ is trifluoromethyl, X² is N, trifluoromethyl cyano Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2584 X¹ is trifluoromethyl, X² is N, trifluoromethyl cyclopropyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2585 X¹ is trifluoromethyl, X² is N, trifluoromethyl ethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2586 X¹ is trifluoromethyl, X² is N, trifluoromethyl fluoro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2587 X¹ is trifluoromethyl, X² is N, trifluoromethyl hydrogen Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2588 X¹ is trifluoromethyl, X² is N, trifluoromethyl methoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2589 X¹ is trifluoromethyl, X² is N, trifluoromethyl methyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2590 X¹ is trifluoromethyl, X² is N, trifluoromethyl nitro Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2591 X¹ is trifluoromethyl, X² is N, trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2592 X¹ is trifluoromethyl, X² is N, trifluoromethyl trifluoromethyl Y¹ is CH, Y² is N, X³ is trifluoromethyl Y³ is CH P.2593 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2594 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2595 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2596 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2597 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2598 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2599 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2600 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2601 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2602 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2603 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2604 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2605 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2606 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2607 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2608 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2609 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2610 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2611 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2612 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2613 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2614 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2615 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2616 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2617 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2618 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2619 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2620 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2621 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2622 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2623 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2624 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2625 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2626 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2627 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2628 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2629 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2630 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2631 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2632 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2633 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2634 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2635 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2636 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2637 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2638 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2639 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2640 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2641 X¹ is chloro, X² is C—F, X³ is difluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2642 X¹ is chloro, X² is C—F, X³ is difluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2643 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2644 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2645 X¹ is chloro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2646 X¹ is chloro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2647 X¹ is chloro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2648 X¹ is chloro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2649 X¹ is chloro, X² is C—F, X³ is difluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2650 X¹ is chloro, X² is C—F, X³ is difluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2651 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2652 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2653 X¹ is chloro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2654 X¹ is chloro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2655 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2656 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2657 X¹ is chloro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2658 X¹ is chloro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2659 X¹ is chloro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2660 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2661 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2662 X¹ is chloro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2663 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2664 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2665 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2666 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2667 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2668 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2669 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2670 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2671 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2672 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2673 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2674 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2675 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2676 X¹ is fluoro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2677 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2678 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2679 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2680 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2681 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2682 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2683 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2684 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2685 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2686 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2687 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2688 X¹ is fluoro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2689 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2690 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2691 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2692 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2693 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2694 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2695 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2696 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2697 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2698 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2699 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2700 X¹ is fluoro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2701 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2702 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2703 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2704 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2705 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2706 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2707 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2708 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2709 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2710 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2711 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2712 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2713 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2714 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2715 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2716 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2717 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2718 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2719 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2720 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2721 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2722 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2723 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2724 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2725 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2726 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2727 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2728 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2729 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2730 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2731 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2732 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2733 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2734 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2735 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2736 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is hydrogen CH, Y³ is N P.2737 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2738 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2739 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2740 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2741 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2742 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2743 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2744 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2745 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2746 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2747 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2748 X¹ is chloro, X² is C—Br, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2749 X¹ is chloro, X² is C—Br, X³ is difluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2750 X¹ is chloro, X² is C—Br, X³ is difluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2751 X¹ is chloro, X² is C—Br, X³ is difluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2752 X¹ is chloro, X² is C—Br, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2753 X¹ is chloro, X² is C—Br, X³ is difluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2754 X¹ is chloro, X² is C—Br, X³ is difluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2755 X¹ is chloro, X² is C—Br, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2756 X¹ is chloro, X² is C—Br, X³ is difluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2757 X¹ is chloro, X² is C—Br, X³ is difluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2758 X¹ is chloro, X² is C—Br, X³ is difluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2759 X¹ is chloro, X² is C—Br, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2760 X¹ is chloro, X² is C—Br, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2761 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2762 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2763 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2764 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2765 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2766 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2767 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2768 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2769 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2770 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2771 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2772 X¹ is chloro, X² is C—Br, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2773 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2774 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2775 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2776 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2777 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2778 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2779 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2780 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2781 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2782 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2783 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2784 X¹ is chloro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2785 X¹ is chloro, X² is C—F, X³ is difluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2786 X¹ is chloro, X² is C—F, X³ is difluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2787 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2788 X¹ is chloro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2789 X¹ is chloro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2790 X¹ is chloro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2791 X¹ is chloro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2792 X¹ is chloro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2793 X¹ is chloro, X² is C—F, X³ is difluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2794 X¹ is chloro, X² is C—F, X³ is difluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2795 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2796 X¹ is chloro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2797 X¹ is chloro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2798 X¹ is chloro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2799 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2800 X¹ is chloro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2801 X¹ is chloro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2802 X¹ is chloro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2803 X¹ is chloro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2804 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2805 X¹ is chloro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2806 X¹ is chloro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2807 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2808 X¹ is chloro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2809 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2810 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2811 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2812 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2813 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2814 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2815 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2816 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2817 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2818 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2819 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2820 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2821 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2822 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2823 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2824 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2825 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2826 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2827 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2828 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2829 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2830 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2831 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2832 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2833 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2834 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2835 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2836 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2837 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2838 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2839 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2840 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2841 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2842 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2843 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2844 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2845 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2846 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2847 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2848 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2849 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2850 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2851 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2852 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2853 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2854 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2855 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2856 X¹ is chloro, X² is C—I, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2857 X¹ is chloro, X² is C—I, X³ is difluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2858 X¹ is chloro, X² is C—I, X³ is difluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2859 X¹ is chloro, X² is C—I, X³ is difluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2860 X¹ is chloro, X² is C—I, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2861 X¹ is chloro, X² is C—I, X³ is difluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2862 X¹ is chloro, X² is C—I, X³ is difluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2863 X¹ is chloro, X² is C—I, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2864 X¹ is chloro, X² is C—I, X³ is difluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2865 X¹ is chloro, X² is C—I, X³ is difluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2866 X¹ is chloro, X² is C—I, X³ is difluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2867 X¹ is chloro, X² is C—I, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2868 X¹ is chloro, X² is C—I, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2869 X¹ is chloro, X² is C—I, X³ is trifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.2870 X¹ is chloro, X² is C—I, X³ is trifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.2871 X¹ is chloro, X² is C—I, X³ is trifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.2872 X¹ is chloro, X² is C—I, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2873 X¹ is chloro, X² is C—I, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2874 X¹ is chloro, X² is C—I, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.2875 X¹ is chloro, X² is C—I, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.2876 X¹ is chloro, X² is C—I, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2877 X¹ is chloro, X² is C—I, X³ is trifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2878 X¹ is chloro, X² is C—I, X³ is trifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.2879 X¹ is chloro, X² is C—I, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.2880 X¹ is chloro, X² is C—I, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.2881 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is fluoro CH, Y³ is N P.2882 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is fluoro CH, Y³ is N P.2883 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is fluoro CH, Y³ is N P.2884 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is fluoro CH, Y³ is N P.2885 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is fluoro CH, Y³ is N P.2886 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is fluoro CH, Y³ is N P.2887 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is fluoro CH, Y³ is N P.2888 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is fluoro CH, Y³ is N P.2889 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is fluoro CH, Y³ is N P.2890 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is fluoro CH, Y³ is N P.2891 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is fluoro CH, Y³ is N P.2892 X¹ is fluoro, X² is C—F, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is fluoro CH, Y³ is N P.2893 X¹ is fluoro, X² is C—F, X³ is difluoromethyl bromo Y¹ is CH, Y² is fluoro CH, Y³ is N P.2894 X¹ is fluoro, X² is C—F, X³ is difluoromethyl chloro Y¹ is CH, Y² is fluoro CH, Y³ is N P.2895 X¹ is fluoro, X² is C—F, X³ is difluoromethyl cyano Y¹ is CH, Y² is fluoro CH, Y³ is N P.2896 X¹ is fluoro, X² is C—F, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is fluoro CH, Y³ is N P.2897 X¹ is fluoro, X² is C—F, X³ is difluoromethyl ethyl Y¹ is CH, Y² is fluoro CH, Y³ is N P.2898 X¹ is fluoro, X² is C—F, X³ is difluoromethyl fluoro Y¹ is CH, Y² is fluoro CH, Y³ is N P.2899 X¹ is fluoro, X² is C—F, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is fluoro CH, Y³ is N P.2900 X¹ is fluoro, X² is C—F, X³ is difluoromethyl methoxy Y¹ is CH, Y² is fluoro CH, Y³ is N P.2901 X¹ is fluoro, X² is C—F, X³ is difluoromethyl methyl Y¹ is CH, Y² is fluoro CH, Y³ is N P.2902 X¹ is fluoro, X² is C—F, X³ is difluoromethyl nitro Y¹ is CH, Y² is fluoro CH, Y³ is N P.2903 X¹ is fluoro, X² is C—F, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is fluoro CH, Y³ is N P.2904 X¹ is fluoro, X² is C—F, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is fluoro CH, Y³ is N P.2905 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl bromo Y¹ is CH, Y² is fluoro CH, Y³ is N P.2906 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl chloro Y¹ is CH, Y² is fluoro CH, Y³ is N P.2907 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl cyano Y¹ is CH, Y² is fluoro CH, Y³ is N P.2908 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is fluoro CH, Y³ is N P.2909 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is fluoro CH, Y³ is N P.2910 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is fluoro CH, Y³ is N P.2911 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is fluoro CH, Y³ is N P.2912 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is fluoro CH, Y³ is N P.2913 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl methyl Y¹ is CH, Y² is fluoro CH, Y³ is N P.2914 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl nitro Y¹ is CH, Y² is fluoro CH, Y³ is N P.2915 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is fluoro CH, Y³ is N P.2916 X¹ is fluoro, X² is C—F, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is fluoro CH, Y³ is N P.2917 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is N P.2918 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is N P.2919 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is N P.2920 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2921 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2922 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is N P.2923 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is N P.2924 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.2925 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2926 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is N P.2927 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.2928 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2929 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is N P.2930 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is N P.2931 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is N P.2932 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2933 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2934 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is N P.2935 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is N P.2936 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.2937 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2938 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is N P.2939 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.2940 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2941 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is N P.2942 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is N P.2943 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is N P.2944 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2945 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2946 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is N P.2947 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is N P.2948 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.2949 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2950 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is N P.2951 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.2952 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2953 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is N P.2954 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is N P.2955 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is N P.2956 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2957 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2958 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is N P.2959 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is N P.2960 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.2961 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2962 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is N P.2963 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.2964 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2965 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is N P.2966 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is N P.2967 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is N P.2968 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2969 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2970 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is N P.2971 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is N P.2972 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.2973 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2974 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is N P.2975 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.2976 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2977 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is N P.2978 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is N P.2979 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is N P.2980 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2981 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2982 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is N P.2983 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is N P.2984 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.2985 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2986 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is N P.2987 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.2988 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2989 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is N P.2990 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is N P.2991 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is N P.2992 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2993 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2994 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is N P.2995 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is N P.2996 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.2997 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is N P.2998 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is N P.2999 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.3000 X¹ is chloro, X² is CH, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.3001 X¹ is chloro, X² is CH, X³ is difluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is N P.3002 X¹ is chloro, X² is CH, X³ is difluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is N P.3003 X¹ is chloro, X² is CH, X³ is difluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is N P.3004 X¹ is chloro, X² is CH, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is N P.3005 X¹ is chloro, X² is CH, X³ is difluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.3006 X¹ is chloro, X² is CH, X³ is difluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is N P.3007 X¹ is chloro, X² is CH, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is N P.3008 X¹ is chloro, X² is CH, X³ is difluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.3009 X¹ is chloro, X² is CH, X³ is difluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is N P.3010 X¹ is chloro, X² is CH, X³ is difluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is N P.3011 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.3012 X¹ is chloro, X² is CH, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.3013 X¹ is chloro, X² is CH, X³ is trifluoromethyl bromo Y¹ is CH, Y² is bromo CH, Y³ is N P.3014 X¹ is chloro, X² is CH, X³ is trifluoromethyl chloro Y¹ is CH, Y² is bromo CH, Y³ is N P.3015 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyano Y¹ is CH, Y² is bromo CH, Y³ is N P.3016 X¹ is chloro, X² is CH, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is bromo CH, Y³ is N P.3017 X¹ is chloro, X² is CH, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.3018 X¹ is chloro, X² is CH, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is bromo CH, Y³ is N P.3019 X¹ is chloro, X² is CH, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is bromo CH, Y³ is N P.3020 X¹ is chloro, X² is CH, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.3021 X¹ is chloro, X² is CH, X³ is trifluoromethyl methyl Y¹ is CH, Y² is bromo CH, Y³ is N P.3022 X¹ is chloro, X² is CH, X³ is trifluoromethyl nitro Y¹ is CH, Y² is bromo CH, Y³ is N P.3023 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is bromo CH, Y³ is N P.3024 X¹ is chloro, X² is CH, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is bromo CH, Y³ is N P.3025 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3026 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3027 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3028 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3029 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3030 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3031 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3032 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3033 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3034 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3035 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3036 X¹ is chloro, X² is C—Cl, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3037 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl bromo Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3038 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl chloro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3039 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyano Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3040 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3041 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl ethyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3042 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl fluoro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3043 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3044 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methoxy Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3045 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl methyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3046 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl nitro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3047 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3048 X¹ is chloro, X² is C—Cl, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3049 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl bromo Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3050 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chloro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3051 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyano Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3052 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3053 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3054 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3055 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3056 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3057 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl methyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3058 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl nitro Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3059 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3060 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is trifluoromethyl CH, Y³ is N P.3061 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3062 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3063 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3064 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3065 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3066 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3067 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3068 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3069 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3070 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3071 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3072 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3073 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3074 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3075 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3076 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3077 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3078 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3079 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3080 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3081 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3082 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3083 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3084 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3085 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3086 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3087 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3088 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3089 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3090 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3091 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3092 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3093 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3094 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3095 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3096 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3097 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3098 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3099 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3100 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3101 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3102 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3103 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3104 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3105 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3106 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3107 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3108 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3109 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3110 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3111 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3112 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3113 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3114 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3115 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3116 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3117 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3118 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3119 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3120 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3121 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3122 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3123 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3124 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3125 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3126 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3127 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3128 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3129 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3130 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3131 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3132 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3133 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl bromo Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3134 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl chloro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3135 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyano Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3136 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3137 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl ethyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3138 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl fluoro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3139 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl hydrogen Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3140 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methoxy Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3141 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl methyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3142 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl nitro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3143 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3144 X¹ is trifluoromethyl, X² is CH, chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3145 X¹ is trifluoromethyl, X² is CH, difluoromethyl bromo Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3146 X¹ is trifluoromethyl, X² is CH, difluoromethyl chloro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3147 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyano Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3148 X¹ is trifluoromethyl, X² is CH, difluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3149 X¹ is trifluoromethyl, X² is CH, difluoromethyl ethyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3150 X¹ is trifluoromethyl, X² is CH, difluoromethyl fluoro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3151 X¹ is trifluoromethyl, X² is CH, difluoromethyl hydrogen Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3152 X¹ is trifluoromethyl, X² is CH, difluoromethyl methoxy Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3153 X¹ is trifluoromethyl, X² is CH, difluoromethyl methyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3154 X¹ is trifluoromethyl, X² is CH, difluoromethyl nitro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3155 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3156 X¹ is trifluoromethyl, X² is CH, difluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3157 X¹ is trifluoromethyl, X² is CH, trifluoromethyl bromo Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3158 X¹ is trifluoromethyl, X² is CH, trifluoromethyl chloro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3159 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyano Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3160 X¹ is trifluoromethyl, X² is CH, trifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3161 X¹ is trifluoromethyl, X² is CH, trifluoromethyl ethyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3162 X¹ is trifluoromethyl, X² is CH, trifluoromethyl fluoro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3163 X¹ is trifluoromethyl, X² is CH, trifluoromethyl hydrogen Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3164 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methoxy Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3165 X¹ is trifluoromethyl, X² is CH, trifluoromethyl methyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3166 X¹ is trifluoromethyl, X² is CH, trifluoromethyl nitro Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3167 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3168 X¹ is trifluoromethyl, X² is CH, trifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is hydrogen CH, Y³ is N P.3169 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.3170 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.3171 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.3172 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.3173 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.3174 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.3175 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.3176 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.3177 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.3178 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.3179 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.3180 X¹ is chloro, X² is N, X³ is chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.3181 X¹ is chloro, X² is N, X³ is difluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.3182 X¹ is chloro, X² is N, X³ is difluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.3183 X¹ is chloro, X² is N, X³ is difluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.3184 X¹ is chloro, X² is N, X³ is difluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.3185 X¹ is chloro, X² is N, X³ is difluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.3186 X¹ is chloro, X² is N, X³ is difluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.3187 X¹ is chloro, X² is N, X³ is difluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.3188 X¹ is chloro, X² is N, X³ is difluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.3189 X¹ is chloro, X² is N, X³ is difluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.3190 X¹ is chloro, X² is N, X³ is difluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.3191 X¹ is chloro, X² is N, X³ is difluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.3192 X¹ is chloro, X² is N, X³ is difluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.3193 X¹ is chloro, X² is N, X³ is trifluoromethyl bromo Y¹ is CH, Y² is chloro CH, Y³ is N P.3194 X¹ is chloro, X² is N, X³ is trifluoromethyl chloro Y¹ is CH, Y² is chloro CH, Y³ is N P.3195 X¹ is chloro, X² is N, X³ is trifluoromethyl cyano Y¹ is CH, Y² is chloro CH, Y³ is N P.3196 X¹ is chloro, X² is N, X³ is trifluoromethyl cyclopropyl Y¹ is CH, Y² is chloro CH, Y³ is N P.3197 X¹ is chloro, X² is N, X³ is trifluoromethyl ethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.3198 X¹ is chloro, X² is N, X³ is trifluoromethyl fluoro Y¹ is CH, Y² is chloro CH, Y³ is N P.3199 X¹ is chloro, X² is N, X³ is trifluoromethyl hydrogen Y¹ is CH, Y² is chloro CH, Y³ is N P.3200 X¹ is chloro, X² is N, X³ is trifluoromethyl methoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.3201 X¹ is chloro, X² is N, X³ is trifluoromethyl methyl Y¹ is CH, Y² is chloro CH, Y³ is N P.3202 X¹ is chloro, X² is N, X³ is trifluoromethyl nitro Y¹ is CH, Y² is chloro CH, Y³ is N P.3203 X¹ is chloro, X² is N, X³ is trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is chloro CH, Y³ is N P.3204 X¹ is chloro, X² is N, X³ is trifluoromethyl trifluoromethyl Y¹ is CH, Y² is chloro CH, Y³ is N P.3205 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3206 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3207 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3208 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3209 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3210 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3211 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3212 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3213 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3214 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3215 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3216 X¹ is trifluoromethyl, X² is N, chlorodifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3217 X¹ is trifluoromethyl, X² is N, difluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3218 X¹ is trifluoromethyl, X² is N, difluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3219 X¹ is trifluoromethyl, X² is N, difluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3220 X¹ is trifluoromethyl, X² is N, difluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3221 X¹ is trifluoromethyl, X² is N, difluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3222 X¹ is trifluoromethyl, X² is N, difluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3223 X¹ is trifluoromethyl, X² is N, difluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3224 X¹ is trifluoromethyl, X² is N, difluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3225 X¹ is trifluoromethyl, X² is N, difluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3226 X¹ is trifluoromethyl, X² is N, difluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3227 X¹ is trifluoromethyl, X² is N, difluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3228 X¹ is trifluoromethyl, X² is N, difluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3229 X¹ is trifluoromethyl, X² is N, trifluoromethyl bromo Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3230 X¹ is trifluoromethyl, X² is N, trifluoromethyl chloro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3231 X¹ is trifluoromethyl, X² is N, trifluoromethyl cyano Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3232 X¹ is trifluoromethyl, X² is N, trifluoromethyl cyclopropyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3233 X¹ is trifluoromethyl, X² is N, trifluoromethyl ethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3234 X¹ is trifluoromethyl, X² is N, trifluoromethyl fluoro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3235 X¹ is trifluoromethyl, X² is N, trifluoromethyl hydrogen Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3236 X¹ is trifluoromethyl, X² is N, trifluoromethyl methoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3237 X¹ is trifluoromethyl, X² is N, trifluoromethyl methyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3238 X¹ is trifluoromethyl, X² is N, trifluoromethyl nitro Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3239 X¹ is trifluoromethyl, X² is N, trifluoromethyl trifluoromethoxy Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N P.3240 X¹ is trifluoromethyl, X² is N, trifluoromethyl trifluoromethyl Y¹ is CH, Y² is X³ is trifluoromethyl CH, Y³ is N

Table 1P:

Table 1P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.001, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 2P:

Table 2P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.002, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 3P:

Table 3P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.003, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 4P:

Table 4P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.004, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 5P:

Table 5P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.005, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 6P:

Table 6P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.006, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 7P:

Table 7P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.007, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 8P:

Table 8P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.008, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 9P:

Table 9P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.009, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 10P:

Table 10P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.010, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 11P:

Table 11P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.011, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 12P:

Table 12P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.012, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 13P:

Table 13P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.013, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 14P:

Table 14P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.014, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 15P:

Table 15P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.015, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 16P:

Table 16P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.016, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 17P:

Table 17P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.017, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 18P:

Table 18P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.018, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 19P:

Table 19P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.019, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 20P:

Table 20P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.020, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 21P:

Table 21P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.021, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 22P:

Table 22P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.022, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 23P:

Table 23P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.023, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 24P:

Table 24P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.024, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 25P:

Table 25P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.025, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 26P:

Table 26P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.026, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 27P:

Table 27P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.027, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 28P:

Table 28P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.028, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 29P:

Table 29P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.029, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 30P:

Table 30P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.030, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 31P:

Table 31P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.031, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 32P:

Table 32P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.032, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 33P:

Table 33P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.033, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 34P:

Table 34P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.034, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 35P:

Table 35P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.035, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 36P:

Table 36P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.036, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 37P:

Table 37P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.037, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 38P:

Table 38P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.038, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 39P:

Table 39P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.039, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 40P:

Table 40P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.040, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 41P:

Table 41P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.041, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 42P:

Table 42P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.042, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 43P:

Table 43P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.043, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 44P:

Table 44P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.044, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 45P:

Table 45P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.045, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 46P:

Table 46P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.046, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 47P:

Table 47P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.047, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 48P:

Table 48P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.048, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 49P:

Table 49P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.049, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 50P:

Table 50P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.050, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 51P:

Table 51P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.051, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 52P:

Table 52P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.052, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 53P:

Table 53P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.053, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 54P:

Table 54P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.054, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 55P:

Table 55P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.055, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 56P:

Table 56P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.056, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 57P:

Table 57P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.057, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 58P:

Table 58P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.058, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 59P:

Table 59P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.059, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 60P:

Table 60P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.060, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 61P:

Table 61P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.061, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 62P:

Table 62P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.062, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 63P:

Table 63P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.063, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 64P:

Table 64P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.064, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 65P:

Table 65P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.065, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 66P:

Table 66P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.066, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 67P:

Table 67P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.067, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 68P:

Table 68P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.068, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 69P:

Table 69P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.069, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 70P:

Table 70P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.070, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 71P:

Table 71P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.071, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 72P:

Table 72P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.072, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 73P:

Table 73P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.073, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 74P:

Table 74P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.074, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 75P:

Table 75P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.075, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 76P:

Table 76P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.076, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 77P:

Table 77P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.077, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 78P:

Table 78P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.078, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 79P:

Table 79P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.079, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 80P:

Table 80P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.080, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 81P:

Table 81P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.081, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 82P:

Table 82P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.082, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 83P:

Table 83P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.083, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 84P:

Table 84P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.084, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 85P:

Table 85P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.085, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 86P:

Table 86P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.086, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 87P:

Table 87P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.087, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 88P:

Table 88P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.088, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 89P:

Table 89P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.089, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 90P:

Table 90P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.090, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 91P

Table 91P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.091, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 92P

Table 92P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.092, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 93P

Table 93P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.093, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 94P

Table 94P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.094, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 95P

Table 95P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.095, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 96P

Table 96P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.096, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 97P

Table 97P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.097, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 98P

Table 98P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.098, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 99P

Table 99P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.099, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 100P

Table 100P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.100, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 101P

Table 101P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.101, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 102P

Table 102P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.102, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 103P

Table 103P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.103, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 104P

Table 104P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.104, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 105P

Table 105P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.105, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 106P

Table 106P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.106, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 107P

Table 107P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.107, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 108P

Table 108P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.108, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 109P

Table 109P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.109, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 110P

Table 110P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.110, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 111P:

Table 111P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.111, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 112 P

Table 112P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.112, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 113 P

Table 113P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.113, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 114 P

Table 114P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.114, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 115 P

Table 115P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.115, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 116 P

Table 116P provides 3240 compounds of formula (I-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.116, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

TABLE Q X1, X2, X3 X4 Q.001 X¹ is chloro, X² is CH, X³ is chloro chlorodifluoromethyl Q.002 X¹ is chloro, X² is CH, X³ is chloro difluoromethyl Q.003 X¹ is chloro, X² is CH, X³ is chloro trifluoromethyl Q.004 X¹ is chloro, X² is C—F, X³ is hydrogen chlorodifluoromethyl Q.005 X¹ is chloro, X² is C—F, X³ is hydrogen difluoromethyl Q.006 X¹ is chloro, X² is C—F, X³ is hydrogen trifluoromethyl Q.007 X¹ is fluoro, X² is C—Cl, X³ is hydrogen chlorodifluoromethyl Q.008 X¹ is fluoro, X² is C—Cl, X³ is hydrogen difluoromethyl Q.009 X¹ is fluoro, X² is C—Cl, X³ is hydrogen trifluoromethyl Q.010 X¹ is chloro, X² is C—Cl, X³ is hydrogen chlorodifluoromethyl Q.011 X¹ is chloro, X² is C—Cl, X³ is hydrogen difluoromethyl Q.012 X¹ is chloro, X² is C—Cl, X³ is hydrogen trifluoromethyl Q.013 X¹ is chloro, X² is C—Br, X³ is chloro chlorodifluoromethyl Q.014 X¹ is chloro, X² is C—Br, X³ is chloro difluoromethyl Q.015 X¹ is chloro, X² is C—Br, X³ is chloro trifluoromethyl Q.016 X¹ is chloro, X² is C—F, X³ is chloro chlorodifluoromethyl Q.017 X¹ is chloro, X² is C—F, X³ is chloro difluoromethyl Q.018 X¹ is chloro, X² is C—F, X³ is chloro trifluoromethyl Q.019 X¹ is chloro, X² is C—Cl, X³ is chloro chlorodifluoromethyl Q.020 X¹ is chloro, X² is C—Cl, X³ is chloro difluoromethyl Q.021 X¹ is chloro, X² is C—Cl, X³ is chloro trifluoromethyl Q.022 X¹ is chloro, X² is C—I, X³ is chloro chlorodifluoromethyl Q.023 X¹ is chloro, X² is C—I, X³ is chloro difluoromethyl Q.024 X¹ is chloro, X² is C—I, X³ is chloro trifluoromethyl Q.025 X¹ is fluoro, X² is C—F, X³ is fluoro chlorodifluoromethyl Q.026 X¹ is fluoro, X² is C—F, X³ is fluoro difluoromethyl Q.027 X¹ is fluoro, X² is C—F, X³ is fluoro trifluoromethyl Q.028 X¹ is chloro, X² is CH, X³ is bromo chlorodifluoromethyl Q.029 X¹ is chloro, X² is CH, X³ is bromo difluoromethyl Q.030 X¹ is chloro, X² is CH, X³ is bromo trifluoromethyl Q.031 X¹ is chloro, X² is CH, X³ is bromo chlorodifluoromethyl Q.032 X¹ is chloro, X² is CH, X³ is bromo difluoromethyl Q.033 X¹ is chloro, X² is CH, X³ is bromo trifluoromethyl Q.034 X¹ is chloro, X² is CH, X³ is bromo chlorodifluoromethyl Q.035 X¹ is chloro, X² is CH, X³ is bromo difluoromethyl Q.036 X¹ is chloro, X² is CH, X³ is bromo trifluoromethyl Q.037 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl chlorodifluoromethyl Q.038 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl difluoromethyl Q.039 X¹ is chloro, X² is C—Cl, X³ is trifluoromethyl trifluoromethyl Q.040 X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl chlorodifluoromethyl Q.041 X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl difluoromethyl Q.042 X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl trifluoromethyl Q.043 X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl chlorodifluoromethyl Q.044 X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl difluoromethyl Q.045 X¹ is trifluoromethyl, X² is CH, X³ is trifluoromethyl trifluoromethyl Q.046 X¹ is trifluoromethyl, X² is CH, X³ is hydrogen chlorodifluoromethyl Q.047 X¹ is trifluoromethyl, X² is CH, X³ is hydrogen difluoromethyl Q.048 X¹ is trifluoromethyl, X² is CH, X³ is hydrogen trifluoromethyl Q.049 X¹ is chloro, X² is N, X³ is chloro chlorodifluoromethyl Q.050 X¹ is chloro, X² is N, X³ is chloro difluoromethyl Q.051 X¹ is chloro, X² is N, X³ is chloro trifluoromethyl Q.052 X¹ is trifluoromethyl, X² is N, X³ is trifluoromethyl chlorodifluoromethyl Q.053 X¹ is trifluoromethyl, X² is N, X³ is trifluoromethyl difluoromethyl Q.054 X¹ is trifluoromethyl, X² is N, X³ is trifluoromethyl trifluoromethyl

Table 1Q:

Table 1Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.001, X¹, X², X³ and X4 have the values listed in the table Q.

Table 2Q:

Table 2 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.002, X¹, X², X³ and X4 have the values listed in the table Q.

Table 3Q:

Table 3 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.003, X¹, X², X³ and X4 have the values listed in the table Q.

Table 4Q:

Table 4 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.004, X¹, X², X³ and X4 have the values listed in the table Q.

Table 5Q:

Table 5 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.005, X¹, X², X³ and X4 have the values listed in the table Q.

Table 6Q:

Table 6 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.006, X¹, X², X³ and X4 have the values listed in the table Q.

Table 7Q:

Table 7 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.007, X¹, X², X³ and X4 have the values listed in the table Q.

Table 8Q:

Table 8 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.008, X¹, X², X³ and X4 have the values listed in the table Q.

Table 9Q:

Table 9 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.009, X¹, X², X³ and X4 have the values listed in the table Q.

Table 10Q:

Table 10 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.010, X¹, X², X³ and X4 have the values listed in the table Q.

Table 11Q:

Table 11Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.011, X¹, X², X³ and X4 have the values listed in the table Q.

Table 12Q:

Table 12 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.012, X¹, X², X³ and X4 have the values listed in the table Q.

Table 13Q

Table 13 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.013, X¹, X², X³ and X4 have the values listed in the table Q.

Table 14Q:

Table 14 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.014, X¹, X², X³ and X4 have the values listed in the table Q.

Table 15Q:

Table 15 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.015, X¹, X², X³ and X4 have the values listed in the table Q.

Table 16Q:

Table 16 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.016, X¹, X², X³ and X4 have the values listed in the table Q.

Table 17Q:

Table 17 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.017, X¹, X², X³ and X4 have the values listed in the table Q.

Table 18Q:

Table 18 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.018, X¹, X², X³ and X4 have the values listed in the table Q.

Table 19Q:

Table 19 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.019, X¹, X², X³ and X4 have the values listed in the table Q.

Table 20Q:

Table 20 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.020, X¹, X², X³ and X4 have the values listed in the table Q.

Table 21Q:

Table 21Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.021, X¹, X², X³ and X4 have the values listed in the table Q.

Table 22Q:

Table 22 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.022, X¹, X², X³ and X4 have the values listed in the table Q.

Table 23Q:

Table 23 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.023, X¹, X², X³ and X4 have the values listed in the table Q.

Table 24Q:

Table 24 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.024, X¹, X², X³ and X4 have the values listed in the table Q.

Table 25Q:

Table 25 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.025, X¹, X², X³ and X4 have the values listed in the table Q.

Table 26Q:

Table 26 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.026, X¹, X², X³ and X4 have the values listed in the table Q.

Table 27Q:

Table 27 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.027, X¹, X², X³ and X4 have the values listed in the table Q.

Table 28Q:

Table 28 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.028, X¹, X², X³ and X4 have the values listed in the table Q.

Table 29Q:

Table 29 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.029, X¹, X², X³ and X4 have the values listed in the table Q.

Table 30Q:

Table 30 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.030, X¹, X², X³ and X4 have the values listed in the table Q.

Table 31Q:

Table 31Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.031, X¹, X², X³ and X4 have the values listed in the table Q.

Table 32Q:

Table 32 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.032, X¹, X², X³ and X4 have the values listed in the table Q.

Table 33Q:

Table 33 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.033, X¹, X², X³ and X4 have the values listed in the table Q.

Table 34Q:

Table 34 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.034, X¹, X², X³ and X4 have the values listed in the table Q.

Table 35Q:

Table 35 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.035, X¹, X², X³ and X4 have the values listed in the table Q.

Table 36Q:

Table 36 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.036, X¹, X², X³ and X4 have the values listed in the table Q.

Table 37Q:

Table 37 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.037, X¹, X², X³ and X4 have the values listed in the table Q.

Table 38Q:

Table 38 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.038, X¹, X², X³ and X4 have the values listed in the table Q.

Table 39Q:

Table 39 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.039, X¹, X², X³ and X4 have the values listed in the table Q.

Table 40Q:

Table 40 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.040, X¹, X², X³ and X4 have the values listed in the table Q.

Table 41Q:

Table 41Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.041, X¹, X², X³ and X4 have the values listed in the table Q.

Table 42Q:

Table 42 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.042, X¹, X², X³ and X4 have the values listed in the table Q.

Table 43Q:

Table 43 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.043, X¹, X², X³ and X4 have the values listed in the table Q.

Table 44Q:

Table 44 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.044, X¹, X², X³ and X4 have the values listed in the table Q.

Table 45Q:

Table 45 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.045, X¹, X², X³ and X4 have the values listed in the table Q.

Table 46Q:

Table 46 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.046, X¹, X², X³ and X4 have the values listed in the table Q.

Table 47Q:

Table 47 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.047, X¹, X², X³ and X4 have the values listed in the table Q.

Table 48Q:

Table 48 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.048, X¹, X², X³ and X4 have the values listed in the table Q.

Table 49Q:

Table 49 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.049, X¹, X², X³ and X4 have the values listed in the table Q.

Table 50Q:

Table 50 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.050, X¹, X², X³ and X4 have the values listed in the table Q.

Table 51Q:

Table 51Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.051, X¹, X², X³ and X4 have the values listed in the table Q.

Table 52Q:

Table 52 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.052, X¹, X², X³ and X4 have the values listed in the table Q.

Table 53Q:

Table 53 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.053, X¹, X², X³ and X4 have the values listed in the table Q.

Table 54Q:

Table 54 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.054, X¹, X², X³ and X4 have the values listed in the table Q.

Table 55Q:

Table 55 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.055, X¹, X², X³ and X4 have the values listed in the table Q.

Table 56Q:

Table 56 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.056, X¹, X², X³ and X4 have the values listed in the table Q.

Table 57Q:

Table 57 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.057, X¹, X², X³ and X4 have the values listed in the table Q.

Table 58Q:

Table 58 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.058, X¹, X², X³ and X4 have the values listed in the table Q.

Table 59Q:

Table 59 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.059, X¹, X², X³ and X4 have the values listed in the table Q.

Table 60Q:

Table 60 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.060, X¹, X², X³ and X4 have the values listed in the table Q.

Table 61Q:

Table 61Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.061, X¹, X², X³ and X4 have the values listed in the table Q.

Table 62Q:

Table 62 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.062, X¹, X², X³ and X4 have the values listed in the table Q.

Table 63Q:

Table 63 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.063, X¹, X², X³ and X4 have the values listed in the table Q.

Table 64Q:

Table 64 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.064, X¹, X², X³ and X4 have the values listed in the table Q.

Table 65Q:

Table 65 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.065, X¹, X², X³ and X4 have the values listed in the table Q.

Table 66Q:

Table 66 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.066, X¹, X², X³ and X4 have the values listed in the table Q.

Table 67Q

Table 67 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.067, X¹, X², X³ and X4 have the values listed in the table Q.

Table 68Q:

Table 68 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.068, X¹, X², X³ and X⁴ have the values listed in the table Q.

Table 69Q:

Table 69 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.069, X¹, X², X³ and X⁴ have the values listed in the table Q.

Table 70Q:

Table 70 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.070, X¹, X², X³ and X⁴ have the values listed in the table Q.

Table 71Q:

Table 71 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.071, X¹, X², X³ and X4 have the values listed in the table Q.

Table 72Q:

Table 72 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.072, X¹, X², X³ and X4 have the values listed in the table Q.

Table 73Q:

Table 73 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.073, X¹, X², X³ and X4 have the values listed in the table Q.

Table 74Q:

Table 74 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.074, x¹, X², X³ and X4 have the values listed in the table Q.

Table 75Q:

Table 75 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.075, X¹, X², X³ and X4 have the values listed in the table Q.

Table 76Q:

Table 76 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.076, X¹, X², X³ and X4 have the values listed in the table Q.

Table 77Q:

Table 77 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.077, X¹, X², X³ and X4 have the values listed in the table Q.

Table 78Q:

Table 78 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.078, X¹, X², X³ and X4 have the values listed in the table Q.

Table 79Q:

Table 79 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.079, X¹, X², X³ and X4 have the values listed in the table Q.

Table 80Q:

Table 80 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.080, X¹, X², X³ and X4 have the values listed in the table Q.

Table 81Q:

Table 81 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.081, X¹, X², X³ and X4 have the values listed in the table Q.

Table 82Q:

Table 82 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.082, X¹, X², X³ and X4 have the values listed in the table Q.

Table 83Q:

Table 83 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.083, X¹, X², X³ and X4 have the values listed in the table Q.

Table 84Q:

Table 84 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.084, X¹, X², X³ and X4 have the values listed in the table Q.

Table 85Q:

Table 85 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.085, X¹, X², X³ and X4 have the values listed in the table Q.

Table 86Q:

Table 86 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.086, X¹, X², X³ and X4 have the values listed in the table Q.

Table 87Q:

Table 87 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.087, X¹, X², X³ and X4 have the values listed in the table Q.

Table 88Q:

Table 88 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.088, X¹, X², X³ and X4 have the values listed in the table Q.

Table 89Q:

Table 89 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.089, X¹, X², X³ and X4 have the values listed in the table Q.

Table 90Q:

Table 90 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.090, X¹, X², X³ and X4 have the values listed in the table Q.

Table 91Q:

Table 91 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.091, X¹, X², X³ and X4 have the values listed in the table Q.

Table 92 Q:

Table 92 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.092, X¹, X², X³ and X4 have the values listed in the table Q.

Table 93 Q:

Table 93 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.093, X¹, X², X³ and X4 have the values listed in the table Q.

Table 94 Q:

Table 94 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.094, X¹, X², X³ and X4 have the values listed in the table Q.

Table 95 Q:

Table 95 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.095, X¹, X², X³ and X4 have the values listed in the table Q.

Table 96 Q:

Table 96 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.096, X¹, X², X³ and X4 have the values listed in the table Q.

Table 97 Q:

Table 97 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.097, X¹, X², X³ and X4 have the values listed in the table Q.

Table 98 Q:

Table 98 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.098, X¹, X², X³ and X4 have the values listed in the table Q.

Table 99 Q:

Table 99 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.099, X¹, X², X³ and X4 have the values listed in the table Q.

Table 100 Q:

Table 100 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.100, X¹, X², X³ and X4 have the values listed in the table Q.

Table 101Q:

Table 101Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.101, X¹, X², X³ and X4 have the values listed in the table Q.

Table 102 Q:

Table 102 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.102, X¹, X², X³ and X4 have the values listed in the table Q.

Table 103 Q:

Table 103 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.103, X¹, X², X³ and X4 have the values listed in the table Q.

Table 104 Q:

Table 104 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.104, X¹, X², X³ and X4 have the values listed in the table Q.

Table 105 Q:

Table 105 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.105, X¹, X², X³ and X4 have the values listed in the table Q.

Table 106 Q:

Table 106 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.106, X¹, X², X³ and X4 have the values listed in the table Q.

Table 107 Q:

Table 107 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.107, X¹, X², X³ and X4 have the values listed in the table Q.

Table 108 Q:

Table 108 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.108, X¹, X², X³ and X4 have the values listed in the table Q.

Table 109 Q:

Table 109 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.109, X¹, X², X³ and X4 have the values listed in the table Q.

Table 110 Q:

Table 110 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.110, X¹, X², X³ and X4 have the values listed in the table Q.

Table 111Q:

Table 111Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.111, X¹, X², X³ and X4 have the values listed in the table Q.

Table 112 Q:

Table 112 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.112, X¹, X², X³ and X4 have the values listed in the table Q.

Table 113 Q:

Table 113 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.113, X¹, X², X³ and X4 have the values listed in the table Q.

Table 114 Q:

Table 114 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.114, X¹, X², X³ and X4 have the values listed in the table Q.

Table 115 Q:

Table 115 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.115, X¹, X², X³ and X4 have the values listed in the table Q.

Table 116 Q:

Table 116 Q provides 54 compounds of formula (I-B) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.116, X¹, X², X³ and X4 have the values listed in the table Q.

Table 117Q:

Table 117Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.001, X¹, X², X³ and X4 have the values listed in the table Q.

Table 118Q:

Table 118Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.002, X¹, X², X³ and X4 have the values listed in the table Q.

Table 119 Q:

Table 119Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.003, X¹, X², X³ and X4 have the values listed in the table Q.

Table 120Q:

Table 120Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.004, X¹, X², X³ and X4 have the values listed in the table Q.

Table 121 Q:

Table 121Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.005, X¹, X², X³ and X4 have the values listed in the table Q.

Table 122Q:

Table 122Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.006, X¹, X², X³ and X4 have the values listed in the table Q.

Table 123Q:

Table 123Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.007, X¹, X², X³ and X4 have the values listed in the table Q.

Table 124Q:

Table 124Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.008, X¹, X², X³ and X4 have the values listed in the table Q.

Table 125Q:

Table 125Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.009, X¹, X², X³ and X4 have the values listed in the table Q.

Table 126Q:

Table 126Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.010, X¹, X², X³ and X4 have the values listed in the table Q.

Table 127Q:

Table 127Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.011, X¹, X², X³ and X4 have the values listed in the table Q.

Table 128Q:

Table 128Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.012, X¹, X², X³ and X4 have the values listed in the table Q.

Table 129 Q:

Table 129Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.013, X¹, X², X³ and X4 have the values listed in the table Q.

Table 130Q:

Table 130Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.014, X¹, X², X³ and X4 have the values listed in the table Q.

Table 131Q:

Table 131Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.015, X¹, X², X³ and X4 have the values listed in the table Q.

Table 132Q:

Table 132Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.016, X¹, X², X³ and X4 have the values listed in the table Q.

Table 133Q:

Table 133Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.017, X¹, X², X³ and X4 have the values listed in the table Q.

Table 134Q:

Table 134Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.018, X¹, X², X³ and X4 have the values listed in the table Q.

Table 135Q:

Table 135Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.019, X¹, X², X³ and X4 have the values listed in the table Q.

Table 136Q:

Table 136Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.020, X¹, X², X³ and X4 have the values listed in the table Q.

Table 137Q:

Table 137Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.021, X¹, X², X³ and X4 have the values listed in the table Q.

Table 138Q:

Table 138Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.022, X¹, X², X³ and X4 have the values listed in the table Q.

Table 139Q:

Table 139Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.023, X¹, X², X³ and X4 have the values listed in the table Q.

Table 140Q:

Table 140Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.024, X¹, X², X³ and X4 have the values listed in the table Q.

Table 141Q:

Table 141Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.025, X¹, X², X³ and X4 have the values listed in the table Q.

Table 142Q:

Table 142Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.026, X¹, X², X³ and X4 have the values listed in the table Q.

Table 143Q:

Table 143Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.027, X¹, X², X³ and X4 have the values listed in the table Q.

Table 144Q:

Table 144Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.028, X¹, X², X³ and X4 have the values listed in the table Q.

Table 145 Q:

Table 145Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.029, X¹, X², X³ and X4 have the values listed in the table Q.

Table 146 Q:

Table 146Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.030, X¹, X², X³ and X4 have the values listed in the table Q.

Table 147 Q:

Table 147Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.031, X¹, X², X³ and X4 have the values listed in the table Q.

Table 148Q:

Table 148Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.032, X¹, X², X³ and X4 have the values listed in the table Q.

Table 149Q:

Table 149Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.033, X¹, X², X³ and X4 have the values listed in the table Q.

Table 150 Q:

Table 150Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.034, X¹, X², X³ and X4 have the values listed in the table Q.

Table 151 Q:

Table 151Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.035, X¹, X², X³ and X4 have the values listed in the table Q.

Table 152Q:

Table 152Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.036, X¹, X², X³ and X4 have the values listed in the table Q.

Table 153Q:

Table 153Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.037, X¹, X², X³ and X4 have the values listed in the table Q.

Table 154Q:

Table 154Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.038, X¹, X², X³ and X4 have the values listed in the table Q.

Table 155 Q:

Table 155Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.039, X¹, X², X³ and X4 have the values listed in the table Q.

Table 156 Q:

Table 156Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.040, X¹, X², X³ and X4 have the values listed in the table Q.

Table 157Q:

Table 157Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.041, X¹, X², X³ and X4 have the values listed in the table Q.

Table 158Q:

Table 158Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.042, X¹, X², X³ and X4 have the values listed in the table Q.

Table 159 Q:

Table 159Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.043, X¹, X², X³ and X4 have the values listed in the table Q.

Table 160Q:

Table 160Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.044, X¹, X², X³ and X4 have the values listed in the table Q.

Table 161Q:

Table 161Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.045, X¹, X², X³ and X4 have the values listed in the table Q.

Table 162 Q:

Table 162Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.046, X¹, X², X³ and X4 have the values listed in the table Q.

Table 163Q:

Table 163Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.047, X¹, X², X³ and X4 have the values listed in the table Q.

Table 164 Q:

Table 164Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.048, X¹, X², X³ and X4 have the values listed in the table Q.

Table 165 Q:

Table 165Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.049, X¹, X², X³ and X4 have the values listed in the table Q.

Table 166Q:

Table 166Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.050, X¹, X², X³ and X4 have the values listed in the table Q.

Table 167 Q:

Table 167Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.051, X¹, X², X³ and X4 have the values listed in the table Q.

Table 168Q:

Table 168Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.052, X¹, X², X³ and X4 have the values listed in the table Q.

Table 169Q:

Table 169Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.053, X¹, X², X³ and X4 have the values listed in the table Q.

Table 170 Q:

Table 170Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.054, X¹, X², X³ and X4 have the values listed in the table Q.

Table 171Q:

Table 171Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.055, X¹, X², X³ and X4 have the values listed in the table Q.

Table 172Q:

Table 172Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.056, X¹, X², X³ and X4 have the values listed in the table Q.

Table 173Q:

Table 173Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.057, X¹, X², X³ and X4 have the values listed in the table Q.

Table 174Q:

Table 174Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.058, X¹, X², X³ and X4 have the values listed in the table Q.

Table 175Q:

Table 175Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.059, X¹, X², X³ and X4 have the values listed in the table Q.

Table 176Q:

Table 176Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.060, X¹, X², X³ and X4 have the values listed in the table Q.

Table 177Q:

Table 177Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.061, X¹, X², X³ and X4 have the values listed in the table Q.

Table 178Q:

Table 178Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.062, X¹, X², X³ and X4 have the values listed in the table Q.

Table 179Q:

Table 179Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.063, X¹, X², X³ and X4 have the values listed in the table Q.

Table 180 Q:

Table 180Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.064, X¹, X², X³ and X4 have the values listed in the table Q.

Table 181 Q:

Table 181Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.065, X¹, X², X³ and X4 have the values listed in the table Q.

Table 182 Q:

Table 182Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.066, X¹, X², X³ and X4 have the values listed in the table Q.

Table 183Q:

Table 183Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.067, X¹, X², X³ and X4 have the values listed in the table Q.

Table 184Q:

Table 184Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.068, X¹, X², X³ and X4 have the values listed in the table Q.

Table 185Q:

Table 185Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.069, X¹, X², X³ and X4 have the values listed in the table Q.

Table 186 Q:

Table 186Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.070, X¹, X², X³ and X4 have the values listed in the table Q.

Table 187Q:

Table 187Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.071, X¹, X², X³ and X4 have the values listed in the table Q.

Table 188Q:

Table 188Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.072, X¹, X², X³ and X4 have the values listed in the table Q.

Table 189Q:

Table 189Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.073, X¹, X², X³ and X4 have the values listed in the table Q.

Table 190 Q:

Table 190Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.074, X¹, X², X³ and X4 have the values listed in the table Q.

Table 191Q:

Table 191Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.075, X¹, X², X³ and X4 have the values listed in the table Q.

Table 192 Q:

Table 192Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.076, X¹, X², X³ and X4 have the values listed in the table Q.

Table 193 Q:

Table 193Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.077, X¹, X², X³ and X4 have the values listed in the table Q.

Table 194Q:

Table 194Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.078, X¹, X², X³ and X4 have the values listed in the table Q.

Table 195Q:

Table 195Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.079, X¹, X², X³ and X4 have the values listed in the table Q.

Table 196Q:

Table 196Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.080, X¹, X², X³ and X4 have the values listed in the table Q.

Table 197Q:

Table 197Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.081, X¹, X², X³ and X4 have the values listed in the table Q.

Table 198Q:

Table 198Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.082, X¹, X², X³ and X4 have the values listed in the table Q.

Table 199Q:

Table 199Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.083, X¹, X², X³ and X4 have the values listed in the table Q.

Table 200Q:

Table 200Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.084, X¹, X², X³ and X4 have the values listed in the table Q.

Table 201Q:

Table 201Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.085, X¹, X², X³ and X4 have the values listed in the table Q.

Table 202Q:

Table 202Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.086, X¹, X², X³ and X4 have the values listed in the table Q.

Table 203Q:

Table 203Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.087, X¹, X², X³ and X4 have the values listed in the table Q.

Table 204 Q:

Table 204Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.088, X¹, X², X³ and X4 have the values listed in the table Q.

Table 205 Q:

Table 205Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.089, X¹, X², X³ and X4 have the values listed in the table Q.

Table 206 Q:

Table 206Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.090, X¹, X², X³ and X4 have the values listed in the table Q.

Table 207Q:

Table 207Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.091, X¹, X², X³ and X4 have the values listed in the table Q.

Table 208Q:

Table 208Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.092, X¹, X², X³ and X4 have the values listed in the table Q.

Table 209Q:

Table 209Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.093, X¹, X², X³ and X4 have the values listed in the table Q.

Table 210Q:

Table 210Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.094, X¹, X², X³ and X4 have the values listed in the table Q.

Table 211Q:

Table 211Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.095, X¹, X², X³ and X4 have the values listed in the table Q.

Table 212Q:

Table 212Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.096, X¹, X², X³ and X4 have the values listed in the table Q.

Table 213Q:

Table 213Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.097, X¹, X², X³ and X4 have the values listed in the table Q.

Table 214 Q:

Table 214Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.098, X¹, X², X³ and X4 have the values listed in the table Q.

Table 215 Q:

Table 215Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.099, X¹, X², X³ and X4 have the values listed in the table Q.

Table 216Q:

Table 216Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.100, X¹, X², X³ and X4 have the values listed in the table Q.

Table 217 Q:

Table 217Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.101, X¹, X², X³ and X4 have the values listed in the table Q.

Table 218 Q:

Table 218Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.102, X¹, X², X³ and X4 have the values listed in the table Q.

Table 219Q:

Table 219Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.103, X¹, X², X³ and X4 have the values listed in the table Q.

Table 220 Q:

Table 220Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.104, X¹, X², X³ and X4 have the values listed in the table Q.

Table 221Q:

Table 221Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.105, X¹, X², X³ and X4 have the values listed in the table Q.

Table 222 Q:

Table 222Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.106, X¹, X², X³ and X4 have the values listed in the table Q.

Table 223 Q:

Table 223Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.107, X¹, X², X³ and X4 have the values listed in the table Q.

Table 224 Q:

Table 224Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.108, X¹, X², X³ and X4 have the values listed in the table Q.

Table 225 Q:

Table 225Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.109, X¹, X², X³ and X4 have the values listed in the table Q.

Table 226 Q:

Table 226Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.110, X¹, X², X³ and X4 have the values listed in the table Q.

Table 227 Q:

Table 227Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.111, X¹, X², X³ and X4 have the values listed in the table Q.

Table 228Q:

Table 228Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.112, X¹, X², X³ and X4 have the values listed in the table Q.

Table 229 Q:

Table 229Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.113, X¹, X², X³ and X4 have the values listed in the table Q.

Table 230Q:

Table 230Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.114, X¹, X², X³ and X4 have the values listed in the table Q.

Table 231Q:

Table 231Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.115, X¹, X², X³ and X4 have the values listed in the table Q.

Table 232 Q:

Table 232Q provides 54 compounds of formula (I-C) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.116, X¹, X², X³ and X4 have the values listed in the table Q.

TABLE HET Het Chemical structure Het.01

Het.02

Het.03

Het.04

Table 117P

Table 117P provides 3240 compounds of formula (I-D) wherein Het is Het.01 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 118P

Table 118P provides 3240 compounds of formula (I-D) wherein Het is Het.02 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 119 P

Table 119P provides 3240 compounds of formula (I-D) wherein Het is Het.03 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 120 P

Table 120P provides 3240 compounds of formula (I-D) wherein Het is Het.04 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 233Q

Table 233Q provides 54 compounds of formula (I-E) wherein G¹ is oxygen, R¹ is hydrogen, Het is Het.01 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 234Q

Table 234Q provides 54 compounds of formula (I-E) wherein G¹ is oxygen, R¹ is hydrogen, Het is Het.02 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 235Q

Table 235Q provides 54 compounds of formula (I-E) wherein G¹ is oxygen, R¹ is hydrogen, Het is Het.03, X¹, X², X³ and X4 have the values listed in the table Q.

Table 236Q

Table 236Q provides 54 compounds of formula (I-E) wherein G¹ is oxygen, R¹ is hydrogen, Het is Het.04, X¹, X², X³ and X4 have the values listed in the table Q.

Table 237Q

Table 237Q provides 54 compounds of formula (I-F) wherein G¹ is oxygen, R¹ is hydrogen, Het is Het.01, X¹, X², X³ and X4 have the values listed in the table Q.

Table 238Q

Table 238Q provides 54 compounds of formula (I-F) wherein G¹ is oxygen, R¹ is hydrogen, Het is Het.02, X¹, X², X³ and X4 have the values listed in the table Q.

Table 239Q

Table 239Q provides 54 compounds of formula (I-F) wherein G¹ is oxygen, R¹ is hydrogen, Het is Het.03, X¹, X², X³ and X4 have the values listed in the table Q.

Table 240Q

Table 240Q provides 54 compounds of formula (I-F) wherein G¹ is oxygen, R¹ is hydrogen, Het is Het.04, X¹, X², X³ and X4 have the values listed in the table Q.

TABLE GI Gi Chemical structure G01

G02

G03

G04

G05 CN G06 F G07 Br G08 I G09 Cl G10 NO₂ G11 OH G12 NH₂ G13 COOH G14 COOMe G15 COOEt G16 COOPr G17 COOBu G18 COOtBu G19 COOPh G20 CH₃

Table 121P

Table 121P provides 3240 compounds of formula (II-A) wherein Gi is G01 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 122P

Table 122P provides 3240 compounds of formula (II-A) wherein Gi is G02 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 123P

Table 123P provides 3240 compounds of formula (II-A) wherein Gi is G03 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 124 P

Table 124P provides 3240 compounds of formula (II-A) wherein Gi is G04 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 125P

Table 125P provides 3240 compounds of formula (II-A) wherein Gi is G051 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 126P

Table 126P provides 3240 compounds of formula (II-A) wherein Gi is G06 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 127P

Table 127P provides 3240 compounds of formula (II-A) wherein Gi is G07 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 128 P

Table 128P provides 3240 compounds of formula (II-A) wherein Gi is G08 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 129P

Table 129P provides 3240 compounds of formula (II-A) wherein Gi is G09 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 130P

Table 130P provides 3240 compounds of formula (II-A) wherein Gi is G10 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 131P

Table 131P provides 3240 compounds of formula (II-A) wherein Gi is G11 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 132 P

Table 132P provides 3240 compounds of formula (II-A) wherein Gi is G12 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 133P

Table 133P provides 3240 compounds of formula (II-A) wherein Gi is G13 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 134P

Table 134P provides 3240 compounds of formula (II-A) wherein Gi is G14 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 135P

Table 135P provides 3240 compounds of formula (II-A) wherein Gi is G15 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 136 P

Table 136P provides 3240 compounds of formula (II-A) wherein Gi is G16 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 137 P

Table 137P provides 3240 compounds of formula (II-A) wherein Gi is G17 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 138P

Table 138P provides 3240 compounds of formula (II-A) wherein Gi is G18 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 139P

Table 139P provides 3240 compounds of formula (II-A) wherein Gi is G19 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 140P

Table 140P provides 3240 compounds of formula (II-A) wherein Gi is G20 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 141P

Table 141P provides 3240 compounds of formula (II-B) wherein Gi is G01 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 142P

Table 142P provides 3240 compounds of formula (II-B) wherein Gi is G02 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 143P

Table 143P provides 3240 compounds of formula (II-B) wherein Gi is G03 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 144 P

Table 144P provides 3240 compounds of formula (II-B) wherein Gi is G04 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 145P

Table 145P provides 3240 compounds of formula (II-B) wherein Gi is G051 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 146P

Table 146P provides 3240 compounds of formula (II-B) wherein Gi is G06 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 147P

Table 147P provides 3240 compounds of formula (II-B) wherein Gi is G07 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 148 P

Table 148P provides 3240 compounds of formula (II-B) wherein Gi is G08 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 149P

Table 149P provides 3240 compounds of formula (II-B) wherein Gi is G09 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 150P

Table 150P provides 3240 compounds of formula (II-B) wherein Gi is G10 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 151P

Table 151P provides 3240 compounds of formula (II-B) wherein Gi is G11 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 152 P

Table 152P provides 3240 compounds of formula (II-B) wherein Gi is G12 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 153P

Table 153P provides 3240 compounds of formula (II-B) wherein Gi is G13 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 154P

Table 154P provides 3240 compounds of formula (II-B) wherein Gi is G14 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 155P

Table 155P provides 3240 compounds of formula (II-B) wherein Gi is G15 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 156 P

Table 156P provides 3240 compounds of formula (II-B) wherein Gi is G16 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 157 P

Table 157P provides 3240 compounds of formula (II-B) wherein Gi is G17 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 158P

Table 158P provides 3240 compounds of formula (II-B) wherein Gi is G18 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 159P

Table 159P provides 3240 compounds of formula (II-B) wherein Gi is G19 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 160P

Table 160P provides 3240 compounds of formula (II-B) wherein Gi is G20 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 161P

Table 161P provides 3240 compounds of formula (II-C) wherein Gi is G01 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 162P

Table 162P provides 3240 compounds of formula (II-C) wherein Gi is G02 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 163P

Table 163P provides 3240 compounds of formula (II-C) wherein Gi is G03 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 164 P

Table 164P provides 3240 compounds of formula (II-C) wherein Gi is G04 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 165P

Table 165P provides 3240 compounds of formula (II-C) wherein Gi is G051 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 166P

Table 166P provides 3240 compounds of formula (II-C) wherein Gi is G06 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 167P

Table 167P provides 3240 compounds of formula (II-C) wherein Gi is G07 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 168 P

Table 168P provides 3240 compounds of formula (II-C) wherein Gi is G08 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 169P

Table 169P provides 3240 compounds of formula (II-C) wherein Gi is G09 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 170P

Table 170P provides 3240 compounds of formula (II-C) wherein Gi is G10 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 171P

Table 171P provides 3240 compounds of formula (II-C) wherein Gi is G11 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 172 P

Table 172P provides 3240 compounds of formula (II-C) wherein Gi is G12 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 173P

Table 173P provides 3240 compounds of formula (II-C) wherein Gi is G13 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 174P

Table 174P provides 3240 compounds of formula (II-C) wherein Gi is G14 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 175P

Table 175P provides 3240 compounds of formula (II-C) wherein Gi is G15 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 176 P

Table 176P provides 3240 compounds of formula (II-C) wherein Gi is G16 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 177 P

Table 177P provides 3240 compounds of formula (II-C) wherein Gi is G17 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 178P

Table 178P provides 3240 compounds of formula (II-C) wherein Gi is G18 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 179P

Table 179P provides 3240 compounds of formula (II-C) wherein Gi is G19 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 180P

Table 180P provides 3240 compounds of formula (II-C) wherein Gi is G20 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 181P

Table 181P provides 3240 compounds of formula (II-D) wherein Gi is G01 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 182P

Table 182P provides 3240 compounds of formula (II-D) wherein Gi is G02 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 183P

Table 183P provides 3240 compounds of formula (II-D) wherein Gi is G03 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 184 P

Table 184P provides 3240 compounds of formula (II-D) wherein Gi is G04 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 185P

Table 185P provides 3240 compounds of formula (II-D) wherein Gi is G051 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 186P

Table 186P provides 3240 compounds of formula (II-D) wherein Gi is G06 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 187P

Table 187P provides 3240 compounds of formula (II-D) wherein Gi is G07 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 188 P

Table 188P provides 3240 compounds of formula (II-D) wherein Gi is G08 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 189P

Table 189P provides 3240 compounds of formula (II-D) wherein Gi is G09 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 190P

Table 190P provides 3240 compounds of formula (II-D) wherein Gi is G10 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 191P

Table 191P provides 3240 compounds of formula (II-D) wherein Gi is G11 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 192 P

Table 192P provides 3240 compounds of formula (II-D) wherein Gi is G12 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 193P

Table 193P provides 3240 compounds of formula (II-D) wherein Gi is G13 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 194P

Table 194P provides 3240 compounds of formula (II-D) wherein Gi is G14 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 195P

Table 195P provides 3240 compounds of formula (II-D) wherein Gi is G15 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 196 P

Table 196P provides 3240 compounds of formula (II-D) wherein Gi is G16 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 197 P

Table 197P provides 3240 compounds of formula (II-D) wherein Gi is G17 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 198P

Table 198P provides 3240 compounds of formula (II-D) wherein Gi is G18 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 199P

Table 199P provides 3240 compounds of formula (II-D) wherein Gi is G19 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 200P

Table 200P provides 3240 compounds of formula (II-D) wherein Gi is G20 and X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 241Q

Table 241Q provides 54 compounds of formula (II-E) wherein Gi is G01 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 242Q

Table 242Q provides 54 compounds of formula (II-E) wherein Gi is G02 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 243Q

Table 243Q provides 54 compounds of formula (II-E) wherein Gi is G03 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 244Q

Table 244Q provides 54 compounds of formula (II-E) wherein Gi is G04 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 245Q

Table 245Q provides 54 compounds of formula (II-E) wherein Gi is G05 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 246Q

Table 246Q provides 54 compounds of formula (II-E) wherein Gi is G06 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 247Q

Table 247Q provides 54 compounds of formula (II-E) wherein Gi is G07 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 248Q

Table 248Q provides 54 compounds of formula (II-E) wherein Gi is G08 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 249Q

Table 249Q provides 54 compounds of formula (II-E) wherein Gi is G09 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 250Q

Table 250Q provides 54 compounds of formula (II-E) wherein Gi is G10 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 251Q

Table 251Q provides 54 compounds of formula (II-E) wherein Gi is G11 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 252Q

Table 252Q provides 54 compounds of formula (II-E) wherein Gi is G12 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 253Q

Table 253Q provides 54 compounds of formula (II-E) wherein Gi is G13 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 254Q

Table 254Q provides 54 compounds of formula (II-E) wherein Gi is G14 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 255Q

Table 255Q provides 54 compounds of formula (II-E) wherein Gi is G15 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 256Q

Table 256Q provides 54 compounds of formula (II-E) wherein Gi is G16 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 257Q

Table 257Q provides 54 compounds of formula (II-E) wherein Gi is G17 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 258Q

Table 258Q provides 54 compounds of formula (II-E) wherein Gi is G18 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 259Q

Table 259Q provides 54 compounds of formula (II-E) wherein Gi is G19 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 260Q

Table 260Q provides 54 compounds of formula (II-E) wherein Gi is G20 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 261Q

Table 261Q provides 54 compounds of formula (II-F) wherein Gi is G01 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 262Q

Table 262Q provides 54 compounds of formula (II-F) wherein Gi is G02 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 263Q

Table 263Q provides 54 compounds of formula (II-F) wherein Gi is G03 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 264Q

Table 264Q provides 54 compounds of formula (II-F) wherein Gi is G04 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 265Q

Table 265Q provides 54 compounds of formula (II-F) wherein Gi is G05 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 266Q

Table 266Q provides 54 compounds of formula (II-F) wherein Gi is G06 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 267Q

Table 267Q provides 54 compounds of formula (II-F) wherein Gi is G07 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 268Q

Table 268Q provides 54 compounds of formula (II-F) wherein Gi is G08 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 269Q

Table 269Q provides 54 compounds of formula (II-F) wherein Gi is G09 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 270Q

Table 270Q provides 54 compounds of formula (II-F) wherein Gi is G10 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 271Q

Table 271Q provides 54 compounds of formula (II-F) wherein Gi is G11 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 272Q

Table 272Q provides 54 compounds of formula (II-F) wherein Gi is G12 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 273Q

Table 273Q provides 54 compounds of formula (II-F) wherein Gi is G13 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 274Q

Table 274Q provides 54 compounds of formula (II-F) wherein Gi is G14 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 275Q

Table 275Q provides 54 compounds of formula (II-F) wherein Gi is G15 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 276Q

Table 276Q provides 54 compounds of formula (II-F) wherein Gi is G16 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 277Q

Table 277Q provides 54 compounds of formula (II-F) wherein Gi is G17 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 278Q

Table 278Q provides 54 compounds of formula (II-F) wherein Gi is G18 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 279Q

Table 279Q provides 54 compounds of formula (II-F) wherein Gi is G19 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 280Q

Table 280Q provides 54 compounds of formula (II-F) wherein Gi is G20 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 281Q

Table 281Q provides 54 compounds of formula (II-G) wherein Gi is G01 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 282Q

Table 282Q provides 54 compounds of formula (II-G) wherein Gi is G02 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 283Q

Table 283Q provides 54 compounds of formula (II-G) wherein Gi is G03 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 284Q

Table 284Q provides 54 compounds of formula (II-G) wherein Gi is G04 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 285Q

Table 285Q provides 54 compounds of formula (II-G) wherein Gi is G05 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 286Q

Table 286Q provides 54 compounds of formula (II-G) wherein Gi is G06 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 287Q

Table 287Q provides 54 compounds of formula (II-G) wherein Gi is G07 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 288Q

Table 288Q provides 54 compounds of formula (II-G) wherein Gi is G08 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 289Q

Table 289Q provides 54 compounds of formula (II-G) wherein Gi is G09 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 290Q

Table 290Q provides 54 compounds of formula (II-G) wherein Gi is G10 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 291Q

Table 291Q provides 54 compounds of formula (II-G) wherein Gi is G11 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 292Q

Table 292Q provides 54 compounds of formula (II-G) wherein Gi is G12 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 293Q

Table 293Q provides 54 compounds of formula (II-G) wherein Gi is G13 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 294Q

Table 294Q provides 54 compounds of formula (II-G) wherein Gi is G14 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 295Q

Table 295Q provides 54 compounds of formula (II-G) wherein Gi is G15 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 296Q

Table 296Q provides 54 compounds of formula (II-G) wherein Gi is G16 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 297Q

Table 297Q provides 54 compounds of formula (II-G) wherein Gi is G17 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 298Q

Table 298Q provides 54 compounds of formula (II-G) wherein Gi is G18 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 299Q

Table 299Q provides 54 compounds of formula (II-G) wherein Gi is G19 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 300Q

Table 300Q provides 54 compounds of formula (II-G) wherein Gi is G20 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 301Q

Table 301Q provides 54 compounds of formula (II-H) wherein Gi is G01 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 302Q

Table 302Q provides 54 compounds of formula (II-H) wherein Gi is G02 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 303Q

Table 303Q provides 54 compounds of formula (II-H) wherein Gi is G03 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 304Q

Table 304Q provides 54 compounds of formula (II-H) wherein Gi is G04 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 305Q

Table 305Q provides 54 compounds of formula (II-H) wherein Gi is G05 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 306Q

Table 306Q provides 54 compounds of formula (II-H) wherein Gi is G06 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 307Q

Table 307Q provides 54 compounds of formula (II-H) wherein Gi is G07 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 308Q

Table 308Q provides 54 compounds of formula (II-H) wherein Gi is G08 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 309Q

Table 309Q provides 54 compounds of formula (II-H) wherein Gi is G09 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 310Q

Table 310Q provides 54 compounds of formula (II-H) wherein Gi is G10 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 311Q

Table 311Q provides 54 compounds of formula (II-H) wherein Gi is G11 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 312Q

Table 312Q provides 54 compounds of formula (II-H) wherein Gi is G12 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 313Q

Table 313Q provides 54 compounds of formula (II-H) wherein Gi is G13 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 314Q

Table 314Q provides 54 compounds of formula (II-H) wherein Gi is G14 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 315Q

Table 315Q provides 54 compounds of formula (II-H) wherein Gi is G15 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 316Q

Table 316Q provides 54 compounds of formula (II-H) wherein Gi is G16 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 317Q

Table 317Q provides 54 compounds of formula (II-H) wherein Gi is G17 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 318Q

Table 318Q provides 54 compounds of formula (II-H) wherein Gi is G18 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 319Q

Table 319Q provides 54 compounds of formula (II-H) wherein Gi is G19 and X¹, X², X³ and X4 have the values listed in the table Q.

Table 320Q

Table 320Q provides 54 compounds of formula (II-H) wherein Gi is G20 and X¹, X², X³ and X4 have the values listed in the table Q.

TABLE S R⁵ Y¹, Y², Y³ S.001 hydrogen Y¹ is CH, Y² is CH, Y³ is CH S.002 chloro Y¹ is CH, Y² is CH, Y³ is CH S.003 bromo Y¹ is CH, Y² is CH, Y³ is CH S.004 fluoro Y¹ is CH, Y² is CH, Y³ is CH S.005 trifluoromethyl Y¹ is CH, Y² is CH, Y³ is CH S.006 methyl Y¹ is CH, Y² is CH, Y³ is CH S.007 ethyl Y¹ is CH, Y² is CH, Y³ is CH S.008 methoxy Y¹ is CH, Y² is CH, Y³ is CH S.009 nitro Y¹ is CH, Y² is CH, Y³ is CH S.010 trifluoromethoxy Y¹ is CH, Y² is CH, Y³ is CH S.011 cyano Y¹ is CH, Y² is CH, Y³ is CH S.012 cyclopropyl Y¹ is CH, Y² is CH, Y³ is CH S.013 hydrogen Y¹ is N, Y² is CH, Y³ is CH S.014 chloro Y¹ is N, Y² is CH, Y³ is CH S.015 bromo Y¹ is N, Y² is CH, Y³ is CH S.016 fluoro Y¹ is N, Y² is CH, Y³ is CH S.017 trifluoromethyl Y¹ is N, Y² is CH, Y³ is CH S.018 methyl Y¹ is N, Y² is CH, Y³ is CH S.019 ethyl Y¹ is N, Y² is CH, Y³ is CH S.020 methoxy Y¹ is N, Y² is CH, Y³ is CH S.021 nitro Y¹ is N, Y² is CH, Y³ is CH S.022 trifluoromethoxy Y¹ is N, Y² is CH, Y³ is CH S.023 cyano Y¹ is N, Y² is CH, Y³ is CH S.024 cyclopropyl Y¹ is N, Y² is CH, Y³ is CH S.025 hydrogen Y¹ is N, Y² is N, Y³ is CH S.026 chloro Y¹ is N, Y² is N, Y³ is CH S.027 bromo Y¹ is N, Y² is N, Y³ is CH S.028 fluoro Y¹ is N, Y² is N, Y³ is CH S.029 trifluoromethyl Y¹ is N, Y² is N, Y³ is CH S.030 methyl Y¹ is N, Y² is N, Y³ is CH S.031 ethyl Y¹ is N, Y² is N, Y³ is CH S.032 methoxy Y¹ is N, Y² is N, Y³ is CH S.033 nitro Y¹ is N, Y² is N, Y³ is CH S.034 trifluoromethoxy Y¹ is N, Y² is N, Y³ is CH S.035 cyano Y¹ is N, Y² is N, Y³ is CH S.036 cyclopropyl Y¹ is N, Y² is N, Y³ is CH S.037 hydrogen Y¹ is CH, Y² is N, Y³ is CH S.038 chloro Y¹ is CH, Y² is N, Y³ is CH S.039 bromo Y¹ is CH, Y² is N, Y³ is CH S.040 fluoro Y¹ is CH, Y² is N, Y³ is CH S.041 trifluoromethyl Y¹ is CH, Y² is N, Y³ is CH S.042 methyl Y¹ is CH, Y² is N, Y³ is CH S.043 ethyl Y¹ is CH, Y² is N, Y³ is CH S.044 methoxy Y¹ is CH, Y² is N, Y³ is CH S.045 nitro Y¹ is CH, Y² is N, Y³ is CH S.046 trifluoromethoxy Y¹ is CH, Y² is N, Y³ is CH S.047 cyano Y¹ is CH, Y² is N, Y³ is CH S.048 cyclopropyl Y¹ is CH, Y² is N, Y³ is CH S.049 hydrogen Y¹ is CH, Y² is CH, Y³ is N S.050 chloro Y¹ is CH, Y² is CH, Y³ is N S.051 bromo Y¹ is CH, Y² is CH, Y³ is N S.052 fluoro Y¹ is CH, Y² is CH, Y³ is N S.053 trifluoromethyl Y¹ is CH, Y² is CH, Y³ is N S.054 methyl Y¹ is CH, Y² is CH, Y³ is N S.055 ethyl Y¹ is CH, Y² is CH, Y³ is N S.056 methoxy Y¹ is CH, Y² is CH, Y³ is N S.0057 nitro Y¹ is CH, Y² is CH, Y³ is N S.058 trifluoromethoxy Y¹ is CH, Y² is CH, Y³ is N S.059 cyano Y¹ is CH, Y² is CH, Y³ is N S.060 cyclopropyl Y¹ is CH, Y² is CH, Y³ is N

Table 1S

Table 1S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.001, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 2S

Table 2S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.002, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 3S

Table 3S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.003, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 4S

Table 4S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.004, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 5S

Table 5S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.005, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 6S

Table 6S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.006, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 7S

Table 7S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.007, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 8S

Table 8S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.008, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 9S

Table 9S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.009, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 10S

Table 10S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.010, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 11S

Table 11S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.011, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 12S

Table 12S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.012, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 13S

Table 13S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.013, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 14S

Table 14S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.014, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 15S

Table 15S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.015, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 16S

Table 16S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.016, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 17S

Table 17S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.017, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 18S

Table 18S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.018, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 19S

Table 19S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.019, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 20S

Table 20S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.020, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 21S

Table 21S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.021, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 22S

Table 22S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.022, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 23S

Table 23S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.023, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 24S

Table 24S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.024, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 25S

Table 25S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.025, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 26S

Table 26S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.026, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 27S

Table 27S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.027, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 28S

Table 28S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.028, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 29S

Table 29S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.029, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 30S

Table 30S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.030, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 31S

Table 31S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.031, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 32S

Table 32S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.032, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 33S

Table 33S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.033, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 34S

Table 34S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.034, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 35S

Table 35S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.035, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 36S

Table 36S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.036, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 37S

Table 37S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.037, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 38S

Table 38S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.038, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 39S

Table 39S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.039, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 40S

Table 40S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.040, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 41S

Table 41S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.041, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 42S

Table 42S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.042, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 43S

Table 43S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.043, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 44S

Table 44S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.044, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 45S

Table 45S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.045, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 46S

Table 46S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.046, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 47S

Table 47S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.047, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 48S

Table 48S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.048, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 49S

Table 49S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.049, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 50S

Table 50S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.050, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 51S

Table 51S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.051, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 52S

Table 52S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.052, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 53S

Table 53S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.053, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 54S

Table 54S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.054, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 55S

Table 55S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.055, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 56S

Table 56S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.056, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 57S

Table 57S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.057, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 58S

Table 58S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.058, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 59S

Table 59S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.059, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 60S

Table 60S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.060, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 61S

Table 61S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.061, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 62S

Table 62S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.062, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 63S

Table 63S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.063, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 64S

Table 64S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.064, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 65S

Table 65S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.065, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 66S

Table 66S provides 3240 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.066, X¹, X², X³, Y¹, Y², Y³, X⁴ and R⁵ have the values listed in the table P.

Table 67S

Table 67S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.067, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 68S

Table 68S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.068, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 69S

Table 69S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.069, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 70S

Table 70S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.070, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 71S

Table 71S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.071, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 72S

Table 72S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.072, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 73S

Table 73S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.073, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 74S

Table 74S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.074, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 75S

Table 75S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.075, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 76S

Table 76S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.076, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 77S

Table 77S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.077, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 78S

Table 78S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.078, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 79S

Table 79S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.079, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 80S

Table 80S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.080, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 81S

Table 81S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.081, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 82S

Table 82S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.082, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 83S

Table 83S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.083, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 84S

Table 84S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.084, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 85S

Table 85S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.085, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 86S

Table 86S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.086, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 87S

Table 87S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.087, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 88S

Table 88S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.088, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 89S

Table 89S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.089, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 90S

Table 90S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.090, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 91S

Table 91S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.091, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 92S

Table 92S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.092, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 93S

Table 93S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.093, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 94S

Table 94S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.094, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 95S

Table 95S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.095, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 96S

Table 96S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.096, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 97S

Table 97S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.097, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 98S

Table 98S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.098, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 99S

Table 99S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.099, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 100S

Table 100S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.100, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 101S

Table 101S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.101, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 102S

Table 102S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.102, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 132S

Table 103S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.103, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 104S

Table 104S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.104, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 105S

Table 105S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.105, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 106S

Table 106S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.106, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 107S

Table 107S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.107, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 108S

Table 108S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.108, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 109S

Table 109S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.109, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 110S

Table 110S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.110, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 111S

Table 111S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.111, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 112S

Table 112S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.112, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 113S

Table 113S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.113, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 114S

Table 114S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.114, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 115S

Table 115S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.115, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 116S

Table 116S provides 60 compounds of formula (III-A) wherein G¹ is oxygen, R¹ is hydrogen, R² is G.116, Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 1T:

Table 1T provides 116 compounds of formula (III-B) wherein G¹ is oxygen, R¹ is hydrogen, R² has the values listed in Table G.

Table 1U:

Table 1U provides 116 compounds of formula (III-C) wherein G¹ is oxygen, R¹ is hydrogen, R² has the values listed in Table G.

Table 117S

Table 117S provides 60 compounds of formula (III-D) wherein Het is Het.01, and Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 118S

Table 1185 provides 60 compounds of formula (III-D) wherein Het is Het.02 and Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 119S

Table 119S provides 60 compounds of formula (III-D) wherein Het is Het.03 and Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 120S

Table 120S provides 60 compounds of formula (III-D) wherein Het is Het.04 and Y¹, Y², Y³ and R⁵ have the values listed in the table S.

Table 1V

Table 1V provides 4 compounds of formula (III-E) wherein Het has the values as listed in Table Het.

Table 1W

Table 1W provides 4 compounds of formula (III-F) wherein Het has the values listed in Table Het.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing insects of the family Curculionidae, preferably in for use in controlling and/or preventing Anthonomus grandis.

Additional examples of insects from the family of Curculionidae. are Anthonomus corvulus, Anthonomus elutus, Anthonomus elongatus, Anthonomus eugenii, Anthonomus consors, Anthonomus haematopus, Anthonomus lecontei, Anthonomus molochinus, Anthonomus morticinus, Anthonomus musculus, Anthonomus nigrinus, Anthonomus phyllocola, Anthonomus pictus, Anthonomus pomorum, Anthonomus quadrigibbus, Anthonomus rectirostris, Anthonomus rubi, Anthonomus santacruzi, Anthonomus signatus, Anthonomus subfasciatus, and Anthonomus tenebrosus.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use against Anthonomus grandis in cotton.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing soil pests.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing corn rootworm, in particular for use against corn root worm from the genus Diabrotica.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing corn Diabrotica virgifera.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing corn Diabrotica barberi.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing corn Diabrotica undecimpunctata howardi.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing wireworms, in particular Agriotes spp.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing Agriotes spp. in cereals, potato or corn.

Additional examples of Agriotes spp. include Agriotes lineatus, Agriotes obscurus, Agriotes brevis, Agriotes gurgistanus, Agriotes sputator, Agriotes ustulatus, Ctenicera destructor, and Limonius californicus.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing grubs, in particular white grubs.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing Phyllophaga spp., particularly on corn, soybean or cotton.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing Diloboderus spp. particularly on corn, soybean or cotton.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing Popillia japonica, particularly on corn, soybean or cotton.

Additional examples of white grubs include Phyllophaga anxia, Phyllophaga crinite, Phyllophaga subnitida, Diloboderus abderus.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing termites, e.g. on sugarcane.

Examples of termites include Reticulitermes, Coptotermes, Macrotermes, Microtermes, Globitermes. Specific of subterranean termites include Reticulitermes flavipes, Reticulitermes hesperus, Reticulitermes verginicus, Reticulitermes hageni, Reticulitermes speratus, Reticulitermes lucifugus, Heterotermes aureus, Coptotermes formosanus, Coptotermes acinaciformis, Coptotermes curvignathus, Nasutitermes exitiosus, Nasutitermes walkeri, Mastotermes darwiniensis, Schedorhinotermes spp, Macrotermes bellicosus, Macrotermes spp., Globitermes sulphureus, Odontotermes spp. Specific examples of dry wood termites include Incisitermes minor, Marginitermes hubbardi, Cryptotermes brevis, Kalotermes flavicollis. Additional examples of termites include procornitermes spp. and procornitermes araujoi

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing subterraneous stinkbugs, e.g. Scaptocoris spp.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing Scaptocoris castaneus, in particular on cereals, soybean or corn.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing cutworms, e.g. agrotis spp.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing Agrotis ipsilon, particularly on cereals, canola, soybean or corn.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing millipedes, e.g. Julus spp.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing Julus spp., particularly on cereals, canola, soybean & corn.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing broca gigante, e.g. Telchin licus, particularly on sugarcane.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing whitefly.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing Bemisia tabaci, particularly on vegetables, cotton, soybean, or potatoes.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing Trialeurodes vaporariorum, particularly on vegetables, cotton, soybean, or potatoes.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing stinkbugs, in particular Euschistus spp.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use in controlling and/or preventing Euschistus spp., particularly in soybean.

Examples of stinkbugs include Nezara spp. (e.g. Nezara viridula, Nezara antennata, Nezara hilare), Piezodorus spp. (e.g. Piezodorus guildinii), Acrosternum spp. Euchistus spp. (e.g. Euchistus heros, Euschistus servus), Halyomorpha halys, Plautia crossota, Riptortus clavatus, Rhopalus msculatus, Antestiopsis orbitalus, Dichelops spp. (e.g. Dichelops furcatus, Dichelops melacanthus), Eurygaster spp. (e.g. Eurygaster intergriceps, Eurygaster maura), Oebalus spp. (e.g. Oebalus mexicana, Oebalus poecilus, Oebalus pugnase, Scotinophara spp. (e.g. Scotinophara lurida, Scotinophara coarctata). Preferred targets include Antestiopsis orbitalus, Dichelops furcatus, Dichelops melacanthus, Euchistus heros, Euschistus servus, Nezara viridula, Nezara hilare, Piezodorus guildinii, Halyomorpha halys. In one embodiment the stinkbug target is Nezara viridula, Piezodorus spp., Acrosternum spp, Euchistus heros.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use against rice pests.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use against stemborer, particularly in rice.

Examples of stemborers include Chilo sp, Chilo suppressalis, Chilo polychrysus, Chilo auricilius, Scirpophaga spp., Scirpophaga incertulas, Scirpophaga innotata, Scirpophaga nivella Sesamia sp, Sesamia inferens.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use against leaffolder, particularly in rice.

Examples of leaffolders include Cnaphalocrocis spp., Cnaphalocrocis medinalis, Marasmia spp., Marasmia patnalis, Marasmia exigua.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use against hoppers, particularly in rice.

Examples of Hoppers include Nephotettix spp., Nephotettix virescens, Nephotettix nigropictus, Nephotettix malayanus, Nephotettix cincticeps, Nilaparvata lugens, Sogatella furcifera.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use against gallmidge, particularly in rice.

Examples of Gall midge include Orseolia sp, Orseolia oryzae.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use against whorl maggot, particularly in rice.

Examples of whorl maggots include Hydrellia sp., Hydrellia philippina.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use against Rice bugs, particularly in rice.

Examples of rice bugs include Leptocorisa sp, Leptocorisa oratorius, Leptocorisa chinensis, Leptocorisa acuta.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use against Black bugs, particularly in rice.

Examples of Black bugs include Scotinophara sp, Scotinophara coarctata, Scotinophara lurida, Scotinophara latiuscula.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use against plutella spp.

In one embodiment the invention provides a compound selected from Tables 1P to 120P and 1Q to 240Q for use against Plutella xylostella, particularly in brassica crops.

The compounds of the invention may be made by a variety of methods as shown in the following Schemes.

-   1) Compounds of formula (IX) wherein Rx is C₁-C₁₅alkoxy can be     prepared by reacting a compound of formula (VIII) with the vinyl     compound of formula (VII) in the presence or not of a suitable     solvent, for example N,N-dimethylformamide, xylene, toluene,     chlorobenzene or dichlorobenzene. The reaction can be performed     under microwave heating preferably at temperatures up to 200° C. and     preferably under neat conditions using a large excess of the     compound of formula VII (e.g. 40 equivalents). Vinyl compounds of     formula (VII) are commercially available or can be made by methods     known to a person skilled in the art. Compounds of formula (VIII)     can be made by methods known to a person skilled in the art, as     described in journal of Organic Chemistry (1981), 46(4), 771-775.

-   2) Compounds of formula (XI) can be prepared by reacting a compound     of formula (X) wherein X is a leaving group, for example a halogen,     such as bromo, with a compound of formula (VII), using the same     methods as described in 1).

-   3) Compounds of formula (I) can be prepared by reacting a compound     of formula (XII) wherein P is as described for the compound I, with     a compound of formula (VII), using the same methods as described in     1).

-   4) Compounds of formula (I-A) can be prepared by reacting a compound     of formula (XI) wherein X is a leaving group, for example a halogen,     such as bromo, with carbon monoxide and an amine of formula (XIII),     in the presence of a catalyst, such as palladium(II) diacetate, a     ligand, such as a phosphine ligand, such as tributylphosphine, and a     base such as cesium carbonate, or diisopropylethylamine (Hunig's     base). The reaction is carried out in a suitable solvent, such as     toluene, at a temperature of from 50° C. to 200° C., preferably from     100° C. to 150° C., in particular at 115° C. The reaction is carried     out at a pressure of from 50 to 200 bar, preferably from 100 to 150     bar, in particular at 120 bar.

-   5) Compounds of formula (I-A) can be made by treatment of a compound     of formula (XIV) with a compound of formula (XIII) and a dehydrating     reagent. Alternatively, carboxylic acid (XIV) is transformed to an     activated derivative, such as an acid chloride, for instance by     treatment with thionyl chloride, or a mixed anhydride, for instance     by treatment with ethyl chloroformate, and the activated derivative     is reacted with a compound of formula (XIII), optionally in the     presence of a base, and in a suitable solvent, such as, for     instance, tetrahydrofuran. The reaction is carried out at a     temperature of from −120° C. to +130° C., preferably from −100° C.     to 100° C. -   6) Alternatively, compounds of formula (I-A) can be made from a     compound of formula (IX) wherein Rx is C₁-C₁₅alkoxy by heating the     ester and an amine of formula (XIII) together in a thermal process     Amines of formula (XIII) are known in the literature or can be     prepared using methods known to a person skilled in the art. -   7) Compounds of formula (XIV) can be made by treatment of a compound     of formula (XI), wherein X is a halogen, for instance bromine, with     a metallating agent, such as a metal, for instance magnesium, or an     organometallic compound, for instance butyllithium, followed by the     treatment with carbon dioxide. The reaction is carried out at a     temperature of from −120° C. to +130° C., preferably from −100° C.     to 100° C. -   8) Compounds of formula (XIV) can be made by hydrolysis of a     compound of formula (IX), and Rx is C₁-C₁₅alkyl, such as methyl or     tert-butyl. For instance, in the case where Rx is methyl or ethyl,     the hydrolysis can be done with water and a base, such as potassium     hydroxide, in the absence or in the presence of a solvent, such as,     for instance, tetrahydrofuran or methanol. In the case where Rx is,     for example, tert-butyl, the hydrolysis is done in the presence of     acid, such as trifluoroacetic acid or hydrochloric acid. The     reaction is carried out at a temperature of from −120° C. to +130°     C., preferably from −100° C. to 100° C. -   9) Compounds of formula (IX) wherein Rx is C₁-C₁₅alkoxy, can be     prepared by reacting a compound of formula (XI) wherein X is a     leaving group, for example a halogen, such as bromo, with carbon     monoxide and an alcohol of formula Rx-OH, such as ethanol, in the     presence of a catalyst, such as bis(triphenylphosphine)palladium(II)     dichloride, and a base, such as pyridine, triethylamine,     4-(dimethylamino)-pyridine (“DMAP”) or diisopropylethylamine     (Hunig's base). The reaction is carried out at a temperature of from     50° C. to 200° C., preferably from 100° C. to 150° C., in particular     at 115° C. The reaction is carried out at a pressure of from 50 to     200 bar, preferably from 100 to 150 bar, in particular at 120 bar.

-   10) Compounds of formula (IA), wherein Pn is an optionally     substituted heterocycle, can be made, for example in the case where     the heterocycle is attached via a nitrogen atom, by treatment of a     compound (XI) wherein X is a halogen, such as fluorine, with a     heterocyclic compound Pn-H and a suitable base, such as potassium     carbonate. Alternatively, compounds of formula (IA), wherein Pn is     an optionally substituted heterocycle, can be made, for example in     the case where the heterocycle is attached via a carbon atom, by     treatment of a compound (XI) wherein X is a halogen, such as     bromine, with a heterocyclic compound Pn-M, wherein M is hydrogen or     a metal, such as boron, magnesium or zinc, in which case M can be     optionally substituted, with a base and a suitable catalyst, such as     a palladium or a copper catalyst, in the presence of a suitable     ligand for the catalyst, such as, for example, a diamine ligand, or     a phosphine ligand. Such reactions are carried out at a temperature     of from −120° C. to +130° C., preferably from −100° C. to 100° C.

-   11) Compounds of formula (XVII) wherein P is as defined for     compounds (I) and Z¹ is hydrogen, halogen, cyano, C₁-C₈alkyl,     aryl-C₁-C₄alkylene-, C₁-C₈alkylcarbonyl-, arylsulfonyl- or     arylthio-, can be obtained by reacting an unsaturated ketone of     formula (XV) wherein G¹ is oxygen, with a sulfur nucleophile, such     as thioacetic acid, hydrogen sulfide, sodium sulfide, ammonium     sulfide, thiourea, benzylmercaptan, Sodium benzenethiosulfonate,     sodium thiomethoxide or tert-butyl mercaptan as shown on Scheme 7.     Such reactions can be performed optionally in the presence of a     base, such as sodium hydroxide, sodium ethoxide, sodium methoxide,     sodium tert-butoxide or potassium hydroxide. Sometimes, such     reactions can also be performed in the presence of an acid, for     example p-toluenesulfonic acid, hydrochloric acid, acetic acid, in a     solvent, such as methanol, ethanol, N,N-dimethylformamide, toluene,     dichloromethane, ethyl acetate, acetonitrile or chlorobenzene or     water, or mixtures thereof, at a temperature of from 0° C. to 100°     C., preferably from ambient temperature to 80° C. Such conditions     are described, for example, in Journal of the American Chemical     Society (1949), 71, 3554-5 or in Tetrahedron: Asymmetry (2003),     14(1), 113-117 and Journal of Organic Chemistry (1996), 61, 1986. -   12) Compounds of formula (XVI) wherein P is as defined for     compounds (I) and Z³ is thiol or aryl substituted     C₁-C₈alkylsulfinyl-, can be made by reaction of the ketone of     formula (XV) with an amine, such as triphenylmethanesulfenamide.     Such reactions are usually carried out in the presence of an acid or     not, for example p-toluenesulfonic acid, hydrochloric acid, acetic     acid, optionally in the presence of a solvent, for example an     alcohol, such as methanol or ethanol, or toluene, dichloromethane,     water, or mixtures thereof. The reaction can be carried our in the     presence or the absence of a dehydrating agent, such as anhydrous     magnesium sulfate or molecular sieves. It can also be performed     using a Dean Stark or Soxhlet apparatus that enables a constant     removal of the water formed during the reaction. The reaction is     carried out at a temperature of from 0° C. to 100° C., preferably     from 15° C. to 30° C., in particular at ambient temperature. -   13) Compounds of formula (XVIII) wherein P is as defined for     compounds (I) and Z² is hydrogen or hydroxyl or C₁-C₈alkoxy- or     C₁-C₈alkylsulfonyloxy- or C₁-C₈arylsulfonyloxy- or     aryl-C₁-C₄alkylene- or aryl, can be made by reaction of the ketone     of formula (XVII) with an amine, such as hydroxylamine     hydrochloride, methoxylamine or ammonia. Such reactions are carried     out in the presence of a base, for example an organic base, such as     triethylamine or sodium acetate, or an inorganic base, such as     sodium hydrogen carbonate, optionally in the presence of a solvent,     for example an alcohol, such as methanol or ethanol, or water, or     mixtures thereof. Such reactions can also be carried out in the     presence of an acid or not, for example p-toluenesulfonic acid,     hydrochloric acid, acetic acid, optionally in the presence of a     solvent, for example an alcohol, such as methanol or ethanol, or     toluene, dichloromethane, water, or mixtures thereof. The reaction     can be carried our in the presence or the absence of a dehydrating     agent, such as anhydrous magnesium sulfate or molecular sieves. It     can also be performed using a Dean Stark or Soxhlet apparatus that     enables a constant removal of the water formed during the reaction.     The reaction is carried out at a temperature of from 0° C. to 100°     C., preferably from 15° C. to 30° C., in particular at ambient     temperature. -   14) Compounds of formula (I) can be obtained by cyclising a compound     of formula (XVI) wherein Z³ is thiol. Such reactions are usually     carried out in the presence of an acid or not, for example     p-toluenesulfonic acid, optionally in the presence of a solvent, for     example dichloroethane, methanol, ethanol, toluene, dichloromethane     or chlorobenzene. The reaction is carried out at a temperature of     from 0° C. to 200° C., preferably from 25° C. to 100° C.     Alternatively, compounds of formula (I) wherein P is as defined for     compounds (I) can be obtained by cyclising a compound of     formula (XVI) wherein Z³ is aryl substituted C₁-C₈alkylsulfinyl-.     Such reactions are usually carried out in the presence of an acid or     not, for example p-toluenesulfonic acid, trifluoroacetic acid or     hydrochloric acid, optionally in the presence of a solvent, for     example dichloroethane, methanol, ethanol, toluene, dichloromethane     or chlorobenzene. The reaction is carried out at a temperature of     from 0° C. to 200° C., preferably from 25° C. to 100° C. Such     reactions usually involve first the deprotection of the thiol to     give a compound of formula (XVI) wherein Z³ is thiol, followed by     the cyclization. -   15) Compounds of formula (I) can be obtained from compound of     formula (XVIII) wherein Z¹ is hydrogen or C₁-C₈alkyl or     aryl-C₁-C₄alkylene- or C₁-C₈alkylcarbonyl- or arylsulfonyl- or     arylthio-, and Z² is hydrogen or hydroxyl or C₁-C₈alkoxy- or     C₁-C₈alkylsulfonyloxy- or C₁-C₈arylsulfonyloxy- or     aryl-C₁-C₄alkylene- or aryl. Such reactions usually involve the     deprotection of Z¹ and of Z² or of both groups. The reaction can     then involve the following intermediates:

Depending on the nature of Z¹ and Z², the deprotection conditions are different and can be made by methods known to a person skilled in the art or as described in T. W. Green, P. G. M. Wuts, Protective Groups in Organic Synthesis, Wiley-Interscience, New York, 1999, 564-566, 740-743.

-   16) Compounds of formula (I) can be obtained from compound of     formula (XVIIIa) from an oxidation step. Such reactions are usually     carried out in the presence of an oxidant, for example iodine,     bromine, thionyl chloride, Bis(trifluoroacetoxy)iodobenzene; The     reaction can be carried our in the presence of an acid or not, such     as trifluoroacetic acid or acetic acid, optionally in the presence     of a solvent, for example dichloroethane, dimethylsulfoxide,     N,N-dimethylformamide, methanol, ethanol, toluene, dichloromethane,     ethyl acetate or chlorobenzene. The reaction is carried out at a     temperature of from 0° C. to 200° C., preferably from 25° C. to     100° C. Such transformations, including reaction conditions and     suitable catalyst, are described in Journal of the Chemical Society,     Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999)     (1985), (1), 153-7 and Organic Letters (2006), 8(21), 4811-4813.     Similarly, compounds of formula (I-I) wherein P is as defined for     compounds (I) can be obtained from a compound of formula (XVIIIb)     wherein Z¹ is arylsulfonyl- or arylthio-, by an oxidation step, are     described in Journal of Organic Chemistry (1990), 55(13), 4156-62. -   17) Compounds of formula (I) can be obtained from compound of     formula (XVIIIc) wherein Z² is C₁-C₈alkoxy-. Such reactions are     usually carried out in the presence of a copper (I) reagent, such     copper-3-methylsalicylate. The reaction can be carried out in the     presence of a solvent, for example dichloroethane,     dimethylsulfoxide, N,N-dimethylformamide, methanol, ethanol,     toluene, dichloromethane, ethyl acetate or chlorobenzene. The     reaction is carried out at a temperature of from 0° C. to 200° C.,     preferably from 25° C. to 100° C., or under microwave heating     conditions. Such transformations are described in Journal of the     American Chemical Society (2011), 133, 6403-6410. -   18) Alternatively, compounds of formula (I) can be obtained directly     from a compound of formula (XVII) wherein Z¹ is hydrogen. Such     reactions are usually carried out in the presence chloramines,     formed in situ from ammonia and chlorine or sodium hypochlorite or     hypochlorous acid, optionally in the presence of a solvent, for     example dichloroethane, methanol, ethanol, toluene, dichloromethane     or chlorobenzene. The reaction is carried out at a temperature of     from −80° C. to 40° C., preferably below −40° C. -   19) Alternatively, compounds of formula (I) can be obtained directly     from a compound of formula (XVII) wherein Z¹ is halogen, cyano,     arylsulfonyl- or arylthio-. Such reactions are usually carried out     in the presence ammonia, optionally in the presence of a solvent,     for example dichloroethane, tetrahydrofuran, methanol, ethanol,     toluene, dichloromethane or chlorobenzene. The reaction is carried     out at a temperature of from −80° C. to 80° C. -   20) Alternatively, compounds of formula (I) can be obtained directly     from a compound of formula (XVII) wherein Z¹ is aryl-C₁-C₄alkylene.     Such reactions are usually carried out in two steps—The first one     involves the treatment of a compound of formula (XVII) wherein Z¹ is     aryl-C₁-C₄alkylene by a suitable oxidant, such as sulfuryl chloride     or chlorine, in the presence of a solvent, for example     dichloroethane, methanol, ethanol, toluene, dichloromethane or     chlorobenzene, to provide a compound of formula (XVII) wherein Z¹ is     chlorine. The second step then involves the treatment a compound of     formula (XVII) wherein Z¹ is chlorine by an ammonia source, such as     ammonia or ammonium bromide in the presence of a base, in the     presence of a solvent, for example dichloroethane, methanol,     ethanol, toluene, tetrahydrofuran, dichloromethane or chlorobenzene.     Both steps are usually carried out at a temperature of from −80° C.     to 80° C. -   21) Alternatively, compounds of formula (I) can be obtained directly     from a compound of formula (XVII) wherein Z¹ is hydrogen. Such     reactions are usually carried out in the presence of a suitable     nitrogen electrophile, such as Hydroxylamine-O-sulfonic acid. Such     reactions are carried out in the presence of a base, for example an     organic base, such as triethylamine or sodium acetate, or an     inorganic base, such as sodium hydrogen carbonate, sodium hydroxide     or potassium hydroxide optionally in the presence of a solvent, for     example tetrahydrofuran, toluene, an alcohol, such as methanol or     ethanol, or water, or mixtures thereof. The reaction is carried out     at a temperature of from −80° C. to 80° C.

-    18)

Similarly to what is described from 11) to 16), compounds of (XI) wherein X is a leaving group, for example a halogen, such as bromo can be obtained.

19)

Similarly to what is described from 11) to 16), compounds of formula (XXVII) wherein Rx is C₁-C₁₅alkoxy can be obtained. Unless otherwise indicated in the above descriptions reference to leaving groups includes leaving groups such as halogen, C₁-C₈alkoxy, C₁-C₈alkylsulfonyloxy, C₁-C₈haloalkylsulfonyloxy, C₁-C₈arylsulfonyloxy, optionally substituted C₁-C₈arylsulfonyloxy (aryl is preferably phenyl), diazonium salts (e.g. the leaving group may be selected from —N₂ ⁺ Cl⁻, —N₂ ⁺ BF₄ ⁻, —N₂ ⁺ Br⁻, —N₂ ⁺ PF₆ ⁻) and phosphonate esters (e.g. —OP(O)(OR)₂, wherein R is methyl or ethyl).

The compounds of formula (I) can be used to combat and control infestations of insect pests such as Lepidoptera, Diptera, Hemiptera, Thysanoptera, Orthoptera, Dictyoptera, Coleoptera, Siphonaptera, Hymenoptera and Isoptera and also other invertebrate pests, for example, acarine, nematode and mollusc pests. Insects, acarines, nematodes and molluscs are hereinafter collectively referred to as pests. The pests which may be combated and controlled by the use of the compounds of the invention include those pests associated with agriculture (which term includes the growing of crops for food and fiber products), horticulture and animal husbandry, companion animals, forestry and the storage of products of vegetable origin (such as fruit, grain and timber); those pests associated with the damage of man-made structures and the transmission of diseases of man and animals; and also nuisance pests (such as flies). The compounds of the invention may be used for example on turf, ornamentals, such as flowers, shrubs, broad-leaved trees or evergreens, for example conifers, as well as for tree injection, pest management and the like. Compositions comprising the compound of formula I may be used on ornamental garden plants (e.g. flowers, shrubs, broad-leaved trees or evergreens), e.g. to control aphids, whitefly, scales, meelybug, beetles and caterpillars. Compositions comprising the compound of formula I may be used on garden plants (e.g. flowers, shrubs, broad-leaved trees or evergreens), on indoor plants (e.g. flowers and shrubs) and on indoor pest e.g. to control aphids, whitefly, scales, meelybug, beetles and caterpillars.

Furthermore, the compounds of the invention may be effective against harmful insects, without substantially imposing any harmful side effects to cultivated plants. Application of the compounds of the invention may increase the harvest yields, and may improve the quality of the harvested material. The compounds of the invention may have favourable properties with respect to amount applied, residue formulation, selectivity, toxicity, production methodology, high activity, wide spectrum of control, safety, control of resistant organisms, e.g. pests that are resistant to organic phosphorus agents and/or carbamate agents.

Examples of pest species which may be controlled by the compounds of formula (I) include: coleopterans, for example, Callosobruchus chinensis, Sitophilus zeamais, Tribolium castaneum, Epilachna vigintioctomaculata, Agriotes fuscicollis, Anomala rufocuprea, Leptinotarsa decemlineata, Diabrotica spp., Monochamus alternatus, Lissorhoptrus oryzophilus, Lyctus bruneus, Aulacophora femoralis; lepidopterans, for example, Lymantria dispar, Malacosoma neustria), Pieris rapae, Spodoptera litura, Mamestra brassicae, Chilo suppressalis), Pyrausta nubilalis, Ephestia cautella, Adoxophyes orana, Carpocapsa pomonella, Agrotisfucosa, Galleria mellonella, Plutella maculipennis, Heliothis virescens, Phyllocnistis citrella; hemipterans, for example, Nephotettix cincticeps, Nilaparvata lugens, Pseudococcus comstocki, Unaspis yanonensis, Myzus persicas, Aphis pomi, Aphis gossypii, Rhopalosiphum pseudobrassicas, Stephanitis nashi, Nezara spp., Trialeurodes vaporariorm, Psylla spp.; thysanopterans, for example, Thrips palmi, Franklinella occidental; orthopterans, for example, Blatella germanica, Periplaneta americana, Gryllotalpa Africana, Locusta migratoria migratoriodes; isopterans, for example, Reticulitermes speratus, Coptotermes formosanus; dipterans, for example, Musca domestica, Aedes aegypti, Hylemia platura, Culex pipiens, Anopheles sinensis, Culex tritaeniorhynchus, Liriomyza trifolii; acari, for example, Tetranychus cinnabarinus, Tetranychus urticae, Panonychus citri, Aculops pelekassi, Tarsonemus spp.; nematodes, for example, Meloidogyne incognita, Bursaphelenchus lignicolus Mamiya et Kiyohara, Aphelenchoides besseyi, Heterodera glycines, Pratylenchus spp.

Examples of further pest species which may be controlled by the compounds of formula (I) include: from the order of the Anoplura (Phthiraptera), for example, Damalinia spp., Haematopinus spp., Linognathus spp., Pediculus spp., Trichodectes spp.; from the class of the Arachnida, for example, Acarus siro, Aceria sheldoni, Aculops spp., Aculus spp., Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa, Chorioptes spp., Dermanyssus gallinae, Eotetranychus spp., Epitrimerus pyri, Eutetranychus spp., Eriophyes spp., Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectus mactans, Metatetranychus spp., Oligonychus spp., Ornithodoros spp., Panonychus spp., Phyllocoptruta oleivora, Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Scorpio maurus, Stenotarsonemus spp., Tarsonemus spp., Tetranychus spp., Vasates lycopersici; from the class of the Bivalva, for example, Dreissena spp.; from the order of the Chilopoda, for example, Geophilus spp., Scutigera spp.; from the order of the Coleoptera, for example, Acanthoscehdes obtectus, Adoretus spp., Agelastica alni, Agriotes spp., Amphimallon solstitialis, Anobium punctatum, Anoplophora spp., Anthonomus spp., Anthrenus spp., Apogonia spp., Atomaria spp., Attagenus spp., Bruchidius obtectus, Bruchus spp., Ceuthorhynchus spp., Cleonus mendicus, Conoderus spp., Cosmopolites spp., Costelytra zealandica, Curculio spp., Cryptorhynchus lapathi, Dermestes spp., Diabrotica spp., Epilachna spp., Faustinus cubae, Gibbium psylloides, Heteronychus arator, Hylamorpha elegans, Hylotrupes bajulus, Hypera postica, Hypothenemus spp., Lachnosterna consanguinea, Leptinotarsa decemlineata, Lissorhoptrus oryzophilus, Lixus spp., Lyctus spp., Meligethes aeneus, Melolontha melolontha, Migdolus spp., Monochamus spp., Naupactus xanthographus, Niptus hololeucus, Oryctes rhinoceros, Oryzaephilus surinamensis, Otiorrhynchus sulcatus, Oxycetonia jucunda, Phaedon cochleariae, Phyllophaga spp., Popillia japonica, Premnotrypes spp., Psylliodes chrysocephala, Ptinus spp., Rhizobius ventralis, Rhizopertha dominica, Sitophilus spp., Sphenophorus spp., Sternechus spp., Symphyletes spp., Tenebrio molitor, Tribolium spp., Trogoderma spp., Tychius spp., Xylotrechus spp., Zabrus spp.; from the order of the Collembola, for example, Onychiurus armatus; from the order of the Dermaptera, for example, Forficula auricularia; from the order of the Diplopoda, for example, Blaniulus guttulatus; from the order of the Diptera, for example, Aedes spp., Anopheles spp., Bibio hortulanus, Calliphora erythrocephala, Ceratitis capitata, Chrysomyia spp., Cochliomyia spp., Cordylobia anthropophaga, Culex spp., Cuterebra spp., Dacus oleae, Dermatobia hominis, Drosophila spp., Fannia spp., Gastrophilus spp., Hylemyia spp., Hyppobosca spp., Hypoderma spp., Liriomyza spp., Lucilia spp., Musca spp., Nezara spp., Oestrus spp., Oscinella frit, Pegomyia hyoscyami, Phorbia spp., Stomoxys spp., Tabanus spp., Tannia spp., Tipula paludosa, Wohlfahrtia spp.; from the class of the Gastropoda, for example, Arion spp., Biomphalaria spp., Bulinus spp., Deroceras spp., Galba spp., Lymnaea spp., Oncomelania spp., Succinea spp.; from the class of the helminths, for example, Ancylostoma duodenale, Ancylostoma ceylanicum, Acylostoma braziliensis, Ancylostoma spp., Ascaris lubricoides, Ascaris spp., Brugia malayi, Brugia timori, Bunostomum spp., Chabertia spp., Clonorchis spp., Cooperia spp., Dicrocoelium spp, Dictyocaulus filaria, Diphyllobothrium latum, Dracunculus medinensis, Echinococcus granulosus, Echinococcus multilocularis, Enterobius vermicularis, Faciola spp., Haemonchus spp., Heterakis spp., Hymenolepis nana, Hyostrongulus spp., Loa Loa, Nematodirus spp., Oesophagostomum spp., Opisthorchis spp., Onchocerca volvulus, Ostertagia spp., Paragonimus spp., Schistosomen spp., Strongyloides fuelleborni, Strongyloides stercoralis, Stronyloides spp., Taenia saginata, Taenia solium, Trichinella spiralis, Trichinella nativa, Trichinella britovi, Trichinella nelsoni, Trichinella pseudopsiralis, Trichostrongulus spp., Trichuris trichuria, Wuchereria bancrofti; ft may be furthermore possible to control protozoa, such as Eimeria; from the order of the Heteroptera, for example, Anasa tristis, Antestiopsis spp., Blissus spp., Calocoris spp., Campylomma livida, Cavelerius spp., Cimex spp., Creontiades dilutus, Dasynus piperis, Dichelops furcatus, Diconocoris hewetti, Dysdercus spp., Euschistus spp., Eurygaster spp., Heliopeltis spp., Horcias nobilellus, Leptocorisa spp., Leptoglossus phyllopus, Lygus spp., Macropes excavatus, Miridae, Nezara spp., Oebalus spp., Pentomidae, Piesma quadrata, Piezodorus spp., Psallus seriatus, Pseudacysta persea, Rhodnius spp., Sahlbergella singularis, Scotinophora spp., Stephanitis nashi, Tibraca spp., Triatoma spp.; from the order of the Homoptera, for example, Acyrthosipon spp., Aeneolamia spp., Agonoscena spp., Aleurodes spp., Aleurolobus barodensis, Aleurothrixus spp., Amrasca spp., Anuraphis cardui, Aonidiella spp., Aphanostigma pini, Aphis spp., Arboridia apicalis, Aspidiella spp., Aspidiotus spp., Atanus spp., Aulaconthum solani, Bemisia spp., Brachycaudus helichrysii, Brachycolus spp., Brevicoryne brassicae, Calligypona manginata, Carneocephala fulgida, Ceratovacuna lanigena, Cercopidae, Cenoplastes spp., Chaetosiphon fragaefolii, Chionaspis tegalensis, Chlorita onukii, Chromaphis juglandicola, Chrysomphalus ficus, Cicadulina mbila, Coccomytilus halli, Coccus spp., Cryptomyzus ribis, Dalbulus spp., Dialeunodes spp., Diaphorina spp., Diaspis spp., Dorsalis spp., Drosicha spp., Dysaphis spp., Dysmicoccus spp., Empoasca spp., Eniosoma spp., Erythnoneuna spp., Euscelis bilobatus, Geococcus coffeae, Homalodisca coagulata, Hyaloptenus arundinis, Icerya spp., Idiocenus spp., Idioscopus spp., Laodelphax stniatellus, Lecanium spp., Lepidosaphes spp., Lipaphis erysimi, Macnosiphum spp., Mahanarva fimbniolata, Melanaphis sacchari, Metcalfiella spp., Metopolophium dinhodum, Monellia costalis, Monelliopsis pecanis, Myzus spp., Nasonovia ribisnigri, Nephotettix spp., Nilaparvata lugens, Oncometopia spp., Onthezia pnaelonga, Panabemisia mynicae, Paratrioza spp., Panlatonia spp., Pemphigus spp., Peregrinus maidis, Phenacoccus spp., Phloeomyzus passeninii, Phorodon humuli, Phylloxera spp., Pinnaspis aspidistrae, Planococcus spp., Protopulvinania pyriformis, Pseudaulacaspis pentagona, Pseudococcus spp., Psylla spp., Ptenomalus spp., Pyrilla spp., Quadnaspidiotus spp., Quesada gigas, Rastrococcus spp., Rhopalosiphum spp., Saissetia spp., Scaphoides titanus, Schizaphis graminum, Selenaspidus anticulatus, Sogata spp., Sogatella furcifera, Sogatodes spp., Stictocephala festina, Tenalaphana malayensis, Tinocallis caryaefoliae, Tomaspis spp., Toxoptera spp., Tnialeunodes vaponanionum, Trioza spp., Typhlocyba spp., Unaspis spp., Viteus vitifolii; from the order of the Hymenoptera, for example, Dipnion spp., Hoplocampa spp., Lasius spp., Mono-monium pharaonis, Vespa spp.; from the order of the Isopoda, for example, Armadillidium vulgane, Oniscus asellus, Poncellio scaber; from the order of the Isoptera, for example, Reticulitermes spp., Odontotermes spp.; from the order of the Lepidoptera, for example, Acronicta major, Aedia leucomelas, Agnotis spp., Alabama angillacea, Anticansia spp., Banathna brassicae, Bucculatrix thurberiella, Bupalus piniarius, Cacoecia podana, Capua reticulana, Carpocapsa pomonella, Chematobia brumata, Chilo spp., Choristoneura fumiferana, Clysia ambiguella, Cnaphalocerus spp., Earias insulana, Ephestia kuehniella, Euproctis chrysorrhoea, Euxoa spp., Feltia spp., Galleria mellonella, Helicoverpa spp., Heliothis spp., Hofmannophila pseudospretella, Homona magnanima, Hyponomeuta padella, Laphygma spp., Lithocolletis blancardella, Lithophane antennata, Loxagrotis albicosta, Lymantria spp., Malacosoma neustria, Mamestra brassicae, Mocis repanda, Mythimna separata, Oria spp., Oulema oryzae, Panolis flammea, Pectinophora gossypiella, Phyllocnistis citrella, Pieris spp., Plutella xylostella, Prodenia spp., Pseudaletia spp., Pseudoplusia includens, Pyrausta nubilalis, Spodoptera spp., Thermesia gemmatalis, Tinea pellionella, Tineola bisselliella, Tortrix viridana, Trichoplusia spp.; from the order of the Orthoptera, for example, Acheta domesticus, Blatta orientalis, Blattella germanica, Gryllotalpa spp., Leucophaea maderae, Locusta spp., Melanoplus spp., Periplaneta americana, Schistocerca gregaria; from the order of the Siphonaptera, for example, Ceratophyllus spp., Xenopsylla cheopis. From the order of the Symphyla, for example, Scutigerella immaculata; from the order of the Thysanoptera, for example, Baliothrips biformis, Enneothrips flavens, Frankliniella spp., Heliothrips spp., Hercinothrips femoralis, Kakothrips spp., Rhipiphorothrips cruentatus, Scirtothrips spp., Taeniothrips cardamoni, Thrips spp.; from the order of the Thysanura, for example, Lepisma saccharina. The phytoparasitic nematodes include, for example, Anguina spp., Aphelenchoides spp., Belonoaimus spp., Bursaphelenchus spp., Ditylenchus dipsaci, Globodera spp., Heliocotylenchus spp., Heterodera spp., Longidorus spp., Meloidogyne spp., Pratylenchus spp., Radopholus similis, Rotylenchus spp., Trichodorus spp., Tylenchorhynchus spp., Tylenchulus spp., Tylenchulus semipenetrans, Xiphinema spp.

In particular, the compounds of the invention may be used to control the following pest species:

Myzus persicae (aphid), Aphis gossypii (aphid), Aphis fabae (aphid), Lygus spp. (capsids), Dysdercus spp. (capsids), Nilaparvata lugens (planthopper), Nephotettixc incticeps (leafhopper), Nezara spp. (stinkbugs), Euschistus spp. (stinkbugs), Leptocorisa spp. (stinkbugs), Frankliniella occidentalis (thrip), Thrips spp. (thrips), Leptinotarsa decemlineata (Colorado potato beetle), Anthonomus grandis (boll weevil), Aonidiella spp. (scale insects), Trialeurodes spp. (white flies), Bemisia tabaci (white fly), Ostrinia nubilalis (European corn borer), Spodoptera littoralis (cotton leafworm), Heliothis virescens (tobacco budworm), Helicoverpa armigera (cotton bollworm), Helicoverpa zea (cotton bollworm), Sylepta derogata (cotton leaf roller), Pieris brassicae (white butterfly), Plutella xylostella (diamond back moth), Agrotis spp. (cutworms), Chilo suppressalis (rice stem borer), Locusta _(—) migratoria (locust), Chortiocetes terminifera (locust), Diabrotica spp. (rootworms), Panonychus ulmi (European red mite), Panonychus citri (citrus red mite), Tetranychus urticae (two-spotted spider mite), Tetranychus cinnabarinus (carmine spider mite), Phyllocoptruta oleivora (citrus rust mite), Polyphagotarsonemus latus (broad mite), Brevipalpus spp. (flat mites), Boophilus microplus (cattle tick), Dermacentor variabilis (American dog tick), Ctenocephalides felis (cat flea), Liriomyza spp. (leafminer), Musca domestica (housefly), Aedes aegypti (mosquito), Anopheles spp. (mosquitoes), Culex spp. (mosquitoes), Lucillia spp. (blowflies), Blattella germanica (cockroach), Periplaneta americana (cockroach), Blatta orientalis (cockroach), termites of the Mastotermitidae (for example Mastotermes spp.), the Kalotermitidae (for example Neotermes spp.), the Rhinotermitidae (for example Coptotermes formosanus, Reticulitermes flavipes, R. speratu, R. virginicus, R. hesperus, and R. santonensis) and the Termitidae (for example Globitermes sulfureus), Solenopsis geminata (fire ant), Monomorium pharaonis (pharaoh's ant), Damalinia spp. and Linognathus spp. (biting and sucking lice), Meloidogyne spp. (root knot nematodes), Globodera spp. and Heterodera spp. (cyst nematodes), Pratylenchus spp. (lesion nematodes), Rhodopholus spp. (banana burrowing nematodes), Tylenchulus spp. (citrus nematodes), Haemonchus contortus (barber pole worm), Caenorhabditis elegans_(vinegar eelworm), Trichostrongylus spp. (gastro intestinal nematodes) and Deroceras reticulatum (slug).

The compound of formula I may be used for pest control on various plants, including soybean (e.g. in some cases 10-70 g/ha), corn (e.g. in some cases 10-70 g/ha), sugarcane (e.g. in some cases 20-200 g/ha), alfalfa (e.g. in some cases 10-70 g/ha), brassicas (e.g. in some cases 10-50 g/ha), oilseed rape (e.g. canola) (e.g. in some cases 20-70 g/ha), potatoes (including sweet potatoes) (e.g. in some cases 10-70 g/ha), cotton (e.g. in some cases 10-70 g/ha), rice (e.g. in some cases 10-70 g/ha), coffee (e.g. in some cases 30-150 g/ha), citrus (e.g. in some cases 60-200 g/ha), almonds (e.g. in some cases 40-180 g/ha), fruiting vegetables, cucurbits and pulses (e.g. tomatoes, pepper, chili, eggplant, cucumber, squash etc.) (e.g. in some cases 10-80 g/ha), tea (e.g. in some cases 20-150 g/ha), bulb vegetables (e.g. onion, leek etc.) (e.g. in some cases 30-90 g/ha), grapes (e.g. in some cases 30-180 g/ha), pome fruit (e.g. apples, pears etc.) (e.g. in some cases 30-180 g/ha), and stone fruit (e.g. pears, plums etc.) (e.g. in some cases 30-180 g/ha).

The compounds of the invention may be used for pest control on various plants, including soybean, corn, sugarcane, alfalfa, brassicas, oilseed rape (e.g. canola), potatoes (including sweet potatoes), cotton, rice, coffee, citrus, almonds, fruiting vegetables, cucurbits and pulses (e.g. tomatoes, pepper, chili, eggplant, cucumber, squash etc.), tea, bulb vegetables (e.g. onion, leek etc.), grapes, pome fruit (e.g. apples, pears etc.), stone fruit (e.g. pears, plums etc.), and cereals.

The compounds of the invention may be used on soybean to control, for example, Elasmopalpus lignosellus, Diloboderus abderus, Diabrotica speciosa, Trialeurodes spp., Bemisia spp., aphids, Sternechus subsignatus, Formicidae, Agrotis ypsilon, Julus spp., Murgantia spp., Halyomorpha spp., Thyanta spp., Megascelis ssp., Procornitermes ssp., Gryllotalpidae, Nezara viridula, Piezodorus spp., Acrosternum spp., Neomegalotomus spp., Cerotoma trifurcata, Popillia japonica, Edessa spp., Liogenys fuscus, Euschistus heros, stalk borer, Scaptocoris castanea, phyllophaga spp., Migdolus spp., Pseudoplusia includens, Anticarsia gemmatalis, Epinotia spp., Rachiplusia spp., Spodoptera spp., Bemisia tabaci, Tetranychus spp., Agriotes spp., Euschistus spp. The compounds of the invention are preferably used on soybean to control Diloboderus abderus, Diabrotica speciosa, Trialeurodes spp., Bemisia spp., Nezara viridula, Piezodorus spp., Acrosternum spp., Cerotoma trifurcata, Popillia japonica, Euschistus heros, Scaptocoris castanea, phyllophaga spp., Migdolus spp., Agriotes spp., Euschistus spp.

The compounds of the invention may be used on corn to control, for example, Euschistus heros, Euschistus spp., Dichelops furcatus, Diloboderus abderus, Thyanta spp., Elasmopalpus lignosellus, Halyomorpha spp., Spodoptera frugiperda, Nezara viridula, Cerotoma trifurcata, Popillia japonica, Agrotis ypsilon, Diabrotica speciosa, aphids, Heteroptera, Procornitermes spp., Scaptocoris castanea, Formicidae, Julus ssp., Dalbulus maidis, Diabrotica virgifera, Diabrotica spp., Mocis latipes, Bemisia tabaci, heliothis spp., Tetranychus spp., thrips spp., phyllophaga spp., Migdolus spp., scaptocoris spp., Liogenys fuscus, Spodoptera spp., Ostrinia spp., Sesamia spp., wireworms, Agriotes spp., Halotydeus destructor. The compounds of the invention are preferably used on corn to control Euschistus heros, Euschistus spp., Dichelops furcatus, Diloboderus abderus, Nezara viridula, Cerotoma trifurcata, Popillia japonica, Diabrotica speciosa, Diabrotica virgifera, Diabrotica spp., Tetranychus spp., Thrips spp., Phyllophaga spp., Migdolus spp., Scaptocoris spp., Agriotes spp.

The compounds of the invention may be used on sugar cane to control, for example, Sphenophorus spp., termites, Migdolus spp., Diloboderus spp., Telchin licus, Diatrea saccharalis, Mahanarva spp., Mealybugs.

The compounds of the invention may be used on alfalfa to control, for example, Hypera brunneipennis, Hypera postica, Colias eurytheme, Collops spp., Empoasca solana, Epitrix spp., Geocoris spp., Lygus hesperus, Lygus lineolaris, Spissistilus spp., Spodoptera spp., Aphids, Trichoplusia ni. The compounds of the invention are preferably used on alfalfa to control Hypera brunneipennis, Hypera postica, Empoasca solana, Epitrix spp., Lygus hesperus, Lygus lineolaris, Trichoplusia ni.

The compounds of the invention may be used on brassicas to control, for example, Plutella xylostella, Pieris spp., Mamestra spp., Plusia spp., Trichoplusia ni, Phyllotreta spp., Spodoptera spp., Empoasca spp., thrips spp., Delia spp., Murgantia spp., Trialeurodes spp., Bemisia spp., Microtheca spp., Aphids. The compounds of the invention are preferably used on brassicas to control Plutella xylostella, Pieris spp., Plusia spp., Trichoplusia ni, Phyllotreta spp., Thrips spp.

The compounds of the invention may be used on oil seed rape, e.g. canola, to control, for example, Meligethes spp., Ceutorhynchus napi, Halotydeus destructor, Psylloides spp.

The compounds of the invention may be used on potatoes, including sweet potatoes, to control, for example, Empoasca spp., Leptinotarsa spp., Diabrotica speciosa, Phthorimaea spp., Paratrioza spp., Maladera matrida, Agriotes spp., Aphids, wireworms. The compounds of the invention are preferably used on potatoes, including sweet potatoes, to control Empoasca spp., Leptinotarsa spp., Diabrotica speciosa, Phthorimaea spp., Paratrioza spp., Agriotes spp.

The compounds of the invention may be used on cotton to control, for example, Anthonomus grandis, Pectinophora spp., heliothis spp., Spodoptera spp., Tetranychus spp., Empoasca spp., Thrips spp., Bemisia tabaci, Trialeurodes spp., Aphids, Lygus spp., phyllophaga spp., Scaptocoris spp., Austroasca viridigrisea, Creontiades spp., Nezara spp., Piezodorus spp., Halotydeus destructor, Oxycaraenus hyalinipennis, Dysdercus cingulatus. The compounds of the invention are preferably used on cotton to control Anthonomus grandis, Tetranychus spp., Empoasca spp., thrips spp., Lygus spp., phyllophaga spp., Scaptocoris spp.

The compounds of the invention may be used on rice to control, for example, Leptocorisa spp., Cnaphalocrosis spp., Chilo spp., Scirpophaga spp., Lissorhoptrus spp., Oebalus pugnax, Scotinophara spp., Nephotettix malayanus, Nephotettix nigropictus, Nephotettix parvus, Nephottetix virescens, Nephotettix spp., Mealybugs, Sogatella furcifera, Nilaparvata lugens, Orseolia spp., Cnaphalocrocis medinalis, Marasmia spp., Stenchaetothrips biformis, Thrips spp., Hydrellia philippina, Grasshoppers, Pomacea canaliculata, Scirpophaga innotata, Chilo suppressalis, Chilo auricilius, Chilo polychrysus, Sesamia inferens, Laodelphax striatellus, Nymphula depunctalis, Oulema oryzae, Stinkbugs. The compounds of the invention are preferably used on rice to control Leptocorisa spp., Lissorhoptrus spp., Oebalus pugnax, Nephotettix malayanus, Nephotettix nigropictus, Nephotettix parvus, Nephottetix virescens, Nephotettix spp., Sogatella furcifera, Stenchaetothrips biformis, Thrips spp., Hydrellia philippina, Grasshoppers, Pomacea canaliculata, Scirpophaga innotata, Chilo suppressalis, Chilo polychrysus, Oulema oryzae.

The compounds of the invention may be used on coffee to control, for example, Hypothenemus Hampei, Perileucoptera Coffeella, Tetranychus spp., Brevipalpus spp., Mealybugs. The compounds of the invention are preferably used on coffee to control Hypothenemus Hampei, Perileucoptera Coffeella.

The compounds of the invention may be used on citrus to control, for example, Panonychus citri, Phyllocoptruta oleivora, Brevipalpus spp., Diaphorina citri, Scirtothrips spp., Thrips spp., Unaspis spp., Ceratitis capitata, Phyllocnistis spp., Aphids, Hardscales, Softscales, Mealybugs. The compounds of the invention are preferably used on citrus to control Panonychus citri, Phyllocoptruta oleivora, Brevipalpus spp., Diaphorina citri, Scirtothrips spp., thrips spp., Phyllocnistis spp.

The compounds of the invention may be used on almonds to control, for example, Amyelois transitella, Tetranychus spp.

The compounds of the invention may be used on fruiting vegetables, cucurbits and pulses, including tomatoes, pepper, chili, eggplant, cucumber, squash etc., to control, for example, Thrips spp., Tetranychus spp., Polyphagotarsonemus spp., Aculops spp., Empoasca spp., Spodoptera spp., heliothis spp., Tuta absoluta, Liriomyza spp., Bemisia tabaci, Trialeurodes spp., Aphids, Paratrioza spp., Frankliniella occidentalis, Frankliniella spp., Anthonomus spp., Phyllotreta spp., Amrasca spp., Epilachna spp., Halyomorpha spp., Scirtothrips spp., Leucinodes spp., Neoleucinodes spp. Maruca spp., Fruit flies, Stinkbugs, Lepidopteras, Coleopteras. The compounds of the invention are preferably used on fruiting vegetables, cucurbits and pulses, including tomatoes, pepper, chili, eggplant, cucumber, squash etc., to control Thrips spp., Tetranychus spp., Polyphagotarsonemus spp., Aculops spp., Empoasca spp., Spodoptera spp., heliothis spp., Tuta absoluta, Liriomyza spp., Paratrioza spp., Frankliniella occidentalis, Frankliniella spp., Amrasca spp., Scirtothrips spp., Leucinodes spp., Neoleucinodes spp.

The compounds of the invention may be used on tea to control, for example, Pseudaulacaspis spp., Empoasca spp., Scirtothrips spp., Caloptilia theivora, Tetranychus spp. The compounds of the invention are preferably used on tea to control Empoasca spp., Scirtothrips spp.

The compounds of the invention may be used on bulb vegetables, including onion, leek etc. to control, for example, Thrips spp., Spodoptera spp., heliothis spp. The compounds of the invention are preferably used on bulb vegetables, including onion, leek etc. to control Thrips spp.

The compounds of the invention may be used on grapes to control, for example, Empoasca spp., Lobesia spp., Eupoecilia ambiguella, Frankliniella spp., Thrips spp., Tetranychus spp., Rhipiphorothrips Cruentatus, Eotetranychus Willamettei, Erythroneura Elegantula, Scaphoides spp., Scelodonta strigicollis, Mealybugs. The compounds of the invention are preferably used on grapes to control Frankliniella spp., Thrips spp., Tetranychus spp., Rhipiphorothrips Cruentatus, Scaphoides spp.

The compounds of the invention may be used on pome fruit, including apples, pears etc., to control, for example, Cacopsylla spp., Psylla spp., Panonychus ulmi, Cydia pomonella, Lepidopteras, Aphids, Hardscales, Softscales. The compounds of the invention are preferably used on pome fruit, including apples, pears etc., to control Cacopsylla spp., Psylla spp., Panonychus ulmi.

The compounds of the invention may be used on stone fruit to control, for example, Grapholita molesta, Scirtothrips spp., Thrips spp., Frankliniella spp., Tetranychus spp., Aphids, Hardscales, Softscales, Mealybugs. The compounds of the invention are preferably used on stone fruit to control Scirtothrips spp., Thrips spp., Frankliniella spp., Tetranychus spp.

The compounds of the invention may be used on cereals to control, for example, Aphids, Stinkbugs, earthmites, Eurygaster integriceps, Zabrus tenebrioides, Anisoplia austriaca, Chaetocnema aridula, Phyllotreta spp., Oulema melanopus, Oscinella spp., Delia spp., Mayetiola spp., Contarinia spp., Cephus spp., Steneotarsonemus spp., Apamea spp.

In another embodiment compounds of formula I and mixtures of the invention may be used on rice to control Baliothrips biformis (Thrips), Chilo spp. (e.g. Chilo polychrysus (Dark headed striped borer), Chilo suppressalis (Rice stemborer), Chilo indicus (Paddy stem borer), Chilo polychrysus (Dark-headed rice borer), Chilo suppressalis (Stripe stem borer)), Cnaphalocrocis medinalis (Rice leaf folder), Dicladispa armigera (Hispa), Hydrellia philipina (Rice whorl-maggot), Laodelphax spp. (Smaller brown planthopper) (e.g. Laodelphax striatellus), Lema oryzae (Rice leafbeetle), Leptocorsia acuta (Rice bug), Leptocorsia oratorius (rice bug), Lissorhoptrus oryzophilus (rice water weevil), Mythemina separata (armyworm), Nephottetix spp. (Green leafhopper) (e.g. Nephotettix cincticeps, Nephotettix malayanus, Nephotettix nigropictus, Nephotettix parvus, Nephottetix virescens), Nilaparvata lugens (Brown Planthopper), Nymphula depunctalis (Rice caseworm), Orseolia oryzae (Rice Gall midge), Oulema oryzae (Rice leafbeetle), Scirpophaga incertulas (Yellow Stemborer), Scirpophaga innotata (White Stemborer), Scotinophara coarctata (Rice black bug), Sogaella frucifera (White-backed planthopper), Steneotarsonemus spinki.

The compounds of the invention may be used to control animal housing pests including: Ants, Bedbugs (adult), Bees, Beetles, Boxelder Bugs, Carpenter Bees, Carpet Beetles, Centipedes, Cigarette, Beetles, Clover Mites, Cockroaches, Confused Flour Beetle, Crickets, Earwigs, Firebrats, Fleas, Flies, Lesser Grain Borers, Millipedes, Mosquitoes, Red Flour Beetles, Rice Weevils, Saw-toothed Grain Beetles, Silverfish, Sowbugs, Spiders, Termites, Ticks, Wasps, Cockroaches, Crickets, Flies, Litter Beetles (such as Darkling, Hide, and Carrion), Mosquitoes, Pillbugs, Scorpions, Spiders, Spider Mites (Twospotted, Spruce), Ticks.

The compounds of the invention may be used to control ornamental pests including: Ants (Including Imported fire ants), Armyworms, Azalea caterpillars, Aphids, Bagworms, Black vine weevils (adult), Boxelder bugs, Budworms, California oakworms, Cankerworms, Cockroaches, Crickets, Cutworms, Eastern tent caterpillars, Elm leaf beetles, European sawflies, Fall webworms, Flea beetles, Forest tent caterpillars, Gypsy moth larvae, Japanese beetles (adults), June beetles (adults), Lace bugs, Leaf-feeding caterpillars, Leafhoppers, Leafminers (adults), Leaf rollers, Leaf skeletonizers, Midges, Mosquitoes, Oleander moth larvae, Pillbugs, Pine sawflies, Pine shoot beetles, Pinetip moths, Plant bugs, Root weevils, Sawflies, Scale insects (crawlers), Spiders, Spittlebugs, Striped beetles, Striped oakworms, Thrips, Tip moths, Tussock moth larvae, Wasps, Broadmites, Brown softscales, California redscales (crawlers), Clover mites, Mealybugs, Pineneedlescales (crawlers), Spider mites, Whiteflies

The compounds of the invention may be used to control turf pests including: Ants (Including Imported fire ants, Armyworms, Centipedes, Crickets, Cutworms, Earwigs, Fleas (adult), Grasshoppers, Japanese beetles (adult), Millipedes, Mites, Mosquitoes (adult), Pillbugs, Sod webworms, Sow bugs, Ticks (including species which transmit Lyme disease), Bluegrass billbugs (adult), Black turfgrass ataenius (adult), Chiggers, Fleas (adult), Grubs (suppression), Hyperodes weevils (adult), Mole crickets (nymphs and young adults), Mole Crickets (mature adults), Chinch Bugs.

The compounds of formula (I) and mixture of the invention, in particular those in the tables above, may be used for soil applications, including as a seed application, to target at least the following: sucking pests such as aphids, thrips, brown plant hopper (e.g. on rice), sting bugs, white flies (e.g. on cotton and vegetables), mites; on soil pests such as corn root worm, wireworms, white grubs, zabrus, termites (e.g. on sugar cane, soy, pasture), maggots, cabbage root fly, red legged earth mite; on lepidoptera, such as spodoptera, cutworms, elasmoplpus, plutella (e.g. brassica), stem borers, leaf miners, flea beetle, Sternechus; on nematicides, such as Heterodera glycines (e.g. on soybean), Pratylenchus brachyurus (e.g. on corn), P. zeae (e.g. oncorn), P. penetrans (e.g. on corn), Meloidogyne incognita (e.g. on vegetables), Heterodera schachtii (e.g. on sugar beet), Rotylenchus reniformis (e.g. on cotton), Heterodera avenae (e.g. on cereals), Pratylenchus neglectus (e.g. on cereals), thornei (e.g. on cereals).

The compounds of formula (I) and mixture of the invention, in particular those in the tables above may be used for seed applications at least on the following: soil grubs for corn, soybeans, sugarcane: Migdolus spp; Phyllophaga spp.; Diloboderus spp; Cyclocephala spp; Lyogenys fuscus; sugarcane weevils: Sphenophorus levis & Metamasius hemipterus; termites for soybeans, sugarcane, pasture, others: Heterotermes tenuis; Heterotermes longiceps; Cornitermes cumulans; Procornitermes triacifer; Neocapritermes opacus; Neocapritermes parvus; corn root worms for corn and potatoes: Diabrotica spp., seed Maggot: Delia platura; soil stinkbugs: Scaptocoris castanea; wireworms: Agriotes spp; Athous spp Hipnodes bicolor; Ctenicera destructor; Limonius canu; Limonius californicus; rice water weevil: Lissorhoptrus oryzophilus; Red Legged earth mites: Halotydeus destructor.

The invention therefore provides a method of combating and/or controlling an animal pest, e.g. an invertebrate animal pest, which comprises applying to the pest, to a locus of the pest, or to a plant susceptible to attack by the pest a pesticidally effective amount of a compound of formula (I). In particular, the invention provides a method of combating and/or controlling insects, acarines, nematodes or molluscs which comprises applying an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I), or a composition containing a compound of formula (I), to a pest, a locus of pest, preferably a plant, or to a plant susceptible to attack by a pest, The compounds of formula (I) are preferably used against insects, acarines or nematodes.

The term “plant” as used herein includes seedlings, bushes and trees. Crops are to be understood as also including those crops which have been rendered tolerant to herbicides or classes of herbicides (e.g. ALS-, GS-, EPSPS-, PPO- and HPPD-inhibitors) by conventional methods of breeding or by genetic engineering. An example of a crop that has been rendered tolerant to imidazolinones, e.g. imazamox, by conventional methods of breeding is Clearfield® summer rape (canola). Examples of crops that have been rendered tolerant to herbicides by genetic engineering methods include e.g. glyphosate- and glufosinate-resistant maize varieties commercially available under the trade names RoundupReady® and LibertyLink®.

The compounds of the invention may be applied to plant parts. Plant parts are to be understood as meaning all parts and organs of plants above and below the ground, such as shoot, leaf, flower and root, examples which may be mentioned being leaves, needles, stalks, stems, flowers, fruit bodies, fruits, seeds, roots, tubers and rhizomes. The plant parts also include harvested material, and vegetative and generative propagation material, for example cuttings, tubers, rhizomes, offshoots and seeds. Treatment according to the invention of the plants and plant parts with the active compounds is carried out directly or by allowing the compounds to act on their surroundings, habitat or storage space by the customary treatment methods, for example by immersion, spraying, evaporation, fogging, scattering, painting on, injecting and, in the case of propagation material, in particular in the case of seed, also by applying one or more coats.

Compounds of formula I may be used on transgenic plants (including cultivars) obtained by genetic engineering methods and/or by conventional methods. These are understood as meaning plants having novel properties (“traits”) which have been obtained by conventional breeding, by mutagenesis or by recombinant DNA techniques. Depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vegetation period, diet), the treatment according to the invention may also result in superadditive “synergistic”) effects.

Thus, for example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the substances and compositions which can be used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, higher quality and/or a higher nutritional value of the harvested products, better storage stability and/or processability of the harvested products are possible, which exceed the effects which were actually to be expected.

The preferred transgenic plants or plant cultivars which are to be treated according to the invention include all plants which, by virtue of the genetic modification, received genetic material which imparts particularly advantageous, useful traits to these plants. Examples of such traits are better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, higher quality and/or a higher nutritional value of the harvested products, better storage stability and/or processability of the harvested products.

Further and particularly emphasized examples of such traits are a better defence of the plants against animal and microbial pests, such as against insects, mites, phytopathogenic fungi, bacteria and/or viruses, and also increased tolerance of the plants to certain herbicidally active compounds.

Examples of transgenic plants which may be mentioned are the important crop plants, such as cereals (wheat, rice), maize, soybean, potatoes, sugar beet, tomatoes, peas and other vegetable varieties, cotton, tobacco, oilseed rape and also fruit plants (with the fruits apples, pears, citrus fruits and grapes).

Compounds of formula I may be used on transgenic plants that are capable of producing one or more pesticidal proteins which confer upon the transgenic plant tolerance or resistance to harmful pests, e.g. insect pests, nematode pests and the like. Such pesticidal proteins include, without limitation, Cry proteins from Bacillus thuringiensis Cry1Ab, Cry1Ac, Cry1F, Cry2Ab, Cry2Ae, Cry3A, Cry3Bb, or Cry9C; engineered proteins such as modified Cry3A (U.S. Pat. No. 7,030,295) or Cry1A105; or vegetative insecticidal proteins such as Vip1, Vip2 or Vip3. A full list of Bt Cry proteins and VIPs useful in the invention can be found on the worldwide web at Bacillus thuringiensis Toxin Nomenclature Database maintained by the University of Sussex (see also, Crickmore et al. (1998) Microbiol. Mol. Biol. Rev. 62:807-813). Other pesticidal proteins useful in the invention include proteins of bacteria colonizing nematodes, e.g. Photorhabdus spp. or Xenorhabdus spp.; toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins, or other insect-specific neurotoxins; toxins produced by fungi, such Streptomycetes toxins, plant lectins, such as pea or barley lectins; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin or papain inhibitors; ribosome-inactivating proteins (RIP), such as ricin, maize-RIP, abrin, luffin, saporin or bryodin; steroid metabolism enzymes, such as 3-hydroxysteroid oxidase, ecdysteroid-IDP-glycosyl-transferase, cholesterol oxidases, ecdysone inhibitors or HMG-CoA-reductase; ion channel blockers, such as blockers of sodium or calcium channels; juvenile hormone esterase; diuretic hormone receptors (helicokinin receptors); stilben synthase, bibenzyl synthase, chitinases or glucanases. Further examples of such pesticidal proteins or transgenic plants capable of synthesizing such proteins are disclosed, e.g., in EP-A 374753, WO 93/007278, WO 95/34656, EP-A 427529, EP-A 451878, WO 03/18810 and WO 03/52073. The methods for producing such transgenic plants are generally known to the person skilled in the art and some of which are commercially available such as Agrisure®CB (corn producing Cry1Ab), Agrisure®RW (corn producing mCry3A), Agrisure® Viptera (corn hybrids producing Vip3Aa); Agrisure300GT (corn hybrids producing Cry1Ab and mCry3A); YieldGard® (corn hybrids producing the Cry1Ab protein), YieldGard® Plus (corn hybrids producing Cry1Ab and Cry3Bb1), Genuity® SmartStax® (corn hybrids with Cry1A.105, Cry2Ab2, Cry1F, Cry34/35, Cry3Bb); Herculex® I (corn hybrids producing Cry1Fa) and Herculex®RW (corn hybrids producing Cry34Ab1, Cry35Ab1 and the enzyme Phosphinothricin-N-Acetyltransferase [PAT]); NuCOTN®33B (cotton cultivars producing Cry1Ac), Bollgard®I (cotton cultivars producing Cry1Ac), Bollgard®II (cotton cultivars producing Cry1Ac and Cry2Ab2) and VIPCOT® (cotton cultivars producing a Vip3Aa). Soybean Cyst Nematode resistance soybean (SCN®—Syngenta) and soybean with Aphid resistant trait (AMT®) are also of interest.

Further examples of such transgenic crops are:

1. Btl1 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France, registration number C/FR/96/05/10. Genetically modified Zea mays which has been rendered resistant to attack by the European corn borer (Ostrinia nubilalis and Sesamia nonagrioides) by transgenic expression of a truncated CryIA(b) toxin. Btl1 maize also transgenically expresses the enzyme PAT to achieve tolerance to the herbicide glufosinate ammonium.

2. Btl76 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France, registration number C/FR/96/05/10. Genetically modified Zea mays which has been rendered resistant to attack by the European corn borer (Ostrinia nubilalis and Sesamia nonagrioides) by transgenic expression of a CryIA(b) toxin. Btl76 maize also transgenically expresses the enzyme PAT to achieve tolerance to the herbicide glufosinate ammonium.

3. MIR604 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France, registration number C/FR/96/05/10. Maize which has been rendered insect-resistant by transgenic expression of a modified CryIIIA toxin. This toxin is Cry3A055 modified by insertion of a cathepsin-D-protease recognition sequence. The preparation of such transgenic maize plants is described in WO 03/018810.

4. MON 863 Maize from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C/DE/02/9. MON 863 expresses a CryIIIB(b1) toxin and has resistance to certain Coleoptera insects.

5. IPC 531 Cotton from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C/ES/96/02.

6. 1507 Maize from Pioneer Overseas Corporation, Avenue Tedesco, 7 B-1160 Brussels, Belgium, registration number C/NL/00/10. Genetically modified maize for the expression of the protein Cry1F for achieving resistance to certain Lepidoptera insects and of the PAT protein for achieving tolerance to the herbicide glufosinate ammonium.

7. NK603×MON 810 Maize from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C/GB/02/M3/03. Consists of conventionally bred hybrid maize varieties by crossing the genetically modified varieties NK603 and MON 810. NK603×MON 810 Maize transgenically expresses the protein CP4 EPSPS, obtained from Agrobacterium sp. strain CP4, which imparts tolerance to the herbicide Roundup® (contains glyphosate), and also a CryIA(b) toxin obtained from Bacillus thuringiensis subsp. kurstaki which brings about tolerance to certain Lepidoptera, include the European corn borer.

Further examples of transgenic plants, and of very high interest, are those carrying traits conferring resistance to 2.4 D (e.g. Enlist®) (e.g. WO 2011066384), glyphosate (e.g. Roundup Ready®, Roundup Ready 2 Yield®), sulfonylurea (e.g. STS®), glufosinate (e.g. Liberty Link®, Ignite®), Dicamba (Monsanto), HPPD tolerance (e.g. isoxaflutole herbicide) (Bayer CropScience, Syngenta). Double or triple stacks of any of the traits described here are also of interest, including glyphosate and sulfonyl-urea tolerance ((e.g. Optimum GAT®), plants stacked with STS® and Roundup Ready® or plants stacked with STS® and Roundup Ready 2 Yield®), dicamba and glyphosate tolerance (Monsanto). Of particular interest are soybean plants carrying trains conferring resistance to 2.4 D (e.g. Enlist®), glyphosate (e.g. Roundup Ready®, Roundup Ready 2 Yield®), sulfonylurea (e.g. STS®), glufosinate (e.g. Liberty Link®, Ignite®), Dicamba (Monsanto) HPPD tolerance (e.g. isoxaflutole herbicide) (Bayer CropScience, Syngenta). Double or triple stack in soybean plants of any of the traits described here are also of interest, including glyphosate and sulfonyl-urea tolerance (e.g. Optimum GAT®, plants stacked with STS® and Roundup Ready® or Roundup Ready 2 Yield®), dicamba and glyphosate tolerance (Monsanto).

Transgenic crops of insect-resistant plants are also described in BATS (Zentrum für Biosicherheit and Nachhaltigkeit, Zentrum BATS, Clarastrasse 13, 4058 Basel, Switzerland) Report 2003, (http://bats.ch).

Examples of cotton transgenic events include MON 531/757/1076 (Bollgard I®—Monsanto), MON1445 (Roundup ready cotton®—Monsanto), MON531×MON1445 (Bollgard I+RR®—Monsanto), MON15985 (Genuity Bollgard II cotton®—Monsanto), MON88913 (Genuity RR FLEX cotton®—Monsanto), MON15985×MON1445 (Genuity Bollgard II+RR FELX cotton®—Monsanto), MON15983×MON88913 (Genuity Bollgard II+RR FLEX cotton®—Monsanto), MON15985 (FibreMax Bollgard II Cotton®—Monsanto), LL25 (FibreMax LL cotton®—BCS Stoneville), GHB614 (FibreMax GlyTol cotton®—BCS Stoneville), LL25×MON15985 (FibreMax LL Bollgard II cotton®—BCS Stoneville/Monsanto), GHB614×LL25 (FibreMax LL GlyTol cotton®—BCS Stoneville), GHB614×LL25×MON15985 (FibreMax RR GlyTol Bollgard II cotton®—BCS Stoneville), MON88913×MON15985 (FibreMax LL GlyTol Bollgard II cotton®—Monsanto), MON88913 (FibreMax RR Flex cotton®—Monsanto), GHB119+T304-40 (Twinlink®—BCS Stoneville), GHB119+T304-40×LL25×GHB614 (Twinlink LL GT®—BCS Stoneville), 3006-210-23×281-24-236 (PhytoGen Widestrike Insect Protection®—Dow), 3006-210-23×281-24-236×MON88913 (PhytoGen Widestrike Insect Protection+RR FLEX—® Dow/Monsanto), 3006-210-23×281-24-236×MON1445 ((PhytoGen Widestrike Insect Protection+RR®—Dow/Monsanto), MON1445 (PhytoGen Roundup Ready®—Monsanto), MON88913 (PhytoGen Roundup Ready FLEX®—Monsanto), COT102×COT67B (Vipcot®—Syngenta), COT102×COT67B×MON88913 (Vipcot RR FLEX®—Syngenta/Monsanto), 281-24-236 (Dow), 3006-210-23 (Dow), COT102 (Syngenta), COT67B (Syngenta), T304-40 (BCS Stoneville).

Examples of Soy transgenic events include MON87701×MON89788 (Genuity Roundup ready 2 Yield soybeans®—Monsanto), MON89788 (Roundup Ready2Yield®, RR2Y®—Monsanto), MON87708 (Monsanto), 40-3-2 (Roundup Ready®, RR1®—Monsanto), MON87701 (Monsanto), DAS-68416 (Enlist Weed Control System®—Dow), DP356043 (Optimum GAT®—Pioneer), A5547-127 (LibertyLink soybean®—Bayercropscience), A2704-12 (Bayercropscience), GU262 (Bayercropscience), W62 W98 (Bayercropscience), CRV127 (Cultivance®—BASF/EMBRAPA) SYHT0H2 (WO2012/082548).

Examples of Maize transgenic events include T25 (LibertyLink®, LL®—Bayerscropscience), DHT-1 (Dow), TC1507 (Herculex I®—Dow), DAS59122-7 (Herculex RW®—Dow), TC1507+DAS59122-7—Herculex Xtra®—Dow), TC1507×DAS-59122-7×NK603 (Herculex Xtra+RR®—Dow), TC1507×DAS-59122-×MON88017×MON89034 (Genuity Smartstax corn®, Genuity Smartstax RIB complete®—Monsanto/Dow), MON89034×NK603 (Genuity VT double PRO®—Monsanto), MON89034+MON88017 (Genuity VT Triple PRO®—Monsanto), NK603 (Roundup Ready 2®, RR2®—Monsanto), MON810 (YieldGard BT®, Yieldgard cornborer®—Monsanto), MON810×NK603 (YieldGard cornborer RR Corn 2®—Monasnto), MON810×MON863 (YieldGard Plus®—Monsanto), MON863×MON810×NK603 (YieldGard Plus+RR Corn2®/YieldGard RR Maize®—Monsanto), MON863×NK603 (YieldGard Rotworm+RR Corn 2®—Monsanto), MON863 (YieldBard RW®—Monsanto), MON89034 (YieldGard RW®—Monsanto), MON88017 (YieldGard VT RW®Monsanto), MON810+MON88017 (YieldGard VT Triplet®—Monsanto), MON88017+MON89034 (YieldGard VT Triple Pro®—Monsanto), Btl1+MIR604+GA21 (Agrisure 3000®—Syngenta), Btl1+TC1507+MIR604+5307+GA21 (Syngenta), Btl1+TC1507+MIR604+DAS59122+GA21 (Agrisure 3122®—Syngenta), BT11 (Agrisure CB®—Syngenta), GA21—(Agrisure GT®—Syngenta), MIR604 (Agrisure RW®—Syngenta), Btl1+MIR162 (Agrisure TL VIP®—Syngenta), BT11+MIR162+GA21 (Agrisure Viptra 31100—Syngenta), BT11+MIR162+MIR604 (Agrisure TM 3100®—Syngenta), Event3272+BT11+MIR604+GA21 (Syngenta), BT11+MIR1692+MIR604+GA21 (Agrisure Viptera 3111®—Syngenta), BT11+MIR162+TC1507+GA21 (Agrisure Viptera 3220®—Syngenta), BT11+MIR162+TC1507+MIR604+5307+GA21 (Agrisure Viptera 3222®—Syngenta), MIR162 (Syngenta), BT11+GA21+MIR162+MIR604+5307 (Syngenta), 5307 (Syngenta).

In order to apply a compound of formula (I) as an insecticide, acaricide, nematicide or molluscicide to a pest, a locus of pest, or to a plant susceptible to attack by a pest, a compound of formula (I) is usually formulated into a composition which includes, in addition to the compound of formula (I), a suitable inert diluent or carrier and, optionally, a surface active agent (SFA). SFAs are chemicals which are able to modify the properties of an interface (for example, liquid/solid, liquid/air or liquid/liquid interfaces) by lowering the interfacial tension and thereby leading to changes in other properties (for example dispersion, emulsification and wetting). It is preferred that all compositions (both solid and liquid formulations) comprise, by weight, 0.0001 to 95%, more preferably 1 to 85%, for example 5 to 60%, of a compound of formula (I). The composition is generally used for the control of pests such that a compound of formula (I) is applied at a rate of from 0.1 g to 10 kg per hectare, preferably from 1 g to 6 kg per hectare, more preferably from 1 g to 1 kg per hectare.

When used in a seed dressing, a compound of formula (I) is generally used at a rate of 0.0001 g to 10 g (for example 0.001 g or 0.05 g), preferably 0.005 g to 10 g, more preferably 0.005 g to 4 g, per kilogram of seed.

In another aspect the present invention provides a composition comprising a pesticidally effective amount of a compound of formula (I), in particular an insecticidal, acaricidal, nematicidal or molluscicidal composition comprising an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I) and a suitable carrier or diluent therefor. The composition is preferably an insecticidal, acaricidal, nematicidal or molluscicidal composition.

The compositions can be chosen from a number of formulation types, including dustable powders (DP), soluble powders (SP), water soluble granules (SG), water dispersible granules (WG), wettable powders (WP), granules (GR) (slow or fast release), soluble concentrates (SL), oil miscible liquids (OL), ultra low volume liquids (UL), emulsifiable concentrates (EC), dispersible concentrates (DC), emulsions (both oil in water (EW) and water in oil (EO)), micro-emulsions (ME), suspension concentrates (SC), aerosols, fogging/smoke formulations, capsule suspensions (CS) and seed treatment formulations. The formulation type chosen in any instance will depend upon the particular purpose envisaged and the physical, chemical and biological properties of the compound of formula (I).

Dustable powders (DP) may be prepared by mixing a compound of formula (I) with one or more solid diluents (for example natural clays, kaolin, pyrophyllite, bentonite, alumina, montmorillonite, kieselguhr, chalk, diatomaceous earths, calcium phosphates, calcium and magnesium carbonates, sulfur, lime, flours, talc and other organic and inorganic solid carriers) and mechanically grinding the mixture to a fine powder.

Soluble powders (SP) may be prepared by mixing a compound of formula (I) with one or more water-soluble inorganic salts (such as sodium bicarbonate, sodium carbonate or magnesium sulfate) or one or more water-soluble organic solids (such as a polysaccharide) and, optionally, one or more wetting agents, one or more dispersing agents or a mixture of said agents to improve water dispersibility/solubility. The mixture is then ground to a fine powder. Similar compositions may also be granulated to form water soluble granules (SG).

Wettable powders (WP) may be prepared by mixing a compound of formula (I) with one or more solid diluents or carriers, one or more wetting agents and, preferably, one or more dispersing agents and, optionally, one or more suspending agents to facilitate the dispersion in liquids. The mixture is then ground to a fine powder. Similar compositions may also be granulated to form water dispersible granules (WG).

Granules (GR) may be formed either by granulating a mixture of a compound of formula (I) and one or more powdered solid diluents or carriers, or from pre-formed blank granules by absorbing a compound of formula (I) (or a solution thereof, in a suitable agent) in a porous granular material (such as pumice, attapulgite clays, fuller's earth, kieselguhr, diatomaceous earths or ground corn cobs) or by adsorbing a compound of formula (I) (or a solution thereof, in a suitable agent) on to a hard core material (such as sands, silicates, mineral carbonates, sulfates or phosphates) and drying if necessary. Agents which are commonly used to aid absorption or adsorption include solvents (such as aliphatic and aromatic petroleum solvents, alcohols, ethers, ketones and esters) and sticking agents (such as polyvinyl acetates, polyvinyl alcohols, dextrins, sugars and vegetable oils). One or more other additives may also be included in granules (for example an emulsifying agent, wetting agent or dispersing agent).

Dispersible Concentrates (DC) may be prepared by dissolving a compound of formula (I) in water or an organic solvent, such as a ketone, alcohol or glycol ether. These solutions may contain a surface active agent (for example to improve water dilution or prevent crystallization in a spray tank).

Emulsifiable concentrates (EC) or oil-in-water emulsions (EW) may be prepared by dissolving a compound of formula (I) in an organic solvent (optionally containing one or more wetting agents, one or more emulsifying agents or a mixture of said agents). Suitable organic solvents for use in ECs include aromatic hydrocarbons (such as alkylbenzenes or alkylnaphthalenes, exemplified by SOLVESSO 100, SOLVESSO 150 and SOLVESSO 200; SOLVESSO is a Registered Trade Mark), ketones (such as cyclohexanone or methylcyclohexanone) and alcohols (such as benzyl alcohol, furfuryl alcohol or butanol), N-alkylpyrrolidones (such as N-methylpyrrolidone or N-octylpyrrolidone), dimethyl amides of fatty acids (such as C₈-C₁₀ fatty acid dimethylamide) and chlorinated hydrocarbons. An EC product may spontaneously emulsify on addition to water, to produce an emulsion with sufficient stability to allow spray application through appropriate equipment. Preparation of an EW involves obtaining a compound of formula (I) either as a liquid (if it is not a liquid at room temperature, it may be melted at a reasonable temperature, typically below 70° C.) or in solution (by dissolving it in an appropriate solvent) and then emulsifiying the resultant liquid or solution into water containing one or more SFAs, under high shear, to produce an emulsion. Suitable solvents for use in EWs include vegetable oils, chlorinated hydrocarbons (such as chlorobenzenes), aromatic solvents (such as alkylbenzenes or alkylnaphthalenes) and other appropriate organic solvents which have a low solubility in water.

Microemulsions (ME) may be prepared by mixing water with a blend of one or more solvents with one or more SFAs, to produce spontaneously a thermodynamically stable isotropic liquid formulation. A compound of formula (I) is present initially in either the water or the solvent/SFA blend. Suitable solvents for use in MEs include those hereinbefore described for use in ECs or in EWs. An ME may be either an oil-in-water or a water-in-oil system (which system is present may be determined by conductivity measurements) and may be suitable for mixing water-soluble and oil-soluble pesticides in the same formulation. An ME is suitable for dilution into water, either remaining as a microemulsion or forming a conventional oil-in-water emulsion.

Suspension concentrates (SC) may comprise aqueous or non-aqueous suspensions of finely divided insoluble solid particles of a compound of formula (I). SCs may be prepared by ball or bead milling the solid compound of formula (I) in a suitable medium, optionally with one or more dispersing agents, to produce a fine particle suspension of the compound. One or more wetting agents may be included in the composition and a suspending agent may be included to reduce the rate at which the particles settle. Alternatively, a compound of formula (I) may be dry milled and added to water, containing agents hereinbefore described, to produce the desired end product.

Aerosol formulations comprise a compound of formula (I) and a suitable propellant (for example n-butane). A compound of formula (I) may also be dissolved or dispersed in a suitable medium (for example water or a water miscible liquid, such as n-propanol) to provide compositions for use in non-pressurized, hand-actuated spray pumps.

A compound of formula (I) may be mixed in the dry state with a pyrotechnic mixture to form a composition suitable for generating, in an enclosed space, a smoke containing the compound.

Capsule suspensions (CS) may be prepared in a manner similar to the preparation of EW formulations but with an additional polymerization stage such that an aqueous dispersion of oil droplets is obtained, in which each oil droplet is encapsulated by a polymeric shell and contains a compound of formula (I) and, optionally, a carrier or diluent therefor. The polymeric shell may be produced by either an interfacial polycondensation reaction or by a coacervation procedure. The compositions may provide for controlled release of the compound of formula (I) and they may be used for seed treatment. A compound of formula (I) may also be formulated in a biodegradable polymeric matrix to provide a slow, controlled release of the compound.

A composition may include one or more additives to improve the biological performance of the composition (for example by improving wetting, retention or distribution on surfaces; resistance to rain on treated surfaces; or uptake or mobility of a compound of formula (I)). Such additives include surface active agents, spray additives based on oils, for example certain mineral oils or natural plant oils (such as soy bean and rape seed oil), and blends of these with other bio-enhancing adjuvants (ingredients which may aid or modify the action of a compound of formula (I)).

A compound of formula (I) may also be formulated for use as a seed treatment, for example as a powder composition, including a powder for dry seed treatment (DS), a water soluble powder (SS) or a water dispersible powder for slurry treatment (WS), or as a liquid composition, including a flowable concentrate (FS), a solution (LS) or a capsule suspension (CS). The preparations of DS, SS, WS, FS and LS compositions are very similar to those of, respectively, DP, SP, WP, SC and DC compositions described above. Compositions for treating seed may include an agent for assisting the adhesion of the composition to the seed (for example a mineral oil or a film-forming barrier).

Wetting agents, dispersing agents and emulsifying agents may be surface SFAs of the cationic, anionic, amphoteric or non-ionic type.

Suitable SFAs of the cationic type include quaternary ammonium compounds (for example cetyltrimethyl ammonium bromide), imidazolines and amine salts.

Suitable anionic SFAs include alkali metals salts of fatty acids, salts of aliphatic monoesters of sulfuric acid (for example sodium lauryl sulfate), salts of sulfonated aromatic compounds (for example sodium dodecylbenzenesulfonate, calcium dodecylbenzenesulfonate, butylnaphthalene sulfonate and mixtures of sodium di-isopropyl- and tri-isopropyl-naphthalene sulfonates), ether sulfates, alcohol ether sulfates (for example sodium laureth-3-sulfate), ether carboxylates (for example sodium laureth-3-carboxylate), phosphate esters (products from the reaction between one or more fatty alcohols and phosphoric acid (predominately mono-esters) or phosphorus pentoxide (predominately di-esters), for example the reaction between lauryl alcohol and tetraphosphoric acid; additionally these products may be ethoxylated), sulfosuccinamates, paraffin or olefine sulfonates, taurates and lignosulfonates.

Suitable SFAs of the amphoteric type include betaines, propionates and glycinates.

Suitable SFAs of the non-ionic type include condensation products of alkylene oxides, such as ethylene oxide, propylene oxide, butylene oxide or mixtures thereof, with fatty alcohols (such as oleyl alcohol or cetyl alcohol) or with alkylphenols (such as octylphenol, nonylphenol or octylcresol); partial esters derived from long chain fatty acids or hexitol anhydrides; condensation products of said partial esters with ethylene oxide; block polymers (comprising ethylene oxide and propylene oxide); alkanolamides; simple esters (for example fatty acid polyethylene glycol esters); amine oxides (for example lauryl dimethyl amine oxide); and lecithins.

Suitable suspending agents include hydrophilic colloids (such as polysaccharides, polyvinylpyrrolidone or sodium carboxymethylcellulose) and swelling clays (such as bentonite or attapulgite).

A compound of formula (I) may be applied by any of the known means of applying pesticidal compounds. For example, it may be applied, formulated or unformulated, to the pests or to a locus of the pests (such as a habitat of the pests, or a growing plant liable to infestation by the pests) or to any part of the plant, including the foliage, stems, branches or roots, to the seed before it is planted or to other media in which plants are growing or are to be planted (such as soil surrounding the roots, the soil generally, paddy water or hydroponic culture systems), directly or it may be sprayed on, dusted on, applied by dipping, applied as a cream or paste formulation, applied as a vapor or applied through distribution or incorporation of a composition (such as a granular composition or a composition packed in a water-soluble bag) in soil or an aqueous environment.

A compound of formula (I) may also be injected into plants or sprayed onto vegetation using electrodynamic spraying techniques or other low volume methods, or applied by land or aerial irrigation systems.

Compositions for use as aqueous preparations (aqueous solutions or dispersions) are generally supplied in the form of a concentrate containing a high proportion of the active ingredient, the concentrate being added to water before use. These concentrates, which may include DCs, SCs, ECs, EWs, MEs, SGs, SPs, WPs, WGs and CSs, are often required to withstand storage for prolonged periods and, after such storage, to be capable of addition to water to form aqueous preparations which remain homogeneous for a sufficient time to enable them to be applied by conventional spray equipment. Such aqueous preparations may contain varying amounts of a compound of formula (I) (for example 0.0001 to 10%, by weight) depending upon the purpose for which they are to be used.

A compound of formula (I) may be used in mixtures with fertilizers (for example nitrogen-, potassium- or phosphorus-containing fertilizers). Suitable formulation types include granules of fertilizer. The mixtures preferably contain up to 25% by weight of the compound of formula (I).

The invention therefore also provides a fertilizer composition comprising a fertilizer and a compound of formula (I).

The compositions of this invention may contain other compounds having biological activity, for example micronutrients or compounds having fungicidal activity or which possess plant growth regulating, herbicidal, insecticidal, nematicidal or acaricidal activity.

The compound of formula (I) may be the sole active ingredient of the composition or it may be admixed with one or more additional active ingredients such as a pesticide, e.g. a insecticide, fungicide or herbicide, or a synergist or plant growth regulator where appropriate. An additional active ingredient may provide a composition having a broader spectrum of activity or increased persistence at a locus; synergize the activity or complement the activity (for example by increasing the speed of effect or overcoming repellency) of the compound of formula (I); or help to overcome or prevent the development of resistance to individual components. The particular additional active ingredient will depend upon the intended utility of the composition.

Examples of suitable pesticides include the following (where “Tx” means a compound of formula (I), and in particular a compound selected from Tables 1P to 120P and 1Q to 240Q which may result in a synergistic combination with the given active ingredient):

-   a) Pyrethroids, such as permethrin+Tx, cypermethrin+Tx,     fenvalerate+Tx, esfenvalerate+Tx, deltamethrin+Tx, cyhalothrin+Tx     (in particular lambda-cyhalothrin+Tx and gamma cyhalothrin+Tx),     bifenthrin+Tx, fenpropathrin+Tx, cyfluthrin+Tx, tefluthrin+Tx, fish     safe pyrethroids+Tx (for example ethofenprox+Tx), natural     pyrethrin+Tx, tetramethrin+Tx, S-bioallethrin+Tx, fenfluthrin+Tx,     prallethrin+Tx, acrinathirin+Tx, etofenprox+Tx or     5-benzyl-3-furylmethyl-(E)-(1R,3S)-2,2-dimethyl-3-(2-oxothiolan-3-ylidenemethyl)cyclopropane     carboxylate+Tx; -   b) Organophosphates, such as profenofos+Tx, sulprofos+Tx,     acephate+Tx, methyl parathion+Tx, azinphos-methyl+Tx,     demeton-s-methy+Tx 1, heptenophos+Tx, thiometon+Tx, fenamiphos+Tx,     monocrotophos+Tx, profenofos+Tx, triazophos+Tx, methamidophos+Tx,     dimethoate+Tx, phosphamidon+Tx, malathion+Tx, chlorpyrifos+Tx,     phosalone+Tx, terbufos+Tx, fensulfothion+Tx, fonofos+Tx, phorate+Tx,     phoxim+Tx, pirimiphos-methyl+Tx, pirimiphos-ethyl+Tx,     fenitrothion+Tx, fosthiazate+Tx or diazinon+Tx; -   c) Carbamates (including aryl carbamates), such as pirimicarb+Tx,     triazamate+Tx, cloethocarb+Tx, carbofuran+Tx, furathiocarb+Tx,     ethiofencarb+Tx, aldicarb+Tx, thiofurox+Tx, carbosulfan+Tx,     bendiocarb+Tx, fenobucarb+Tx, propoxur+Tx, methomyl+Tx or oxamyl+Tx; -   d) Benzoyl ureas, such as diflubenzuron+Tx, triflumuron+Tx,     hexaflumuron+Tx, flufenoxuron+Tx, diafenthiuron+Tx, lufeneron+Tx,     novaluron+Tx, noviflumuron+Tx or chlorfluazuron+Tx; -   e) Organic tin compounds, such as cyhexatin+Tx, fenbutatin oxide+Tx     or azocyclotin+Tx; -   f) Pyrazoles, such as tebufenpyrad+Tx, tolfenpyrad+Tx, ethiprole+Tx,     pyriprole+Tx, fipronil+Tx, and fenpyroximate+Tx; -   g) Macrolides, such as avermectins or milbemycins, for example     abamectin+Tx, emamectin benzoate+Tx, ivermectin+Tx, milbemycin+Tx,     spinosad+Tx, azadirachtin+Tx, milbemectin+Tx, lepimectin+Tx or     spinetoram+Tx; -   h) Hormones+Tx or pheromones+Tx; -   i) Organochlorine compounds, such as endosulfan+Tx (in particular     alpha-endosulfan+Tx), benzene hexachloride+Tx, DDT+Tx, chlordane+Tx     or dieldrin+Tx; -   j) Amidines, such as chlordimeform+Tx or amitraz+Tx; -   k) Fumigant agents, such as chloropicrin+Tx, dichloropropane+Tx,     methyl bromide+Tx or metam+Tx; -   l) Neonicotinoid compounds, such as imidacloprid+Tx, thiacloprid+Tx,     acetamiprid+Tx, nitenpyram+Tx, dinotefuran+Tx, thiamethoxam+Tx,     clothianidin+Tx, or nithiazine+Tx; -   m) Diacylhydrazines+Tx, such as tebufenozide+Tx, chromafenozide+Tx     or methoxyfenozide+Tx; -   n) Diphenyl ethers, such as diofenolan+Tx or pyriproxifen+Tx; -   o) Pyrazolines such as Indoxacarb+Tx or metaflumizone+Tx; -   p) Ketoenols, such as Spirotetramat+Tx, spirodiclofen+Tx or     spiromesifen+Tx; -   q) Diamides, such as flubendiamide+Tx, chlorantraniliprole+Tx     (Rynaxypyr®) or cyantraniliprole+Tx; -   r) Essential oils such as Bugoil®—(PlantImpact); or -   s) a compound selected from buprofezine+Tx, flonicamid+Tx,     acequinocy+Tx 1, bifenazate+Tx, cyenopyrafen+Tx, cyflumetofen+Tx,     etoxazole+Tx, flometoquin+Tx, fluacrypyrim+Tx, fluensulfone+Tx,     flufenerim+Tx, flupyradifuone+Tx, harpin+Tx, iodomethane+Tx,     dodecadienol+Tx, pyridaben+Tx, pyridalyl+Tx, pyrimidifen+Tx,     flupyradifurone+Tx,     4-[(6-Chloro-pyridin-3-ylmethyl)-(2,2-difluoro-ethyl)-amino]-5H-furan-2-one     (DE 102006015467), CAS: 915972-17-7+Tx (WO 2006129714;     WO2011/147953; WO2011/147952), CAS: 26914-55-8 (WO 2007020986),     chlorfenapyr+Tx, pymetrozine+Tx, sulfoxaflor+Tx and     pyrifluqinazon+Tx.

In addition to the major chemical classes of pesticide listed above, other pesticides having particular targets may be employed in the composition, if appropriate for the intended utility of the composition. For instance, selective insecticides for particular crops, for example stemborer specific insecticide (combinations such as cartap+Tx) or hopper specific insecticides (combinations such as buprofezin+Tx) for use in rice may be employed. Alternatively insecticides or acaricides specific for particular insect species/stages may also be included in the compositions (for example acaricidal ovo-larvicides, to give combinations such as clofentezine+Tx, flubenzimine+Tx, hexythiazox+Tx or tetradifon+Tx; acaricidal motilicides, to give combinations such as dicofol+Tx or propargite+Tx; acaricides, to give combinations such as bromopropylate+Tx or chlorobenzilate+Tx; or growth regulators, such as hydramethylnon+Tx, cyromazine+Tx, methoprene+Tx, chlorfluazuron+Tx or diflubenzuron+Tx).

Examples of fungicidal compounds and combinations which may be included in the composition of the invention are (E)-N-methyl-2-[2-(2,5-dimethylphenoxymethyl)phenyl]-2-methoxy-iminoacetamide (SSF-129)+Tx, 4-bromo-2-cyano-N,N-dimethyl-6-trifluoromethyl-benzimidazole-1-sulfonamide+Tx, α-[N-(3-chloro-2,6-xylyl)-2-methoxyacetamido]-γ-butyrolactone+Tx, 4-chloro-2-cyano-N,N-dimethyl-5-p-tolylimidazole-1-sulfonamide (IKF-916, cyamidazosulfamid)+Tx, 3-5-dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-4-methylbenzamide (RH-7281, zoxamide)+Tx, N-allyl-4,5,-dimethyl-2-trimethylsilylthiophene-3-carboxamide (MON65500)+Tx, N-(1-cyano-1,2-dimethylpropyl)-2-(2,4-dichlorophenoxy)-propionamide (AC382042)+Tx, N-(2-methoxy-5-pyridyl)-cyclopropane carboxamide+Tx, acibenzolar (CGA245704) (e.g. acibenzolar-S-methyl)+Tx, alanycarb+Tx, aldimorph+Tx, anilazine+Tx, azaconazole+Tx, azoxystrobin+Tx, benalaxyl+Tx, benomyl+Tx, benthiavalicarb+Tx, biloxazol+Tx, bitertanol+Tx, bixafen+Tx, blasticidin S+Tx, boscalid+Tx, bromuconazole+Tx, bupirimate+Tx, captafol+Tx, captan+Tx, carbendazim+Tx, carbendazim+Tx, chlorhydrate+Tx, carboxin+Tx, carpropamid+Tx, carvone+Tx, CGA41396+Tx, CGA41397+Tx, chinomethionate+Tx, chlorothalonil+Tx, chlorozolinate+Tx, clozylacon+Tx, copper containing compounds to give combintations such as copper oxychloride+Tx, copper oxyquinolate+Tx, copper sulfate+Tx, copper tallate+Tx and Bordeaux mixture+Tx, cyclufenamid+Tx, cymoxanil+Tx, cyproconazole+Tx, cyprodinil+Tx, debacarb+Tx, di-2-pyridyl disulfide 1,1′-dioxide+Tx, dichlofluanid+Tx, diclomezine+Tx, dicloran+Tx, diethofencarb+Tx, difenoconazole+Tx, difenzoquat+Tx, diflumetorim+Tx, O,O-di-iso-propyl-5-benzyl thiophosphate+Tx, dimefluazole+Tx, dimetconazole+Tx, dimethomorph+Tx, dimethirimol+Tx, diniconazole+Tx, dinocap+Tx, dithianon+Tx, dodecyl dimethyl ammonium chloride+Tx, dodemorph+Tx, dodine+Tx, doguadine+Tx, edifenphos+Tx, epoxiconazole+Tx, ethirimo+Tx 1, ethyl-(Z)—N-benzyl-N-([methyl(methyl-thioethylideneaminooxycarbonyl)amino]thio)-β-alaninate+Tx, etridiazole+Tx, famoxadone+Tx, fenamidone (RPA407213)+Tx, fenarimol+Tx, fenbuconazole+Tx, fenfuram+Tx, fenhexamid (KBR2738)+Tx, fenpiclonil+Tx, fenpropidin+Tx, fenpropimorph+Tx, fentin acetate+Tx, fentin hydroxide+Tx, ferbam+Tx, ferimzone+Tx, fluazinam+Tx, fludioxonil+Tx, flumetover+Tx, fluopyram+Tx, fluoxastrobin+Tx, fluoroimide+Tx, fluquinconazole+Tx, flusilazole+Tx, flutolanil+Tx, flutriafol+Tx, fluxapyroxad+Tx, folpet+Tx, fuberidazole+Tx, furalaxyl+Tx, furametpyr+Tx, guazatine, +Tx hexaconazole+Tx, hydroxyisoxazole+Tx, hymexazole+Tx, imazalil+Tx, imibenconazole+Tx, iminoctadine+Tx, iminoctadine triacetate+Tx, ipconazole+Tx, iprobenfos+Tx, iprodione+Tx, iprovalicarb (SZX0722)+Tx, isopropanyl butyl carbamate+Tx, isoprothiolane+Tx, isopyrazam+Tx, kasugamycin+Tx, kresoxim-methyl+Tx, LY186054+Tx, LY211795+Tx, LY248908+Tx, mancozeb+Tx, mandipropamid+Tx, maneb+Tx, mefenoxam+Tx, metalaxyl+Tx, mepanipyrim+Tx, mepronil+Tx, metalaxyl+Tx, metconazole+Tx, metiram+Tx, metiram-zinc+Tx, metominostrobin+Tx, myclobutanil+Tx, neoasozin+Tx, nickel dimethyldithiocarbamate+Tx, nitrothal-isopropyl+Tx, nuarimol+Tx, ofurace+Tx, organomercury compounds, +Tx oxadixyl+Tx, oxasulfuron+Tx, oxolinic acid+Tx, oxpoconazole+Tx, oxycarboxin+Tx, pefurazoate+Tx, penconazole+Tx, pencycuron+Tx, penflufen+Tx, penthiopyrad+Tx, phenazin oxide+Tx, phosetyl-Al+Tx, phosphorus acids+Tx, phthalide+Tx, picoxystrobin (ZA1963)+Tx, polyoxinD+Tx, polyram+Tx, probenazole+Tx, prochloraz+Tx, procymidone+Tx, propamocarb+Tx, propiconazole+Tx, propineb+Tx, propionic acid+Tx, prothioconazole+Tx, pyrazophos+Tx, pyrifenox+Tx, pyrimethanil+Tx, pyraclostrobin+Tx, pyroquilon+Tx, pyroxyfur+Tx, pyrroInitrin+Tx, quaternary ammonium compounds+Tx, quinomethionate+Tx, quinoxyfen+Tx, quintozene+Tx, sedaxane+Tx, sipconazole (F-155)+Tx, sodium pentachlorophenate+Tx, spiroxamine+Tx, streptomycin+Tx, sulfur+Tx, tebuconazole+Tx, tecloftalam+Tx, tecnazene+Tx, tetraconazole+Tx, thiabendazole+Tx, thifluzamid+Tx, 2-(thiocyanomethylthio)benzothiazole+Tx, thiophanate-methyl+Tx, thiram+Tx, timibenconazole+Tx, tolclofos-methyl+Tx, tolylfluanid+Tx, triadimefon+Tx, triadimenol+Tx, triazbutil+Tx, triazoxide+Tx, tricyclazole+Tx, tridemorph+Tx, trifloxystrobin (CGA279202)+Tx, triforine+Tx, triflumizole+Tx, triticonazole+Tx, validamycin A+Tx, vapam+Tx, vinclozolin+Tx, zineb+Tx and ziram+Tx, N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide [1072957-71-1]+Tx, 1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylic acid (2-dichloromethylene-3-ethyl-1-methyl-indan-4-yl)-amide+Tx, and 1-methyl-3-difluoromethyl-4H-pyrazole-4-carboxylic acid [2-(2,4-dichloro-phenyl)-2-methoxy-1-methyl-ethyl]-amide+Tx.

The active ingredients combinations described above comprising a compound selected of the invention, in particularly from Tables 1P to 90P and 1Q to 36Q and an active ingredient as described above are preferably combined in a mixing ratio of from 100:1 to 1:6000, especially from 50:1 to 1:50, more especially in a ratio of from 20:1 to 1:20, even more especially from 10:1 to 1:10, very especially from 5:1 and 1:5, special preference being given to a ratio of from 2:1 to 1:2, and a ratio of from 4:1 to 2:1 being likewise preferred, above all in a ratio of 1:1, or 5:1, or 5:2, or 5:3, or 5:4, or 4:1, or 4:2, or 4:3, or 3:1, or 3:2, or 2:1, or 1:5, or 2:5, or 3:5, or 4:5, or 1:4, or 2:4, or 3:4, or 1:3, or 2:3, or 1:2, or 1:600, or 1:300, or 1:150, or 1:35, or 2:35, or 4:35, or 1:75, or 2:75, or 4:75, or 1:6000, or 1:3000, or 1:1500, or 1:350, or 2:350, or 4:350, or 1:750, or 2:750, or 4:750. Those mixing ratios are understood to include, on the one hand, ratios by weight and also, on other hand, molar ratios.

In addition, biological agents may be included in the composition of the invention e.g. Bacillus species such as Bacillus firmus+Tx, Bacillus cereus+Tx, Bacillus subtilis+Tx, and Pasteuria species such as Pasteuria penetrans+Tx and Pasteuria nishizawae+Tx. A suitable Bacillus firmus strain is strain CNCM I-1582 which is commercially available as BioNem™. A suitable Bacillus cereus strain is strain CNCM I-1562. Of both Bacillus strains more details can be found in U.S. Pat. No. 6,406,690. Other biological organisms that may be included in the compositions of the invention are bacteria such as Streptomyces spp. such as S. avermitilis, and fungi such as Pochonia spp. such as P. chlamydosporia+Tx. Also of interest are Metarhizium spp. such as M. anisopliae+Tx; Pochonia spp. such as P. chlamydosporia+Tx.

The compounds of formula (I) may be mixed with soil, peat or other rooting media for the protection of plants against seed-borne, soil-borne or foliar fungal diseases.

Examples of suitable synergists for use in the compositions include piperonyl butoxide, sesamex, safroxan and dodecyl imidazole.

Suitable herbicides and plant-growth regulators for inclusion in the compositions will depend upon the intended target and the effect required.

An example of a rice selective herbicide which may be included is propanil. An example of a plant growth regulator for use in cotton is PIX™.

Some mixtures may comprise active ingredients which have significantly different physical, chemical or biological properties such that they do not easily lend themselves to the same conventional formulation type. In these circumstances other formulation types may be prepared. For example, where one active ingredient is a water insoluble solid and the other a water insoluble liquid, it may nevertheless be possible to disperse each active ingredient in the same continuous aqueous phase by dispersing the solid active ingredient as a suspension (using a preparation analogous to that of an SC) but dispersing the liquid active ingredient as an emulsion (using a preparation analogous to that of an EW). The resultant composition is a suspoemulsion (SE) formulation.

The compounds of the invention are also useful in the field of animal health, e.g. they may be used against parasitic invertebrate pests, more preferably against parasitic invertebrate pests in or on an animal. Examples of pests include nematodes, trematodes, cestodes, flies, mites, tricks, lice, fleas, true bugs and maggots. The animal may be a non-human animal, e.g. an animal associated with agriculture, e.g. a cow, a pig, a sheep, a goat, a horse, or a donkey, or a companion animal, e.g. a dog or a cat.

In a further aspect the invention provides a compound of the invention for use in a method of therapeutic treatment.

In a further aspect the invention relates to a method of controlling parasitic invertebrate pests in or on an animal comprising administering a pesticidally effective amount of a compound of the invention. The administration may be for example oral administration, parenteral administration or external administration, e.g. to the surface of the animal body. In a further aspect the invention relates to a compound of the invention for controlling parasitic invertebrate pests in or on an animal. In a further aspect the invention relates to use of a compound of the invention in the manufacture of a medicament for controlling parasitic invertebrate pests in or on an animal

In a further aspect, the invention relates to a method of controlling parasitic invertebrate pests comprising administering a pesticidally effective amount of a compound of the invention to the environment in which an animal resides.

In a further aspect the invention relates to a method of protecting an animal from a parasitic invertebrate pest comprising administering to the animal a pesticidally effective amount of a compound of the invention. In a further aspect the invention relates to a compound of the invention for use in protecting an animal from a parasitic invertebrate pest. In a further aspect the invention relates to use of a compound of the invention in the manufacture of a medicament for protecting an animal from a parasitic invertebrate pest.

In a further aspect the invention provides a method of treating an animal suffering from a parasitic invertebrate pest comprising administering to the animal a pesticidally effective amount of a compound of the invention. In a further aspect the invention relates to a compound of the invention for use in treating an animal suffering from a parasitic invertebrate pest. In a further aspect the invention relates to use of a compound of the invention in the manufacture of a medicament for treating an animal suffering from a parasitic invertebrate pest.

In a further aspect, the invention provides a pharmaceutical composition comprising a compound of the invention and a pharmaceutically suitable excipient.

The compounds of the invention may be used alone or in combination with one or more other biologically active ingredients.

In one aspect the invention provides a combination product comprising a pesticidally effective amount of a component A and a pesticidally effective amount of component B wherein component A is a compound of the invention and component B is a compound as described below.

The compounds of the invention may be used in combination with anthelmintic agents. Such anthelmintic agents include, compounds selected from the macrocyclic lactone class of compounds such as ivermectin, avermectin, abamectin, emamectin, eprinomectin, doramectin, selamectin, moxidectin, nemadectin and milbemycin derivatives as described in EP-357460, EP-444964 and EP-594291. Additional anthelmintic agents include semisynthetic and biosynthetic avermectin/milbemycin derivatives such as those described in U.S. Pat. No. 5,015,630, WO-9415944 and WO-9522552. Additional anthelmintic agents include the benzimidazoles such as albendazole, cambendazole, fenbendazole, flubendazole, mebendazole, oxfendazole, oxibendazole, parbendazole, and other members of the class. Additional anthelmintic agents include imidazothiazoles and tetrahydropyrimidines such as tetramisole, levamisole, pyrantel pamoate, oxantel or morantel. Additional anthelmintic agents include flukicides, such as triclabendazole and clorsulon and the cestocides, such as praziquantel and epsiprantel.

The compounds of the invention may be used in combination with derivatives and analogues of the paraherquamide/marcfortine class of anthelmintic agents, as well as the antiparasitic oxazolines such as those disclosed in U.S. Pat. Nos. 5,478,855, 4,639,771 and DE-19520936.

The compounds of the invention may be used in combination with derivatives and analogues of the general class of dioxomorpholine antiparasitic agents as described in WO-9615121 and also with anthelmintic active cyclic depsipeptides such as those described in WO-9611945, WO-9319053, WO-9325543, EP-626375, EP-382173, WO-9419334, EP-382173, and EP-503538.

The compounds of the invention may be used in combination with other ectoparasiticides; for example, fipronil; pyrethroids; organophosphates; insect growth regulators such as lufenuron; ecdysone agonists such as tebufenozide and the like; neonicotinoids such as imidacloprid and the like.

The compounds of the invention may be used in combination with terpene alkaloids, for example those described in International Patent Application Publication Numbers WO95/19363 or WO04/72086, particularly the compounds disclosed therein.

Other examples of such biologically active compounds that the compounds of the invention may be used in combination with include but are not restricted to the following:

Organophosphates: acephate, azamethiphos, azinphos-ethyl, azinphos-methyl, bromophos, bromophos-ethyl, cadusafos, chlorethoxyphos, chlorpyrifos, chlorfenvinphos, chlormephos, demeton, demeton-S-methyl, demeton-S-methyl sulphone, dialifos, diazinon, dichlorvos, dicrotophos, dimethoate, disulfoton, ethion, ethoprophos, etrimfos, famphur, fenamiphos, fenitrothion, fensulfothion, fenthion, flupyrazofos, fonofos, formothion, fosthiazate, heptenophos, isazophos, isothioate, isoxathion, malathion, methacriphos, methamidophos, methidathion, methyl-parathion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, paraoxon, parathion, parathion-methyl, phenthoate, phosalone, phosfolan, phosphocarb, phosmet, phosphamidon, phorate, phoxim, pirimiphos, pirimiphos-methyl, profenofos, propaphos, proetamphos, prothiofos, pyraclofos, pyridapenthion, quinalphos, sulprophos, temephos, terbufos, tebupirimfos, tetrachlorvinphos, thimeton, triazophos, trichlorfon, vamidothion.

Carbamates: alanycarb, aldicarb, 2-sec-butylphenyl methylcarbamate, benfuracarb, carbaryl, carbofuran, carbosulfan, cloethocarb, ethiofencarb, fenoxycarb, fenthiocarb, furathiocarb, HCN-801, isoprocarb, indoxacarb, methiocarb, methomyl, 5-methyl-m-cumenylbutyryl(methyl)carbamate, oxamyl, pirimicarb, propoxur, thiodicarb, thiofanox, triazamate, UC-51717.

Pyrethroids: acrinathin, allethrin, alphametrin, 5-benzyl-3-furylmethyl (E)-(1R)-cis-2,2-dimethyl-3-(2-oxothiolan-3-ylidenemethyl)cyclopropanecarboxylate, bifenthrin, beta-cyfluthrin, cyfluthrin, a-cypermethrin, beta-cypermethrin, bioallethrin, bioallethrin((S)-cyclopentylisomer), bioresmethrin, bifenthrin, NCI-85193, cycloprothrin, cyhalothrin, cythithrin, cyphenothrin, deltamethrin, empenthrin, esfenvalerate, ethofenprox, fenfluthrin, fenpropathrin, fenvalerate, flucythrinate, flumethrin, fluvalinate (D isomer), imiprothrin, cyhalothrin, lambda-cyhalothrin, permethrin, phenothrin, prallethrin, pyrethrins (natural products), resmethrin, tetramethrin, transfluthrin, theta-cypermethrin, silafluofen, t-fluvalinate, tefluthrin, tralomethrin, Zeta-cypermethrin.

Arthropod growth regulators: a) chitin synthesis inhibitors: benzoylureas: chlorfluazuron, diflubenzuron, fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, teflubenzuron, triflumuron, buprofezin, diofenolan, hexythiazox, etoxazole, chlorfentazine; b) ecdysone antagonists: halofenozide, methoxyfenozide, tebufenozide; c) juvenoids: pyriproxyfen, methoprene (including S-methoprene), fenoxycarb; d) lipid biosynthesis inhibitors: spirodiclofen.

Other antiparasitics: acequinocyl, amitraz, AKD-1022, ANS-118, azadirachtin, Bacillus thuringiensis, bensultap, bifenazate, binapacryl, bromopropylate, BTG-504, BTG-505, camphechlor, cartap, chlorobenzilate, chlordimeform, chlorfenapyr, chromafenozide, clothianidine, cyromazine, diacloden, diafenthiuron, DBI-3204, dinactin, dihydroxymethyldihydroxypyrrolidine, dinobuton, dinocap, endosulfan, ethiprole, ethofenprox, fenazaquin, flumite, MTI-800, fenpyroximate, fluacrypyrim, flubenzimine, flubrocythrinate, flufenzine, flufenprox, fluproxyfen, halofenprox, hydramethylnon, IKI-220, kanemite, NC-196, neem guard, nidinorterfuran, nitenpyram, SD-35651, WL-108477, pirydaryl, propargite, protrifenbute, pymethrozine, pyridaben, Buprofezine pyrimidifen, NC-1111, R-195, RH-0345, RH-2485, RYI-210, S-1283, S-1833, SI-8601, silafluofen, silomadine, spinosad, tebufenpyrad, tetradifon, tetranactin, thiacloprid, thiocyclam, thiamethoxam, tolfenpyrad, triazamate, triethoxyspinosyn, trinactin, verbutin, vertalec, YI-5301.

Fungicides: acibenzolar, aldimorph, ampropylfos, andoprim, azaconazole, azoxystrobin, benalaxyl, benomyl, bialaphos, blasticidin-S, Bordeaux mixture, bromuconazole, bupirimate, carpropamid, captafol, captan, carbendazim, chlorfenazole, chloroneb, chloropicrin, chlorothalonil, chlozolinate, copper oxychloride, copper salts, cyflufenamid, cymoxanil, cyproconazole, cyprodinil, cyprofuram, RH-7281, diclocymet, diclobutrazole, diclomezine, dicloran, difenoconazole, RP-407213, dimethomorph, domoxystrobin, diniconazole, diniconazole-M, dodine, edifenphos, epoxiconazole, famoxadone, fenamidone, fenarimol, fenbuconazole, fencaramid, fenpiclonil, fenpropidin, fenpropimorph, fentin acetate, fluazinam, fludioxonil, flumetover, flumorf/flumorlin, fentin hydroxide, fluoxastrobin, fluquinconazole, flusilazole, flutolanil, flutriafol, folpet, fosetyl-aluminium, furalaxyl, furametapyr, hexaconazole, ipconazole, iprobenfos, iprodione, isoprothiolane, kasugamycin, krsoxim-methyl, mancozeb, maneb, mefenoxam, mepronil, metalaxyl, metconazole, metominostrobin/fenominostrobin, metrafenone, myclobutanil, neo-asozin, nicobifen, orysastrobin, oxadixyl, penconazole, pencycuron, probenazole, prochloraz, propamocarb, propioconazole, proquinazid, prothioconazole, pyrifenox, pyraclostrobin, pyrimethanil, pyroquilon, quinoxyfen, spiroxamine, sulfur, tebuconazole, tetrconazole, thiabendazole, thifluzamide, thiophanate-methyl, thiram, tiadinil, triadimefon, triadimenol, tricyclazole, trifloxystrobin, triticonazole, validamycin, vinclozin.

Biological agents: Bacillus thuringiensis ssp aizawai, kurstaki, Bacillus thuringiensis delta endotoxin, baculovirus, entomopathogenic bacteria, virus and fungi.

Bactericides: chlortetracycline, oxytetracycline, streptomycin.

Other biological agents: enrofloxacin, febantel, penethamate, moloxicam, cefalexin, kanamycin, pimobendan, clenbuterol, omeprazole, tiamulin, benazepril, pyriprole, cefquinome, florfenicol, buserelin, cefovecin, tulathromycin, ceftiour, carprofen, metaflumizone, praziquarantel, triclabendazole.

When used in combination with other active ingredients, the compounds of the invention are preferably used in combination with the following (where “Tx” means a compound of formula (I), and in particular a compound selected from Tables 1P to 90P and 1Q to 36Q, which may result in a synergistic combination with the given active ingredient): imidacloprid+Tx, enrofloxacin+Tx, praziquantel+Tx, pyrantel embonate+Tx, febantel+Tx, penethamate+Tx, moloxicam+Tx, cefalexin+Tx, kanamycin+Tx, pimobendan+Tx, clenbuterol+Tx, fipronil+Tx, ivermectin+Tx, omeprazole+Tx, tiamulin+Tx, benazepril+Tx, milbemycin+Tx, cyromazine+Tx, thiamethoxam+Tx, pyriprole+Tx, deltamethrin+Tx, cefquinome+Tx, florfenicol+Tx, buserelin+Tx, cefovecin+Tx, tulathromycin+Tx, ceftiour+Tx, selamectin+Tx, carprofen+Tx, metaflumizone+Tx, moxidectin+Tx, methoprene (including S-methoprene)+Tx, clorsulon+Tx, pyrantel+Tx, amitraz+Tx, triclabendazole+Tx, avermectin+Tx, abamectin+Tx, emamectin+Tx, eprinomectin+Tx, doramectin+Tx, selamectin+Tx, nemadectin+Tx, albendazole+Tx, cambendazole+Tx, fenbendazole+Tx, flubendazole+Tx, mebendazole+Tx, oxfendazole+Tx, oxibendazole+Tx, parbendazole+Tx, tetramisole+Tx, levamisole+Tx, pyrantel pamoate+Tx, oxantel+Tx, morantel+Tx, triclabendazole+Tx, epsiprantel+Tx, fipronil+Tx, lufenuron+Tx, ecdysone+Tx or tebufenozide+Tx; more preferably, enrofloxacin+Tx, praziquantel+Tx, pyrantel embonate+Tx, febantel+Tx, penethamate+Tx, moloxicam+Tx, cefalexin+Tx, kanamycin+Tx, pimobendan+Tx, clenbuterol+Tx, omeprazole+Tx, tiamulin+Tx, benazepril+Tx, pyriprole+Tx, cefquinome+Tx, florfenicol+Tx, buserelin+Tx, cefovecin+Tx, tulathromycin+Tx, ceftiour+Tx, selamectin+Tx, carprofen+Tx, moxidectin+Tx, clorsulon+Tx, pyrantel+Tx, eprinomectin+Tx, doramectin+Tx, selamectin+Tx, nemadectin+Tx, albendazole+Tx, cambendazole+Tx, fenbendazole+Tx, flubendazole+Tx, mebendazole+Tx, oxfendazole+Tx, oxibendazole+Tx, parbendazole+Tx, tetramisole+Tx, levamisole+Tx, pyrantel pamoate+Tx, oxantel+Tx, morantel+Tx, triclabendazole+Tx, epsiprantel+Tx, lufenuron+Tx or ecdysone+Tx; even more preferably enrofloxacin+Tx, praziquantel+Tx, pyrantel embonate+Tx, febantel+Tx, penethamate+Tx, moloxicam+Tx, cefalexin+Tx, kanamycin+Tx, pimobendan+Tx, clenbuterol+Tx, omeprazole+Tx, tiamulin+Tx, benazepril+Tx, pyriprole+Tx, cefquinome+Tx, florfenicol+Tx, buserelin+Tx, cefovecin+Tx, tulathromycin+Tx, ceftiour+Tx, selamectin+Tx, carprofen+Tx, moxidectin+Tx, clorsulon+Tx or pyrantel+Tx.

Examples of ratios of the compound of formula Ito any mixing partner described herein include 100:1 to 1:6000, 50:1 to 1:50, 20:1 to 1:20, even more especially from 10:1 to 1:10, 5:1 to 1:5, 2:1 to 1:2, 4:1 to 2:1, 1:1, or 5:1, or 5:2, or 5:3, or 5:4, or 4:1, or 4:2, or 4:3, or 3:1, or 3:2, or 2:1, or 1:5, or 2:5, or 3:5, or 4:5, or 1:4, or 2:4, or 3:4, or 1:3, or 2:3, or 1:2, or 1:600, or 1:300, or 1:150, or 1:35, or 2:35, or 4:35, or 1:75, or 2:75, or 4:75, or 1:6000, or 1:3000, or 1:1500, or 1:350, or 2:350, or 4:350, or 1:750, or 2:750, or 4:750. Those mixing ratios are understood to include, on the one hand, ratios by weight and also, on other hand, molar ratios.

Of particular note is a combination where the additional active ingredient has a different site of action from the compound of formula I. In certain instances, a combination with at least one other parasitic invertebrate pest control active ingredient having a similar spectrum of control but a different site of action will be particularly advantageous for resistance management. Thus, a combination product of the invention may comprise a pesticidally effective amount of a compound of formula I and pesticidally effective amount of at least one additional parasitic invertebrate pest control active ingredient having a similar spectrum of control but a different site of action.

One skilled in the art recognizes that because in the environment and under physiological conditions salts of chemical compounds are in equilibrium with their corresponding non salt forms, salts share the biological utility of the non salt forms.

Thus a wide variety of salts of compounds of the invention (and active ingredients used in combination with the active ingredients of the invention) may be useful for control of invertebrate pests and animal parasites. Salts include acid-addition salts with inorganic or organic acids such as hydrobromic, hydrochloric, nitric, phosphoric, sulfuric, acetic, butyric, fumaric, lactic, maleic, malonic, oxalic, propionic, salicylic, tartaric, 4-toluenesulfonic or valeric acids.

The compounds of the invention also include N-oxides. Accordingly, the invention comprises combinations of compounds of the invention including N-oxides and salts thereof and an additional active ingredient including N-oxides and salts thereof.

The compositions for use in animal health may also contain formulation auxiliaries and additives, known to those skilled in the art as formulation aids (some of which may be considered to also function as solid diluents, liquid diluents or surfactants). Such formulation auxiliaries and additives may control: pH (buffers), foaming during processing (antifoams such polyorganosiloxanes), sedimentation of active ingredients (suspending agents), viscosity (thixotropic thickeners), in-container microbial growth (antimicrobials), product freezing (antifreezes), color (dyes/pigment dispersions), wash-off (film formers or stickers), evaporation (evaporation retardants), and other formulation attributes. Film formers include, for example, polyvinyl acetates, polyvinyl acetate copolymers, polyvinylpyrrolidone-vinyl acetate copolymer, polyvinyl alcohols, polyvinyl alcohol copolymers and waxes. Examples of formulation auxiliaries and additives include those listed in McCutcheon's Volume 2: Functional Materials, annual International and North American editions published by McCutcheon's Division, The Manufacturing Confectioner Publishing Co.; and PCT Publication WO 03/024222.

The compounds of the invention can be applied without other adjuvants, but most often application will be of a formulation comprising one or more active ingredients with suitable carriers, diluents, and surfactants and possibly in combination with a food depending on the contemplated end use. One method of application involves spraying a water dispersion or refined oil solution of the combination products. Compositions with spray oils, spray oil concentrations, spreader stickers, adjuvants, other solvents, and synergists such as piperonyl butoxide often enhance compound efficacy. Such sprays can be applied from spray containers such as a can, a bottle or other container, either by means of a pump or by releasing it from a pressurized container, e.g., a pressurized aerosol spray can. Such spray compositions can take various forms, for example, sprays, mists, foams, fumes or fog. Such spray compositions thus can further comprise propellants, foaming agents, etc. as the case may be. Of note is a spray composition comprising a pesticidally effective amount of a compound of the invention and a carrier. One embodiment of such a spray composition comprises a pesticidally effective amount of a compound of the invention and a propellant. Representative propellants include, but are not limited to, methane, ethane, propane, butane, isobutane, butene, pentane, isopentane, neopentane, pentene, hydrofluorocarbons, chlorofluorocarbons, dimethyl ether, and mixtures of the foregoing. Of note is a spray composition (and a method utilizing such a spray composition dispensed from a spray container) used to control at least one parasitic invertebrate pest selected from the group consisting of mosquitoes, black flies, stable flies, deer flies, horse flies, wasps, yellow jackets, hornets, ticks, spiders, ants, gnats, and the like, including individually or in combinations.

The controlling of animal parasites includes controlling external parasites that are parasitic to the surface of the body of the host animal (e.g., shoulders, armpits, abdomen, inner part of the thighs) and internal parasites that are parasitic to the inside of the body of the host animal (e.g., stomach, intestine, lung, veins, under the skin, lymphatic tissue). External parasitic or disease transmitting pests include, for example, chiggers, ticks, lice, mosquitoes, flies, mites and fleas. Internal parasites include heartworms, hookworms and helminths. The compounds of the invention may be particularly suitable for combating external parasitic pests. The compounds of the invention may be suitable for systemic and/or non-systemic control of infestation or infection by parasites on animals.

The compounds of the invention may be suitable for combating parasitic invertebrate pests that infest animal subjects including those in the wild, livestock and agricultural working animals. Livestock is the term used to refer (singularly or plurally) to a domesticated animal intentionally reared in an agricultural setting to make produce such as food or fiber, or for its labor; examples of livestock include cattle, sheep, goats, horses, pigs, donkeys, camels, buffalo, rabbits, hens, turkeys, ducks and geese (e.g., raised for meat, milk, butter, eggs, fur, leather, feathers and/or wool), cultured fish, honeybees. By combating parasites, fatalities and performance reduction (in terms of meat, milk, wool, skins, eggs, etc.) are reduced, so that applying the compounds of the invention allows more economic and simple husbandry of animals.

By controlling these pests it is intended to reduce deaths and improve performance (in the case of meat, milk, wool, hides, eggs, honey and the like) and health of the host animal. Also, controlling parasites may help to prevent the transmittance of infectious agents, the term “controlling” referring to the veterinary field, meaning that the active compounds are effective in reducing the incidence of the respective parasite in an animal infected with such parasites to innocuous levels, e.g. the active compound is effective in killing the respective parasite, inhibiting its growth, or inhibiting its proliferation.

The compounds of the invention may be suitable for combating parasitic invertebrate pests that infest companion animals and pets (e.g., dogs, cats, pet birds and aquarium fish), research and experimental animals (e.g., hamsters, guinea pigs, rats and mice), as well as animals raised for/in zoos, wild habitats and/or circuses.

In an embodiment of this invention, the animal is preferably a vertebrate, and more preferably a mammal, avian or fish. In a particular embodiment, the animal subject is a mammal (including great apes, such as humans). Other mammalian subjects include primates (e.g., monkeys), bovine (e.g., cattle or dairy cows), porcine (e.g., hogs or pigs), ovine (e.g., goats or sheep), equine (e.g., horses), canine (e.g., dogs), feline (e.g., house cats), camels, deer, donkeys, buffalos, antelopes, rabbits, and rodents (e.g., guinea pigs, squirrels, rats, mice, gerbils, and hamsters). Avians include Anatidae (swans, ducks and geese), Columbidae (e.g., doves and pigeons), Phasianidae (e.g., partridges, grouse and turkeys), Thesienidae (e.g., domestic chickens), Psittacines (e.g., parakeets, macaws, and parrots), game birds, and ratites (e.g., ostriches).

Birds treated or protected by the compounds of the invention can be associated with either commercial or noncommercial aviculture. These include Anatidae, such as swans, geese, and ducks, Columbidae, such as doves and domestic pigeons, Phasianidae, such as partridge, grouse and turkeys, Thesienidae, such as domestic chickens, and Psittacines, such as parakeets, macaws and parrots raised for the pet or collector market, among others.

For purposes of the present invention, the term “fish” is understood to include without limitation, the Teleosti grouping of fish, i.e., teleosts. Both the Salmoniformes order (which includes the Salmonidae family) and the Perciformes order (which includes the Centrarchidae family) are contained within the Teleosti grouping. Examples of potential fish recipients include the Salmonidae, Serranidae, Sparidae, Cichlidae, and Centrarchidae, among others.

Other animals are also contemplated to benefit from the inventive methods, including marsupials (such as kangaroos), reptiles (such as farmed turtles), and other economically important domestic animals for which the inventive methods are safe and effective in treating or preventing parasite infection or infestation.

Examples of parasitic invertebrate pests controlled by administering a pesticidally effective amount of the compounds of the invention to an animal to be protected include ectoparasites (arthropods, acarines, etc.) and endoparasites (helminths, e.g., nematodes, trematodes, cestodes, acanthocephalans, etc. and protozoae, such as coccidia).

The disease or group of diseases described generally as helminthiasis is due to infection of an animal host with parasitic worms known as helminths. The term ‘helminths’ is meant to include nematodes, trematodes, cestodes and acanthocephalans. Helminthiasis is a prevalent and serious economic problem with domesticated animals such as swine, sheep, horses, cattle, goats, dogs, cats and poultry.

Among the helminths, the group of worms described as nematodes causes widespread and at times serious infection in various species of animals.

Nematodes that are contemplated to be treated by the compounds of the invention include, without limitation, the following genera: Acanthocheilonema, Aelurostrongylus, Ancylostoma, Angiostrongylus, Ascaridia, Ascaris, Brugia, Bunostomum, Capillaria, Chabertia, Cooperia, Crenosoma, Dictyocaulus, Dioctophyme, Dipetalonema, Diphyllobothrium, Dirofilaria, Dracunculus, Enterobius, Filaroides, Haemonchus, Heterakis, Lagochilascaris, Loa, Mansonella, Muellerius, Necator, Nematodirus, Oesophagostomum, Ostertagia, Oxyuris, Parafilaria, Parascaris, Physaloptera, Protostrongylus, Setaria, Spirocerca, Stephanofilaria, Strongyloides, Strongylus, Thelazia, Toxascaris, Toxocara, Trichinella, Trichonema, Trichostrongylus, Trichuris, Uncinaria and Wuchereria.

Of the above, the most common genera of nematodes infecting the animals referred to above are Haemonchus, Trichostrongylus, Ostertagia, Nematodirus, Cooperia, Ascaris, Bunostomum, Oesophagostomum, Chabertia, Trichuris, Strongylus, Trichonema, Dictyocaulus, Capillaria, Heterakis, Toxocara, Ascaridia, Oxyuris, Ancylostoma, Uncinaria, Toxascaris and Parascaris. Certain of these, such as Nematodirus, Cooperia and Oesophagostomum attack primarily the intestinal tract while others, such as Haemonchus and Ostertagia, are more prevalent in the stomach while others such as Dictyocaulus are found in the lungs. Still other parasites may be located in other tissues such as the heart and blood vessels, subcutaneous and lymphatic tissue and the like.

Trematodes that are contemplated to be treated by the invention and by the inventive methods include, without limitation, the following genera: Alaria, Fasciola, Nanophyetus, Opisthorchis, Paragonimus and Schistosoma.

Cestodes that are contemplated to be treated by the invention and by the inventive methods include, without limitation, the following genera: Diphyllobothrium, Diplydium, Spirometra and Taenia.

The most common genera of parasites of the gastrointestinal tract of humans are Ancylostoma, Necator, Ascaris, Strongy hides, Trichinella, Capillaria, Trichuris and Enterobius. Other medically important genera of parasites which are found in the blood or other tissues and organs outside the gastrointestinal tract are the filarial worms such as Wuchereria, Brugia, Onchocerca and Loa, as well as Dracunculus and extra intestinal stages of the intestinal worms Strongyloides and Trichinella.

Numerous other helminth genera and species are known to the art, and are also contemplated to be treated by the compounds of the invention. These are enumerated in great detail in Textbook of Veterinary Clinical Parasitology, Volume 1, Helminths, E. J. L. Soulsby, F. A. Davis Co., Philadelphia, Pa.; Helminths, Arthropods and Protozoa, (6^(th) Edition of Monnig's Veterinary Helminthology and Entomology), E. J. L. Soulsby, Williams and Wilkins Co., Baltimore, Md.

The compounds of the invention may be effective against a number of animal ectoparasites (e.g., arthropod ectoparasites of mammals and birds in particular insects such as flies (stinging and licking), parasitic fly larvae, lice, hair lice, bird lice, fleas and the like; or acarids, such as ticks, for examples hard ticks or soft ticks, or mites, such as scab mites, harvest mites, bird mites and the like).

Insect and acarine pests include, e.g., biting insects such as flies and mosquitoes, mites, ticks, lice, fleas, true bugs, parasitic maggots, and the like.

Adult flies include, e.g., the horn fly or Haematobia irritans, the horse fly or Tabanus spp., the stable fly or Stomoxys calcitrans, the black fly or Simulium spp., the deer fly or Chrysops spp., the louse fly or Melophagus ovinus, and the tsetse fly or Glossina spp. Parasitic fly maggots include, e.g., the bot fly (Oestrus ovis and Cuterebra spp.), the blow fly or Phaenicia spp., the screwworm or Cochliomyia hominivorax, the cattle grub or Hypoderma spp., the fleeceworm and the Gastrophilus of horses. Mosquitoes include, for example, Culex spp., Anopheles spp. and Aedes spp.

Mites include Mesostigmalphatalpha spp. e.g., mesostigmatids such as the chicken mite, Dermalphanyssus galphallinalphae; itch or scab mites such as Sarcoptidae spp. for example, Salpharcoptes scalphabiei; mange mites such as Psoroptidae spp. including Chorioptes bovis and Psoroptes ovis; chiggers e.g., Trombiculidae spp. for example the North American chigger, Trombiculalpha alphalfreddugesi.

Ticks include, e.g., soft-bodied ticks including Argasidae spp. for example Argalphas spp. and Ornithodoros spp.; hard-bodied ticks including Ixodidae spp., for example Rhipicephalphalus sanguineus, Dermacentor variabilis, Dermacentor andersoni, Amblyomma americanum, Ixodes scapularis and other Rhipicephalus spp. (including the former Boophilus genera).

Lice include, e.g., sucking lice, e.g., Menopon spp. and Bovicola spp.; biting lice, e.g., Haematopinus spp., Linognathus spp. and Solenopotes spp.

Fleas include, e.g., Ctenocephalides spp., such as dog flea (Ctenocephalides canis) and cat flea (Ctenocephalides felis); Xenopsylla spp. such as oriental rat flea (Xenopsylla cheopis); and Pulex spp. such as human flea (Pulex irritans).

True bugs include, e.g., Cimicidae or e.g., the common bed bug (Cimex lectularius); Triatominae spp. including triatomid bugs also known as kissing bugs; for example Rhodnius prolixus and Triatoma spp.

Generally, flies, fleas, lice, mosquitoes, gnats, mites, ticks and helminths cause tremendous losses to the livestock and companion animal sectors. Arthropod parasites also are a nuisance to humans and can vector disease-causing organisms in humans and animals.

Numerous other parasitic invertebrate pests are known to the art, and are also contemplated to be treated by the compounds of the invention. These are enumerated in great detail in Medical and Veterinary Entomology, D. S. Kettle, John Wiley AND Sons, New York and Toronto; Control of Arthropod Pests of Livestock: A Review of Technology, R. O. Drummand, J. E. George, and S. E. Kunz, CRC Press, Boca Raton, Fla.

The compounds of the invention may also be effective against ectoparasites, e.g. insects such as flies (stinging and licking), parasitic fly larvae, lice, hair lice, bird lice, fleas and the like; or acarids, such as ticks, for examples hard ticks or soft ticks, or mites, such as scab mites, harvest mites, bird mites and the like. These include e.g. flies such as Haematobia (Lyperosia) irritans (horn fly), Simulium spp. (blackfly), Glossina spp. (tsetse flies), Hydrotaea irritans (head fly), Musca autumnalis (face fly), Musca domestica (house fly), Morellia simplex (sweat fly), Tabanus spp. (horse fly), Hypoderma bovis, Hypoderma lineatum, Lucilia sericata, Lucilia cuprina (green blowfly), Calliphora spp. (blowfly), Protophormia spp., Oestrus ovis (nasal botfly), Culicoides spp. (midges), Hippobosca equine, Gastrophilus intestinalis, Gastrophilus haemorrhoidalis and Gastrophilus nasalis; lice such as Bovicola (Damalinia) bovis, Bovicola equi, Haematopinus asini, Felicola subrostratus, Heterodoxus spiniger, Lignonathus setosus and Trichodectes canis; keds such as Melophagus ovinus; and mites such as Psoroptes spp., Sarcoptes scabei, Chorioptes bovis, Demodex equi, Cheyletiella spp., Notoedres cati, Trombicula spp. and Otodectes cyanotis (ear mites).

Examples of species of animal health pesets include those from the order of the Anoplurida, for example Haematopinus spp., Linognathus spp., Pediculus spp., Phtirus spp., Solenopotes spp.; particular examples are: Linognathus setosus, Linognathus vituli, Linognathus ovillus, Linognathus oviformis, Linognathus pedalis, Linognathus stenopsis, Haematopinus asini macrocephalus, Haematopinus eurysternus, Haematopinus suis, Pediculus humanus capitis, Pediculus humanus corporis, Phylloera vastatrix, Phthirus pubis, Solenopotes capillatus; from the order of the Mallophagida and the suborders Amblycerina and Ischnocerina, for example Trimenopon spp., Menopon spp., Trinoton spp., Bovicola spp., Werneckiella spp., Lepikentron spp., Damalina spp., Trichodectes spp., Felicola spp.; particular examples are: Bovicola bovis, Bovicola ovis, Bovicola limbata, Damalina bovis, Trichodectes canis, Felicola subrostratus, Bovicola caprae, Lepikentron ovis, Werneckiella equi; from the order of the Diptera and the suborders Nematocerina and Brachycerina, for example Aedes spp., Anopheles spp., Culex spp., Simulium spp., Eusimulium spp., Phlebotomus spp., Lutzomyia spp., Culicoides spp., Chrysops spp., Odagmia spp., Wilhelmia spp., Hybomitra spp., Atylotus spp., Tabanus spp., Haematopota spp., Philipomyia spp., Braula spp., Musca spp., Hydrotaea spp., Stomoxys spp., Haematobia spp., Morellia spp., Fannia spp., Glossina spp., Calliphora spp., Lucilia spp., Chrysomyia spp., Wohlfahrtia spp., Sarcophaga spp., Oestrus spp., Hypoderma spp., Gasterophilus spp., Hippobosca spp., Lipoptena spp., Melophagus spp., Rhinoestrus spp., Tipula spp.; particular examples are: Aedes aegypti, Aedes albopictus, Aedes taeniorhynchus, Anopheles gambiae, Anopheles maculipennis, Calliphora erythrocephala, Chrysozona pluvialis, Culex quinquefasciatus, Culex pipiens, Culex tarsalis, Fannia canicularis, Sarcophaga carnaria, Stomoxys calcitrans, Tipula paludosa, Lucilia cuprina, Lucilia sericata, Simulium reptans, Phlebotomus papatasi, Phlebotomus longipalpis, Odagmia ornata, Wilhelmia equina, Boophthora erythrocephala, Tabanus bromius, Tabanus spodopterus, Tabanus atratus, Tabanus sudeticus, Hybomitra ciurea, Chrysops caecutiens, Chrysops relictus, Haematopota pluvialis, Haematopota italica, Musca autumnalis, Musca domestica, Haematobia irritans irritans, Haematobia irritans exigua, Haematobia stimulans, Hydrotaea irritans, Hydrotaea albipuncta, Chrysomya chloropyga, Chrysomya bezziana, Oestrus ovis, Hypoderma bovis, Hypoderma lineatum, Przhevalskiana silenus, Dermatobia hominis, Melophagus ovinus, Lipoptena capreoli, Lipoptena cervi, Hippobosca variegata, Hippobosca equina, Gasterophilus intestinalis, Gasterophilus haemorroidalis, Gasterophilus inermis, Gasterophilus nasalis, Gasterophilus nigricornis, Gasterophilus pecorum, Braula coeca; from the order of the Siphonapterida, for example Pulex spp., Ctenocephalides spp., Tunga spp., Xenopsylla spp., Ceratophyllus spp.; particular examples are: Ctenocephalides canis, Ctenocephalides felis, Pulex irritans, Tunga penetrans, Xenopsylla cheopis; from the order of the Heteropterida, for example Cimex spp., Triatoma spp., Rhodnius spp., Panstrongylus spp; from the order of the Blattarida, for example Blatta orientalis, Periplaneta americana, Blattela germanica, Supella spp. (e.g. Suppella longipalpa); from the subclass of the Acari (Acarina) and the orders of the Meta- and Mesostigmata, for example Argas spp., Ornithodorus spp., Otobius spp., Ixodes spp., Amblyomma spp., Rhipicephalus (Boophilus) spp Dermacentor spp., Haemophysalis spp., Hyalomma spp., Dermanyssus spp., Rhipicephalus spp. (the original genus of multi host ticks) Ornithonyssus spp., Pneumonyssus spp., Raillietia spp., Pneumonyssus spp., Sternostoma spp., Varroa spp., Acarapis spp.; particular examples are: Argas persicus, Argas reflexus, Ornithodorus moubata, Otobius megnini, Rhipicephalus (Boophilus) microplus, Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) annulatus, Rhipicephalus (Boophilus) calceratus, Hyalomma anatolicum, Hyalomma aegypticum, Hyalomma marginatum, Hyalomma transiens, Rhipicephalus evertsi, Ixodes ricinus, Ixodes hexagonus, Ixodes canisuga, Ixodes pilosus, Ixodes rubicundus, Ixodes scapularis, Ixodes holocyclus, Haemaphysalis concinna, Haemaphysalis punctata, Haemaphysalis cinnabarina, Haemaphysalis otophila, Haemaphysalis leachi, Haemaphysalis longicorni, Dermacentor marginatus, Dermacentor reticulatus, Dermacentor pictus, Dermacentor albipictus, Dermacentor andersoni, Dermacentor variabilis, Hyalomma mauritanicum, Rhipicephalus sanguineus, Rhipicephalus bursa, Rhipicephalus appendiculatus, Rhipicephalus capensis, Rhipicephalus turanicus, Rhipicephalus zambeziensis, Amblyomma americanum, Amblyomma variegatum, Amblyomma maculatum, Amblyomma hebraeum, Amblyomma cajennense, Dermanyssus gallinae, Ornithonyssus bursa, Ornithonyssus sylviarum, Varroa jacobsoni; from the order of the Actinedida (Prostigmata) and Acaridida (Astigmata), for example Acarapis spp., Cheyletiella spp., Ornithocheyletia spp., Myobia spp., Psorergates spp., Demodex spp., Trombicula spp., Listrophorus spp., Acarus spp., Tyrophagus spp., Caloglyphus spp., Hypodectes spp., Pterolichus spp., Psoroptes spp., Chorioptes spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cytodites spp., Laminosioptes spp.; particular examples are: Cheyletiella yasguri, Cheyletiella blakei, Demodex canis, Demodex bovis, Demodex ovis, Demodex caprae, Demodex equi, Demodex caballi, Demodex suis, Neotrombicula autumnalis, Neotrombicula desaleri, Neoschongastia xerothermobia, Trombicula akamushi, Otodectes cynotis, Notoedres cati, Sarcoptis canis, Sarcoptes bovis, Sarcoptes ovis, Sarcoptes rupicaprae (S. caprae), Sarcoptes equi, Sarcoptes suis, Psoroptes ovis, Psoroptes cuniculi, Psoroptes equi, Chorioptes bovis, Psoergates ovis, Pneumonyssoidic mange, Pneumonyssoides caninum, Acarapis woodi; Gasterophilus spp., Stomoxys spp., Trichodectes spp., Rhodnius spp., Ctenocephalides canis, Cimx lecturius, Ctenocephalides felis, Lucilia cuprina; examples of acari include Ornithodoros spp., Ixodes spp., Boophilus spp.

Treatments of the invention are by conventional means such as by enteral administration in the form of, for example, tablets, capsules, drinks, drenching preparations, granulates, pastes, boli, feed-through procedures, or suppositories; or by parenteral administration, such as, for example, by injection (including intramuscular, subcutaneous, intravenous, intraperitoneal) or implants; or by nasal administration; or by dermal application in the form of, for example, bathing or dipping, spraying, pouring-on and spotting-on, washing, dusting, and with the aid of active-compound-comprising shaped articles such as collars, ear tags, tail tags, limb bands, halters, marking devices and the like.

When compounds of the invention are applied in combination with an additional biologically active ingredient, they may be administered separately e.g. as separate compositions. In this case, the biologically active ingredients may be administered simultaneously or sequentially. Alternatively, the biologically active ingredients may be components of one composition.

The compounds of the invention may be administered in a controlled release form, for example in subcutaneous or orally adminstered slow release formulations.

Typically a parasiticidal composition according to the present invention comprises a compound of the invention, optionally in combination with an additional biologically active ingredient, or N-oxides or salts thereof, with one or more pharmaceutically or veterinarily acceptable carriers comprising excipients and auxiliaries selected with regard to the intended route of administration (e.g., oral or parenteral administration such as injection) and in accordance with standard practice. In addition, a suitable carrier is selected on the basis of compatibility with the one or more active ingredients in the composition, including such considerations as stability relative to pH and moisture content. Therefore of note are compounds of the invention for protecting an animal from an invertebrate parasitic pest comprising a parasitically effective amount of a compound of the invention, optionally in combination with an additional biologically active ingredient and at least one carrier.

For parenteral administration including intravenous, intramuscular and subcutaneous injection, the compounds of the invention can be formulated in suspension, solution or emulsion in oily or aqueous vehicles, and may contain adjuncts such as suspending, stabilizing and/or dispersing agents.

The compounds of the invention may also be formulated for bolus injection or continuous infusion. Pharmaceutical compositions for injection include aqueous solutions of water-soluble forms of active ingredients (e.g., a salt of an active compound), preferably in physiologically compatible buffers containing other excipients or auxiliaries as are known in the art of pharmaceutical formulation. Additionally, suspensions of the active compounds may be prepared in a lipophilic vehicle. Suitable lipophilic vehicles include fatty oils such as sesame oil, synthetic fatty acid esters such as ethyl oleate and triglycerides, or materials such as liposomes.

Aqueous injection suspensions may contain substances that increase the viscosity of the suspension, such as sodium carboxymethyl cellulose, sorbitol, or dextran. Formulations for injection may be presented in unit dosage form, e.g., in ampoules or in multi-dose containers. Alternatively, the active ingredient may be in powder form for constitution with a suitable vehicle, e.g., sterile, pyrogen-free water, before use.

In addition to the formulations described supra, the compounds of the invention may also be formulated as a depot preparation. Such long acting formulations may be administered by implantation (for example, subcutaneously or intramuscularly) or by intramuscular or subcutaneous injection.

The compounds of the invention may be formulated for this route of administration with suitable polymeric or hydrophobic materials (for instance, in an emulsion with a pharmacologically acceptable oil), with ion exchange resins, or as a sparingly soluble derivative such as, without limitation, a sparingly soluble salt.

For administration by inhalation, the compounds of the invention can be delivered in the form of an aerosol spray using a pressurized pack or a nebulizer and a suitable propellant, e.g., without limitation, dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane or carbon dioxide. In the case of a pressurized aerosol, the dosage unit may be controlled by providing a valve to deliver a metered amount. Capsules and cartridges of, for example, gelatin for use in an inhaler or insufflator may be formulated containing a powder mix of the compound and a suitable powder base such as lactose or starch.

The compounds of the invention may have favourable pharmacokinetic and pharmacodynamic properties providing systemic availability from oral administration and ingestion. Therefore after ingestion by the animal to be protected, parasiticidally effective concentrations of a compound of the invention in the bloodstream may protect the treated animal from blood-sucking pests such as fleas, ticks and lice. Therefore of note is a composition for protecting an animal from an invertebrate parasite pest in a form for oral administration (i.e. comprising, in addition to a parasiticidally effective amount of a compound of the invention, one or more carriers selected from binders and fillers suitable for oral administration and feed concentrate carriers).

For oral administration in the form of solutions (the most readily available form for absorption), emulsions, suspensions, pastes, gels, capsules, tablets, boluses, powders, granules, rumen-retention and feed/water/lick blocks, the compounds of the invention can be formulated with binders/fillers known in the art to be suitable for oral administration compositions, such as sugars and sugar derivatives (e.g., lactose, sucrose, mannitol, sorbitol), starch (e.g., maize starch, wheat starch, rice starch, potato starch), cellulose and derivatives (e.g., methylcellulose, carboxymethylcellulose, ethylhydroxycellulose), protein derivatives (e.g., zein, gelatin), and synthetic polymers (e.g., polyvinyl alcohol, polyvinylpyrrolidone). If desired, lubricants (e.g., magnesium stearate), disintegrating agents (e.g., cross-linked polyvinylpyrrolidinone, agar, alginic acid) and dyes or pigments can be added. Pastes and gels often also contain adhesives (e.g., acacia, alginic acid, bentonite, cellulose, xanthan gum, colloidal magnesium aluminum silicate) to aid in keeping the composition in contact with the oral cavity and not being easily ejected.

In one embodiment a composition of the present invention is formulated into a chewable and/or edible product (e.g., a chewable treat or edible tablet). Such a product would ideally have a taste, texture and/or aroma favored by the animal to be protected so as to facilitate oral administration of the compounds of the invention.

If the parasiticidal compositions are in the form of feed concentrates, the carrier is typically selected from high-performance feed, feed cereals or protein concentrates. Such feed concentrate-containing compositions can, in addition to the parasiticidal active ingredients, comprise additives promoting animal health or growth, improving quality of meat from animals for slaughter or otherwise useful to animal husbandry.

These additives can include, for example, vitamins, antibiotics, chemotherapeutics, bacteriostats, fungistats, coccidiostats and hormones.

The compound of the invention may also be formulated in rectal compositions such as suppositories or retention enemas, using, e.g., conventional suppository bases such as cocoa butter or other glycerides.

The formulations for the method of this invention may include an antioxidant, such asBHT (butylated hydroxytoluene). The antioxidant is generally present in amounts of at 0.1-5 percent (wt/vol). Some of the formulations require a solubilizer, such as oleic acid, to dissolve the active agent, particularly if spinosad is included. Common spreading agents used in these pour-on formulations include isopropyl myristate, isopropyl palmitate, caprylic/capric acid esters of saturated C₁₂-C₁₈ fatty alcohols, oleic acid, oleyl ester, ethyl oleate, triglycerides, silicone oils and dipropylene glycol methyl ether. The pour-on formulations for the method of this invention are prepared according to known techniques. Where the pour-on is a solution, the parasiticide/insecticide is mixed with the carrier or vehicle, using heat and stirring if required. Auxiliary or additional ingredients can be added to the mixture of active agent and carrier, or they can be mixed with the active agent prior to the addition of the carrier. Pour-on formulations in the form of emulsions or suspensions are similarly prepared using known techniques.

Other delivery systems for relatively hydrophobic pharmaceutical compounds may be employed. Liposomes and emulsions are well-known examples of delivery vehicles or carriers for hydrophobic drugs. In addition, organic solvents such as dimethylsulfoxide may be used, if needed.

The rate of application required for effective parasitic invertebrate pest control (e.g. “pesticidally effective amount”) will depend on such factors as the species of parasitic invertebrate pest to be controlled, the pest's life cycle, life stage, its size, location, time of year, host crop or animal, feeding behavior, mating behavior, ambient moisture, temperature, and the like. One skilled in the art can easily determine the pesticidally effective amount necessary for the desired level of parasitic invertebrate pest control.

In general for veterinary use, the compounds of the invention are administered in a pesticidally effective amount to an animal, particularly a homeothermic animal, to be protected from parasitic invertebrate pests.

A pesticidally effective amount is the amount of active ingredient needed to achieve an observable effect diminishing the occurrence or activity of the target parasitic invertebrate pest. One skilled in the art will appreciate that the pesticidally effective dose can vary for the various compounds and compositions useful for the method of the present invention, the desired pesticidal effect and duration, the target parasitic invertebrate pest species, the animal to be protected, the mode of application and the like, and the amount needed to achieve a particular result can be determined through simple experimentation.

For oral or parenteral administration to animals, a dose of the compositions of the present invention administered at suitable intervals typically ranges from about 0.01 mg/kg to about 100 mg/kg, and preferably from about 0.01 mg/kg to about 30 mg/kg of animal body weight.

Suitable intervals for the administration of the compositions of the present invention to animals range from about daily to about yearly. Of note are administration intervals ranging from about weekly to about once every 6 months. Of particular note are monthly administration intervals (i.e. administering the compounds to the animal once every month).

The following Examples illustrate, but do not limit, the invention.

The following abbreviations were used in this section: DMF: dimethylformamide; THF: tetrahydrofuran; EtOAc: ethyl acetate; s=singlet; bs=broad singlet; d=doublet; dd=double doublet; dt=double triplet; t=triplet, tt=triple triplet, q=quartet, sept=septet; m=multiplet; Me=methyl; Et=ethyl; Pr=propyl; Bu=butyl; M.p.=melting point; RT=retention time, [M+H]⁺=molecular mass of the molecular cation, [M−H]⁻=molecular mass of the molecular anion.

The following abbreviations were used throughout this section: s=singlet; bs=broad singlet; d=doublet; dd=double doublet; dt=double triplet; t=triplet, tt=triple triplet, q=quartet, sept=septet; m=multiplet; Me=methyl; Et=ethyl; Pr=propyl; Bu=butyl; RT=retention time; MH⁺=molecular cation.

The invention is now described by way of non-limiting Examples.

PREPARATION EXAMPLES

The following preparation examples describe synthesis of compounds of formula I and intermediates thereof.

Example 1 Preparation of tert-butyl 2-methyl-4-(2-oxo-1,3,4-oxathiazol-5-yl)benzoate

To a stirring solution of tert-butyl 4-carbamoyl-2-methyl-benzoate (10 g) in mixture of Toluene and Dioxane (3:1, 240 mL) was added potassium carbonate (5.88 g) then chlorocarbonylsulfenyl chloride (5.5 mL). The mixture was heated at 100° C. for 2 hours. The reaction mixture was allowed to cool to room temperature, filtered and the filtrate was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/ethyl acetate) to give tert-butyl 2-methyl-4-(2-oxo-1,3,4-oxathiazol-5-yl)benzoate (11.12 g) as a solid. ¹H-NMR (CDCl₃, 400 MHz): δ=7.87-7.96 (m, 1 H), 7.79-7.87 (m, 2 H), 2.63 (s, 3 H), 1.56-1.64 ppm (m, 9 H).

Example 2 Preparation of tert-butyl 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-benzoate

A solution of tert-butyl 2-methyl-4-(2-oxo-1,3,4-oxathiazol-5-yl)benzoate (50 mg) in 1,3-dichloro-5-[1-(trifluoromethyl)vinyl]benzene (5 mL, prepared according to WO 2005085216) was heated 190° C. during 10 minutes in a microwave. The residue was purified by chromatography on silica gel (eluent: cyclohexane/ethyl acetate) then on preparative HPLC to give tert-butyl 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-benzoate (18.5 mg) as a solid. ¹H-NMR (CDCl₃, 400 MHz): δ=7.86 (d, 1 H), 7.54-7.64 (m, 2 H), 7.41 (t, 1 H), 7.31 (s, 2 H), 4.23 (d, 1 H), 3.88 (d, 1 H), 2.61 (s, 3 H), 1.61 ppm (s, 9 H).

Example 3 Preparation of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-benzoic acid

To a solution of tert-butyl 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-benzoate (164 mg) in dichloromethane (1.7 mL) was added trifluoroacetic acid (0.17 mL). The reaction mixture was stirred at room temperature for 6 hours then the solution was concentrated under vacuo. The residue was extracted with water and ethyl acetate. The organic extract was washed with water, dried over sodium sulfate and concentrated to give 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-benzoic acid (140 mg) as a white foam.

¹H-NMR (CDCl₃, 400 MHz): δ=8.11 (d, 1 H), 7.59-7.71 (m, 2 H), 7.42 (t, 1 H), 7.30-7.34 (m, 2 H), 4.25 (d, 1 H), 3.90 (d, 1 H), 2.71 ppm (s, 3 H).

Example 4 Preparation of 3-Benzylsulfanyl-1-(4-bromo-3-methyl-phenyl)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butan-1-one

Benzylmercaptan (0.18 g) and a solution of sodium hydroxide (0.1 eq) were added to a solution of (E)-1-(4-Bromo-3-methyl-phenyl)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-en-1-one (0.5 g) in tetrahydrofurane (11.4 mL). The solution was stirred at room temperature for 19 hours then heated at 80° C. for 4 hours. Then, more benzylmercaptan (0.5 mL) was added and the solution was stirred at 80° C. for 16 hours. More sodium hydroxide (20 mg) was added and after 90 minutes, the reaction was quenched by the addition of a saturated solution of sodium chloride, and then extracted with diethyl ether. The collected organic phases were dried over magnesium sulfate, filtered and the filtrate was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/ethyl acetate) to give 3-Benzylsulfanyl-1-(4-bromo-3-methyl-phenyl)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butan-1-one (276 mg).

¹H NMR (CDCl₃, 400 MHz): δ=7.65 (d, J=1.8 Hz, 1 H), 7.61 (d, J=8.1 Hz, 1 H), 7.52-7.55 (m, 2 H), 7.48 (dd, J=8.3, 2.0 Hz, 1 H), 7.34 (t, J=1.8 Hz, 1 H), 7.17-7.26 (m, 5 H), 3.87-3.94 (m, 1 H), 3.85 (d, J=11.7 Hz, 1 H), 3.69-3.79 (m, 1 H), 3.63 (d, J=11.4 Hz, 1 H), 2.44 (s, 3 H). ¹⁹F NMR (CDCl₃, 376 MHz): δ=−67.33 ppm

Example 5 Preparation of tert-butyl 4-[3-benzylsulfanyl-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-butanoyl]-2-methyl-benzoate

Benzylmercaptan (1.5 eq.) and 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1R,2R)-2-(dimethylamino)cyclohexyl]thiourea (0.01 eq.) were added to a solution of tert-butyl 4-[(E)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-but-2-enoyl]-2-methyl-benzoate (200 mg) in toluene (1.5 mL) at −40° C. The solution was stirred at −40° C. for 6 hours then at room temperature for 17 hours. The reaction was quenched by the addition of a saturated solution of sodium chloride, and then extracted with ethylacetate. The collected organic phases were dried over magnesium sulfate, filtered and the filtrate was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/ethyl acetate) to give tert-butyl 4-[3-benzylsulfanyl-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-butanoyl]-2-methyl-benzoate (205 mg) as a mixture of two enantiomers.

Chiral HPLC analysis using a Waters UPLC—Hclass, DAD Detector Waters UPLC.

-   Column: Daicel CHIRALPAK® IB, 3 μm, 0.46 cm×10 cm -   Mobile phase: Heptane/iPrOH 95/05 -   Flow rate: 1.0 ml/min -   Detection: 254 nm -   Sample concentration: 1 mg/mL in Hept/iPrOH 70/30 -   Injection: 4 μL -   1^(st) eluting isomer: rt=2.43 min, 14% -   2^(nd) eluting isomer: rt=2.95 min, 85%

¹H NMR (CHLOROFORM-d, 400 MHz): δ=7.83 (d, J=8.1 Hz, 1 H), 7.59-7.69 (m, 2 H), 7.51-7.57 (m, 2 H), 7.34 (t, J=1.8 Hz, 1 H), 7.14-7.29 (m, 5 H), 3.94 (d, J=16.9 Hz, 1 H), 3.84 (d, J=11.7 Hz, 1 H), 3.73-3.81 (m, 1 H), 3.64 (d, J=11.7 Hz, 1 H), 2.59 (s, 3 H), 1.61 ppm (s, 9 H).

Similarly, 5-[(3S)-3-benzylsulfanyl-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)butanoyl]-2-(1,2,4-triazol-1-yl)benzonitrile could be prepared.

¹H NMR (CDCl₃, 400 MHz): δ=8.96 (s, 1 H), 8.23 (s, 1 H), 8.11-8.18 (m, 2 H), 7.95 (d, J=8.8 Hz, 1 H), 7.65 (s, 2 H), 7.15-7.26 (m, 5 H), 3.93 (d, J=12.5 Hz, 1 H), 3.89 (d, J=17.2 Hz, 1 H), 3.74 (d, J=16.9 Hz, 1 H), 3.69 ppm (d, J=12.5 Hz, 1 H)

19H NMR (CDCl₃, 376 MHz): δ=−67.03

Chiral HPLC analysis using a Waters UPLC (Alliance 2695)—Hclass, DAD Detector Waters UPLC (996).

-   Column: Daicel CHIRALPAK® IA, 3 μm, 0.46 cm×10 cm -   Mobile phase: TBME/EtOH 98/02 -   Flow rate: 1 ml/min -   Detection: 254 nm -   Sample concentration: 1 mg/mL in TBM -   Injection: 2 μL -   1^(st) eluting isomer: rt=2.52 min; 80.5% -   2^(nd) eluting isomer: rt=3.24 min; 19.5%

Example 6 Preparation of 1-(4-bromo-3-methyl-phenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-sulfanyl-butan-1-one

To (E)-1-(4-Bromo-3-methyl-phenyl)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-en-1-one (2 g) was added thioacetic acid (6 eq.) under argon. The solution was stirred at room temperature then 2 drops of triethylamine were added. The solution was stirred at room temperature for 4 days.

The mixture was then diluted with ethyl acetate, washed with brine, then water. The collected organic phases were dried over magnesium sulfate, filtered and the filtrate was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/dichloromethane) to give 1-(4-Bromo-3-methyl-phenyl)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butan-1-one (382 mg).

¹H NMR (CDCl₃, 400 MHz): δ=7.77 (d, J=2.2 Hz, 1 H), 7.68 (d, J=8.4 Hz, 1 H), 7.58-7.63 (m, 1 H), 7.51-7.58 (m, 2 H), 7.35 (t, J=1.8 Hz, 1 H), 4.27 (d, J=18.7 Hz, 1 H), 3.94 (d, J=18.3 Hz, 1 H), 3.29 (s, 1H), 2.48 ppm (s, 3 H). ¹⁹F NMR (CDCl₃, 376 MHz): δ=−73.56 ppm

Another fraction contained Thioacetic acid 3-(4-bromo-3-methyl-phenyl)-1-(3,5-dichloro-phenyl)-3-oxo-1-trifluoromethyl-propyl ester (782 mg). ¹H NMR (CDCl₃, 400 MHz): δ=7.78-7.84 (m, 1 H), 7.62-7.69 (m, 2 H), 7.37 (s, 3 H), 5.16 (d, J=18.0 Hz, 1 H), 3.96 (d, J=18.3 Hz, 1 H), 2.48 (s, 3 H), 2.32 ppm (s, 3 H). ¹⁹F NMR (CDCl₃, 376 MHz): δ=−71.26 ppm

Example 7 Preparation of 3-(4-Bromo-3-methyl-phenyl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazole

To a solution of 1-(4-Bromo-3-methyl-phenyl)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butan-1-one (382 mg) in a solution of potassium hydroxide (162 mg in 8 mL of water) was added a solution of Hydroxylamine-O-sulfonic acid (2 equiv.) in a solution of potassium hydroxide (243 mg in 16 mL of water). After stirring at room temperature for 30 minutes, the mixture was diluted with ethyl acetate, and washed with brine. The collected organic phases were dried over magnesium sulfate, filtered and the filtrate was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/dichloromethane) to give 3-(4-Bromo-3-methyl-phenyl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazole (184 mg).

¹H NMR (CDCl₃, 400 MHz): δ=7.64 (d, J=1.8 Hz, 1 H), 7.60 (d, J=8.4 Hz, 1 H), 7.39-7.44 (m, 2 H), 7.28-7.33 (m, 2 H), 4.19 (d, J=17.6 Hz, 1 H), 3.86 (d, J=17.6 Hz, 1 H), 2.46 ppm (s, 3 H). ¹⁹F NMR (CDCl₃, 376 MHz): δ=−74.76 ppm

Using the same sequence, 2-chloro-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]benzonitrile could be obtained, starting from 2-chloro-4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-but-2-enoyl]benzonitrile:

¹H NMR (CDCl₃, 400 MHz): δ=7.90 (t, J=0.9 Hz, 1 H), 7.74 (d, J=0.7 Hz, 2 H), 7.43 (t, J=1.8 Hz, 1 H), 7.29 (d, J=1.1 Hz, 2 H), 4.19 (d, J=17.6 Hz, 1 H), 3.86 (d, J=18.0 Hz, 1 H) ppm.

Example 8 Preparation of 4-[3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-benzoic acid tert-butyl ester

To 4-[(E)-3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-methyl-benzoic acid tert-butyl ester (25 g) was added thioacetic acid (6 eq.) and triethylamine (200 μL) The solution was stirred at room temperature 2 drops of triethylamine were added. After stirring at room temperature for 24 hours, the mixture was poured in a mixture of water and ethyl acetate, extracted with ethyl acetate and washed with brine. The collected organic phases were dried over magnesium sulfate, filtered and the filtrate was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/dichloromethane) to give 4-[3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-benzoic acid tert-butyl ester (3.78 g) ¹H NMR (CDCl₃, 400 MHz): δ=7.89 (d, J=8.8 Hz, 1 H), 7.72-7.79 (m, 2 H), 7.53-7.57 (m, 2 H), 7.35 (t, J=1.8 Hz, 1 H), 4.30 (d, J=18.3 Hz, 1 H), 3.97 (d, J=18.3 Hz, 1 H), 3.30 (s, 1 H), 2.59-2.65 (m, 3 H), 1.58-1.66 (m, 10 H), 1.56 ppm (s, 1 H).

¹⁹F NMR (CDCl₃, 376 MHz): δ=−73.58 ppm.

Another collected fractions contained 4-[3-Acetylsulfanyl-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butyryl]-2-methyl-benzoic acid tert-butyl ester (12.51 g).

¹H NMR (CDCl₃, 400 MHz): δ=7.84-7.91 (m, 1 H), 7.77-7.84 (m, 2 H), 7.38 (s, 3 H), 5.20 (d, J=18.3 Hz, 1 H), 4.00 (d, J=18.3 Hz, 1 H), 2.63 (s, 3 H), 2.28-2.36 (m, 3 H), 1.62 ppm (s, 9 H). ¹⁹F NMR (CDCl₃, 376 MHz): δ=−71.25 ppm

Example 9 Preparation of 4-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazol-3-yl]-2-methyl-benzoic acid tert-butyl ester

To a solution of 4-[3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-benzoic acid tert-butyl ester (1.875 g) in tetrahydrofuran (6 mL) was added a solution of Hydroxylamine-O-sulfonic acid (2 equiv.) in a solution of potassium hydroxide (1.2 g in 75 mL of water). After stirring at room temperature for 30 minutes, the mixture was quenched with a solution of hydrochloric acid (1N), extracted with ethyl acetate and washed with brine. The collected organic phases were dried over magnesium sulfate, filtered and the filtrate was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/dichloromethane) to give 4-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazol-3-yl]-2-methyl-benzoic acid tert-butyl ester (881 mg)

¹H NMR (CDCl₃, 400 MHz): δ=7.86 (d, J=8.4 Hz, 1 H), 7.56-7.63 (m, 2 H), 7.41 (t, J=1.8 Hz, 1 H), 7.29-7.33 (m, 2 H), 4.22 (d, J=17.6 Hz, 1 H), 3.88 (d, J=18.0 Hz, 1 H), 2.62 (s, 3 H), 1.62 ppm (s, 10 H).

¹⁹F NMR (CDCl₃, 376 MHz): δ=−74.73 ppm

Example 10 Preparation of 4-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazol-3-yl]-2-methyl-benzoic acid butyl ester

To a solution of 3-(4-Bromo-3-methyl-phenyl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazole (166 mg) in n-butanol (3 mL) was added palladium acetate (0.1 equiv.), butyl-1-adamantylphosphincataxium (0.3 equiv.) then tetramethylethylenediamine (TMEDA) (1 equiv.). The reactor was sealed and a carbon monoxide pressure (5 bars) was applied to the mixture. The reaction was stirred at 110° C. for 18 hours. The mixture was then filtered and the filtrate was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/ethyl acetate) to give 4-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazol-3-yl]-2-methyl-benzoic acid butyl ester (62 mg).

¹H NMR (CDCl₃, 400 MHz): δ=7.96 (d, J=8.1 Hz, 1 H), 7.59-7.64 (m, 2 H), 7.42 (t, J=1.8 Hz, 1 H), 7.31 (d, J=0.7 Hz, 2 H), 4.33 (t, J=6.6 Hz, 2 H), 4.23 (d, J=17.6 Hz, 1 H), 3.89 (d, J=17.6 Hz, 1 H), 2.65 (s, 3 H), 1.71-1.81 (m, 2 H), 1.35-1.63 (m, 2 H), 1.00 ppm (t, J=7.5 Hz, 3 H). ¹⁹F NMR (CDCl₃, 376 MHz): δ=−74.73 ppm

Example 11 Preparation of 4-[3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-N-thietan-3-yl-benzamide

To 4-[(E)-3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-methyl-N-thietan-3-yl-benzamide (500 mg) was added thioacetic acid (6 eq.) and triethylamine (4 μL). The solution was stirred under argon at room temperature for 41 hours. To this mixture was added a minimum of dichloromethane and then isolute. The suspension was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/ethyl acetate) to give:

4-[3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-N-thietan-3-yl-benzamide (493 mg).

¹H NMR (CDCl₃, 400 MHz): δ=7.69-7.81 (m, 2 H), 7.56 (s, 2 H), 7.44-7.51 (m, 1 H), 7.34-7.42 (m, 1H), 6.20 (d, J=8.1 Hz, 1 H), 5.44 (q, J=8.1 Hz, 1 H), 4.29 (d, J=18.3 Hz, 1 H), 3.96 (d, J=18.7 Hz, 1 H), 3.45-3.55 (m, 2 H), 3.35-3.45 (m, 2 H), 3.29 (s, 1 H), 2.51 ppm (s, 3 H) ¹⁹F NMR (CDCl₃, 376 MHz): δ=−73.55 ppm

Example 12 Preparation of 2-Methyl-4-[4,4,4-trifluoro-3-mercapto-3-(3,4,5-trichloro-phenyl)-butyryl]-benzoic acid tert-butyl ester

To 2-Methyl-4-[(E)-4,4,4-trifluoro-3-(3,4,5-trichloro-phenyl)-but-2-enoyl]-benzoic acid tert-butyl ester (1.29 g) was added thioacetic acid (6 eq.) and triethylamine (12 μL). The solution was stirred under argon at room temperature for 24 hours. More thioacetic acid (1 mL) and triethylamine (1 drop) were added and the solution was stirred under argon at room temperature for 72 hours. To this mixture was added a minimum of dichloromethane and then isolute. The suspension was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/dichloromethane) to give 2-Methyl-4-[4,4,4-trifluoro-3-mercapto-3-(3,4,5-trichloro-phenyl)-butyryl]-benzoic acid tert-butyl ester (573 mg).

¹H NMR (CDCl₃, 400 MHz): δ=7.89 (d, J=8.8 Hz, 1 H), 7.73-7.78 (m, 2 H), 7.69 (s, 2 H), 4.29 (d, J=18.3 Hz, 1 H), 3.99 (d, J=18.7 Hz, 1 H), 3.30 (s, 1 H), 2.63 (s, 3 H), 1.60-1.63 ppm (m, 9 H). ¹⁹F NMR (CDCl₃, 376 MHz): δ=−73.63 ppm

Example 13 Preparation of 5-[3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-[1,2,4]triazol-1-yl-benzonitrile

To 5-[(E)-3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-[1,2,4]triazol-1-yl-benzonitrile (100 mg) was added thioacetic acid (6 eq.) and triethylamine (4 μL). To dissolve the suspension more thioacetic acid (400 μL) was added. The solution was stirred under argon at room temperature for 20 hours. To this mixture was added a minimum of dichloromethane and then isolute. The suspension was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/dichloromethane) to give 5-[3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-[1,2,4]triazol-1-yl-benzonitrile (108 mg).

¹H NMR (CDCl₃, 400 MHz): δ=8.99 (s, 1 H), 8.39 (d, J=1.8 Hz, 1 H), 8.30 (dd, J=8.8, 2.2 Hz, 1 H), 8.23-8.26 (m, 1 H), 8.05 (d, J=8.8 Hz, 1 H), 7.54-7.60 (m, 2 H), 7.37-7.41 (m, 1 H), 4.30 (d, J=18.3 Hz, 1H), 4.01 (d, J=18.3 Hz, 1 H), 3.22 ppm (s, 1 H). ¹⁹F NMR (CDCl₃, 376 MHz): δ=−73.52 ppm

Example 14 Preparation of 4-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazol-3-yl]-2-methyl-N-thietan-3-yl-benzamide

To a solution of 4-[3-(3,5-Dichloro-phenyl)-4,4,4-trifluoro-3-mercapto-butyryl]-2-methyl-N-thietan-3-yl-benzamide (493 mg) dissolved in a minimum amount of tetrahydrofuran then was added Hydroxylamine-O-sulfonic acid (2 equiv.). Then a solution of potassium hydroxide (5.6 equiv.) in water (19 mL) was added dropwise. After stirring at room temperature for 30 minutes, the mixture was quenched with a solution of hydrochloric acid (1N), extracted with ethyl acetate and washed with brine. The collected organic phases were dried over magnesium sulfate, filtered and the filtrate was evaporated under vacuo. The crude mixture was then redissolved in a minimum amount of tetrahydrofuran then was added Hydroxylamine-O-sulfonic acid (2 equiv.) Then a solution of potassium hydroxide (5.6 equiv.) in water (19 mL) was added dropwise. After stirring at room temperature for 30 minutes, the mixture was quenched with a solution of hydrochloric acid (1N), extracted with ethyl acetate and washed with brine. The collected organic phases were dried over magnesium sulfate, filtered and the filtrate was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/dichloromethane) to give 4-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazol-3-yl]-2-methyl-N-thietan-3-yl-benzamide (128 mg)

¹H NMR (CDCl₃, 400 MHz): δ=7.56-7.62 (m, 2 H), 7.37-7.43 (m, 2 H), 7.31 (s, 2 H), 6.30 (d, J=8.1 Hz, 1 H), 4.21 (d, J=17.6 Hz, 1 H), 3.87 (d, J=17.6 Hz, 1 H), 3.45-3.54 (m, 2 H), 3.36-3.44 (m, 2 H), 2.44-2.52 ppm (m, 3 H). ¹⁹F NMR (CDCl₃, 376 MHz): δ=−74.82 ppm

Similarly, 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isothiazol-3-yl]-2-(1,2,4-triazol-1-yl)benzonitrile (B1) can be obtained.

¹H NMR (CDCl₃, 400 MHz): δ=8.89 (s, 1 H), 8.18-8.24 (m, 2 H), 8.16 (dd, J=8.6, 2.0 Hz, 1 H), 7.92 (d, J=8.8 Hz, 1 H), 7.44 (t, J=1.8 Hz, 1 H), 7.31 (d, J=0.7 Hz, 2 H), 4.24 (d, J=17.6 Hz, 1 H), 3.92 ppm (d, J=17.6 Hz, 1 H). ¹⁹F NMR (CDCl₃, 376 MHz): δ=−74.88 ppm

Similarly, tert-butyl 2-methyl-4-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isothiazol-3-yl]benzoate can be obtained.

¹H NMR (CDCl₃, 400 MHz): δ=7.86 (d, J=8.4 Hz, 1 H), 7.54-7.63 (m, 2 H), 7.46 (s, 2 H), 4.22 (d, J=17.6 Hz, 1 H), 3.87 (d, J=17.6 Hz, 1 H), 2.61 (s, 3 H), 1.61 ppm (s, 9 H)

Example 15 Preparation of 2-Methyl-4-[4,4,4-trifluoro-3-mercapto-3-(3,4,5-trichloro-phenyl)-butyryl]-benzoic acid tert-butyl ester

A solution of 4-[3-Acetylsulfanyl-4,4,4-trifluoro-3-(3,4,5-trichloro-phenyl)-butyryl]-2-methyl-benzoic acid tert-butyl ester (1.33 g) in aniline (13 mL) was stirred at room temperature for 3 hours. The mixture was quenched with a solution of hydrochloric acid (1N), extracted with ethyl acetate and washed with brine. The collected organic phases were dried over magnesium sulfate, filtered and the filtrate was evaporated under vacuo. The residue was purified by chromatography on silica gel (eluent: cyclohexane/dichloromethane) to give 2-Methyl-4-[4,4,4-trifluoro-3-mercapto-3-(3,4,5-trichloro-phenyl)-butyryl]-benzoic acid tert-butyl ester (950 mg).

¹H NMR (CDCl₃, 400 MHz): δ=7.89 (d, J=8.8 Hz, 1 H), 7.72-7.78 (m, 2 H), 7.69 (s, 2 H), 4.28 (d, J=18.7 Hz, 1 H), 3.98 (d, J=18.7 Hz, 1 H), 3.30 (s, 1 H), 2.63 (s, 3 H), 1.59-1.65 ppm (m, 9 H).

Example 16 Preparation of 2-chloro-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]benzamide

To a solution of 2-chloro-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]benzonitrile (50 mg) in toluene (1 mL) were added acetaldehyde oxime (3 eq.) then indium trichloride (0.05 eq.). The mixture was stirred at 120° C. for 2 hours then it was allowed to cool to room temperature. The solution was diluted with ethyl acetate, then treated with ammonium hydroxide (2N). The mixture was washed two times with brine then the organic phase were collected and they were dried over magnesium sulfate, filtered and evaporated under vacuo to give 2-chloro-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]benzamide (50 mg).

¹H NMR (CDCl₃, 400 MHz): δ=7.90 (d, J=8.1 Hz, 1 H), 7.84 (d, J=1.8 Hz, 1 H), 7.66-7.74 (m, 1 H), 7.37-7.46 (m, 1 H), 7.28-7.34 (m, 2 H), 6.40 (br. s., 1 H), 5.96 (br. s., 1 H), 4.19 (d, J=18.0 Hz, 1 H), 3.87 ppm (d, J=18.0 Hz, 1 H)

Example 17 Preparation of 2-chloro-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-N-[(E)-methoxyiminomethyl]benzamide (C3)

A solution of 2-chloro-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]benzamide (50 mg) and N,N-Dimethylformamide dimethylacetal (1 mL) was refluxed under Argon for 30 min then the solution was concentrated in vacuo. The residue was dissolved in 1,4-dioxane (0.48 mL) and a solution of O-methylhydroxylamine hydrochloride (2.8 eq.) and sodium hydroxide (6 eq.) in water (0.43 mL) and acetic acid (0.43 mL) was added. The solution was stirred at rt for one hour. It was then quenched by addition of water and extracted with methyl tert-butyl ether. The combined organic extracts were washed with brine, dried over sodium sulfate and evaporated. Flash Chromatography eluting with Cyclohexane:EtOAc afforded 30 mg of the title compound.

¹H-NMR (CDCl₃, 400 MHz): δ=9.21 (d, J=9.5 Hz, 1 H), 7.93 (d, J=8.4 Hz, 1 H), 7.85-7.89 (m, 1 H), 7.81 (d, J=9.5 Hz, 1 H), 7.74 (dd, J=8.1, 1.5 Hz, 1 H), 7.43 (t, J=1.8 Hz, 1 H), 7.29-7.33 (m, 2 H), 4.20 (d, J=17.6 Hz, 1 H), 3.93 (s, 3 H), 3.88 ppm (d, J=17.6 Hz, 1 H)

Example 18 Preparation of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-N-[(E)-ethoxyiminomethyl]-2-methyl-benzamide (C2)

A solution of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-benzamide (200 mg) and N,N-Dimethylformamide dimethylacetal (4 mL) was refluxed under Argon for one hour then the solution was concentrated in vacuo. The residue was dissolved in 1,4-dioxane (2 mL) and a solution of O-ethylhydroxylamine hydrochloride (2.8 eq.) and sodium hydroxide (6 eq.) in water (1.6 mL) and acetic acid (1.6 mL) was added. The solution was stirred at rt for 10 minutes. It was then quenched by addition of water and extracted with methyl tert-butyl ether. The combined organic extracts were washed with brine, dried over magnesium sulfate and evaporated. Flash Chromatography eluting with Cyclohexane:EtOAc afforded 237 mg of the title compound.

¹H-NMR (CDCl₃, 400 MHz): δ=8.52 (d, J=9.5 Hz, 1 H), 7.79 (d, J=9.2 Hz, 1 H), 7.67 (d, J=5.5 Hz, 2H), 7.56 (d, J=8.4 Hz, 1 H), 7.42 (t, J=1.7 Hz, 1 H), 7.31 (s, 2 H), 4.23 (d, J=17.6 Hz, 1 H), 4.16 (q, J=7.2 Hz, 2 H), 3.89 (d, J=18.0 Hz, 1 H), 2.56 (s, 3 H), 1.29 ppm (t, J=7.2 Hz, 3 H)

Example 19 Preparation of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-N-[(E)-methoxyiminomethyl]-2-methyl-benzamide (C1)

A solution of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-benzamide (200 mg) and N,N-Dimethylformamide dimethylacetal (4 mL) was refluxed under argon for one hour then the solution was concentrated in vacuo. The residue was dissolved in 1,4-dioxane (2 mL) and a solution of O-methylhydroxylamine hydrochloride (2.8 eq.) and sodium hydroxide (6 eq.) in water (1.6 mL) and acetic acid (1.6 mL) was added. The solution was stirred at rt for 10 minutes. It was then quenched by addition of water and extracted with methyl tert-butyl ether. The combined organic extracts were washed with brine, dried over magnesium sulfate and evaporated. Flash Chromatography eluting with Cyclohexane:EtOAc afforded 243 mg of the title compound.

¹H-NMR (CDCl₃, 400 MHz) δ=8.50 (d, J=9.9 Hz, 1 H), 7.79 (d, J=9.5 Hz, 1 H), 7.63-7.71 (m, 2 H), 7.55 (d, J=8.4 Hz, 1 H), 7.42 (s, 1 H), 7.31 (s, 2 H), 4.22 (d, J=17.6 Hz, 1 H), 3.91 (s, 3 H), 3.83 (d, 1 H), 2.56 ppm (s, 3 H).

Example 20 Preparation of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-benzamide

A solution of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-benzoic acid (1.65 g) was suspended in dichloromethane (16 mL). A catalytic amount of N,N-dimethylformamide (“DMF”) and oxalyl chloride (1.2 eq.) were added to the suspension. The reaction mixture was stirred at ambient temperature for 1.5 hour. The reaction mixture was concentrated and the residue dissolved in dry tetrahydrofuran (16 mL). To the solution was added a solution of ammonium hydroxide (8 mL, 25%). The reaction mixture was stirred at ambient temperature for two hours. It was then quenched by addition of water and extracted with ethyl acetate. The organic extract was washed with a saturated solution of sodium hydrogenocarbonate, dried over magnesium sulfate and concentrated in vacuo. The crude residue was triturated with tert-butylmethylether then the precipitate was filtered and dried under vacuo to give the title compound (841 mg) as a solid. ¹H-NMR (CDCl₃, 400 MHz): δ=7.50-7.61 (m, 2 H), 7.39-7.50 (m, 1 H), 7.29-7.39 (m, 1 H), 7.14-7.27 (m, 2 H), 6.40 (br. s., 1 H), 6.05 (br. s., 1 H), 4.16 (m, J=17.4, 1 H), 3.74-3.91 (m, 1 H), 2.44-2.49 (m, 3 H).

Example 21 Compound A1: 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-N-(1,1-dioxothietan-3-yl)-2-methyl-benzamide

To a stirred solution of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-benzoic acid (100 mg) in dichloromethane (3.8 mL) was added triethylamine (0.065 mL) at ambient temperature. The solution was stirred under argon and the hydrochloride salt of thietan-3-ylamine (44 mg) was added. To this solution, 1-hydroxyazabenzotriazole (35 mg) then 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (50 mg) were added. The solution was stirred for 24 hours at ambient temperature. The residue was extracted with ethyl acetate and a saturated solution of ammonium chloride. The organic extract was washed with water, dried over sodium sulfate and concentrated under vacuo. The crude residue was purified by chromatography on silica gel (eluent: heptane/ethyl acetate) to give 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-N-(1,1-dioxothietan-3-yl)-2-methyl-benzamide (34 mg) as a white solid.

¹H-NMR (CDCl₃, 400 MHz): δ=7.60-7.69 (m, 2 H), 7.40-7.50 (m, 2 H), 7.30-7.33 (m, 2 H), 6.48 (d, 1H), 4.83-4.99 (m, 1 H), 4.56-4.71 (m, 2 H), 4.22 (d, 1 H), 3.99-4.07 (m, 2 H), 3.88 (d, 1 H), 2.51 ppm (s, 3 H).

Similarly, using the trifluoroacetate salt of 2-amino-N-(2,2,2-trifluoroethyl)acetamide as an amine, 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide (compound A2) could be prepared. ¹H-NMR (CDCl₃, 400 MHz): δ=7.63-7.69 (m, 1 H), 7.60 (d, 1 H), 7.48 (d, 1 H), 7.42 (t, 1 H), 7.29-7.34 (m, 2 H), 6.68 (br. s., 1H), 6.58 (s, 1 H), 4.16-4.26 (m, 3 H), 3.92-4.03 (m, 2 H), 3.88 (d, 1 H), 2.51 ppm (s, 3 H).

Similarly, 2-methyl-N-(1-oxothietan-3-yl)-4-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]benzamide (compound D3) could be prepared. ¹H-NMR (DMSO-d₆, 400 MHz): δ=8.93 (d, J=7.3 Hz, 1 H), 7.81 (s, 2 H), 7.69-7.79 (m, 2 H), 7.48 (d, J=7.7 Hz, 1 H), 4.51-4.64 (m, 1 H), 4.30-4.47 (m, 2 H), 4.03-4.15 (m, 2 H), 3.15-3.29 (m, 2 H), 2.39 ppm (s, 3 H)

Similarly, 2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-4-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]benzamide (compound D1) could be prepared. ¹H-NMR (CDCl₃, 400 MHz): δ=7.8-7.7 (m, 2 H), 7.52-7.46 (m, 3 H), 6.72 (m, 1 H), 6.61 (m, 1 H), 4.3-4.17 (m, 3 H), 4.05-3.82 (m, 3 H), 2.51 ppm (s, 3 H)

Similarly, N-(1,1-dioxothietan-3-yl)-2-methyl-4-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]benzamide (compound D2) could be prepared. ¹H-NMR (CDCl₃, 400 MHz): δ=7.7-7.6 (m, 2 H), 7.45-7.51 (m, 3 H), 6.51 (m, 1 H), 5.0-4.75 (m, 1 H), 4.7-4.6 (m, 2 H), 4.30-4.19 (m, 1 H), 4.1-4.0 (m, 2 H), 3.95-3.80 (m, 1 H), 2.52 ppm (s, 3 H)

Similarly, 4-[(5S)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-N-[(4R)-2-ethyl-3-oxo-isoxazolidin-4-yl]-2-methyl-benzamide (compound A78) could be prepared. ¹H-NMR (CDCl₃, 400 MHz): δ=7.64 (s, 1 H), 7.60 (d, J=8.1 Hz, 1 H), 7.51 (d, J=8.1 Hz, 1 H), 7.42 (t, J=1.7 Hz, 1 H), 7.29-7.34 (m, 2 H), 6.40 (d, J=3.7 Hz, 1 H), 4.94-5.06 (m, 1 H), 4.87 (dd, J=10.8, 3.9 Hz, 1 H), 4.22 (d, J=17.6 Hz, 1 H), 4.06 (dd, J=10.8, 8.6 Hz, 1 H), 3.88 (d, J=17.6 Hz, 1 H), 3.57-3.78 (m, 2 H), 2.52 (s, 3H), 1.20-1.32 ppm (m, 3 H).

Chiral HPLC analysis using a Waters UPLC—Hclass, DAD Detector Waters UPLC

-   Column: Daicel CHIRALPAK® IB, 3 μm, 0.46 cm×10 cm -   Mobile phase: Heptane/iPrOH 80/20 -   Flow rate: 1.0 ml/min -   Detection: 313 -   Sample concentration: 1 mg/mL in Hept/iPrOH 50/50 -   Injection: 2 μL -   1^(st) eluting isomer: rt=4.23 min; 1.1% -   2^(nd) eluting isomer: rt=5.66 min; 98.9%

Similarly, 4-[(5S)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-N-[(4R)-3-oxo-2-(2,2,2-trifluoroethyl)isoxazolidin-4-yl]benzamide (compound A79) could be prepared. ¹H-NMR (CDCl₃, 400 MHz): δ=7.57-7.70 (m, 2 H), 7.51 (d, J=8.1 Hz, 1 H), 7.42 (t, J=1.8 Hz, 1 H), 7.29-7.34 (m, 2 H), 6.36 (d, J=4.0 Hz, 1 H), 5.00-5.09 (m, 1 H), 4.97 (dd, J=10.5, 4.6 Hz, 1 H), 4.06-4.33 (m, 4H), 3.88 (d, J=17.6 Hz, 1 H), 2.52 ppm (s, 3 H).

Chiral HPLC analysis using a Waters UPLC—Hclass, DAD Detector Waters UPLC

-   Column: Column: Daicel CHIRALPAK® IB, 3 μm, 0.46 cm×10 cm -   Mobile phase: Heptane/iPrOH 80/20 -   Flow rate: 1.0 ml/min -   Detection: 313 -   Sample concentration: 1 mg/mL in Hept/iPrOH 70/30 -   Injection: 4 μL -   1^(st) eluting isomer: rt=4.19 min; 0.9% -   2^(nd) eluting isomer: rt=4.94 min; 99.1%

Example 22 Preparation of 4-bromo-2-methyl-benzoic acid tert-butyl ester

4-Bromo-2-methyl-benzoic acid (commercially available) (50 g) was suspended in dichloromethane (500 mL). A catalytic amount of N,N-dimethylformamide (“DMF”) and oxalyl chloride (23 mL) were added to the suspension. The reaction mixture was stirred at ambient temperature for 3 hours. The reaction mixture was concentrated and the residue dissolved in dry tetrahydrofuran (800 mL). The solution was cooled to 2° C. and added to a solution of potassium tert-butoxide (39.2 g) in dry tetrahydrofuran (300 mL) dropwise at 5-10° C. The reaction mixture was stirred at ambient temperature for 30 minutes and then poured onto a mixture of ice and water. The mixture was extracted with ethyl acetate. The organic extract was washed with water, dried over sodium sulfate and concentrated to give 4-bromo-2-methyl-benzoic acid tert-butyl ester (65.3 g) as yellow oil.

¹H-NMR (CDCl₃, 400 MHz): δ=7.70 (d, 1 H), 7.40 (s, 1 H), 7.35 (d, 1 H), 2.58 (s, 3 H), 1.60 (s, 9 H).

Example 23 Preparation of tert-butyl 4-formyl-2-methyl-benzoate

To a solution of 4-bromo-2-methyl-benzoic acid tert-butyl ester (500 g, 1.8 mol) in tetrahydrofuran (5 L) was added n-butyl lithium (1.6 M solution, 1.4 L, 2.2 mol) at such a rate that the reaction temperature is between −95° C. to −100° C. After completion of the addition, the reaction mixture was stirred for 30 min at −100° C. and monitored by quenching the reaction mixture with water and following the product by TLC. After complete conversion, DMF (170 ml, 2.2 mol) was added to the reaction mixture and after 15 min the reaction mixture was quenched with ammonium chloride (sat. solution, 5 L). The organic layers were separated at room temperature and the aqueous layer was extracted with ethyl acetate (3×2 L). The combined organic layer was washed with water (3×5 L), dried over sodium sulphate and concentrated to yield tert-butyl 4-formyl-2-methyl-benzoate (390 g, 96% isolated yield, 75-78% HPLC purity). The crude product was used as such without any further purification for the next step. ¹H-NMR (CDCl₃, 400 MHz): δ in ppm=1.59 (s, 9 H), 2.61 (s, 3 H), 7.71 (d, 2 H), 7.92 (d, 1 H), 10.01 (s, 1 H).

Example 24 Preparation of 4-tert-butoxycarbonyl-3-methyl-benzoic acid

To a solution of tert-butyl 4-formyl-2-methyl-benzoate (390 g, ˜78% purity, 1.8 mol) in DMF (2.0 L) was added oxone (270 g, 1.8 mol) over a period of 15 min at 10° C. After complete addition, the reaction mixture was warmed to room temperature and stirred for 12 h. After complete conversion of starting material, the reaction mixture was diluted with water at 10° C. The aqueous layer was extracted with ethyl acetate (2×5 L), washed with water (3×1 L) dried over sodium sulphate and concentrated to yield a crude residue (217 g). Pure 4-tert-butoxycarbonyl-3-methyl-benzoic acid (115 g) was obtained by column chromatography with ethyl acetate (6%) in hexane.

¹H-NMR (DMSO d₆, 400 MHz): δ in ppm=1.55 (s, 9 H), 2.51 (s, 3 H), 7.83 (m, 3 H), 13.11 (br, OH).

Example 25 Preparation of tert-butyl 4-carbamoyl-2-methyl-benzoate

A solution of 4-tert-butoxycarbonyl-3-methyl-benzoic acid (40 g) was suspended in tetrahydrofuran (160 mL). This solution was cooled to −30 C then N-methyl morpholine (18.7 mL) followed by isobutylchloroformate (24.2 mL) were added. A white precipitate appeared. The solution was stirred for 8 hours then a solution of ammonium hydroxide (100 mL) was added. The reaction mixture was slowly allowed to warm to room temperature over 48 hours. Then water was added and the mixture was extracted with ethyl acetate. The organic extract was washed with water, dried over sodium sulfate and concentrated to give a solid which was further triturated with a mixture of dichloromethane/ethyl acetate, filtered, to give tert-butyl 4-carbamoyl-2-methyl-benzoate (29.9 g) as a white solid. ¹H-NMR (CDCl₃, 400 MHz): 7.90 (d, 1 H), 7.72 (s, 1 H), 7.65 (d, 1 H), 2.63 (s, 3 H), 1.62 (s, 9 H).

Example 26 Preparation of 2-(1,2,4-triazol-1-yl)-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]benzonitrile (B2)

Sulfuryl chloride (5.97 mL) was slowly added to a solution of 5-[(3S)-3-benzylsulfanyl-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)butanoyl]-2-(1,2,4-triazol-1-yl)benzonitrile (40.54 g) in dichloromethane (264 mL) at 0° C. The mixture was stirred at room temperature for two hours.

The solvent was then evaporated, then tetrahydrofuran (264 mL) was added and slowly ammonia in ethanol (48.6 mL, 7N in ethanol) was added at 0° C. The reaction was stirred for another hour then a hydrochloric acid (2N) solution was added. The mixture was extracted with ethyl acetate. The organic phases were dried over magnesium sulfate and concentrated under vacuo. The crude residue was purified by chromatography on silica gel (eluent: cyclohexane/ethyl acetate) to give the desired compound as a mixture which was further purified using a preparative reverse phase HPLC to give with 2-(1,2,4-triazol-1-yl)-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]benzonitrile (4.056 g) as a white solid.

¹H NMR (CDCl₃, 400 MHz): δ=8.90 (s, 1 H), 8.17-8.27 (m, 2 H), 8.10-8.17 (m, 1 H), 7.92 (d, J=8.8 Hz, 1 H), 7.46 (s, 2 H), 4.24 (d, J=17.6 Hz, 1 H), 3.90 ppm (d, J=17.6 Hz, 1 H). ¹⁹H NMR (CDCl₃, 376 MHz): δ=−74.61

Chiral HPLC analysis using a Waters UPLC (Alliance 2695)—Hclass, DAD Detector Waters UPLC (996).

-   Column: Daicel CHIRALPAK® IA, 3□m, 0.46 cm×10 cm -   Mobile phase: Hept/EtOH/DEA 80/20/0.1% -   Flow rate: 1 ml/min -   Detection: 325 nm -   Sample concentration: 1 mg/mL in Heptan/iPrOH 50/50 -   Injection: 2 μL -   1^(st) eluting isomer: rt=6.17 min; 83.2% -   2^(nd) eluting isomer: rt=9.09 min; 16.8%

Similarly, tert-butyl 4-[(5S)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-benzoate could be obtained from tert-butyl 4-[(3S)-3-benzylsulfanyl-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-butanoyl]-2-methyl-benzoate

Chiral HPLC analysis using a Waters UPLC—Hclass, DAD Detector Waters UPLC

-   Column: Daicel CHIRALPAK® IA, 3 μm, 0.46 cm×10 cm -   Mobile phase: Heptane/iPrOH 95/05 -   Flow rate: 1.0 ml/min -   Detection: 318 nm -   Sample concentration: 1 mg/mL in Hept/iPrOH 50/50 -   Injection: 2 μL -   1^(st) eluting isomer: rt=1.80 min; 98.6% -   2^(nd) eluting isomer: rt=2.33 min; 1.4%

Example 27 Method for Preparing Compounds of the Invention from a Carboxylic Acid

To a solution of the 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]-2-methyl-benzoic acid (22 μmol) in dimethylacetamide (0.4 ml) was added successively a solution of an amine of formula HNR⁶R⁷ (26 μmol), for example thietan-3-ylamine (preparation described in, for example, WO 2007/080131) in the case of Compound No. A22 of Table A, in dimethylacetamide (0.11 ml), diisopropylethylamine (Hunig's Base) (0.030 ml), and a solution of bis(2-oxo-3-oxazolidinyl)phosphonic chloride (“BOP-Cl”) (11.2 mg) in dimethylacetamide (0.02 ml). The reaction mixture was stirred at 80° C. for 16 hours. Then the reaction mixture was diluted with acetonitrile (0.6 ml) and a sample was used for LC-MS analysis. The remaining mixture was further diluted with acetonitrile/dimethylformamide (4:1) (0.8 ml) and purified by HPLC. This method was used to prepare a number of compounds (Compound Nos. A1 to A77 of Table A) in parallel.

TABLE A (I-a)

Comp No. R¹ R² RT (min) [M + H]⁺ A01 H (2,2,2-Trifluoro-ethylcarbamoyl)- 1.97 572.23 methyl A02 H 1,1-Dioxo-thietan-3-yl 1.91 537.14 A03 H 2,2,2-Trifluoro-ethyl 2.1 515.23 A04 H ethyl 2.02 461.23 A05 H butyl 2.18 489.27 A06 H 1-methoxypropan-2-yl 2.06 505.25 A07 H 3,3,3-trifluoroprop-1-yl 2.12 529.22 A08 H butan-2-yl 2.17 489.26 A09 H tetrahydrofuran-2-ylmethyl 2.04 517.24 A10 H benzyl 2.18 523.23 A11 H (2-fluorophenyl)-methyl 2.19 541.22 A12 H 1-phenylethyl 2.23 537.25 A13 H (4-methoxyphenyl)-methyl 2.16 553.25 A14 H (6-chloro-3-pyridyl)methyl 2.1 558.22 A15 H 3-fluorophenyl 2.27 527.24 A16 H 2-pyridylmethyl 1.9 524.24 A17 H 2,5-dimethylpyrazol-3-yl 2.01 527.25 A18 H 4-methylthiazol-2-yl 2.21 530.2 A19 H 3-Methyl-thietan-3-yl 2.19 519.22 A20 H 2-methyl-1-methylsulfanyl-propan-2-yl 2.28 535.27 A21 H 1-Oxo-thietan-3-yl 1.82 521.19 A22 H Thietan-3-yl 2.1 505.22 A23 H (1R,2R,4S)-N-methylnorbornan-2-yl 2.3 527.27 A24 H Cyclobotuyl 2.13 487.27 A25 H N-methyl-2-methylsulfinyl-ethyl 1.77 523.19 A26 H 2-methylsulfanylethyl 2.09 507.26 A27 H tetrahydrothiophen-3-yl 2.12 519.22 A28 H thietan-3-ylmethyl 2.14 519.33 A29 H 3-(2,2,2-trifluoroethoxyimino) 2.2 598.32 cyclobutyl A30 H thietan-2-ylmethyl 2.16 519.3 A31 H (1,1-dioxothietan-2-yl)methyl 1.93 551.31 A32 H 2-(thietan-3-yl)ethyl 2.18 533.35 A33 H 2-(1,1-dioxothietan-3-yl)ethyl 1.93 565.34 A34 H 2-fluoroethyl 2.01 479.29 A35 H prop-2-ynyl 2.03 471.32 A36 H propanyl 2.13 475.35 A37 H 2-oxotetrahydrothiophen-3-yl 2.07 533.27 A38 H pyrimidin-2-yl 1.95 511.12 A39 H propan-2-yl 2.13 475.34 A40 H cyclobutylmethyl 2.25 501.36 A41 H 1-oxidopyridin-1-ium-4-yl 1.82 526.32 A42 H 2,2-difluoroethyl 2.07 497.32 A43 H cyano 2.01 458.4 A44 H 4,5-dihydrothiazol-2-yl 2.02 518.31 A45 H 1-cyanocyclopropyl 2.03 498.32 A46 H 2-methylpropan-1-yl 2.21 489.35 A47 H 4,6-dimethylpyrimidin-2-yl 2.09 538.85 A48 H pyrimidin-5-yl 2 511.31 A49 H 6-(diethylcarbamoyl)-2-pyridyl 2.24 609.38 A50 H indan-1-yl 2.31 549.31 A51 H 2-methoxyethyl 2.01 491.33 A52 H cyclopropyl 2.05 473.34 A53 H cyclopropylmethyl 2.15 487.33 A54 H 2-(1,3-dioxolan-2-yl)ethyl 2.03 533.34 A55 H 2,4-difluorophenyl 2.28 545.35 A56 H pyridin-2-yl 2.19 510.31 A57 H [4-(trifluoromethyl)phenyl]methyl 2.31 591.29 A58 H 4-(trifluoromethyl)phenyl 2.39 577.33 A59 H 4-fluorophenyl 2.26 527.32 A60 H 2-fluorophenyl 2.28 527.32 A61 H p-tolylmethyl 2.28 537.38 A62 H methyl 1.96 447.32 A63 H allyl 2.09 473.33 A64 H 4-methylphenyl 2.32 523.35 A65 H quinolin-8-yl 2.54 560.35 A66 H 4H-1,2,4-triazol-3-yl 2.23 501.35 A67 H cyclopentyl 2.1 505.34 A68 H 2-ethoxyethyl 2.18 499.33 A69 H cyclopent-3-en-1-yl 1.73 550.34 A70 H 1-(3-pyridyl)cyclopropyl 2.08 517.36 A71 H pentan-3-yl 2.03 491.31 A72 H cis-2-fluorocyclopropyl 2.23 532.36 A73 H (1E)-1-methoxyimino-2-methyl-propan- 2.06 546.37 2-yl A74 H 1-methoxypiperidin-4-yl 2.02 560.39 A75 H (1-methoxy-4-piperidyl)methyl 2.17 507.3 A76 H 2-chloroprop-2-en-1-yl 2.05 500.3 A77 H 3,3-dichloroprop-2-en-1-yl 2.26 541.29

Corresponding LC/MS Method

MS ACQUITY SQD Mass Spectrometer from Waters (Single quadrupole mass) spectrometer Ionisation method: Electrospray Polarity: positive ions Capillary (kV) 3.00, Cone (V) 20.00, Extractor (V) 3.00, Source Temperature (° C.) 150, Desolvation Temperature (° C.) 400, Cone Gas Flow (L/Hr) 60, Desolvation Gas Flow (L/Hr) 700 Mass range: 100 to 800 Da DAD Wavelength range (nm): 210 to 400 LC Method Waters the ACQUITY UPLC with following HPLC gradient conditions (Solvent A: Water/Methanol 9:1, 0.1% formic acid and Solvent B: Acetonitrile, 0.1% formic acid) Time Flow rate (minutes) A (%) B (%) (ml/min) 0 100 0 0.75 2.5 0 100 0.75 2.8 0 100 0.75 3.0 100 0 0.75 Type of column: Waters ACQUITY UPLC HSS T3; Column length: 30 mm; Internal diameter of column: 2.1 mm; Particle Size: 1.8 micron; Temperature: 60° C.

BIOLOGICAL EXAMPLES

Spodoptera littoralis (Egyptian Cotton Leafworm):

Cotton leaf discs were placed on agar in a 24-well microtiter plate and sprayed with test solutions at an application rate of 200 ppm. After drying, the leaf discs were infested with 5 μl larvae. The samples were checked for mortality, feeding behavior, and growth regulation 3 days after treatment (DAT).

The following compound gave at least 80% control of Spodoptera littoralis: A01, A02, A03, A04, A05, A06, A07, A08, A09, A10, A11, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, A42, A43, A44, A45, A46, A47, A48, A49, A50, A51, A52, A53, A54, A55, A56, A57, A58, A59, A60, A61, A62, A63, A64, A67, A68, A69, A70, A71, A72, A73, A74, A75, A76, A77, A78, A79, B1, B2, C1, C2, C3, D1, D2, D3.

Heliothis virescens (Tobacco Budworm):

Eggs (0-24 h old) were placed in 24-well microtiter plate on artificial diet and treated with test solutions at an application rate of 200 ppm (concentration in well 18 ppm) by pipetting. After an incubation period of 4 days, samples were checked for egg mortality, larval mortality, and growth regulation.

The following compound gave at least 80% control of Heliothis virescens: A01, A02, A03, A04, A05, A06, A07, A08, A09, A10, A11, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, A42, A43, A44, A45, A46, A48, A49, A50, A51, A52, A53, A54, A55, A56, A57, A58, A59, A60, A61, A62, A63,

A64, A66, A67, A68, A69, A70, A71, A72, A73, A74, A75, A76, A77, A78, A79, B1, B2, C1, C2, C3, D1, D2, D3.

Plutella xylostella (Diamond Back Moth):

24-well microtiter plate (MTP) with artificial diet was treated with test solutions at an application rate of 200 ppm (concentration in well 18 ppm) by pipetting. After drying, the MTPs were infested with L2 larvae (7-12 per well). After an incubation period of 6 days, samples were checked for larval mortality and growth regulation.

The following compound gave at least 80% control of Plutella xylostella: A01, A02, A03, A04, A05, A06, A07, A08, A09, A10, A11, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, A42, A43, A44, A45, A46, A48, A49, A50, A51, A52, A53, A54, A55, A56, A57, A58, A59, A60, A62, A63, A64, A67, A68, A69, A70, A71, A72, A73, A74, A75, A76, A77, A78, A79, B1, B2, C1, C2, C3, D1, D2, D3.

Diabrotica balteata (Corn Root Worm):

A 24-well microtiter plate (MTP) with artificial diet was treated with test solutions at an application rate of 200 ppm (concentration in well 18 ppm) by pipetting. After drying, the MTPs were infested with L2 larvae (6-10 per well). After an incubation period of 5 days, samples were checked for larval mortality and growth regulation.

The following compound gave at least 80% control of Diabrotica balteata: A01, A02, A03, A04, A05, A06, A07, A08, A09, A10, A11, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A42, A43, A44, A45, A46, A48, A49, A50, A51, A52, A53, A54, A55, A56, A57, A58, A59, A60, A61, A62, A63, A64, A66, A67, A68, A69, A70, A71, A72, A73, A74, A75, A76, A77, A78, A79, B1, B2, C1, C2, C3, D1, D2, D3.

Thrips tabaci (Onion Thrips):

Sunflower leaf discs were placed on agar in a 24-well microtiter plate and sprayed with test solutions at an application rate of 200 ppm. After drying, the leaf discs were infested with a thrips population of mixed ages. After an incubation period of 7 days, samples were checked for mortality.

The following compounds gave at least 80% control of Thrips tabaci: A01, A02, A03, A04, A05, A06, A07, A08, A09, A10, A11, A12, A13, A14, A15, A16, A17, A18, A19, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A38, A39, A40, A42, A43, A45, A46, A48, A50, A51, A52, A53, A54, A55, A56, A58, A59, A60, A62, A63, A64, A67, A68, A69, A70, A71, A72, A73, A74, A75, A76, A77, A78, A79, B1, B2, C1, C2, C3, D1, D2, D3.

Tetranychus urticae (Two-Spotted Spider Mite):

Bean leaf discs on agar in 24-well microtiter plates were sprayed with test solutions at an application rate of 200 ppm. After drying, the leaf discs are infested with mite populations of mixed ages. 8 days later, discs are checked for egg mortality, larval mortality, and adult mortality.

The following compound gave at least 80% control of Tetranychus urticae: A01, A02, A03, A04, A05, A06, A07, A08, A09, A10, A11, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A42, A45, A46, A48, A49, A50, A51, A52, A53, A54, A55, A57, A59, A60, A62, A63, A66, A67, A68, A69, A70, A71, A72, A73, A74, A75, A76, A77, A78, A79, B1, B2, C1, C2, C3, D1, D2, D3.

Biological Examples Showing Increased Safety Profile:

Spodoptera littoralis (Egyptian Cotton Leafworm)

Cotton plants in the 5^(th) leaf stage (around 5 weeks old) are treated in an automated turn table spray chamber. Plants are stored in the greenhouse length during the whole test period.

2, 16 and optionally 10 days after treatment 4 leaves from each sample are excised, placed into 14 cm plastic petri dishes on wet filter paper. The infestation of 10 L3-Spodoptera littoralis is made immediately afterwards. After an incubation period of 6 days the samples are checked for mortality.

Test Results:

Application rate Control after Control after Compound (in ppm) 2 days/% 16 days/% Compound A12 12.5 30 Compound A24 12.5 100 0 Compound D1 12.5 100 10 Compound C1 12.5 100 5 Compound C3 12.5 100 0 Compound A45 12.5 75 0 Compound A46 12.5 40 0 Compound A53 12.5 85 0 Compound A59 12.5 100 10 Compound A76 12.5 65 0 Comparative Tests

In the following series of experiments the compounds of the invention are compared with the corresponding isoxazoline analogues from the prior art on Spodoptera littoralis (Egyptian cotton leafworm) performed as described in the method above.

Comparative Table 1 In this comparison it can be seen that the structures of the two compounds are identical apart from the replacement of the oxygen atom with a sulphur atom in the isoxazoline moiety.

Application Control after Control after Control after Compound rate/ppm 2 days/% 10 days/% 16 days/% Compound 1-061 from EP1731512 12.5 100 100 100 Compound A16 present invention 12.5 100  25  10

Comparative Table 2 In this comparison it can be seen that the structures of the two compounds are identical apart from the replacement of the oxygen atom with a sulphur atom in the isoxazoline moiety.

Application Control after Control after Control after Compound rate/ppm 2 days/% 10 days/% 16 days/% Compound A10 from WO2009/080250 12.5 100 100 100 Compound A02 present invention 12.5 100  35  5

Comparative Table 3 In this comparison it can be seen that the structures of the two compounds are identical apart from the replacement of the oxygen atom with a sulphur atom in the isoxazoline moiety.

Application Control after Control after Control after Compound rate/ppm 2 days/% 10 days/% 16 days/% Compound 3-086 from EP1731512 12.5 100 100 100 Compound A01 present invention 12.5 100  60  10

CONCLUSIONS

Compounds that exhibit high control of pests at low application rates and that are readily bio-degradable are highly desirable for environmental safety reasons. The data shown above indicate that the compounds of the invention exhibit high pesticidal activity during the days immediately after application, with the activity significantly reduced after 10 to 16 days indicating that the compounds are bio-degrading. In contract, the close structural analogues from the prior art show little or no reduction in activity during the testing period, indicating that the compounds show no significant bio-degradation.

From the perspective of environmental safety the compounds of the invention are superior to those of the prior art and in addition retain a high level of pest control at low application rates. In the light of the structural similarities of the tested compounds, this significant difference in bio-degradability in favour of the compounds of the invention is completely unexpected and cannot be derived from what is known from the prior art. 

The invention claimed is:
 1. A compound of formula (I)

wherein P is P0, heterocyclyl or heterocyclyl substituted by one to five Z;

Y¹, Y², Y³ and Y⁴ are independently of each other C—H, C—R⁵, or nitrogen; G¹ is oxygen or sulfur; R¹ is hydrogen, C₁-C₈alkyl, C₁-C₈alkoxy-, C₁-C₈alkylcarbonyl-, or C₁-C₈alkoxycarbonyl-; R² is C₁-C₈alkyl or C₁-C₈alkyl substituted by one to five R⁶, C₃-C₁₀cycloalkyl or C₃-C₁₀cycloalkyl substituted by one to five R⁷, aryl-C₁-C₄alkylene- or aryl-C₁-C₄alkylene-wherein the aryl moiety is substituted by one to five R⁸, heterocyclyl-C₁-C₄alkylene-or heterocyclyl-C₁-C₄alkylene- wherein the heterocyclyl moiety is substituted by one to five R⁸, aryl-N(R²⁰)- or aryl-N(R²⁰)- wherein the aryl moiety is substituted by one to five R⁸, heterocyclyl-N(R²⁰)- or heterocyclyl-N(R²⁰)- wherein the heterocyclyl moiety is substituted by one to five R⁸, aryl or aryl substituted by one to five R⁸, heterocyclyl or heterocyclyl substituted by one to five R⁸, C₁-C₈alkylaminocarbonyl-C₁-C₄ alkylene, C₁-C₈ haloalkylaminocarbonyl-C₁-C₄ alkylene, C₃-C₈ cycloalkyl-aminocarbonyl-C₁-C₄alkylene, C₁-C₈alkylaminocarbonyl-, C₁-C₈haloalkylaminocarbonyl, C₃-C₈cycloalkyl-aminocarbonyl, C₁-C₆alkyl-O—N═CH— or C₁-C₆haloaklyl-O—N═CH—; or R¹ and R² together represent group A

G² is O(R¹³), N(R¹⁴)(R¹⁵) or S(R¹⁶); G³ is N(R¹⁷)(R¹⁸) or S(R¹⁹); X⁴ is C₁-C₈haloalkyl; R⁴ is aryl or aryl substituted by one to five R⁹, or heteroaryl or heteroaryl substituted by one to five R⁹; each R⁵ is independently halogen, cyano, nitro, C₂-C₈alkenyl, C₂-C₈haloalkenyl, C₂-C₈alkynyl, C₂-C₈haloalkynyl, C₁-C₈alkynyl, C₁-C₈haloalkynyl, C₃-C₁₀cycloalkyl, C₁-C ₈alkoxy-, C₁-C₈haloalkoxy-, C₁-C₈alkylthio-, C₁-C₈haloalkylthio-, C₁-C₈alkylsulfinyl-, C₁-C₈haloalkylsulfinyl-, C₁-C₈alkylsulfonyl-, or C₁-C₈haloalkylsulfonyl-; or two R⁵ on adjacent carbon atoms together form a —CH═CH—CH═CH— bridge; each R⁶ is independently halogen, cyano, nitro, hydroxy, amino, C₁-C₈alkylamino, (C₁-C₈alkyl)₂amino, C₁-C₈alkylcarbonylamino, C₁-C₈haloalkylcarbonylamino, C₁-C₈alkoxy-, C₁-C₈haloalkoxy-, aryloxy or aryloxy substituted by one to five R¹⁰, aryloxy-C₁-C₄alkylene or aryloxy-C₁-C₄alkylene wherein the aryl moiety is substituted by one to five R¹⁰, C₁-C₈alkylcarbonyl-, C₁-C₈alkoxycarbonyl-, mercapto, C₁-C₈alkylthio-, C₁-C₈haloalkylthio-, C₁-C₈alkylsulfinyl-, C₁-C₈haloalkylsulfinyl-, C₁-C₈alkylsulfonyl-, C₁-C₈haloalkylsulfonyl-, aryl-C₁-C₄alkylthio or aryl-C₁-C₄alkylthio wherein the aryl moiety is substituted by one to five R¹⁰; each R⁷ is independently halogen, C₁-C₈alkyl, C₂-C₈alkenyl, C₂-C₈alkynyl, C₁-C₈alkyl-O—N═, C₁-C₈haloalkyl-O—N═; C₁-C₈alkoxy or C₁-C₈alkoxycarbonyl; each R⁸ is independently halogen, cyano, nitro, oxo, C₁-C₈alkyl, C₁-C₈haloalkyl, C₁-C₈cyanoalkyl, C₂-C₈alkenyl, C₂-C₈haloalkenyl, C₂-C₈alkynyl, C₂-C₈haloalkynyl, C₃-C₁₀cycloalkyl, C₃-C₁₀cycloalkyl-C₁-C₄alkylene, hydroxy, C₁-C₈alkoxy-, C₁-C₈haloalkoxy-, mercapto, C₁-C₈alkylthio-, C₁-C₈haloalkylthio-, C₁-C₈alkylsulfinyl-, C₁-C₈haloalkylsulfinyl-, C₁-C₈alkylsulfonyl-, C₁-C₈haloalkylsulfonyl-, C₁-C₈alkylaminosulfonyl, (C₁-C₈alkyl)₂aminosulfonyl-, C₁-C₈alkylcarbonyl-, C₁-C₈alkoxycarbonyl-, aryl or aryl substituted by one to five R¹⁰, heterocyclyl or heterocyclyl substituted by one to five R¹⁰, aryl-C₁-C₄alkylene or aryl-C₁-C₄alkylene wherein the aryl moiety is substituted by one to five R¹⁰, heterocyclyl-C₁-C₄alkylene or heterocyclyl-C₁-C₄alkylene wherein the heterocyclyl moiety is substituted by one to five R¹⁰, aryloxy or aryloxy substituted by one to five R¹⁰, aryloxy-C₁-C₄alkylene or aryloxy-C₁-C₄alkylene wherein the aryl moiety is substituted by one to five R¹⁰; each R⁹ is independently halogen, cyano, nitro, C₁-C₈alkyl, C₁-C₈haloalkyl, C₂-C₈alkenyl, C₂-C₈haloalkenyl, C₂-C₈alkynyl, C₂-C₈haloalkynyl, hydroxy, C₁-C₈alkoxy-, C₁-C₈haloalkoxy-, mercapto, C₁-C₈alkylthio-, C₁-C₈haloalkylthio-, C₁-C₈alkylsulfinyl-, C₁-C₈haloalkylsulfinyl-, C₁-C₈alkylsulfonyl-, C₁-C₈haloalkylsulfonyl-, C₁-C₈alkylcarbonyl-, C₁-C₈alkoxycarbonyl-, aryl or aryl substituted by one to five R¹⁰, or heterocyclyl or heterocyclyl substituted by one to five R¹⁰; each R¹⁰ is independently halogen, cyano, nitro, C₁C₄alkyl, C₁C₄haloalkyl, C₁-C₄alkoxy-, or C₁C₄haloalkoxy-; each Z is independently halogen, C₁-C₁₂alkyl or C₁-C₁₂alkyl substituted by one to five R⁶, nitro, C₁-C₁₂alkoxy or C₁-C₁₂alkoxy substituted by one to five R⁶, cyano, C₁-C₁₂alkylsulfinyl, C₁-C₁₂alkylsulfonyl, C₁-C₁₂haloalkylsulfinyl, C₁-C₁₂haloalkylsulfonyl, hydroxyl or thiol; R¹³, R¹⁶ and R¹⁹ are independently C₁-C₄ alkyl; R¹⁴, R¹⁵, R¹⁷, and R¹⁸ are independently hydrogen or C₁-C₄ alkyl; R²⁰ is hydrogen or C₁-C₄ alkyl; or a salt or N-oxide thereof.
 2. A compound according to claim 1 wherein Y¹ is C—R^(5b), C—H or nitrogen, Y² and Y³ are independently C—H or nitrogen and Y⁴ is C—R⁵; wherein no more than two of Y¹, Y² and Y³ are nitrogen and wherein Y² and Y³ are not both nitrogen, and wherein R^(5b) when present forms a —CH═CH—CH═CH— bridge with R⁵.
 3. A compound according to claim 1 wherein G¹ is oxygen.
 4. A compound according to claim 1, wherein P is P0 or a heterocycle selected from H1 to H9

k is 0, 1 or
 2. 5. A compound according to claim 1 wherein R¹ is hydrogen, methyl, ethyl, methylcarbonyl-, or methoxycarbonyl-.
 6. A compound according to claim 1 wherein R² is C₁-C₈alkyl or C₁-C₈alkyl substituted by one to five R⁶, C₃-C₁₀cycloalkyl or C₃-C₁₀cycloalkyl substituted by one to five R⁷, aryl-C₁-C₄alkylene- or aryl-C₁-C₄alkylene- wherein the aryl moiety is substituted by one to five R⁸, heterocyclyl-C₁-C₄alkylene- or heterocyclyl-C₁-C₄alkylene- wherein the heterocyclyl moiety is substituted by one to five R⁸, aryl or aryl substituted by one to five R⁸, heterocyclyl or heterocyclyl substituted by one to five R⁸, C₁-C₈alkylaminocarbonyl-C₁-C₄ alkylene, C₁-C₈haloalkylaminocarbonyl-C₁-C₄ alkylene, C₃-C₈cycloalkyl-aminocarbonyl-C₁-C₄ alkylene, or group C1

R¹¹ is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, cyclopropyl, cyclopropyl-methyl, cyclobutyl, cyclobutyl-methyl, oxetanyl, thietanyl, trifluoroethyl, difluoroethyl, allyl, propargyl, cyanomethyl, benzyl, benzyl substituted by one to three R¹², or R¹¹ is pyridyl-methyl- or pyridyl-methyl- substituted by one to three R¹²; each R¹² is independently fluoro, chloro, bromo, trifluoromethyl, trifluoromethoxy, cyano or methoxy; wherein each aryl group is a phenyl group and each heterocyclyl group is independently selected from pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, tetrahydrothiophenyl, tetrazolyl, furanyl, thiophenyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, quinolinyl, cinnolinyl, quinoxalinyl, indolyl, indazolyl, benzimidazolyl, benzothiophenyl, benzothiazolyl, oxetanyl, thietanyl, oxo-thietanyl, dioxo-thietanyl, pyrrolidinyl, tetrahydrofuranyl, [1,3]dioxolanyl, piperidinyl, piperazinyl, [1,4]dioxanyl, and morpholinyl, 2,3-dihydro-benzofuranyl, benzo[1,3]dioxolanyl, and 2,3-dihydro-benzo-[1 ,4]dioxinyl.
 7. A compound according to claim 6 wherein R² is C₁-C₈alkyl or C₁-C₈alkyl substituted by one to five R⁶, C₃-C₁₀cycloalkyl or C₃-C₁₀cycloalkyl substituted by one to five R⁷, phenyl-C₁-C₄alkylene- or phenyl-C₁-C₄alkylene- wherein the phenyl moiety is substituted by one to five R⁸, pyridyl-C₁-C₄alkylene- or pyridyl-C₁-C₄alkylene-wherein the pyridyl moiety is substituted by one to four R⁸, oxetanyl or oxetanyl substituted by one to five R⁸, thietanyl-C₁-C₄ alkylene or thietanyl-C₁-C₄ alkylene wherein the thietanyl moiety is substituted by one to five R⁸, oxo-thietanyl-C₁-C₄ alkylene or oxo-thietanyl-C₁-C₄ alkylene wherein the oxo-thietanyl moiety is substituted by one to five R⁸, dioxo-thietanyl-C₁-C₄ alkylene or dioxo-thietanyl-C₁-C₄ alkylene wherein the dioxo-thietanyl moiety is substituted by one to five R⁸, thietanyl or thietanyl substituted by one to five R⁸, oxo-thietanyl or oxo-thietanyl substituted by one to five R⁸, dioxo-thietanyl or dioxo-thietanyl substituted by one to five R⁸, C₁-C₈alkylaminocarbonyl-C₁-C₄ alkylene, C₁-C₈haloalkylaminocarbonyl-C₁-C₄ alkylene, or C₃-C₈cycloalkyl-aminocarbonyl-C₁-C₄ alkylene or group C1


8. A compound according to claim 1 wherein X⁴ is chlorodifluoromethyl or trifluoromethyl.
 9. A compound according to claim 1 wherein R⁴ is aryl or aryl substituted by one to five R⁹.
 10. A compound according to claim 1, wherein the compound of formula I is a compound of formula Ic

wherein Y¹ is C—R^(5b), CH or nitrogen; Y² and Y³ are independently CH or nitrogen; wherein no more than two of Y¹, Y² and Y³ are nitrogen and wherein Y² and Y³ are not both nitrogen; R⁵ is hydrogen, halogen, cyano, nitro, NH₂, C₁-C₂alkyl, C₁-C₂haloalkyl, C₃-C₅cycloalkyl, C₃-C₅halocycloalkyl, C₁-C₂alkoxy or C₁-C₂haloalkoxy; R^(5b) when present together with R⁵ forms a —CH═CH—CH═CH— bridge; X² is C—X⁶ or nitrogen; X¹, X³ and X⁶ are independently hydrogen, halogen or trihalomethyl, wherein at least two of X¹, X³ and X⁶ are not hydrogen; X⁴ is trifluoromethyl, difluoromethyl or chlorodifluoromethyl.
 11. A method of controlling insects, acarines, nematodes or molluscs which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I) as defined in claim
 1. 12. An insecticidal, acaricidal, nematicidal or molluscicidal composition comprising an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I) as defined in claim
 1. 13. An insecticidal, acaricidal, nematicidal or molluscicidal composition according to claim 12 comprising at least one additional compound having biological activity.
 14. A combination product comprising a pesticidally effective amount of a component A and a pesticidally effective amount of component B, wherein component A is a compound of formula (I) as defined in claim 1, and compound B is imidacloprid, enrofloxacin, praziquantel, pyrantel embonate, febantel, penethamate, moloxicam, cefalexin, kanamycin, pimobendan, clenbuterol, fipronil, ivermectin, omeprazole, tiamulin, benazepril, milbemycin, cyromazine, thiamethoxam, pyriprole, deltamethrin, cefquinome, florfenicol, buserelin, cefovecin, tulathromycin, ceftiour, selamectin, carprofen, metaflumizone, moxidectin, methoprene (including S-methoprene), clorsulon, pyrantel, amitraz, triclabendazole, avermectin, abamectin, emamectin, eprinomectin, doramectin, selamectin, nemadectin, albendazole, cambendazole, fenbendazole, flubendazole, mebendazole, oxfendazole, oxibendazole, parbendazole, tetramisole, levamisole, pyrantel pamoate, oxantel, morantel, triclabendazole, epsiprantel, fipronil, lufenuron, ecdysone or tebufenozide. 